KEGG ORTHOLOGY: K07440

ORTHOLOGY: K07440

Entry

K07440                      KO

Symbol

CYP46A1

Name

cholesterol 24-hydroxylase [EC:1.14.14.25]

Pathway

map00120

Primary bile acid biosynthesis

Reaction

R07207

cholesterol,NADPH-hemoprotein reductase:oxygen oxidoreductase (24-hydroxylating)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K07440  CYP46A1; cholesterol 24-hydroxylase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07440  CYP46A1; cholesterol 24-hydroxylase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.25  cholesterol 24-hydroxylase
     K07440  CYP46A1; cholesterol 24-hydroxylase
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP46 family
   K07440  CYP46A1; cholesterol 24-hydroxylase

Other DBs

GO:

0033781

Genes

HSA:	10858(CYP46A1)

PTR:	453154(CYP46A1)

PPS:	100978372(CYP46A1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:	102140307(CYP46A1)

MTHB:

126958426

MNI:

105467428

CSAB:

103229682(CYP46A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100403833(CYP46A1)

SBQ:

101048333

CIMI:

108304092(CYP46A1)

ANAN:

105730202(CYP46A1)

CSYR:

103252598

MMUR:

105861542

LCAT:

123640115

ERUF:

138380838(CYP46A1)

PCOQ:

105814966

OGA:

100967073

MMU:	13116(Cyp46a1)

MCAL:

110306885

MPAH:

110324576

RNO:	362782(Cyp46a1)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

PMAV:

102908607(Cyp46a1)

MORG:

MFOT:

AAMP:

CNL:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

DMER:

138810452(Cyp46a1)

PLOP:

NCAR:

MMMA:

ITI:

OCU:

OPI:

OCZ:

TUP:

GVR:

CFA:	480432(CYP46A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101093112(CYP46A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:

PPAD:

PUC:	125917830 125917833

PLEZ:

122221441

HHV:

120245736

BTA:	506438(CYP46A1)

BOM:	102270768(CYP46A1)

BBUB:

BKE:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

138095518(CYP46A1)

ODA:

120875206

CCAD:

122419692

MREE:

136147435(CYP46A1)

OVR:	110140597(CYP46A1)

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

LALB:

GMF:	115867244(CYP46A1)

DDP:	132419422(CYP46A1)

DLE:

111176091

PCAD:

102976598

PSIU:

116749111

PPHC:

136118834(CYP46A1)

NASI:

112409398

ECB:

100051131

EPZ:	103550566(CYP46A1)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

139001397(CYP46A1) 139001749

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

SHR:

AFZ:

PCW:

TVP:

PBRV:

OAA:

GGA:	423450(CYP46A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

AACU:

137856905(CYP46A1)

ACYG:

106036083(CYP46A1)

CATA:

118258199

AFUL:

116489988

TGU:

100221970

LSR:	110481165(CYP46A1)

SCAN:

PMOA:

OTC:

PRUF:

ATRC:

139589786(CYP46A1)

GFR:

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ACOE:

138111831(CYP46A1)

ETL:

ZAB:

ZLE:

ACHL:

SVG:

MMEA:

HRT:

SATI:

136362912(CYP46A1)

CCIC:

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

SURA:

141943449(CYP46A1)

TALA:

ACHC:

HALD:

HLE:

AGEN:

HHAR:

BBUT:

142031947(CYP46A1)

GCL:

LDI:

MNB:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

FGA:

CBOR:

142082731(CYP46A1)

GSTE:

104264892

CBOY:

140653480(CYP46A1)

MAME:

142410651(CYP46A1)

CLV:

CNIC:

MUI:

PGUU:

PLET:

EHS:

CMAC:

CUCA:

TEO:

BREG:

OHA:

ACAR:

CPEA:

CVF:

RTD:

CRID:

LMIC:

141742240(CYP46A1)

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102574122(CYP46A1)

CPOO:

109321748

GGN:

109298462

PSS:

102449598

CIZ:	142014257(CYP46A1) 142014259

CMY:

102937516

CCAY:

125639047

LKP:	140913361(CYP46A1)

NDS:	141989481(CYP46A1)

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100552409 100552607

ASAO:

132761810 132762545

PVT:	110089659 110089661

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

139308109(CYP46A1)

APRI:

131187907

PTEX:

113434994

NSS:

113420326

VKO:	123018897 123032045

PMUA:

114585569 114585577 114588390

PRAF:

128407201 128407211 128407225

ZVI:	118080655 118080672

HCG:	128336795 128336801

GJA:	107121530 107121531

STOW:

125427125

EMC:	129324065 129324066 129324802 129324893 129324895 129324896 129324924

XLA:	100126648(cyp46a1.3.L) 108704878(cyp46a1.1.L) 379470(cyp46a1.2.L)

