KEGG   ORTHOLOGY: K08041
Entry
K08041                      KO                                     
Symbol
ADCY1
Name
adenylate cyclase 1 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05142  Chagas disease
map05146  Amoebiasis
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Disease
H00605  Deafness, autosomal recessive
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08041  ADCY1; adenylate cyclase 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04371 Apelin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04020 Calcium signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04072 Phospholipase D signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04024 cAMP signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04022 cGMP-PKG signaling pathway
    K08041  ADCY1; adenylate cyclase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08041  ADCY1; adenylate cyclase 1
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08041  ADCY1; adenylate cyclase 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08041  ADCY1; adenylate cyclase 1
   04062 Chemokine signaling pathway
    K08041  ADCY1; adenylate cyclase 1
  09152 Endocrine system
   04911 Insulin secretion
    K08041  ADCY1; adenylate cyclase 1
   04923 Regulation of lipolysis in adipocytes
    K08041  ADCY1; adenylate cyclase 1
   04912 GnRH signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04913 Ovarian steroidogenesis
    K08041  ADCY1; adenylate cyclase 1
   04915 Estrogen signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04914 Progesterone-mediated oocyte maturation
    K08041  ADCY1; adenylate cyclase 1
   04921 Oxytocin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04926 Relaxin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04935 Growth hormone synthesis, secretion and action
    K08041  ADCY1; adenylate cyclase 1
   04918 Thyroid hormone synthesis
    K08041  ADCY1; adenylate cyclase 1
   04928 Parathyroid hormone synthesis, secretion and action
    K08041  ADCY1; adenylate cyclase 1
   04916 Melanogenesis
    K08041  ADCY1; adenylate cyclase 1
   04925 Aldosterone synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
   04927 Cortisol synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08041  ADCY1; adenylate cyclase 1
   04270 Vascular smooth muscle contraction
    K08041  ADCY1; adenylate cyclase 1
  09154 Digestive system
   04970 Salivary secretion
    K08041  ADCY1; adenylate cyclase 1
   04971 Gastric acid secretion
    K08041  ADCY1; adenylate cyclase 1
   04972 Pancreatic secretion
    K08041  ADCY1; adenylate cyclase 1
   04976 Bile secretion
    K08041  ADCY1; adenylate cyclase 1
  09156 Nervous system
   04724 Glutamatergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04727 GABAergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04725 Cholinergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04720 Long-term potentiation
    K08041  ADCY1; adenylate cyclase 1
   04723 Retrograde endocannabinoid signaling
    K08041  ADCY1; adenylate cyclase 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08041  ADCY1; adenylate cyclase 1
  09149 Aging
   04211 Longevity regulating pathway
    K08041  ADCY1; adenylate cyclase 1
   04213 Longevity regulating pathway - multiple species
    K08041  ADCY1; adenylate cyclase 1
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08041  ADCY1; adenylate cyclase 1
   04714 Thermogenesis
    K08041  ADCY1; adenylate cyclase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08041  ADCY1; adenylate cyclase 1
   05207 Chemical carcinogenesis - receptor activation
    K08041  ADCY1; adenylate cyclase 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08041  ADCY1; adenylate cyclase 1
   05163 Human cytomegalovirus infection
    K08041  ADCY1; adenylate cyclase 1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K08041  ADCY1; adenylate cyclase 1
   05142 Chagas disease
    K08041  ADCY1; adenylate cyclase 1
  09165 Substance dependence
   05032 Morphine addiction
    K08041  ADCY1; adenylate cyclase 1
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08041  ADCY1; adenylate cyclase 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08041  ADCY1; adenylate cyclase 1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08041  ADCY1; adenylate cyclase 1
