KEGG   ORTHOLOGY: K08014
Entry
K08014                      KO                                     
Symbol
RAPGEF3, EPAC1
Name
Rap guanine nucleotide exchange factor 3
Pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04072  Phospholipase D signaling pathway
map04261  Adrenergic signaling in cardiomyocytes
map04670  Leukocyte transendothelial migration
map04720  Long-term potentiation
map04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04072 Phospholipase D signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04024 cAMP signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09156 Nervous system
   04726 Serotonergic synapse
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04720 Long-term potentiation
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
Genes
HSA: 10411(RAPGEF3)
PTR: 467198(RAPGEF3)
PPS: 100979763(RAPGEF3)
GGO: 101153785(RAPGEF3)
PON: 100174087(RAPGEF3)
PPYG: 129009692(RAPGEF3)
NLE: 100592347(RAPGEF3)
HMH: 116461620
SSYN: 129491169(RAPGEF3)
MCC: 703967(RAPGEF3)
MCF: 101865707(RAPGEF3)
MTHB: 126930152
MNI: 105470060(RAPGEF3)
CSAB: 103238211(RAPGEF3)
CATY: 105580438(RAPGEF3)
PANU: 101025773 116268864(RAPGEF3) 116273061
TGE: 112635556(RAPGEF3)
MLEU: 105544948(RAPGEF3)
RRO: 104654834(RAPGEF3)
RBB: 108515949(RAPGEF3)
TFN: 117090223(RAPGEF3)
PTEH: 111555300(RAPGEF3)
CANG: 105507675(RAPGEF3)
CJC: 100399583(RAPGEF3)
SBQ: 101043933(RAPGEF3)
CIMI: 108304876(RAPGEF3)
ANAN: 105721841(RAPGEF3)
CSYR: 103255783(RAPGEF3)
MMUR: 105864995(RAPGEF3)
LCAT: 123640470(RAPGEF3)
PCOQ: 105805565(RAPGEF3)
OGA: 100962179(RAPGEF3)
MMU: 223864(Rapgef3)
MCAL: 110310170(Rapgef3)
MPAH: 110334708(Rapgef3)
RNO: 59326(Rapgef3)
MCOC: 116078746(Rapgef3)
ANU: 117719035(Rapgef3)
MUN: 110546167(Rapgef3)
CGE: 100767619(Rapgef3)
MAUA: 101828520(Rapgef3)
PROB: 127226010(Rapgef3)
PLEU: 114708554(Rapgef3)
MORG: 121441440(Rapgef3)
MFOT: 126493026
AAMP: 119823360(Rapgef3)
NGI: 103740631(Rapgef3)
HGL: 101711127(Rapgef3)
CPOC: 100723672(Rapgef3)
CCAN: 109691611(Rapgef3)
DORD: 105987528(Rapgef3)
DSP: 122106262(Rapgef3)
PLOP: 125365569(Rapgef3)
NCAR: 124982354
MMMA: 107148572(Rapgef3)
OCU: 100356363
OPI: 101523807(RAPGEF3)
TUP: 102502265(RAPGEF3)
GVR: 103595451
CFA: 486591(RAPGEF3)
CLUD: 112678240(RAPGEF3)
VVP: 112921075(RAPGEF3)
VLG: 121479984(RAPGEF3)
NPO: 129505637(RAPGEF3)
AML: 100473947(RAPGEF3)
UMR: 103675595(RAPGEF3)
UAH: 113257686(RAPGEF3)
UAR: 123794811(RAPGEF3)
ELK: 111157928
LLV: 125107069
MPUF: 101682435(RAPGEF3)
MNP: 132019619(RAPGEF3)
MLK: 131838837(RAPGEF3)
NVS: 122891124(RAPGEF3)
ORO: 101371953(RAPGEF3)
EJU: 114224104(RAPGEF3)
ZCA: 113922250(RAPGEF3)
MLX: 118008918(RAPGEF3)
NSU: 110593498(RAPGEF3)
LWW: 102749024(RAPGEF3)
FCA: 101085387(RAPGEF3)
PYU: 121038668(RAPGEF3)
PCOO: 112867519(RAPGEF3)
PBG: 122473326(RAPGEF3)
PVIV: 125169634(RAPGEF3)
LRUF: 124502372
PTG: 102966186(RAPGEF3)
PPAD: 109249020(RAPGEF3)
PUC: 125919002
AJU: 106969310
HHV: 120239023(RAPGEF3)
BTA: 535383(RAPGEF3)
BOM: 102282215(RAPGEF3)
BIU: 109559177(RAPGEF3)
BBUB: 102407658(RAPGEF3)
BBIS: 104986831(RAPGEF3)
CHX: 102178145(RAPGEF3)
OAS: 101109786(RAPGEF3)
BTAX: 128049033(RAPGEF3)