XTR:	100145328 100498621 613109(cyp46a1.3) 613111(cyp46a1.1) 780005(cyp46a1.2)

NPR:	108790745 108795063 108795064 108795072

RTEM:

120920042 120920174 120920768 120920898

ACAT:

141116736 141117072 141117196 141117421 141117547 141117627 141117628 141117631

PADS:

140341637 140341856 140342016 140342017 140342018 140342020 140342041

BBUF:

120982153 120982331 120982402 120982403 120982405 120982407 120982408 120982409 120982490

BGAR:

122921922 122921989 122922124 122922206

DTC:	141078031 141091922 141091923 141091925 141091926 141091928 141091953 141092086

PWL:	138260050 138260123 138260124 138260125

MUO:

115478032

GSH:	117363605 117363915

DRE:	393433(cyp46a1.2) 393451(cyp46a1.4) 553543(cyp46a1.1) 641477(cyp46a1.5) 692332(cyp46a1.3)

SRX:	107728353 107747947

SANH:

107678664 107678670 107679679

SGH:	107555298 107572123

CCAR:

109113289 109113290

CAUA:

113121257 113121258

CGIB:

127983802

PTET:

122324318 122324319 122324561 122325035

LROH:

127183027

GRF:	141348832 141348931 141348933(cyp46a1.2)

OMC:	131526937 131527697

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:	130434024 130434519 130434833

MANU:

141350441 141350445

PDAB:

135750080 135750100 135750146 141279807

AMEX:

103039880

CMAO:

118800336

EEE:	113571915 113586723

CHAR:

105889656 105901399 105910686

SPIL:

134063424 134063425 134063427 134065799 134098124

ASAD:

121688862 121712332

TRU:	101061882 101077010

TFS:	130515942 130515943

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:	117270337 117270909

EFO:	125897078 125897080

PLEP:

121955336 121955367

SLUC:

116041942 116041943 116041944

ECRA:

117961088

ESP:

116706702

PFLV:

114573150 114573151 114573152 114573153

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

CVE:

MSAM:

SCHU:

EARM:

CUD:	121510023 121521266 121521471

SPUL:

LMIX:

HTC:

ALAT:

ASTR:

137613859 137613891 137613892

PKLU:

139217456

MZE:	101466901 101484290 101484552 106676579 111500322

ONL:	100692681 100703511 100704054 102076821 102077122

OAU:	116315530 116315535 116315536 116332193 116332210 120433299

OLA:	101165021 101165274

OML:	112157723 112157725

CSAI:

133464385 133464386 133464538

XMA:	102224087 106699939

XCO:	114158714 114158715

XHE:	116734217 116734218

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122825489 122825709

PPRL:

129368916 129368917

CVG:	107097647 107097654

CTUL:

119784179 119784180 119784181

GMU:	124882165 124882166 124882576

NFU:	107378149 107378150

KMR:	108231774 108231837 108231838 112450290

ALIM:

106525137 106525457 106525458

NWH:	119418059 119418455 119418456 119418457 119418458

AOCE:

111578258

EJA:	138203614 138203617

BFRE:

MCEP:

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110161286 110173902 110173912

ENY:	140359758 140359765 140359773 140359780

MALB:

109962169 109962173 109962186 109962187

BSPL:

114849186 114849188

SJO:	128377315 128377316 128377317 128377319

SSCO:

133997843 133997844

TTY:

137168813

GMH:	115533935 115534632 115534633 115534635 115534636

SASA:

106571109 106571110 106571111 106608238

STRU:

115157569 115175113 115175114 115175200

OTW:	112235780 112249824 112249887 112249888

OMY:	110522567 110529322 110529323 110529324 110529326 118965490

OGO:	123990517 123995395

ONE:	115107524 115122868

OKI:	109866694 109900502 109900504 109900505 109901317 109901319

OKE:

118371881

OMM:	135506217 135506218 135557924

OCLA:

139407385 139414916 139414917 139414918

SALP:

111954047 111972528

SNH:	120019174 120024159 120024160

SFON:

129817756 129817757 129824866

CCLU:

121548510 121552816 121552818

ELS:	105020476 105020477 105020478 106024908 109614563

OEP:	134024525 134024565 134024981

SFM:	114910933 114912327 114912328 114912329

PKI:

111850949

AANG:

118230143 118230144 118230145 118230146 118230147

AROT:

CCOG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

CPLA:

CPUN:

HOC:	132818016 132818018

SCAU:

BFO:

BBEL:

SPU:

LPIC:

129260635 129261079 129265168 129265494 129269742 129270038 129270403 129279633

LVG:	121413733 121416788 121419210 121419220 121419407 121420851 121420862 121422912 121423228 121429803

AJJ:	139970583 139970584 139970585 139970650 139970651 139970774 139970785 139971223 139971785 139971794 139971796 139971797 139971919 139971932 139971934