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08041  ADCY1; adenylate cyclase 1
Other DBs
GO: 0008294
Genes
HSA: 107(ADCY1)
PTR: 463392(ADCY1)
PPS: 100984585(ADCY1)
GGO: 101125943(ADCY1)
PON: 100449504(ADCY1)
PPYG: 129040360(ADCY1)
NLE: 100595636(ADCY1)
HMH: 116812469(ADCY1)
SSYN: 129489943(ADCY1)
MCC: 697230(ADCY1)
MCF: 102147015(ADCY1)
MTHB: 126950155
MNI: 105494232(ADCY1)
CSAB: 103226115(ADCY1)
CATY: 105588320(ADCY1)
PANU: 100998237(ADCY1)
TGE: 112620936(ADCY1)
MLEU: 105541972
RRO: 104671165(ADCY1)
RBB: 108534793(ADCY1)
TFN: 117073333(ADCY1)
CANG: 105515072(ADCY1)
CJC: 100394265(ADCY1)
SBQ: 101027981(ADCY1)
CIMI: 108301433(ADCY1)
ANAN: 105721461(ADCY1)
MMUR: 105870668(ADCY1)
LCAT: 123647256(ADCY1)
PCOQ: 105812499(ADCY1)
OGA: 100955472(ADCY1)
MMU: 432530(Adcy1)
MCAL: 110305998(Adcy1)
MPAH: 110330584(Adcy1)
RNO: 305509(Adcy1)
MCOC: 116069116(Adcy1)
ANU: 117712590(Adcy1)
MUN: 110555169(Adcy1)
CGE: 100764561(Adcy1)
MAUA: 101822607(Adcy1)
PROB: 127233912(Adcy1)
PLEU: 114693962(Adcy1)
MORG: 121459308(Adcy1)
MFOT: 126500995
AAMP: 119800365(Adcy1)
NGI: 103741433(Adcy1)
HGL: 101711366(Adcy1)
CPOC: 100715672(Adcy1)
CCAN: 109694874(Adcy1)
DORD: 105998287(Adcy1)
DSP: 122128067(Adcy1)
PLOP: 125345732(Adcy1)
NCAR: 124990345
MMMA: 107146235(Adcy1)
OCU: 103347035
OPI: 101533323(ADCY1)
TUP: 102468873(ADCY1)
GVR: 103599611(ADCY1)
CFA: 607357(ADCY1)
CLUD: 112650921(ADCY1) 112670489
VVP: 112911455(ADCY1)
VLG: 121490100(ADCY1) 121492610
NPO: 129515724 129516202
AML: 100472777(ADCY1)
UMR: 103674675(ADCY1)
UAH: 113257705(ADCY1)
UAR: 123789481(ADCY1)
ELK: 111157054
LLV: 125081029
MPUF: 101676834(ADCY1)
MNP: 132016088(ADCY1)
MLK: 131829179(ADCY1)
NVS: 122904661(ADCY1)
ORO: 101379158(ADCY1)
EJU: 114213699(ADCY1)
ZCA: 113911474(ADCY1)
MLX: 118024512(ADCY1)
NSU: 110592662(ADCY1)
LWW: 102739347(ADCY1)
FCA: 101101375(ADCY1)
PYU: 121016977(ADCY1)
PCOO: 112859788(ADCY1)
PBG: 122487650(ADCY1)
PVIV: 125160918(ADCY1)
LRUF: 124524637
PTG: 102961712(ADCY1)
PPAD: 109267948(ADCY1)
PUC: 125930396
AJU: 106968223
HHV: 120238897(ADCY1)
BTA: 281601(ADCY1)
BOM: 102267116(ADCY1)
BIU: 109557525(ADCY1)
BBUB: 102415323(ADCY1)
BBIS: 104980414(ADCY1)
CHX: 102180724(ADCY1)
OAS: 101117327(ADCY1)
BTAX: 128046764(ADCY1)
ODA: 120877473(ADCY1)
CCAD: 122438514(ADCY1)
MBEZ: 129552085(ADCY1)
SSC: 100624934(ADCY1)
CFR: 102517882(ADCY1)
CBAI: 105080525(ADCY1)
CDK: 105095715(ADCY1)
VPC: 102538400(ADCY1)
BACU: 102998650(ADCY1)
BMUS: 118900990(ADCY1)
LVE: 103081539(ADCY1)
OOR: 101278368(ADCY1)
DLE: 111184534(ADCY1)
PCAD: 102981199(ADCY1)
PSIU: 116759445(ADCY1)
NASI: 112400149(ADCY1)
ECB: 100065563(ADCY1)
EPZ: 103550430(ADCY1)
EAI: 106822932(ADCY1)
MYB: 102257679(ADCY1)
MYD: 102759978(ADCY1)
MMYO: 118665883(ADCY1)
MDT: 132211234(ADCY1)
PKL: 118720332(ADCY1)
EFUS: 103303616(ADCY1)
MNA: 107526004(ADCY1)
DRO: 112306844(ADCY1)
SHON: 118983483(ADCY1)
AJM: 119057313(ADCY1)
PDIC: 114490247
PHAS: 123811468(ADCY1)
MMF: 118620164(ADCY1)
PPAM: 129068928(ADCY1)
HAI: 109373011(ADCY1)
RFQ: 117012305(ADCY1)
PALE: 102887497(ADCY1)
PGIG: 120589581(ADCY1)
PVP: 105308299
RAY: 107512406(ADCY1)
MJV: 108403511(ADCY1)
TOD: 119231485(ADCY1)
SARA: 101557843(ADCY1)
SETR: 126029834(ADCY1)
LAV: 100671072(ADCY1)
TMU: 101354868
ETF: 101661014(ADCY1)
DNM: 101411559(ADCY1)
MDO: 100030463(ADCY1)
GAS: 123247570(ADCY1)
SHR: 100922193(ADCY1)
AFZ: 127544134
PCW: 110197533(ADCY1)
TVP: 118831094(ADCY1)
OAA: 103168601(ADCY1)
GGA: 420788(ADCY1)
PCOC: 116228264(ADCY1)
CJO: 107309766(ADCY1)
TPAI: 128087769(ADCY1)
LMUT: 125690968(ADCY1)
NMEL: 110390836(ADCY1)
APLA: 101804073(ADCY1)
ACYG: 106046455(ADCY1)
CATA: 118249703(ADCY1)
AFUL: 116486732(ADCY1)
TGU: 100226080(ADCY1)
LSR: 110477391(ADCY1)
SCAN: 103819377(ADCY1)
PMOA: 120503563(ADCY1)
OTC: 121333301(ADCY1)
PRUF: 121356124
GFR: 102040399(ADCY1)
FAB: 101807752(ADCY1)
OMA: 130249364(ADCY1)
PHI: 102110269(ADCY1)
PMAJ: 107201036(ADCY1)
CCAE: 111923918(ADCY1)
CCW: 104689252(ADCY1)
CBRC: 103614095(ADCY1)
ETL: 114068677(ADCY1)
ZAB: 102073009(ADCY1)
ZLE: 135444019(ADCY1)
ACHL: 103807063(ADCY1)
SVG: 106853841(ADCY1)
MMEA: 130574316(ADCY1)
HRT: 120758617(ADCY1)
SATI: 136363707(ADCY1)
FPG: 101914769(ADCY1)
FCH: 102056699(ADCY1)
NNT: 104406517(ADCY1)
SHAB: 115612821(ADCY1)
ACUN: 113477314(ADCY1)