ODA: 120858453 120861325
CCAD: 122427721(RAPGEF3)
MBEZ: 129536287(RAPGEF3)
SSC: 100620989(RAPGEF3)
CFR: 102524040(RAPGEF3)
CBAI: 105076166(RAPGEF3)
CDK: 105103807(RAPGEF3)
VPC: 102527378(RAPGEF3)
BACU: 103005728(RAPGEF3)
BMUS: 118902169(RAPGEF3)
LVE: 103080613(RAPGEF3)
OOR: 101278657(RAPGEF3)
DLE: 111174075(RAPGEF3)
PCAD: 102987186
PSIU: 116761070(RAPGEF3)
NASI: 112394063(RAPGEF3)
ECB: 100050541(RAPGEF3)
EPZ: 103546793(RAPGEF3)
EAI: 106836844(RAPGEF3)
MYB: 102257237(RAPGEF3)
MYD: 102768579(RAPGEF3)
MMYO: 118651234(RAPGEF3)
MLF: 102423490(RAPGEF3)
MDT: 132227498(RAPGEF3)
PKL: 118729444(RAPGEF3)
EFUS: 103285230(RAPGEF3)
MNA: 107528219(RAPGEF3)
DRO: 112318292(RAPGEF3)
SHON: 118997444(RAPGEF3)
AJM: 119041969(RAPGEF3)
PDIC: 114513019(RAPGEF3)
PHAS: 123812417(RAPGEF3)
MMF: 118623856(RAPGEF3)
PPAM: 129084894(RAPGEF3)
HAI: 109372517
RFQ: 117028527(RAPGEF3)
PALE: 102895678(RAPGEF3)
PVP: 105297498(RAPGEF3)
RAY: 107499884(RAPGEF3)
MJV: 108392459(RAPGEF3)
TOD: 119247598(RAPGEF3)
SARA: 101540127(RAPGEF3)
SETR: 126022758(RAPGEF3)
LAV: 100655802(RAPGEF3)
TMU: 101344659
ETF: 101663954(RAPGEF3)
DNM: 101417819(RAPGEF3)
GAS: 123249342(RAPGEF3)
SHR: 100925807(RAPGEF3)
AFZ: 127537825
PCW: 110201486(RAPGEF3)
TVP: 118850582(RAPGEF3)
OAA: 100680839(RAPGEF3)
GGA: 426888(RAPGEF3)
PCOC: 116239648(RAPGEF3)
MGP: 100539538(RAPGEF3)
CJO: 107325717(RAPGEF3)
TPAI: 128091845(RAPGEF3)
LMUT: 125685547(RAPGEF3)
NMEL: 110389221(RAPGEF3)
APLA: 101791788(RAPGEF3)
ACYG: 106047705(RAPGEF3)
CATA: 118260218(RAPGEF3)
AFUL: 116499913(RAPGEF3)
TGU: 115491504(RAPGEF3)
LSR: 110481646(RAPGEF3)
SCAN: 115483875
PMOA: 120500674(RAPGEF3)
OTC: 121333700(RAPGEF3)
PRUF: 121353961(RAPGEF3)
GFR: 102039560(RAPGEF3)
FAB: 101814980(RAPGEF3)
OMA: 130265849(RAPGEF3)
PHI: 102110109(RAPGEF3)
PMAJ: 107198895
CBRC: 103613210
ZLE: 135459209(RAPGEF3)
HRT: 120764425(RAPGEF3)
FPG: 101924930(RAPGEF3)
FCH: 102048878(RAPGEF3)
SHAB: 115618683(RAPGEF3)
ACUN: 113491036(RAPGEF3)
TALA: 116964163(RAPGEF3)
ACHC: 115351213(RAPGEF3)
HLE: 104831163(RAPGEF3)
AGEN: 126046519
GCL: 127028385
EGZ: 104132693(RAPGEF3)
NNI: 104011982(RAPGEF3)
PADL: 103914893(RAPGEF3)
AFOR: 103894937(RAPGEF3)
CLV: 102094087(RAPGEF3)
MUI: 104535844(RAPGEF3)
CUCA: 104055138(RAPGEF3)
OHA: 104336076
CVF: 104284838(RAPGEF3)
RTD: 128901349(RAPGEF3)
AAM: 106485098(RAPGEF3)
AROW: 112975385(RAPGEF3)
NPD: 112950330(RAPGEF3)
TGT: 104574250(RAPGEF3)
DNE: 112991008(RAPGEF3)
SCAM: 104144388(RAPGEF3)
ASN: 102381678(RAPGEF3)
AMJ: 102574517(RAPGEF3)
CPOO: 109324408(RAPGEF3)
GGN: 109293213(RAPGEF3)
PSS: 102443863(RAPGEF3)
CMY: 102939607(RAPGEF3)
CCAY: 125629135(RAPGEF3)
DCC: 119845965(RAPGEF3)
CPIC: 101931835(RAPGEF3)
TST: 117889092(RAPGEF3)
CABI: 116826941(RAPGEF3)
MRV: 120391129(RAPGEF3)
ACS: 100560594(rapgef3)
ASAO: 132768165(RAPGEF3)
PVT: 110071318(RAPGEF3)
SUND: 121920804(RAPGEF3)
PBI: 103063904(RAPGEF3)
PMUR: 107288970(RAPGEF3)
CTIG: 120312211(RAPGEF3)
TSR: 106556124
PGUT: 117666559(RAPGEF3)
APRI: 131191262(RAPGEF3)
PTEX: 113444818(RAPGEF3)
NSS: 113416153(RAPGEF3)
VKO: 123024026(RAPGEF3)
PMUA: 114592897(RAPGEF3)
PRAF: 128404243(RAPGEF3)
