KEGG ORTHOLOGY: K07438

ORTHOLOGY: K07438

Entry

K07438                      KO

Symbol

CYP27B1

Name

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]

Pathway

map00100

Steroid biosynthesis

map01100

Metabolic pathways

map04928

Parathyroid hormone synthesis, secretion and action

map05152

Tuberculosis

Module

M00103

Cholecalciferol biosynthesis

Reaction

R03610

calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)

R11324

secalciferol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)

Disease

H00408

Type 1 diabetes mellitus

H01143

Vitamin D-dependent rickets

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.18  calcidiol 1-monooxygenase
     K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP27 family
   K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)

Other DBs

GO:

0004498

Genes

HSA:	1594(CYP27B1)

PTR:	452027(CYP27B1)

PPS:	100974264(CYP27B1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	715747(CYP27B1)

MCF:	102117707(CYP27B1)

MTHB:

126930378

MNI:

105474079

CSAB:

103238591(CYP27B1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100388588(CYP27B1)

SBQ:

101042462

CIMI:

108309743(CYP27B1)

ANAN:

105729111(CYP27B1)

CSYR:

103264442

MMUR:

105877998

LCAT:

123639587

ERUF:

138397423(CYP27B1)

PCOQ:

105816771

OGA:

100961635

MMU:	13115(Cyp27b1)

MCAL:

110303958

MPAH:

110327080

RNO:	114700(Cyp27b1)

MCOC:

116075946

ANU:	143436276(Cyp27b1)

ASYL:

127670962

MMIU:

308435292(CYP27B1)

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102904812(Cyp27b1)

MORG:

MFOT:

AAMP:

CNL:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138803640(Cyp27b1)

PLOP:

125362044

NCAR:

124983979

SVUL:

306660733(CYP27B1)

MMMA:

107140112

ITI:

101978323

SCIL:

308657710(CYP27B1)

MAVE:

308269891(CYP27B1)

OCU:

OPI:

OCZ:

TUP:

GVR:	103588480 103609177

CFA:	481133(CYP27B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

MMAQ:

308348431(CYP27B1)

ORO:

EJU:

ZCA:

MLX:

MANO:

NSU:

LWW:

FCA:	100750221(CYP27B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:

PLEZ:

HHV:

CCRU:

144226141(CYP27B1)

BTA:	539630(CYP27B1)

BOM:	102278257(CYP27B1)

BIU:

BJV:

BBUB:

BKE:

BBIS:

CHX:

OAS:

OCAN:

138437470(CYP27B1)

BTAX:

128048747

CSUM:

138079116(CYP27B1)

ODA:

120857512

CCAD:

122427212

MREE:

136167271(CYP27B1)

OVR:	110124817(CYP27B1)

MBEZ:

129537200

SSC:	397055(CYP27B1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115858539(CYP27B1)

DDP:	132433827(CYP27B1)

SCOO:

307194659(CYP27B1)

PCRS:

137202123(CYP27B1)

DLE:

111173817

PCAD:

102984886

PSIU:

116760774

PPHC:

136131140(CYP27B1)

NASI:

112394343

HAMP:

307059910(CYP27B1)

ECB:	100034100(CYP27B1)

EPZ:	103553643(CYP27B1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139006968(CYP27B1)

PKL:

118730267

EFUS:

103292480

POTS:

308244692(CYP27B1)

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

RHII:

308502241(CYP27B1)

PALE:

PGIG:

PVP:

RAY:

MJV:	108387803(CYP27B1)

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

PBRV:

138155305(CYP27B1)

MLAO:

141515029(CYP27B1)

OAA:

114814717

TACU:

119933482

AACU:

137846012(CYP27B1)

LSR:

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139604804(CYP27B1)

FAB:

OMA:

PHI:

PMAJ:

CBRC:

ACOE:

138099900(CYP27B1)

ZLE:

ACHL:

SVG:

HRT:

SATI:

136372739(CYP27B1)

CCIC:

SHAB:

TALA:

ACHC:

HLE:

AGEN:

BBUT:

142041206(CYP27B1)

DPUB:

104304660

NNI:

104021543

PARX:

142048678(CYP27B1)

CBOR:

142073609(CYP27B1)

CBOY:

140644484(CYP27B1)

MAME:

142403484(CYP27B1)

CNIC:

CPEA:

AROW:

NPD:

ASN:

AMJ:

CPOO:

PSS:	102443605(CYP27B1)

CIZ:	142003098(CYP27B1)