TALA: 104361601(ADCY1)
ACHC: 115352949(ADCY1)
HALD: 104319114(ADCY1)
HLE: 104837744(ADCY1)
AGEN: 126048595
GCL: 127013036
CSTI: 104559934
LDI: 104346969(ADCY1)
MNB: 103768479(ADCY1)
DPUB: 104298308(ADCY1)
EGZ: 104125965(ADCY1)
NNI: 104015394(ADCY1)
PCAO: 104052958(ADCY1)
PADL: 103916246(ADCY1)
AFOR: 103904001(ADCY1)
GSTE: 104257710(ADCY1)
CLV: 102094612(ADCY1)
MUI: 104547636(ADCY1)
PGUU: 104469426(ADCY1)
EHS: 104510986(ADCY1)
CUCA: 104065956(ADCY1)
TEO: 104371857(ADCY1)
OHA: 104334085(ADCY1)
CPEA: 104392180(ADCY1)
CVF: 104295315(ADCY1)
RTD: 128905714(ADCY1)
AAM: 106492856(ADCY1)
AROW: 112965172(ADCY1)
NPD: 112942706(ADCY1)
TGT: 104573631(ADCY1)
DNE: 112997517(ADCY1)
SCAM: 104150331(ADCY1)
ASN: 102372645(ADCY1)
AMJ: 102573818(ADCY1)
CPOO: 109310610(ADCY1)
GGN: 109291654(ADCY1)
PSS: 102445759(ADCY1)
CMY: 102939135(ADCY1)
CCAY: 125631858(ADCY1)
DCC: 119851996(ADCY1)
CPIC: 101935286(ADCY1)
TST: 117872635(ADCY1)
CABI: 116834610(ADCY1)
MRV: 120398088(ADCY1)
ACS: 100564004(adcy1)
ASAO: 132778512(ADCY1)
PVT: 110091617(ADCY1)
SUND: 121933610
PBI: 103068192
PMUR: 107287848(ADCY1)
CTIG: 120312767(ADCY1)
TSR: 106543976(ADCY1)
PGUT: 117664957(ADCY1)
APRI: 131198710(ADCY1)
PTEX: 113437370(ADCY1)
NSS: 113421046(ADCY1)
VKO: 123035478(ADCY1)
PMUA: 114607043(ADCY1)
PRAF: 128398543(ADCY1)
ZVI: 118077681(ADCY1)
HCG: 128329145(ADCY1)
GJA: 107119176(ADCY1)
STOW: 125440744(ADCY1)
EMC: 129337825(ADCY1)
XLA: 108705348(adcy1.S) 108718988(adcy1.L)
XTR: 100492373(adcy1)
NPR: 108796974(ADCY1)
RTEM: 120940455(ADCY1)
BBUF: 121001993(ADCY1)
BGAR: 122939040(ADCY1)
MUO: 115472502(ADCY1)
GSH: 117353894(ADCY1)
DRE: 557026(adcy1a) 569499(adcy1b)
SRX: 107708029 107712833 107721119 107722299
SANH: 107662517 107687179 107697434 107698950
SGH: 107559745 107563079 107568325 107568330 107581454
CCAR: 109062843 109064752 109104203
CAUA: 113039324 113046191 113063272 113121087
CGIB: 127938175 127938196 127950468 127983864 128022044
PTET: 122325165(adcy1a) 122332448(adcy1b)
LROH: 127173117(adcy1b) 127183422(adcy1a)
OMC: 131527742(adcy1a) 131550870(adcy1b)
PPRM: 120461652(adcy1b) 120493956(adcy1a)
RKG: 130096140(adcy1a) 130100699(adcy1b)
MAMB: 125251308(adcy1b) 125279119(adcy1a)
CIDE: 127501836 127502168
CERY: 137002841(adcy1b) 137018759(adcy1a)
MASI: 127410376 127416510 127440716 127442858
TROS: 130554346 130565530(adcy1a)
TDW: 130415317(adcy1b) 130434981(adcy1a)
MANU: 129424293 129429335(adcy1a)
IPU: 108257925(adcy1a) 108267157(adcy1b)
IFU: 128601211(adcy1a)
PHYP: 113545185 113547307(adcy1)
SMEO: 124377387(adcy1a) 124387690(adcy1b)
TFD: 113662326(adcy1b) 113663988(adcy1a)
TVC: 132842435(adcy1a) 132849005(adcy1b)
TRN: 134311736(adcy1b) 134320659(adcy1a)
AMEX: 103026793(adcy1a) 103044091(adcy1b)
CMAO: 118815470(adcy1a) 118826566(adcy1b)
EEE: 113582988 113588648
CHAR: 105898467 105910685(adcy1a)
TRU: 101074661(adcy1)
TFS: 130529086 130538675(adcy1a)
TNG: GSTEN00004784G001 GSTEN00012275G001
LCO: 104927730 104929332
NCC: 104962323
TBEN: 117489047 117495927(adcy1a)
CGOB: 115007486 115022993
PGEO: 117444953 117462870
GACU: 117558416 117560499
EMAC: 134865993 134869993
ELY: 117254244 117272452
EFO: 125895322 125902213
PLEP: 121941164 121952008
SLUC: 116038182 116046040
ECRA: 117950827 117954024
ESP: 116695549 116699106
PFLV: 114560976 114565945
GAT: 120816002 120824385
PPUG: 119209156 119216787
AFB: 129088688 129094658
CLUM: 117729878 117746280
PSWI: 130193885(adcy1a) 130197934
MSAM: 119900267 119902050
SCHU: 122877981 122887421
CUD: 121512420 121520404
ALAT: 119011864 119027991
MZE: 101466326 101470179
ONL: 100702846 100706434
OAU: 116314396(adcy1a) 116318699
OLA: 101165720 101166500
OML: 112147429(adcy1a) 112150580
CSAI: 133452758(adcy1a)
XMA: 102227141 102232616
XCO: 114146909 114151481
XHE: 116721781 116726292
PRET: 103463403 103479636 108167103
PFOR: 103129619 103142996
PLAI: 106948616(adcy1)
PMEI: 106914433 106925933
GAF: 122838016 122841230
PPRL: 129362301 129377558
CVG: 107083005 107092411
CTUL: 119787741(adcy1a) 119795701
GMU: 124870286 124874521
NFU: 107383914 107393050
KMR: 108239683 108248366
ALIM: 106532267 106533941
NWH: 119407638(adcy1a) 119415057
AOCE: 111568697 111569882
MCEP: 125008823 125011216
CSEM: 103396283 103399855
POV: 109637504(adcy1) 109643317
SSEN: 122771664 122780642(adcy1a)
HHIP: 117760300 117778082
HSP: 118118137 118120649