ZVI: 118077695(RAPGEF3)
HCG: 128346368(RAPGEF3)
GJA: 107109551(RAPGEF3)
STOW: 125429966(RAPGEF3)
EMC: 129346376(RAPGEF3)
XLA: 108708626(rapgef3.L) 108709885
XTR: 100491495(rapgef3)
NPR: 108800976(RAPGEF3)
RTEM: 120929384(RAPGEF3)
BGAR: 122930866(RAPGEF3)
MUO: 115466785(RAPGEF3)
GSH: 117357024(RAPGEF3)
DRE: 101886094(rapgef3)
SRX: 107723737 107756413
SANH: 107671875 107697977
SGH: 107594040 107598495
CCAR: 109047993 109048004
CAUA: 113041515 113065575
CGIB: 127945124 128011334
PTET: 122328968(rapgef3) 122333675
LROH: 127154573(rapgef3)
OMC: 131532333(rapgef3)
PPRM: 120462943(rapgef3) 120463796
RKG: 130090498(rapgef3)
MAMB: 125259848(rapgef3)
CIDE: 127504743
CERY: 137009190(rapgef3)
MASI: 127418663 127419898
TROS: 130571899(rapgef3)
TDW: 130409242(rapgef3)
MANU: 129430871(rapgef3)
IPU: 108275659(rapgef3)
IFU: 128618979(rapgef3)
PHYP: 113530617
SMEO: 124398619(rapgef3)
TFD: 113641742(rapgef3)
TVC: 132862155(rapgef3)
TRN: 134333116(rapgef3)
AMEX: 103025506(rapgef3)
CMAO: 118822570(rapgef3)
EEE: 113576412(rapgef3)
CHAR: 105906747(rapgef3)
TRU: 101068679
TFS: 130529794(rapgef3)
TNG: GSTEN00023559G001
LCO: 104919939
TBEN: 117484371(rapgef3)
CGOB: 115004794
PGEO: 117449045(rapgef3)
GACU: 117542226(rapgef3)
EMAC: 134866624(rapgef3)
ELY: 117257965(rapgef3)
EFO: 125891149(rapgef3)
PLEP: 121946557(rapgef3)
SLUC: 116043746(rapgef3)
ECRA: 117946996(rapgef3)
ESP: 116692193
PFLV: 114558191
GAT: 120828846(rapgef3)
PPUG: 119221891(rapgef3)
AFB: 129100281(rapgef3)
CLUM: 117733002(rapgef3)
PSWI: 130198926(rapgef3)
MSAM: 119905182(rapgef3)
SCHU: 122883673(rapgef3)
CUD: 121517284(rapgef3)
ALAT: 119022621(rapgef3)
MZE: 101480994
ONL: 100711715
OAU: 116322009(rapgef3)
OLA: 101158525
OML: 112158872(rapgef3)
CSAI: 133456771(rapgef3)
XMA: 102222768
XCO: 114140440
XHE: 116716747
PRET: 103467797
PFOR: 103139154
PLAI: 106955063
PMEI: 106904967
GAF: 122829278(rapgef3)
PPRL: 129376979(rapgef3)
CVG: 107091899
CTUL: 119799402(rapgef3)
GMU: 124866665(rapgef3)
NFU: 107390402
KMR: 108237632(rapgef3)
ALIM: 106522985
NWH: 119416619(rapgef3)
AOCE: 111581117
MCEP: 125005434(rapgef3)
CSEM: 103385263
POV: 109643141
SSEN: 122777200(rapgef3)
HHIP: 117764433(rapgef3)
HSP: 118111533(rapgef3)
PPLT: 128442196(rapgef3)
SMAU: 118316234(rapgef3)
LCF: 108886373(rapgef3)
SDU: 111235101
SLAL: 111661896
XGL: 120803283(rapgef3)
HCQ: 109513787(rapgef3)
SSCV: 125989075
SBIA: 133511041(rapgef3)
PEE: 133407501(rapgef3)
PTAO: 133485671(rapgef3)
BPEC: 110164588
MALB: 109970308
BSPL: 114858485(rapgef3)
SJO: 128357085(rapgef3)
SASA: 106567164 106572513
STRU: 115165650 115167990
OTW: 112216258 112221521
OMY: 110492097(rapgef3) 110532567
OGO: 124032166 124045982(rapgef3)
ONE: 115102440 115132407
OKI: 109869277 109908218
OKE: 118360324 118360768
SALP: 111966719 111977003
SNH: 120059261 120061105
CCLU: 121537424 121545735
ELS: 105022286
SFM: 108939388
PKI: 111840326(rapgef3)
AANG: 118208262(rapgef3)
LOC: 102696564(rapgef3)
PSPA: 121308884(rapgef3)
ARUT: 117401125 117967082
PSEX: 120524956(rapgef3)
 » show all
Reference
PMID:20055708
  Authors
Gloerich M, Bos JL
  Title
Epac: defining a new mechanism for cAMP action.