CMY:

102946801

CCAY:

125627714

LKP:	140900862(CYP27B1)

NDS:	141974960(CYP27B1)

DCC:

CPIC:

TST:

EOB:

CABI:

116828443(CYP27B1)

MRV:	120391239(LOC120391239)

EMQ:	137140925(CYP27B1)

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139310714(CYP27B1)

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108708601(cyp27b1.L) 108709871(cyp27b1.S)

XTR:	448754(cyp27b1)

NPR:

108791588

RTEM:

120929439

ACAT:

141129835(CYP27B1)

PADS:

140327832(CYP27B1)

BBUF:

120996179

BGAR:

122931986

DTC:	141091388(CYP27B1)

HSQ:

130358804

PCOB:

135050659

PWL:	138292362(CYP27B1)

MUO:	115465067(CYP27B1)

GSH:	117357711(CYP27B1)

DRE:	793309(cyp27b1)

DAES:

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

GRF:	141293698(cyp27b1)

OMC:

131549861

PPRM:

120467743

RKG:

130077768

SCEP:

307150805(cyp27b1)

PPHX:

306991030(cyp27b1)

MAMB:

125256888 125261911

CIDE:

127522570

CERY:

137021300(cyp27b1)

MASI:

127428324

TROS:

130551291

TDW:

130410704

MANU:

129427074(cyp27b1)

PDAB:

135719304(cyp27b1)

IPU:

IFU:

SMEO:

TFD:

TVC:

CGAR:

NGRA:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

SPIL:

ASAD:

TRU:	101062641(cyp27b1)

TFS:

130524606

TNG:	GSTEN00033821G001

NCC:

104955571

TBEN:

117489730

CGOB:

115008521

PGEO:

117446167(cyp27b1)

GACU:

117534149

EMAC:

134882379

ELY:	117257290(cyp27b1)

EFO:

125895893

PLEP:

121956007

SLUC:

116066246

SVIT:

144516211(cyp27b1)

ECRA:

117942881

ESP:	116679836 116687227

PFLV:

PFLT:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137796239(cyp27b1)

TBU:	306736869(cyp27b1)

CVE:	137879467(cyp27b1)

AMIR:

142970541(cyp27b1)

MSAM:

119886596

SCHU:

122864359

EARM:

139282807(cyp27b1)

CUD:

121528681

SPUL:

138605413(cyp27b1)

LMIX:

132977828

HTC:	141791269(cyp27b1)

ALAT:

119021281

ASTR:

137595501(cyp27b1)

PKLU:

139216755(cyp27b1)

LCO:

109142364

AMMM:

307248979(cyp27b1)

MZE:	101476393(cyp27b1)

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

103465325(cyp27b1)

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

LTU:	140303562(cyp27b1)

TBT:	306757521(cyp27b1)

MCEP:

125007137

AOCE:

111587639

EJA:	138199261(cyp27b1)

BFRE:

138630689(cyp27b1)

LCF:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125976793(cyp27b1)

SBIA:

PEE:

PTAO:

BPEC:

ENY:	140365262(cyp27b1)

MALB:

BSPL:

SJO:

SSCO:

TTY:	137181714(cyp27b1)

GMH:

115556734

ZFA:	307230422(cyp27b1)

SASA:

106565446 106583283

STRU:

115150468 115207954

OTW:	112254699 112262073

OMY:	110494198 110528221

OGO:	124003988 124019410

ONE:	115143688 115146075

OKI:	109882615 109902824

OKE:	118389508 118400368

OMM:	135527292 135541843

OCLA:

139369781 139414377

SALP:

111965588 111970194

SNH:	120062013 120064579

SFON:

CCLU:

ELS:

OEP:

SFM:	108918367 108939170

PKI:

AANG:

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

CPUN:

140471344(cyp27b1)

HOC:

132805718

SCAU:

119958221(cyp27b1)

LERI:

129714633

HAKA:

140741304(cyp27b1)

PMRN:

LRJ:

AJJ:

ARUN:

AAMU:

AFIL:

140169047 140169450 140170168

PFLL:

139140609 139149513 139149514

PPOT:

106099942

PVUL:

126815583 126817612 126819097

BGT:

GAE:

CRG:

CANU:

MMER:

RPHI:

DPOL:

MAEA:

OSN:

LJP:	135465801 135466673

ATEN:

116299174

MCAZ:

138019740 138021305 138022234

MFOO:

137973050 137974724

» show all

Reference

PMID:12496369

Authors

Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R

Title

Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion.

