KEGG   ORTHOLOGY: K07545
Entry
K07545                      KO                                     
Symbol
bbsG
Name
(R)-benzylsuccinyl-CoA dehydrogenase [EC:1.3.8.3]
Pathway
map00623  Toluene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00623 Toluene degradation
    K07545  bbsG; (R)-benzylsuccinyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.8  With a flavin as acceptor
    1.3.8.3  (R)-benzylsuccinyl-CoA dehydrogenase
     K07545  bbsG; (R)-benzylsuccinyl-CoA dehydrogenase
Other DBs
RN: R05584
Genes
BFZ: BAU07_03785
BGM: CAL15_20545
ADY: HLG70_07275
BOZ: DBV39_02120
VEI: Veis_2517
EBA: c2A310(bbsG)
APET: ToN1_01540(bbsG)
AZI: AzCIB_4519
AZD: CDA09_07455 CDA09_21960
TCL: Tchl_1391
GME: Gmet_1523(bbsG)
GEO: Geob_2422(bbsG)
DTO: TOL2_C01530(bbsG)
DMM: dnm_089810(bhsG)
AG: AAF89842(bbsG)
 » show all
Reference
  Authors
Leuthner B, Heider J
  Title
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of beta oxidation of the intermediate benzylsuccinate.
  Journal
J Bacteriol 182:272-7 (2000)
DOI:10.1128/JB.182.2.272-277.2000
  Sequence
Reference
  Authors
Leutwein C, Heider J
  Title
(R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway.
  Journal
Arch Microbiol 178:517-24 (2002)
DOI:10.1007/s00203-002-0484-5
  Sequence
LinkDB

KEGG   ENZYME: 1.3.8.3
Entry
EC 1.3.8.3                  Enzyme                                 
Name
(R)-benzylsuccinyl-CoA dehydrogenase;
BbsG;
(R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
Sysname
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase
Reaction(IUBMB)
(R)-2-benzylsuccinyl-CoA + electron-transfer flavoprotein = (E)-2-benzylidenesuccinyl-CoA + reduced electron-transfer flavoprotein
Reaction(KEGG)
(other) R05584
Substrate
(R)-2-benzylsuccinyl-CoA [CPD:C09817];
electron-transfer flavoprotein [CPD:C04253]
Product
(E)-2-benzylidenesuccinyl-CoA [CPD:C09818];
reduced electron-transfer flavoprotein [CPD:C04570]
Comment
Requires FAD as prosthetic group. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor.
History
EC 1.3.8.3 created 2003 as EC 1.3.99.21, transferred 2012 to EC 1.3.8.3
Pathway
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07545  (R)-benzylsuccinyl-CoA dehydrogenase
Genes
BFZBAU07_03785
BGMCAL15_20545
ADYHLG70_07275
BOZDBV39_02120
VEIVeis_2517
EBAc2A310(bbsG)
APETToN1_01540(bbsG)
AZIAzCIB_4519
AZDCDA09_07455 CDA09_21960
TCLTchl_1391
TAKTharo_3084
GMEGmet_1523(bbsG)
GEOGeob_2422(bbsG)
DTOTOL2_C01530(bbsG)
DMMdnm_089810(bhsG)
DGIDesgi_0647
CHREIE160_04110
 » show all
Reference
1  [PMID:10589736]
  Authors
Leutwein C, Heider J.
  Title
Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and beta-oxidation of the first intermediate, (R)-(+)-benzylsuccinate.
  Journal
Microbiology 145 ( Pt 11):3265-71 (1999)
DOI:10.1099/00221287-145-11-3265
Reference
2  [PMID:12420174]
  Authors
Leutwein C, Heider J
  Title
(R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway.
  Journal
Arch Microbiol 178:517-24 (2002)
DOI:10.1007/s00203-002-0484-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.8.3
IUBMB Enzyme Nomenclature: 1.3.8.3
ExPASy - ENZYME nomenclature database: 1.3.8.3
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.8.3
BRENDA, the Enzyme Database: 1.3.8.3
LinkDB

KEGG   REACTION: R05584
Entry
R05584                      Reaction                               
Name
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase
Definition
Benzylsuccinyl-CoA + 2 Electron-transferring flavoprotein <=> E-Phenylitaconyl-CoA + 2 Reduced electron-transferring flavoprotein
Equation
C09817 + 2 C04253 <=> C09818 + 2 C04570
Comment
BbsG
Reaction class
RC02037  C09817_C09818
Enzyme
Pathway
rn00623  Toluene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00418  Toluene degradation, anaerobic, toluene => benzoyl-CoA
Orthology
K07545  (R)-benzylsuccinyl-CoA dehydrogenase [EC:1.3.8.3]
LinkDB

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