PPLT: 128448351 128455053(adcy1a)
SMAU: 118310526 118317718
LCF: 108879606 108883418
SDU: 111227562 111231027
SLAL: 111670478 111671788
XGL: 120790683 120799286
HCQ: 109521217 109524669
SSCV: 125970028 125985324
SBIA: 133503554 133511312
PEE: 133406201(adcy1a) 133411174
PTAO: 133480709(adcy1a) 133489512
BPEC: 110159474(adcy1) 110172262
MALB: 109957656 109961254
BSPL: 114843864 114854552
SJO: 128361501 128369208(adcy1a)
SASA: 106560395 106569164 106584068 106599721
STRU: 115157130 115158652 115169640
OTW: 112226841 112251320 112260578
OMY: 110508629 110523017 110530970
OGO: 123997178(adcy1a) 124010162 124041773
ONE: 115102992 115114521
OKI: 109872139 109875142 109886998
OKE: 118378895(adcy1a) 118394766 118402008
SALP: 111978905 112070221
SNH: 120020682 120054302 120055308
CCLU: 121533872(adcy1a) 121535312 121581006
ELS: 105011947 105018654
SFM: 108937596 108939197
PKI: 111845834 111850159
AANG: 118224561(adcy1a) 118233055
LOC: 102692556(adcy1)
PSPA: 121313146 121314511
ARUT: 117394455 117399269
PSEX: 120529518
CMK: 103187011
RTP: 109910491(adcy1a)
CPLA: 122549912
HOC: 132816069
LERI: 129710284
PMRN: 116941104 116947844(ADCY1)
LRJ: 133344717 133345152
DME: Dmel_CG9533(rut)
DER: 6550736
DSE: 6619554
DSI: Dsimw501_GD15838(Dsim_rut)
DYA: Dyak_GE16101
DAN: 6504270
DSR: 110182103
DPO: 6901423
DPE: 6598394
DMN: 108161375
DWI: 6653130
DGR: 6564853
DMO: Dmoj_GI15743
DAZ: 108618185
DNV: 108656529
DHE: 111600202
DVI: 6631926
CCAT: 101452382
BOD: 106625393
BDR: 105225223
RZE: 108372117 108373959
AOQ: 129236831
TDA: 119671131
MDE: 101890662
SCAC: 106085694
LCQ: 111684525
LSQ: 119608374
GFS: 119633415
ECOE: 129947535
CLON: 129619147
HIS: 119658368
AGA: 1272318
ACOZ: 120959989
AARA: 120906721
AMER: 121590606
ASTE: 118511090
AFUN: 125766985
AMOU: 128307435
AALI: 118468659
AAG: 5571379
AALB: 109401880
ASUA: 134206954
CQU: CpipJ_CPIJ017287 CpipJ_CPIJ019946
CPII: 120420252
CNS: 116346299
BCOO: 119081617
TCA: 661438(rut)
DPA: 109546607
SOY: 115880233
AGRG: 126749160
ATD: 109599121
CSET: 123312770
AGB: 108904553
LDC: 111515079
DVV: 114325217
NVL: 108566779
APLN: 108736715
PPYR: 116176544
OTU: 111427516
BMOR: 101741402
BMAN: 114248717
MSEX: 115454133
DPL: KGM_213815
BANY: 112053190
MJU: 123880988
NIQ: 126770280
VCD: 124533457
MCIX: 123653493
PMAC: 106720337
PPOT: 106109142
PXU: 106127108
PRAP: 110991594
PBX: 123720704
PNAP: 125054267
ZCE: 119834784
CCRC: 123690912
LSIN: 126976461
AAGE: 121731794
HAW: 110369899
HZE: 124631248
TNL: 113501500
SLIU: 111351639
OFU: 114365405
ATRA: 106139091
GMW: 113517375
PXY: 105380532
PGW: 126367434
LGLY: 125228195
CCRN: 123296813
API: 100164676
DNX: 107168960
AGS: 114126041
RMD: 113559605
ACOO: 126837253
DVT: 126898505
BTAB: 109030117
DCI: 103514692
CLEC: 106662482
HHAL: 106680561 106692546(rut)
NLU: 111062756
HVI: 124366297
MQU: 129004284
PHU: Phum_PHUM559430
FOC: 113210518
TPAL: 117645669
ZNE: 110826860
CSEC: 111871901
BROR: 134536770
FCD: 110861546
DPX: DAPPUDRAFT_48469(Adcy2)
DMK: 116925520
DPZ: 124313984
PVM: 113821369
PJA: 122256518
PCHN: 125036314
PMOO: 119592519
HAME: 121871085
PCLA: 123759647
PTRU: 123510504
ESN: 127000221
MNZ: 135206942
EAF: 111709929
LSM: 121126640
PPOI: 119109966
DSV: 119442413
RSAN: 119386353
RMP: 119159511
VDE: 111243789 111245060
VJA: 111259800 111271998
TUT: 107360550
DPTE: 113792109
DFR: 124498931
CSCU: 111626639
CVS: 136985683
PTEP: 107453371
ABRU: 129958256
UDV: 129219156
SDM: 118191600
LPOL: 106459518 106459597 106462092 106466221 106469035 106471819
LGI: LOTGIDRAFT_141290
PVUL: 126831524
PCAN: 112564559
BGT: 106067245
GAE: 121380643
HRF: 124125393
HRJ: 124278151
CRG: 105340585
CANU: 128162932
OED: 125665530
MYI: 110465124
PMAX: 117343252
MMER: 123533026
RPHI: 132712910
DPOL: 127855248
MAEA: 128231525
OBI: 106868905
OSN: 115219753
LJP: 135477484
LAK: 106159379
LLON: 135500106
PTM: GSPATT00035327001
 » show all
Reference
PMID:9662407
  Authors
Abdel-Majid RM, Leong WL, Schalkwyk LC, Smallman DS, Wong ST, Storm DR, Fine A, Dobson MJ, Guernsey DL, Neumann PE
  Title
Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex.
  Journal
Nat Genet 19:289-91 (1998)
DOI:10.1038/980
  Sequence
[mmu:432530]
Reference
PMID:8314585
  Authors
Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR
  Title
Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase.