Journal

Mol Cancer Res 1:56-67 (2002)

Sequence

[hsa:1594]

Reference

PMID:9344864

Authors

Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T

Title

Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.

Journal

Biochem Biophys Res Commun 239:527-33 (1997)
DOI:10.1006/bbrc.1997.7508

Sequence

[hsa:1594]

Reference

PMID:10518789

Authors

Sawada N, Sakaki T, Kitanaka S, Takeyama K, Kato S, Inouye K

Title

Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli.

Journal

Eur J Biochem 265:950-6 (1999)
DOI:10.1046/j.1432-1327.1999.00794.x

LinkDB

ENZYME: 1.14.15.18

Entry

EC 1.14.15.18               Enzyme

Name

calcidiol 1-monooxygenase;
25-hydroxycholecalciferol 1-hydroxylase;
25-hydroxycholecalciferol 1-monooxygenase;
1-hydroxylase-25-hydroxyvitamin D3;
25-hydroxy D3-1alpha-hydroxylase;
25-hydroxycholecalciferol 1alpha-hydroxylase;
25-hydroxyvitamin D3 1alpha-hydroxylase

Class

Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor

Sysname

calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)

Reaction(IUBMB)

(1) calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitriol + 2 oxidized adrenodoxin + H2O [RN:R03610];
(2) secalciferol + 2 reduced adrenodoxin + 2 H+ + O2 = calcitetrol + 2 oxidized adrenodoxin + H2O [RN:R11324]

Reaction(KEGG)

R03610 R11324

Substrate

calcidiol [CPD:C01561];
reduced adrenodoxin [CPD:C00662];
H+ [CPD:C00080];
O2 [CPD:C00007];
secalciferol [CPD:C07712]

Product

calcitriol [CPD:C01673];
oxidized adrenodoxin [CPD:C00667];
H2O [CPD:C00001];
calcitetrol [CPD:C18231]

Comment

A P-450 (heme-thiolate) enzyme found in mammals.

History

EC 1.14.15.18 created 1976 as EC 1.14.13.13, transferred 2016 to EC 1.14.15.18

Pathway

ec00100

Steroid biosynthesis

ec01100

Metabolic pathways

Orthology

K07438

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)

Genes

HSA:	1594(CYP27B1)

PTR:	452027(CYP27B1)

PPS:	100974264(CYP27B1)

GGO:

101146696

PON:

100443915

PPYG:

129009550

NLE:

100594622

HMH:

116480846

SSYN:

129465890

MCC:	715747(CYP27B1)

MCF:	102117707(CYP27B1)

MTHB:

126930378

MNI:

105474079

CSAB:

103238591(CYP27B1)

CATY:

105587234

PANU:

101009903

TGE:

112634833

MLEU:

105545594

RRO:

104682342

RBB:

108524407

TFN:

117089857

PTEH:

111541786

CANG:

105500481

CJC:	100388588(CYP27B1)

SBQ:

101042462

CIMI:

108309743(CYP27B1)

ANAN:

105729111(CYP27B1)

CSYR:

103264442

MMUR:

105877998

LCAT:

123639587

ERUF:

138397423(CYP27B1)

PCOQ:

105816771

OGA:

100961635

MMU:	13115(Cyp27b1)

MCAL:

110303958

MPAH:

110327080

RNO:	114700(Cyp27b1)

MCOC:

116075946

ANU:	143436276(Cyp27b1)

ASYL:

127670962

MMIU:

308435292(CYP27B1)

MUN:

110561784

CGE:

100760414

MAUA:

101840476

PROB:

127215682

PLEU:

114704779

PMAV:

102904812(Cyp27b1)

MORG:

121464015

MFOT:

126514764

AAMP:

119803686

CNL:

130866204

NGI:

103742896

HGL:

101700851

CPOC:

100717678

CCAN:

109686086

DORD:

105990140

DSP:

122124179

DMER:

138803640(Cyp27b1)

PLOP:

125362044

NCAR:

124983979

SVUL:

306660733(CYP27B1)

MMMA:

107140112

ITI:

101978323

SCIL:

308657710(CYP27B1)

MAVE:

308269891(CYP27B1)

OCU:

100341053

OPI:

101530921

OCZ:

121162918

TUP:

102492875

GVR:	103588480 103609177

CFA:	481133(CYP27B1)

CLUD:

112677953

VVP:

112922328

VLG:

121491053

NPO:

129511339

AML:

100481484

UMR:

103656705

UAH:

113256358

UAR:

123787194

ELK:

111160181

LLV:

125106498

MPUF:

101674682

MNP:

132019859

MLK:

131838536

NVS:

122892188

MMAQ:

308348431(CYP27B1)

ORO:

101363421

EJU:

114215050

ZCA:

113922553

MLX:

118008655

MANO:

123843580

NSU:

110577862

LWW:

102746290

FCA:	100750221(CYP27B1)

PYU:

121040851

PCOO:

112863857

PBG:

122473840

PVIV:

125169980

LRUF:

124501071

LGF:

123591098

AJU:

106975877

PTG:

102971063

PPAD:

109270394

PUC:

125919261

PLEZ:

122223653

HHV:

120248015

CCRU:

144226141(CYP27B1)

BTA:	539630(CYP27B1)

BOM:	102278257(CYP27B1)

BIU:

109559305

BJV:

133247643

BBUB:

102414554

BKE:

129650394

BBIS:

104988136

CHX:

102170758

OAS:

101116039

OCAN:

138437470(CYP27B1)

BTAX:

128048747

CSUM:

138079116(CYP27B1)

ODA:

120857512

CCAD:

122427212

MREE:

136167271(CYP27B1)

OVR:	110124817(CYP27B1)

MBEZ:

129537200

SSC:	397055(CYP27B1)

CFR:

102522811

CBAI:

105062143

CDK:

105100328

VPC:

102532825

BACU:

103001013

BMUS:

118901854

LVE:

103084276

OOR:

101284262

LALB:

132529360

GMF:	115858539(CYP27B1)

DDP:	132433827(CYP27B1)

SCOO:

307194659(CYP27B1)

PCRS:

137202123(CYP27B1)

DLE:

111173817

PCAD:

102984886

PSIU:

116760774

PPHC:

136131140(CYP27B1)

NASI:

112394343

HAMP:

307059910(CYP27B1)

ECB:	100034100(CYP27B1)

EPZ:	103553643(CYP27B1)

EAI:

106833020

MYB:

102262846

MYD:

102757775

MMYO:

118649575

MLF:

102431071

MDT:

132227832

MYUM:

139006968(CYP27B1)

PKL:

118730267

EFUS:

103292480

POTS:

308244692(CYP27B1)

MNA:

107546167

DRO:

112319168

SHON:

118975885

AJM:

119065237

PDIC:

114513469

PHAS:

123812846

MMF:

118623548

PPAM:

129076031

HAI:

109390756

RFQ:

117028656

RHII:

308502241(CYP27B1)

PALE:

102894468

PGIG:

120604970

PVP:

105307396

RAY:

107501490

MJV:	108387803(CYP27B1)

TOD:

119248104

SARA:

101536895

SFUM:

130026980

SETR:

126022227

LAV:

100657886

TMU:

101355020

ETF:

101646226

DNM:

101414278

MDO:

100031497

GAS:

123250198

SHR:

100913970

AFZ:

127538226

PCW:

110210991

TVP:

118852217

PBRV:

138155305(CYP27B1)

MLAO:

141515029(CYP27B1)

OAA:

114814717

TACU:

119933482

AACU:

137846012(CYP27B1)

LSR:

110473893

SCAN:

103824978

PMOA:

120499536

OTC:

121334301

PRUF:

121356351

ATRC:

139604804(CYP27B1)

FAB:

101816678

OMA:

130265843

PHI:

102103763

PMAJ:

107199279

CBRC:

103611929

ACOE:

138099900(CYP27B1)

ZLE:

135459043

ACHL:

103807649

SVG:

106862648

HRT:

120748275

SATI:

136372739(CYP27B1)

CCIC:

134054833

SHAB:

115618603

TALA:

116963700 122153819

ACHC:

115350948

HLE:

104832391

AGEN:

126037398

BBUT:

142041206(CYP27B1)

DPUB:

104304660

NNI:

104021543

PARX:

142048678(CYP27B1)

CBOR:

142073609(CYP27B1)

CBOY:

140644484(CYP27B1)

MAME:

142403484(CYP27B1)

CNIC:

136000605

CPEA:

104393340

AROW:

112972148

NPD:

112952263

ASN:

102386966

AMJ:

102574984

CPOO:

109324487

PSS:	102443605(CYP27B1)

CIZ:	142003098(CYP27B1)

CMY:

102946801

CCAY:

125627714

LKP:	140900862(CYP27B1)

NDS:	141974960(CYP27B1)

DCC:

119845937

CPIC:

101954100

TST:

117888845

EOB:

135891974

CABI:

116828443(CYP27B1)

MRV:	120391239(LOC120391239)

EMQ:	137140925(CYP27B1)

ACS:

100559713

ASAO:

132766522

PVT:

110074451

SUND:

121920838

PBI:

103060795

PMUR:

107291644

CTIG:

120297684

TSR:

106552999

PGUT:

117662682

PCAE:

139310714(CYP27B1)

APRI:

131191545

PTEX:

113445553

NSS:

113418481

VKO:

123029856

PMUA:

114593032

PRAF:

128405812

ZVI:

118078986

HCG:

128343754

GJA:

107119675

STOW:

125427926

EMC:

129346642

XLA:	108708601(cyp27b1.L) 108709871(cyp27b1.S)

XTR:	448754(cyp27b1)

NPR:

108791588

RTEM:

120929439

ACAT:

141129835(CYP27B1)

PADS:

140327832(CYP27B1)

BBUF:

120996179

BGAR:

122931986

DTC:	141091388(CYP27B1)

HSQ:

130358804

PCOB:

135050659

PWL:	138292362(CYP27B1)

MUO:	115465067(CYP27B1)

GSH:	117357711(CYP27B1)

DRE:	793309(cyp27b1)

DAES:

130237497 130237763

SRX:

107747831

SANH:

107684010

SGH:

107561793

CCAR:

122133866

CAUA:

113068164

CGIB:

127968595

PTET:

122353667

LROH:

127173226

GRF:	141293698(cyp27b1)

OMC:

131549861

PPRM:

120467743

RKG:

130077768

SCEP:

307150805(cyp27b1)

PPHX:

306991030(cyp27b1)

MAMB:

125256888 125261911

CIDE:

127522570

CERY:

137021300(cyp27b1)

MASI:

127428324

TROS:

130551291

TDW:

130410704

MANU:

129427074(cyp27b1)

PDAB:

135719304(cyp27b1)

IPU:

108254794

IFU:

128625019

SMEO:

124402328

TFD:

113639045

TVC:

132838018

CGAR:

128511431

NGRA:

132874620

TRN:

134301741

AMEX:

103035224

CMAO:

118799357

EEE:

113572450

CHAR:

105907733

SPIL:

134092554

ASAD:

121707698

TRU:	101062641(cyp27b1)

TFS:

130524606

TNG:	GSTEN00033821G001

NCC:

104955571

TBEN:

117489730

CGOB:

115008521

PGEO:

117446167(cyp27b1)

GACU:

117534149

EMAC:

134882379

ELY:	117257290(cyp27b1)

EFO:

125895893

PLEP:

121956007

SLUC:

116066246

SVIT:

144516211(cyp27b1)

ECRA:

117942881

ESP:	116679836 116687227

PFLV:

114554512

PFLT:

120558053

GAT:

120835315

PPUG:

119194159

AFB:

129105820

CLUM:

117731316

PSWI:

130208381

CANA:

137796239(cyp27b1)

TBU:	306736869(cyp27b1)

CVE:	137879467(cyp27b1)

AMIR:

142970541(cyp27b1)

MSAM:

119886596

SCHU:

122864359

EARM:

139282807(cyp27b1)

CUD:

121528681

SPUL:

138605413(cyp27b1)

LMIX:

132977828

HTC:	141791269(cyp27b1)

ALAT:

119021281

ASTR:

137595501(cyp27b1)

PKLU:

139216755(cyp27b1)

LCO:

109142364

AMMM:

307248979(cyp27b1)

MZE:	101476393(cyp27b1)

ONL:

100706100

OAU:

116326616

OLA:

101172325

OML:

112145670

CSAI:

133448712

XMA:

102222483

XCO:

114134887

XHE:

116709734

PRET:

103465325(cyp27b1)

PFOR:

103129584

PLAI:

106935833

PMEI:

106929457

GAF:

122834207

PPRL:

129358301

CVG:

107082096

CTUL:

119795482

GMU:

124856373

NFU:

107385653

KMR:

108235620

ALIM:

106518084

NWH:

119412594

LTU:	140303562(cyp27b1)

TBT:	306757521(cyp27b1)

MCEP:

125007137

AOCE:

111587639

EJA:	138199261(cyp27b1)

BFRE:

138630689(cyp27b1)