  Journal
Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714
Reference
PMID:9856955
  Authors
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM
  Title
A family of cAMP-binding proteins that directly activate Rap1.
  Journal
Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275
  Sequence
[hsa:10411]
LinkDB

KEGG   ORTHOLOGY: K04351
Entry
K04351                      KO                                     
Symbol
RAPGEF4, EPAC2
Name
Rap guanine nucleotide exchange factor 4
Pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04072  Phospholipase D signaling pathway
map04261  Adrenergic signaling in cardiomyocytes
map04670  Leukocyte transendothelial migration
map04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04072 Phospholipase D signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04024 cAMP signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09152 Endocrine system
   04911 Insulin secretion
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
Membrane trafficking [BR:ko04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   Rab associated proteins
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
Genes
HSA: 11069(RAPGEF4)
PTR: 459744(RAPGEF4)
PPS: 100995002(RAPGEF4)
GGO: 101151388(RAPGEF4)
PON: 100189911(RAPGEF4)
PPYG: 129031142(RAPGEF4)
NLE: 100602878(RAPGEF4)
HMH: 116810653(RAPGEF4)
SSYN: 129488054(RAPGEF4)
MCC: 698148(RAPGEF4)
MCF: 101865166(RAPGEF4)
MTHB: 126932480
MNI: 105483229(RAPGEF4)
CSAB: 103217330(RAPGEF4)
CATY: 105579810(RAPGEF4)
PANU: 100997024(RAPGEF4)
TGE: 112636245(RAPGEF4)
MLEU: 105548062(RAPGEF4)
RRO: 104673512(RAPGEF4)
RBB: 108518542(RAPGEF4)
TFN: 117094851(RAPGEF4)
PTEH: 111522172(RAPGEF4)
CANG: 105514542
CJC: 100401754(RAPGEF4)
SBQ: 101043595(RAPGEF4)
CIMI: 108310986(RAPGEF4)
ANAN: 105724053(RAPGEF4)
CSYR: 103267141(RAPGEF4)
MMUR: 105880732(RAPGEF4)
LCAT: 123644044(RAPGEF4)
PCOQ: 105815593(RAPGEF4)
OGA: 100944201(RAPGEF4)
MMU: 56508(Rapgef4)
MCAL: 110289761(Rapgef4)
MPAH: 110318780(Rapgef4)
RNO: 252857(Rapgef4)
MCOC: 116090303(Rapgef4)
ANU: 117703098(Rapgef4)
MUN: 110554362(Rapgef4)
CGE: 100774346
MAUA: 101839349(Rapgef4)
PROB: 127222420(Rapgef4)
PLEU: 114704477(Rapgef4)
MORG: 121433185(Rapgef4) 121439272
MFOT: 126489701
AAMP: 119819683(Rapgef4)
NGI: 103751742(Rapgef4)
HGL: 101706913(Rapgef4)
CPOC: 100730964(Rapgef4)
CCAN: 109687932(Rapgef4)
DORD: 105996072(Rapgef4)
DSP: 122120106(Rapgef4)
PLOP: 125350552(Rapgef4)
NCAR: 124978987
MMMA: 107136927(Rapgef4)
OCU: 100348394
OPI: 101534512(RAPGEF4)
TUP: 102485451(RAPGEF4)
GVR: 103586837
CFA: 488402(RAPGEF4)
CLUD: 112668098(RAPGEF4)
VVP: 112916400(RAPGEF4)
VLG: 121471317(RAPGEF4)
NPO: 129498672(RAPGEF4)
AML: 100480097(RAPGEF4)
UMR: 103659569(RAPGEF4)
UAH: 113250770(RAPGEF4)
UAR: 123780680(RAPGEF4)
ELK: 111158917
LLV: 125095734
MPUF: 101683321(RAPGEF4)
MNP: 132013837(RAPGEF4)
MLK: 131827087(RAPGEF4)
NVS: 122902598(RAPGEF4)
ORO: 101382059(RAPGEF4)
EJU: 114223796(RAPGEF4)
ZCA: 113919486(RAPGEF4)
MLX: 118012324(RAPGEF4)
NSU: 110592242(RAPGEF4)
LWW: 102748988(RAPGEF4)