  Journal
Genomics 16:473-8 (1993)
DOI:10.1006/geno.1993.1213
  Sequence
[hsa:107]
LinkDB

KEGG   ORTHOLOGY: K08042
Entry
K08042                      KO                                     
Symbol
ADCY2
Name
adenylate cyclase 2 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04922  Glucagon signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08042  ADCY2; adenylate cyclase 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04371 Apelin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04020 Calcium signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04072 Phospholipase D signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04024 cAMP signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04022 cGMP-PKG signaling pathway
    K08042  ADCY2; adenylate cyclase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08042  ADCY2; adenylate cyclase 2
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08042  ADCY2; adenylate cyclase 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08042  ADCY2; adenylate cyclase 2
   04062 Chemokine signaling pathway
    K08042  ADCY2; adenylate cyclase 2
  09152 Endocrine system
   04911 Insulin secretion
    K08042  ADCY2; adenylate cyclase 2
   04922 Glucagon signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04923 Regulation of lipolysis in adipocytes
    K08042  ADCY2; adenylate cyclase 2
   04912 GnRH signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04913 Ovarian steroidogenesis
    K08042  ADCY2; adenylate cyclase 2
   04915 Estrogen signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04914 Progesterone-mediated oocyte maturation
    K08042  ADCY2; adenylate cyclase 2
   04921 Oxytocin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04926 Relaxin signaling pathway
    K08042  ADCY2; adenylate cyclase 2
   04935 Growth hormone synthesis, secretion and action
    K08042  ADCY2; adenylate cyclase 2
   04918 Thyroid hormone synthesis
    K08042  ADCY2; adenylate cyclase 2
   04928 Parathyroid hormone synthesis, secretion and action
    K08042  ADCY2; adenylate cyclase 2
   04916 Melanogenesis
    K08042  ADCY2; adenylate cyclase 2
   04925 Aldosterone synthesis and secretion
    K08042  ADCY2; adenylate cyclase 2
   04927 Cortisol synthesis and secretion
    K08042  ADCY2; adenylate cyclase 2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08042  ADCY2; adenylate cyclase 2
   04270 Vascular smooth muscle contraction
    K08042  ADCY2; adenylate cyclase 2
  09154 Digestive system
   04970 Salivary secretion
    K08042  ADCY2; adenylate cyclase 2
   04971 Gastric acid secretion
    K08042  ADCY2; adenylate cyclase 2
   04972 Pancreatic secretion
    K08042  ADCY2; adenylate cyclase 2
   04976 Bile secretion
    K08042  ADCY2; adenylate cyclase 2
  09156 Nervous system
   04724 Glutamatergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04727 GABAergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04725 Cholinergic synapse
    K08042  ADCY2; adenylate cyclase 2
   04723 Retrograde endocannabinoid signaling
    K08042  ADCY2; adenylate cyclase 2
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08042  ADCY2; adenylate cyclase 2
  09149 Aging
   04211 Longevity regulating pathway
    K08042  ADCY2; adenylate cyclase 2
   04213 Longevity regulating pathway - multiple species
    K08042  ADCY2; adenylate cyclase 2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08042  ADCY2; adenylate cyclase 2
   04714 Thermogenesis
    K08042  ADCY2; adenylate cyclase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08042  ADCY2; adenylate cyclase 2
   05207 Chemical carcinogenesis - receptor activation
    K08042  ADCY2; adenylate cyclase 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08042  ADCY2; adenylate cyclase 2
   05163 Human cytomegalovirus infection
    K08042  ADCY2; adenylate cyclase 2
  09165 Substance dependence
   05032 Morphine addiction
    K08042  ADCY2; adenylate cyclase 2
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08042  ADCY2; adenylate cyclase 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08042  ADCY2; adenylate cyclase 2
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08042  ADCY2; adenylate cyclase 2
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08042  ADCY2; adenylate cyclase 2