LCF:

108898968

CSEM:

103386049

POV:

109628943

SSEN:

122767755

SSOE:

131460954

HHIP:

117761420

HSP:

118104984

PPLT:

128449127

SMAU:

118310005

SDU:

111221905

SLAL:

111667688

XGL:

120806983

HCQ:

109522134

SSCV:

125976793(cyp27b1)

SBIA:

133507929

PEE:

133408676

PTAO:

133484068

BPEC:

110171326

ENY:	140365262(cyp27b1)

MALB:

109956137

BSPL:

114856290

SJO:

128356147

SSCO:

134005454

TTY:	137181714(cyp27b1)

GMH:

115556734

ZFA:	307230422(cyp27b1)

SASA:

106565446 106583283

STRU:

115150468 115207954

OTW:	112254699 112262073

OMY:	110494198 110528221

OGO:	124003988 124019410

ONE:	115143688 115146075

OKI:	109882615 109902824

OKE:	118389508 118400368

OMM:	135527292 135541843

OCLA:

139369781 139414377

SALP:

111965588 111970194

SNH:	120062013 120064579

SFON:

129815414 129846153

CCLU:

121575162 121577839

ELS:

105017033

OEP:

134031175

SFM:	108918367 108939170

PKI:

111854850

AANG:

118210837

AROT:

135238034

CCOG:

133109991

LOC:

102685924

PSPA:

121308962

ARUT:

117400985 117966943

PSEX:

120524845

LCM:

102346327

CMK:

103191415

RTP:

109925523

CPLA:

122543275

CPUN:

140471344(cyp27b1)

HOC:

132805718

SCAU:

119958221(cyp27b1)

LERI:

129714633

HAKA:

140741304(cyp27b1)

PMRN:

116941144

LRJ:

133344635

AJJ:

139958855

ARUN:

117289714

AAMU:

139934598

AFIL:

140169047 140169450 140170168

PFLL:

139140609 139149513 139149514

PPOT:

106099942

PVUL:

126815583 126817612 126819097

BGT:

106053581

GAE:

121389521

CRG:

105346613

CANU:

128189445

MMER:

123550682

RPHI:

132726491

DPOL:

127856113

MAEA:

128243703

OSN:

115209661

LJP:	135465801 135466673

ATEN:

116299174

MCAZ:

138019740 138021305 138022234

MFOO:

137973050 137974724

» show all

Reference

1 [PMID:4404596]

Authors

Gray RW, Omdahl JL, Ghazarian JG, DeLuca HF.

Title

25-Hydroxycholecalciferol-1-hydroxylase. Subcellular location and properties.

Journal

J Biol Chem 247:7528-32 (1972)

Reference

2 [PMID:10092858]

Authors

Sakaki T, Sawada N, Takeyama K, Kato S, Inouye K

Title

Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli.

Journal

Eur J Biochem 259:731-8 (1999)
DOI:10.1046/j.1432-1327.1999.00096.x

Reference

3 [PMID:10518789]

Authors

Sawada N, Sakaki T, Kitanaka S, Takeyama K, Kato S, Inouye K

Title

Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli.

Journal

Eur J Biochem 265:950-6 (1999)
DOI:10.1046/j.1432-1327.1999.00794.x

Other DBs

ExplorEnz - The Enzyme Database:

1.14.15.18

IUBMB Enzyme Nomenclature:

1.14.15.18

ExPASy - ENZYME nomenclature database:

1.14.15.18

BRENDA, the Enzyme Database:

1.14.15.18

CAS:

9081-36-1

LinkDB

REACTION: R03610

Entry

R03610                      Reaction

Name

calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)

Definition

Calcidiol + 2 Reduced adrenal ferredoxin + 2 H+ + Oxygen <=> Calcitriol + Oxidized adrenal ferredoxin + H2O

Equation

C01561 + 2 C00662 + 2 C00080 + C00007 <=> C01673 + C00667 + C00001

Reaction class

RC00723

C01561_C01673

Enzyme

1.14.15.18

Pathway

rn00100

Steroid biosynthesis

rn01100

Metabolic pathways

Module

M00103

Cholecalciferol biosynthesis

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.18
     R03610  Calcidiol + 2 Reduced adrenal ferredoxin + 2 H+ + Oxygen <=> Calcitriol + Oxidized adrenal ferredoxin + H2O

Orthology

K07438

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]

Other DBs

RHEA:

20576

LinkDB

DBGET integrated database retrieval system