FCA: 101092955(RAPGEF4)
PYU: 121030705(RAPGEF4)
PCOO: 112848530(RAPGEF4)
PBG: 122481463(RAPGEF4)
PVIV: 125172826(RAPGEF4)
LRUF: 124515318
PTG: 102959994(RAPGEF4)
PPAD: 109273039
PUC: 125911545
AJU: 106987935
HHV: 120236410(RAPGEF4)
BTA: 537312(RAPGEF4)
BOM: 102264805(RAPGEF4)
BIU: 109566435(RAPGEF4)
BBUB: 102396497(RAPGEF4)
BBIS: 104991386(RAPGEF4)
CHX: 102184383(RAPGEF4)
OAS: 101112196(RAPGEF4)
BTAX: 128043585(RAPGEF4)
ODA: 120854931(RAPGEF4)
CCAD: 122453597(RAPGEF4)
MBEZ: 129537653(RAPGEF4)
SSC: 100511786(RAPGEF4)
CFR: 102519185(RAPGEF4)
CBAI: 105073438(RAPGEF4)
CDK: 105091096(RAPGEF4)
VPC: 102528724(RAPGEF4)
BACU: 103018315(RAPGEF4)
BMUS: 118898159(RAPGEF4)
LVE: 103078675(RAPGEF4)
OOR: 101271995(RAPGEF4)
DLE: 111172871(RAPGEF4)
PCAD: 102985646(RAPGEF4)
PSIU: 116757044(RAPGEF4)
NASI: 112391501(RAPGEF4)
ECB: 100064121(RAPGEF4)
EPZ: 103559592(RAPGEF4)
EAI: 106834741(RAPGEF4)
MYB: 102262528(RAPGEF4)
MYD: 102765492(RAPGEF4)
MMYO: 118661427(RAPGEF4)
MLF: 102423839(RAPGEF4)
MDT: 132238527(RAPGEF4)
PKL: 118709358(RAPGEF4)
EFUS: 103283310(RAPGEF4)
MNA: 107531114(RAPGEF4)
DRO: 112305728(RAPGEF4)
SHON: 118985700(RAPGEF4)
AJM: 119053630
PDIC: 114494369(RAPGEF4)
PHAS: 123805328(RAPGEF4)
MMF: 118625354(RAPGEF4)
PPAM: 129061838(RAPGEF4)
HAI: 109388735(RAPGEF4)
RFQ: 117026182(RAPGEF4)
PALE: 102884268
PGIG: 120596952(RAPGEF4)
PVP: 105290355(RAPGEF4)
RAY: 107505164(RAPGEF4)
MJV: 108395539(RAPGEF4)
TOD: 119255936(RAPGEF4)
SARA: 101558391(RAPGEF4)
SETR: 126009160(RAPGEF4)
LAV: 100660747(RAPGEF4)
TMU: 101341572
ETF: 101661303(RAPGEF4)
DNM: 101440135(RAPGEF4)
MDO: 100025283(RAPGEF4)
GAS: 123242207(RAPGEF4)
SHR: 100933298(RAPGEF4)
AFZ: 127557765
PCW: 110211578(RAPGEF4)
TVP: 118837614(RAPGEF4)
OAA: 100084234(RAPGEF4)
GGA: 429022(RAPGEF4)
PCOC: 116232848(RAPGEF4)
MGP: 100550956 100551109
CJO: 107316695(RAPGEF4)
TPAI: 128077013(RAPGEF4)
LMUT: 125696707(RAPGEF4)
NMEL: 110399900(RAPGEF4)
APLA: 101803499(RAPGEF4)
ACYG: 106029998(RAPGEF4)
CATA: 118258884(RAPGEF4)
AFUL: 116490762(RAPGEF4)
TGU: 100231316(RAPGEF4)
LSR: 110482918(RAPGEF4)
SCAN: 103814439(RAPGEF4)
PMOA: 120497563(RAPGEF4)
OTC: 121335480(RAPGEF4)
PRUF: 121356710(RAPGEF4)
GFR: 102033413(RAPGEF4)
FAB: 101808736(RAPGEF4)
OMA: 130255658(RAPGEF4)
PHI: 102102247(RAPGEF4)
PMAJ: 107207670(RAPGEF4)
CCAE: 111932077(RAPGEF4)
CCW: 104693870(RAPGEF4)
CBRC: 103616563(RAPGEF4)
ETL: 114054913(RAPGEF4)
ZAB: 102069630(RAPGEF4)
ZLE: 135450095(RAPGEF4)
SVG: 106855496(RAPGEF4)
MMEA: 130572172(RAPGEF4)
HRT: 120754971(RAPGEF4)
SATI: 136363500(RAPGEF4)
FPG: 101910581(RAPGEF4)
FCH: 102051155(RAPGEF4)
CCRI: 104157562(RAPGEF4)
NNT: 104401272(RAPGEF4)
SHAB: 115607922(RAPGEF4)
ACUN: 113482011(RAPGEF4)
TALA: 104359765(RAPGEF4)
ACHC: 115342849(RAPGEF4)
HALD: 104322661(RAPGEF4)
HLE: 104831200(RAPGEF4)
AGEN: 126043551
GCL: 127018187
CSTI: 104553476(RAPGEF4)
LDI: 104343627(RAPGEF4)
MNB: 103775971(RAPGEF4)
DPUB: 104305755(RAPGEF4)
AVIT: 104278781(RAPGEF4)
EGZ: 104128060(RAPGEF4)
NNI: 104010004(RAPGEF4)
PCRI: 104035177
PCAO: 104041757(RAPGEF4)