Other DBs
GO: 0004016
Genes
HSA: 108(ADCY2)
PTR: 100608010(ADCY2)
PPS: 100992014(ADCY2)
GGO: 101141389(ADCY2)
PON: 100445431(ADCY2)
PPYG: 129036477(ADCY2)
NLE: 100600367(ADCY2)
HMH: 116457100(ADCY2)
SSYN: 129464955(ADCY2)
MCC: 695328(ADCY2)
MCF: 102130114(ADCY2)
MTHB: 126956053
MNI: 105489474(ADCY2)
CSAB: 103214981(ADCY2)
CATY: 105585972(ADCY2)
PANU: 101006754(ADCY2)
TGE: 112625956(ADCY2)
MLEU: 105535662(ADCY2)
RRO: 104674083(ADCY2)
RBB: 108536960(ADCY2)
TFN: 117064735(ADCY2)
PTEH: 111546755(ADCY2)
CANG: 105510962(ADCY2)
CJC: 100385658(ADCY2)
SBQ: 101043334(ADCY2)
CIMI: 108281387(ADCY2)
ANAN: 105732981(ADCY2)
CSYR: 103252919(ADCY2)
MMUR: 105859934(ADCY2)
LCAT: 123648063(ADCY2)
PCOQ: 105821322(ADCY2)
OGA: 100941250(ADCY2)
MMU: 210044(Adcy2)
MCAL: 110307661(Adcy2)
MPAH: 110328764(Adcy2)
RNO: 81636(Adcy2)
MCOC: 116083593(Adcy2)
ANU: 117723703(Adcy2)
MUN: 110550962(Adcy2)
CGE: 100773811(Adcy2)
MAUA: 101836580(Adcy2)
PROB: 127220711(Adcy2)
PLEU: 114696121(Adcy2)
MORG: 121433645(Adcy2)
MFOT: 126503179
AAMP: 119809754(Adcy2)
NGI: 103735350(Adcy2)
HGL: 101718304(Adcy2)
CPOC: 100731999(Adcy2)
CCAN: 109695818(Adcy2)
DORD: 105983849(Adcy2)
DSP: 122120987(Adcy2)
PLOP: 125367715(Adcy2)
NCAR: 124987010
MMMA: 107146314(Adcy2)
OCU: 100009201
OPI: 101528674(ADCY2)
TUP: 102492353(ADCY2)
GVR: 103597918(ADCY2)
CFA: 478624(ADCY2)
CLUD: 112662652(ADCY2)
VVP: 112934273(ADCY2)
VLG: 121477531(ADCY2)
NPO: 129498939(ADCY2)
AML: 100473195(ADCY2)
UMR: 103679250(ADCY2)
UAH: 113260807(ADCY2)
UAR: 123791264(ADCY2)
ELK: 111153427
LLV: 125099871
MPUF: 101674868(ADCY2)
MNP: 132028199(ADCY2)
MLK: 131831568(ADCY2)
NVS: 122896073(ADCY2)
ORO: 101365382(ADCY2)
EJU: 114223681(ADCY2)
ZCA: 113929853(ADCY2)
MLX: 118006264(ADCY2)
NSU: 110591563(ADCY2)
FCA: 101094327(ADCY2)
PYU: 121042416(ADCY2)
PCOO: 112860207(ADCY2)
PBG: 122495529(ADCY2)
PVIV: 125170902(ADCY2)
LRUF: 124508049
PTG: 102949732(ADCY2)
PPAD: 109267830(ADCY2)
PUC: 125934726
AJU: 106971248
HHV: 120225093(ADCY2)
BTA: 510708(ADCY2)
BOM: 102274117(ADCY2)
BIU: 109574822(ADCY2)
BBUB: 102412622(ADCY2)
BBIS: 105001032(ADCY2)
CHX: 102171922(ADCY2)
OAS: 101102089(ADCY2)
BTAX: 128066123(ADCY2)
ODA: 120879368(ADCY2)
CCAD: 122454210(ADCY2)
MBEZ: 129553378(ADCY2)
SSC: 100517503(ADCY2)
CFR: 102510993(ADCY2)
CBAI: 105081234(ADCY2)
CDK: 105094039(ADCY2)
VPC: 102539698(ADCY2)
BACU: 103020085(ADCY2)
BMUS: 118893277(ADCY2)
LVE: 103084817(ADCY2)
OOR: 101286207(ADCY2)
DLE: 111178556(ADCY2)
PCAD: 102991224(ADCY2)
PSIU: 116752275(ADCY2)
NASI: 112404518(ADCY2)
ECB: 100071337(ADCY2)
EPZ: 103562505
EAI: 106823001(ADCY2)
MYB: 102260356(ADCY2)
MYD: 102774384(ADCY2)
MMYO: 118656192(ADCY2)
MLF: 102430354(ADCY2)
MDT: 132233655(ADCY2)
PKL: 118703044(ADCY2)
EFUS: 103305103(ADCY2)
MNA: 107540528(ADCY2)
DRO: 112321008(ADCY2)
SHON: 118998674(ADCY2)
AJM: 119049317(ADCY2)
PDIC: 114508056(ADCY2)
PHAS: 123824963(ADCY2)
MMF: 118642779(ADCY2)
PPAM: 129074539(ADCY2)
HAI: 109375976(ADCY2)
RFQ: 117025090(ADCY2)
PALE: 102893265(ADCY2)
PGIG: 120586284(ADCY2)
PVP: 105299581(ADCY2)
RAY: 107502700(ADCY2)
MJV: 108409724(ADCY2)
TOD: 119260631(ADCY2)
SARA: 101539413(ADCY2)
SETR: 126000769(ADCY2)
LAV: 100673570(ADCY2)
TMU: 101360334
ETF: 101645045(ADCY2)
MDO: 100013164(ADCY2)
GAS: 123252650(ADCY2)
SHR: 100922434(ADCY2)
AFZ: 127543614
PCW: 110220436(ADCY2)
TVP: 118838251
OAA: 100089708(ADCY2)
GGA: 420935(ADCY2)
PCOC: 116226507(ADCY2)
MGP: 100540738(ADCY2)
CJO: 107309543(ADCY2)
TPAI: 128091036(ADCY2)
LMUT: 125690720(ADCY2)
NMEL: 110394300(ADCY2)
APLA: 101803512(ADCY2)
ACYG: 106036531(ADCY2)
CATA: 118251040(ADCY2)
TGU: 100223820(ADCY2)
LSR: 110479527(ADCY2)
SCAN: 103815408(ADCY2)
PMOA: 120504898(ADCY2)
OTC: 121339726(ADCY2)
PRUF: 121358032(ADCY2)
GFR: 102038853(ADCY2)
FAB: 101808400(ADCY2)
OMA: 130250026(ADCY2)
PHI: 102113898(ADCY2)
PMAJ: 107199935(ADCY2)
CCAE: 111925673(ADCY2)
CCW: 104685925(ADCY2)
CBRC: 103618790(ADCY2)
ETL: 114055132(ADCY2)
ZAB: 102072826(ADCY2)
ZLE: 135444214(ADCY2)
SVG: 106850751(ADCY2)
MMEA: 130576265(ADCY2)
HRT: 120758559(ADCY2)
SATI: 136365938(ADCY2)
FPG: 101911647(ADCY2)
FCH: 102049688(ADCY2)
NNT: 104405117(ADCY2)
SHAB: 115614173(ADCY2)
ACUN: 113476067(ADCY2)
TALA: 104359690(ADCY2)
ACHC: 115353041(ADCY2)
HLE: 104834280(ADCY2)
AGEN: 126048732
GCL: 127012822
DPUB: 104299276(ADCY2)