PADL: 103924207(RAPGEF4)
AFOR: 103898333(RAPGEF4)
FGA: 104075741(RAPGEF4)
GSTE: 104262313(RAPGEF4)
CLV: 102085464(RAPGEF4)
MUI: 104541519(RAPGEF4)
PGUU: 104464280(RAPGEF4)
EHS: 104511936(RAPGEF4)
CMAC: 104475986(RAPGEF4)
CUCA: 104054567(RAPGEF4)
BREG: 104638361(RAPGEF4)
OHA: 104328968(RAPGEF4)
ACAR: 104521139(RAPGEF4)
CPEA: 104387393(RAPGEF4)
CVF: 104294877(RAPGEF4)
RTD: 128912585(RAPGEF4)
AAM: 106499302(RAPGEF4)
AROW: 112963929(RAPGEF4)
NPD: 112950323(RAPGEF4)
TGT: 104574482(RAPGEF4)
DNE: 112979077(RAPGEF4)
SCAM: 104148529(RAPGEF4)
ASN: 102376494(RAPGEF4)
AMJ: 102568614(RAPGEF4)
CPOO: 109323037(RAPGEF4)
GGN: 109301694(RAPGEF4)
PSS: 102444117(RAPGEF4)
CMY: 102944298(RAPGEF4)
CCAY: 125644871(RAPGEF4)
DCC: 119863573(RAPGEF4)
CPIC: 101939565(RAPGEF4)
TST: 117884859(RAPGEF4)
CABI: 116827216(RAPGEF4)
MRV: 120374757(RAPGEF4)
ACS: 100567156(rapgef4)
ASAO: 132776970(RAPGEF4)
PVT: 110088585(RAPGEF4)
SUND: 121928870(RAPGEF4)
PBI: 103053910(RAPGEF4)
PMUR: 107290439(RAPGEF4)
CTIG: 120316341(RAPGEF4)
TSR: 106551336(RAPGEF4)
PGUT: 117671562(RAPGEF4)
APRI: 131201982(RAPGEF4)
PTEX: 113434185(RAPGEF4)
NSS: 113418704(RAPGEF4)
VKO: 123017010(RAPGEF4)
PMUA: 114606886(RAPGEF4)
PRAF: 128398388(RAPGEF4)
ZVI: 118094642(RAPGEF4)
HCG: 128332163(RAPGEF4)
GJA: 107107055(RAPGEF4)
STOW: 125426059(RAPGEF4)
EMC: 129323994(RAPGEF4)
XLA: 108701373(rapgef4.L) 108702995(rapgef4.S)
XTR: 100497690(rapgef4)
NPR: 108800352(RAPGEF4)
RTEM: 120944439(RAPGEF4)
BBUF: 121008125
BGAR: 122944653(RAPGEF4)
MUO: 115474722(RAPGEF4)
GSH: 117361565(RAPGEF4)
DRE: 559170(rapgef4)
SRX: 107718455 107742951 107752096 107753902
SANH: 107657351(rapgef4) 107659975 107671325 107678227
SGH: 107551930 107581390 107588249 107602296
CCAR: 109060408 109060410 109105477
CAUA: 113050934 113053515 113091381 113109117(rapgef4)
CGIB: 127960269 127965430 128015343 128019598
PTET: 122346688(rapgef4b) 122351193
LROH: 127167219(rapgef4b) 127171230(rapgef4a)
OMC: 131542994(rapgef4b) 131547186(rapgef4a)
PPRM: 120459799(rapgef4a) 120491575(rapgef4b)
RKG: 130078027(rapgef4a) 130101256
MAMB: 125269808(rapgef4a) 125274151(rapgef4b)
CIDE: 127514703 127518416
CERY: 137011736(rapgef4b) 137035568(rapgef4a)
MASI: 127446678 127446825 127448371 127449171
TROS: 130555827(rapgef4a) 130556503(rapgef4b)
TDW: 130425099(rapgef4b) 130427164(rapgef4a)
MANU: 129450276 129451945(rapgef4a)
IPU: 108266644(rapgef4a)
IFU: 128608878(rapgef4a)
PHYP: 113525881(rapgef4)
SMEO: 124383164(rapgef4a)
TFD: 113654530(rapgef4a)
TVC: 132850221(rapgef4a)
TRN: 134316985(rapgef4b) 134324711(rapgef4a)
AMEX: 103032232(rapgef4b) 103034068(rapgef4a)
CMAO: 118805561(rapgef4a) 118808073(rapgef4b)
EEE: 113580024 113588392(rapgef4)
CHAR: 105901602(rapgef4a) 122130829
TRU: 101065114(rapgef4) 101070245
TFS: 130526728(rapgef4a) 130538422
TNG: GSTEN00020951G001 GSTEN00031438G001
LCO: 104927784(rapgef4) 104932605
NCC: 104955735 104966264
TBEN: 117480967(rapgef4) 117488461
CGOB: 115022857 115026764(rapgef4)
PGEO: 117462889 117467004(rapgef4)
GACU: 117532676 117544418(rapgef4)
EMAC: 134865777 134867810(rapgef4a)
ELY: 117251637(rapgef4) 117272549
EFO: 125899934(rapgef4a) 125902486
PLEP: 121948803(rapgef4a) 121951212
SLUC: 116037213 116048428(rapgef4a)
ECRA: 117952605(rapgef4) 117953716
ESP: 116697608(rapgef4) 116698831
PFLV: 114564554(rapgef4) 114564996
GAT: 120816034 120834404(rapgef4a)
PPUG: 119209246 119228636(rapgef4a)
AFB: 129104187(rapgef4a) 129112767
CLUM: 117746382 117750235(rapgef4)
PSWI: 130197844 130201454(rapgef4a)
MSAM: 119902204 119904105(rapgef4a)
SCHU: 122885530(rapgef4a) 122886329
CUD: 121519779 121522485(rapgef4a)
ALAT: 119011472 119025409(rapgef4a)
MZE: 101472391 101483582
ONL: 100689894 100695746(rapgef4)
OAU: 116316203 116322950(rapgef4a)
OLA: 101160608 101167824
OML: 112147447 112155522(rapgef4a)
CSAI: 133445937(rapgef4a) 133451916
XMA: 102217330 102228535(rapgef4)
XCO: 114146798 114148913
XHE: 116721841 116723656
PRET: 103458407 103479350
PFOR: 103134298(rapgef4) 103147034
PLAI: 106946958(rapgef4) 106961733
PMEI: 106905601 106930772
GAF: 122839682(rapgef4a) 122841093
PPRL: 129361427(rapgef4a) 129362135
CVG: 107085744 107091853(rapgef4)
CTUL: 119773841 119797528(rapgef4a)
GMU: 124869392 124871919(rapgef4a)
NFU: 107384114 107390013(rapgef4)
KMR: 108239540 108239698(rapgef4a)
ALIM: 106512861 106526166
NWH: 119414635 119419154(rapgef4a)
AOCE: 111576806 111582170
MCEP: 125011243 125017392(rapgef4a)
CSEM: 103391849 103395904
POV: 109631150 109642976
SSEN: 122765254(rapgef4a) 122771580
HHIP: 117755448(rapgef4) 117777823
HSP: 118118428 118120570(rapgef4a)
PPLT: 128454606 128456339(rapgef4a)
SMAU: 118283145(rapgef4a) 118311753
LCF: 108883636 108888702(rapgef4a)
SDU: 111218206(rapgef4) 111228847
SLAL: 111668523(rapgef4) 111671130
XGL: 120798593 120801397(rapgef4a)
HCQ: 109507461 109507910(rapgef4)
SSCV: 125973369 125985124
SBIA: 133511524 133512504(rapgef4a)
PEE: 133410505(rapgef4a) 133411895
PTAO: 133487225(rapgef4a) 133488788
BPEC: 110166573(rapgef4) 110173508
MALB: 109958072(rapgef4) 109969253
BSPL: 114843849 114847209(rapgef4a)
SJO: 128367479(rapgef4a) 128368569
SASA: 106569502(rapgef4) 106581759 106586233 106600087
STRU: 115156011 115157370 115160763 115169445
OTW: 112224179 112225240 112226664 112260806
OMY: 110501447(rapgef4a) 110509209 110520113 110530658
OGO: 124041551 124043170(rapgef4a) 124043863
ONE: 115102745 115102844(rapgef4) 115109130 115114721
OKI: 109866706 109871314 109872094 109875107
OKE: 118367067 118386046(rapgef4a) 118395028 118402498
SALP: 111959839 111975159 111979745 112072432
SNH: 120020596 120055392 120057870 120064388(rapgef4a)
CCLU: 121535525 121536783 121552494 121581168
ELS: 105007217 105016205(rapgef4)
SFM: 108920347 108920713(rapgef4)
PKI: 111838585 111840792
AANG: 118223290(rapgef4)
LOC: 102688111(rapgef4)
PSPA: 121321946 121323653
ARUT: 117414305 117426178
PSEX: 120530676(rapgef4a)
LCM: 102366727(RAPGEF4)
CMK: 103176454(rapgef4a)
CPLA: 122551557(rapgef4a)
HOC: 132808965(rapgef3) 132817610(rapgef4a)
LERI: 129698745(rapgef4a)
PMRN: 116938521(RAPGEF4)
LRJ: 133346121(RAPGEF4)
BFO: 118424000
BBEL: 109474534