EGZ: 104126191(ADCY2)
NNI: 104018888(ADCY2)
PCRI: 104031366(ADCY2)
PADL: 103915154(ADCY2)
AFOR: 103898441(ADCY2)
CLV: 102097532(ADCY2)
PGUU: 104469219(ADCY2)
PLET: 104617889
CUCA: 104067554(ADCY2)
OHA: 104337731(ADCY2)
CPEA: 104398276(ADCY2)
CVF: 104285350(ADCY2)
RTD: 128905654(ADCY2)
AAM: 106492356(ADCY2)
AROW: 112974051(ADCY2)
NPD: 112955254(ADCY2)
TGT: 104573956
DNE: 112982724(ADCY2)
SCAM: 104137842(ADCY2)
ASN: 102383838(ADCY2)
AMJ: 102562034(ADCY2)
CPOO: 109314286(ADCY2)
GGN: 109298362(ADCY2)
PSS: 102444057(ADCY2)
CMY: 102930552(ADCY2)
CCAY: 125631991(ADCY2)
DCC: 119851129(ADCY2)
CPIC: 101952054(ADCY2)
TST: 117872756
CABI: 116828360(ADCY2)
MRV: 120397653(ADCY2)
ACS: 100555265(adcy2)
ASAO: 132774200(ADCY2)
PVT: 110089596
SUND: 121929529(ADCY2)
PBI: 103050340(ADCY2)
PMUR: 107297625(ADCY2)
CTIG: 120301698(ADCY2)
TSR: 106545186
PGUT: 117662380(ADCY2)
APRI: 131195502(ADCY2)
PTEX: 113436537(ADCY2)
NSS: 113415231(ADCY2)
VKO: 123029667(ADCY2)
PMUA: 114601220(ADCY2)
PRAF: 128418090(ADCY2)
ZVI: 118077623(ADCY2)
HCG: 128322473(ADCY2)
GJA: 107108835(ADCY2)
STOW: 125443640(ADCY2)
EMC: 129333200(ADCY2)
MUO: 115471653(ADCY2)
GSH: 117353592(ADCY2)
DRE: 557902(adcy2b) 563724(adcy2a)
SRX: 107711297 107746972 107751899 107754795(adcy2)
SANH: 107664610 107691497 107694336
SGH: 107551198 107584338(adcy2) 107595616
CCAR: 109066542 109086675
CAUA: 113090787 113116166 113119536
CGIB: 127935848 127974531 127979001
PTET: 122324064(adcy2b) 122360815 122361036(adcy2a)
LROH: 127179109(adcy2a) 127181325(adcy2b)
OMC: 131521759(adcy2a) 131525946(adcy2b)
PPRM: 120485252(adcy2b) 120495022(adcy2a)
RKG: 130087915(adcy2b) 130089999(adcy2a)
MAMB: 125242992(adcy2a) 125274762(adcy2b)
CIDE: 127497118 127500508
CERY: 137024677(adcy2a) 137037709(adcy2b)
MASI: 127421050 127425459 127452715 127453613
TROS: 130557784(adcy2a) 130566633(adcy2b)
TDW: 130415934(adcy2b) 130432459(adcy2a)
MANU: 129447712(adcy2a) 129454869(adcy2b)
IPU: 108272199(adcy2a) 108272792(adcy2b)
IFU: 128605578(adcy2a) 128615257(adcy2b)
PHYP: 113534051 113543796
SMEO: 124381992(adcy2b) 124384555(adcy2a)
TFD: 113634724(adcy2b) 113662752(adcy2a)
TVC: 132842768(adcy2b) 132846468(adcy2a)
TRN: 134310274(adcy2a) 134328752(adcy2b)
AMEX: 103036916(adcy2a) 103043428(adcy2b)
CMAO: 118805420(adcy2b) 118821927(adcy2a)
EEE: 113578463 113590334
CHAR: 105892081(adcy2b) 105905473(adcy2a) 105908817
TRU: 101074943 101077175
TFS: 130518647(adcy2b) 130532478(adcy2a)
TNG: GSTEN00007551G001 GSTEN00017582G001
LCO: 104933548 104936739 104940420
NCC: 104952475 104962256(adcy2)
TBEN: 117478365(adcy2b) 117480716(adcy2a)
CGOB: 115020798(adcy2)
PGEO: 117455202(adcy2b) 117460587(adcy2a)
GACU: 117537493(adcy2a) 117562961(adcy2b)
EMAC: 134861941(adcy2a) 134875530(adcy2b)
ELY: 117263948(adcy2b) 117265672(adcy2a)
EFO: 125893938(adcy2a) 125904538(adcy2b)
PLEP: 121946261(adcy2a) 121957695(adcy2b)
SLUC: 116041211(adcy2b) 116049201(adcy2a)
ECRA: 117946352(adcy2a) 117957152(adcy2b)
ESP: 116690645 116701410(adcy2)
PFLV: 114556982 114568098(adcy2)
GAT: 120810605(adcy2a) 120826532
PPUG: 119197448(adcy2a) 119219461
AFB: 129097035 129109595(adcy2a)
CLUM: 117739285 117745342(adcy2a)
PSWI: 130194309 130212629(adcy2a)
MSAM: 119897894(adcy2a) 119907366(adcy2b)
SCHU: 122864522(adcy2b) 122881549(adcy2a)
CUD: 121513506(adcy2a) 121524111(adcy2b)
ALAT: 119006711(adcy2a) 119017049(adcy2b)
MZE: 101464825 101472004 101474342
ONL: 100693919 100706736(adcy2) 100707801
OAU: 116313447(adcy2b) 116329362(adcy2a)
OLA: 101159207 101172459
OML: 112136286(adcy2b) 112143511(adcy2a)
CSAI: 133426855(adcy2a) 133460481(adcy2b)
XMA: 102219843 102225654
XCO: 114141804 114156097(adcy2)
XHE: 116717194 116731245
PRET: 103472071 103478370
PFOR: 103146018 103151564
PLAI: 106949352 106961924(adcy2)
PMEI: 106922633 106926897
GAF: 122831188(adcy2a) 122844085(adcy2b)
PPRL: 129367614(adcy2a) 129376322(adcy2b)
CVG: 107084393 107091823(adcy2)
CTUL: 119791316(adcy2a) 119792954(adcy2b)
GMU: 124865559(adcy2a) 124879381(adcy2b)
NFU: 107376988 107378756 107383184
KMR: 108232311(adcy2a) 108238708(adcy2b)
ALIM: 106514248 106516755
NWH: 119410353(adcy2a) 119425622(adcy2b)
AOCE: 111562440 111573422(adcy2) 111585533
MCEP: 125016395(adcy2a) 125020520(adcy2b)
CSEM: 103388319 103394729
POV: 109631507(adcy2) 109632042
SSEN: 122774912(adcy2a) 122786587(adcy2b)