CIN: 100186896
SCLV: 120338473
SPU: 579050
LPIC: 129273931 129273934
APLC: 110973481
ARUN: 117299822
AJC: 117106767
SKO: 100373735
DME: Dmel_CG34392(Epac)
DER: 6540983
DSI: Dsimw501_GD10302(Dsim_GD10302)
DYA: Dyak_GE24498
DSR: 110189781
DPO: 6898079
DPE: 6590280
DMN: 108160374
DWI: 6643336
DGR: 6559823
DMO: Dmoj_GI20231
DAZ: 108614880
DNV: 108653799
DHE: 111601122
CCAT: 101451839
BOD: 106617320
BDR: 105230672 105230727
RZE: 108360130
AOQ: 129244441
TDA: 119678298 119678299
MDE: 101899941 131801359
SCAC: 106087471
LCQ: 111681708
GFS: 119636601
ECOE: 129952461
CLON: 129607216
HIS: 119649168
AGA: 1269861
ACOZ: 120954006
AARA: 120894130
AMER: 121591809
ASTE: 118514493
AFUN: 125771279
AMOU: 128301082
AALI: 118466107
AAG: 5573236
AALB: 109423294
ASUA: 134218388
CQU: CpipJ_CPIJ017680
CPII: 120423495
CNS: 116352135
BCOO: 119081367
TCA: 661613
DPA: 109539619
SOY: 115890798
AGRG: 126742504
ATD: 109609621
AGB: 108912795
LDC: 111506459
NVL: 108564753
PPYR: 116176076
OTU: 111419213
CFEL: 113364023
CCRN: 123296970
API: 100162065
DNX: 107163321
AGS: 114131920
RMD: 113551411
ACOO: 126846168
DVT: 126895583
BTAB: 109044228
DCI: 103514638 103517552
CLEC: 106668425
HHAL: 106682206(Epac)
NLU: 111055288 120355727
HVI: 124366216
MQU: 129002617
PHU: Phum_PHUM523770
FOC: 113207618
TPAL: 117645704
ZNE: 110836465
CSEC: 111867584
SGRE: 126354710
BROR: 134539698
IEL: 124159017
FCD: 110846921
DPX: DAPPUDRAFT_210921
DMK: 116918971
DPZ: 124344093
PVM: 113819322
PJA: 122254571
PMOO: 119597554
HAME: 121860080
PCLA: 123760276
CQD: 128686469
PTRU: 123503082
ESN: 126980411
MNZ: 135201449
PPOI: 119096759
ISC: 8043730
DSV: 119441883
RSAN: 119386996
RMP: 119178506
VDE: 111252027
VJA: 111269305
TUT: 107363025
DPTE: 113792243
DFR: 124499241
CSCU: 111621959
CVS: 136985694(Epac)
PTEP: 107457381
ABRU: 129965482
UDV: 129227930
SDM: 118184275
LPOL: 106458479 106466050 106473199
PMEO: 129586911
CEL: CELE_T20G5.5(epac-1)
CBR: CBG_09801(Cbr-epac-1)
CRQ: GCK72_009608
NAI: NECAME_09247
BMY: BM_BM5869(Bma-epac-1)
LOA: LOAG_17670
TSP: Tsp_01532
LGI: LOTGIDRAFT_135052
PVUL: 126831901
PCAN: 112564521
BGT: 106074727
GAE: 121380852
HRF: 124110717
HRJ: 124281639
CRG: 105320113
CANU: 128177666
CVN: 111130373
OED: 125649172
MYI: 110442375
PMAX: 117324132
MCAF: 127698449
OBI: 106867327
OSN: 115210368
LJP: 135478333
LAK: 106158702 106181129
OVI: T265_07226
LLON: 135500810
NVE: 5508916
EPA: 110238364
ATEN: 116296698
ADF: 107350554
AMIL: 114946958
PDAM: 113675988
SPIS: 111323510
DGT: 114538354
XEN: 124441892
TAD: TRIADDRAFT_51758
AQU: 100638923
 » show all
Reference
PMID:20055708
  Authors
Gloerich M, Bos JL
  Title
Epac: defining a new mechanism for cAMP action.
  Journal
Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714
Reference
PMID:9856955
  Authors
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM
  Title
A family of cAMP-binding proteins that directly activate Rap1.
  Journal
Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275
  Sequence
[hsa:11069]
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