HHIP: 117770401(adcy2b) 117777130(adcy2a)
HSP: 118114339(adcy2a) 118125234(adcy2b)
PPLT: 128449595(adcy2a) 128462106(adcy2b)
SMAU: 118306240(adcy2a) 118311293(adcy2b)
LCF: 108889001(adcy2a) 108900397(adcy2b)
SDU: 111227902 111233172 111238586
SLAL: 111655934 111661694 111671420(adcy2)
XGL: 120783631(adcy2a) 120786774(adcy2b)
HCQ: 109508262 109521934(adcy2)
SSCV: 125974623 125986948
SBIA: 133498674(adcy2b) 133500634(adcy2a)
PEE: 133395411(adcy2b) 133401813(adcy2a)
PTAO: 133470756 133479239(adcy2a)
BPEC: 110167228 110171614
MALB: 109958353 109971723
BSPL: 114843187(adcy2a) 114865538(adcy2b)
SJO: 128365975(adcy2a) 128374183(adcy2b)
SASA: 106570343 106588693
STRU: 115173833 115175633
OTW: 112229303(adcy2b) 112265839
OMY: 110489405 110496472
OGO: 124027005 124043321(adcy2b)
ONE: 115128595
OKI: 109881128 109908625
OKE: 118373036 118378037
SALP: 111954801(adcy2) 111955524
SNH: 120022775 120027455
CCLU: 121571883 121585784
ELS: 105012408(adcy2)
SFM: 108919207(adcy2) 108930627 108940527 114911923
PKI: 111844387 111852779
AANG: 118225550(adcy2a) 118234313(adcy2b)
LOC: 102696921(adcy2)
PSPA: 121309305 121314788
ARUT: 117394673 117399819
PSEX: 120515751
LCM: 102365947 102367170
CMK: 103183192
RTP: 109920424(adcy2b)
CPLA: 122549721
HOC: 132815957
LERI: 129711549
PMRN: 116944096(ADCY2) 116945842
LRJ: 133340218 133350806(ADCY2)
BFO: 118417332
BBEL: 109481983
SPU: 575180
APLC: 110980095
ARUN: 117289612
AJC: 117124042
SKO: 102803250
DME: Dmel_CG7978(Ac76E)
DER: 6545709
DSE: 6619425
DSI: Dsimw501_GD14841(Dsim_GD14841)
DYA: Dyak_GE19638 Dyak_GE27856
DAN: 6506248
DSR: 110189922
DPO: 4813656
DPE: 6599071
DMN: 108152507
DWI: 6638793
DGR: 6557116
DMO: Dmoj_GI11655
DAZ: 108614292
DNV: 108651863
DHE: 111604449
DVI: 6622821
CCAT: 101458244
BOD: 106621071
BDR: 105227411
RZE: 108358964
AOQ: 129243025
TDA: 119668078
MDE: 101893904
SCAC: 106091398
LCQ: 111683625
LSQ: 119600226
GFS: 119645009
ECOE: 129943002
CLON: 129613622
HIS: 119647624
AGA: 1272602
ACOZ: 120955519
AARA: 120900861
AMER: 121598772 121599449
ASTE: 118506236
AFUN: 125772338
AMOU: 128299462
AALI: 118463332
AAG: 5571159
AALB: 109418769
ASUA: 134224678
CQU: CpipJ_CPIJ004739
CPII: 120425270
CNS: 116340485
BCOO: 119078357
AME: 552216
ACER: 107992970
ALAB: 122713476
ADR: 102677870
AFLR: 100866955
BIM: 100745521
BBIF: 117207730
BVK: 117238217
BVAN: 117159965
BTER: 100647623
BAFF: 126919930
BPYO: 122570472
BPAS: 132905830
FVI: 122533982
CCAL: 108631101
OBB: 114880740
OLG: 117606140
MGEN: 117228009
NMEA: 116428151
CGIG: 122404122
SOC: 105197184
MPHA: 105835065
AEC: 105143483
ACEP: 105617405
PBAR: 105425936
VEM: 105559069
HST: 105184375
DQU: 106746346
CFO: 105250746
FEX: 115233348
LHU: 105670932(Ac76E)
PGC: 109855918
OBO: 105285379
PCF: 106792130
PFUC: 122526144
VPS: 122635235
VCRB: 124431413
VVE: 124955028
NVI: 100118148
CSOL: 105367877
TPRE: 106651693
LHT: 122511655
LBD: 127279196
MDL: 103577402
CGLO: 123264131
FAS: 105265325
DAM: 107046806
AGIF: 122851073
CINS: 118068550
VCAN: 122415889 122416826
CCIN: 107263506 107267175
AROA: 105685036 105688167
TCA: 660403
DPA: 109533154
SOY: 115878992 115885861
AGRG: 126735301 126739261
ATD: 109608976
CSET: 123309201 123314494
AGB: 108913278 108915947
LDC: 111507767
DVV: 126881922
NVL: 108567526
APLN: 108733663 108742235
PPYR: 116174497 116175132
OTU: 111424772
BMOR: 101737606
BMAN: 114243277
MSEX: 115452886
DPL: KGM_212333
BANY: 112043432
MJU: 123868152
NIQ: 126774451
VCD: 124536066
MCIX: 123660016
PMAC: 106718962
PPOT: 106100281
PXU: 106121310
PRAP: 110995397
PBX: 123709733
PNAP: 125048745
ZCE: 119840764
CCRC: 123694127
LSIN: 126976576
AAGE: 121739116
HAW: 110373694
HZE: 124635025
TNL: 113497935
SLIU: 111359092
OFU: 114363060
ATRA: 106133297
GMW: 113520078
PXY: 105382235
PGW: 126372724
LGLY: 125232035
CFEL: 113388323 113388622
CCRN: 123299263
API: 100164066
DNX: 107167195
AGS: 114123846
RMD: 113553384
ACOO: 126846651
DVT: 126895353
BTAB: 109030143
DCI: 103508920
CLEC: 106667432
HHAL: 106691350(Adcy2)
NLU: 111045768
HVI: 124354225
MQU: 129002028 129003094
PHU: Phum_PHUM294440
ZNE: 110829129
CSEC: 111868923
SGRE: 126355193
BROR: 134533756
IEL: 124159055 124163423
FCD: 110849688
PVM: 113818924
PJA: 122256199 122266929
PCHN: 125027067 125042258
HAME: 121867730 121880075
PCLA: 123770600 123773323
CQD: 128694392 128698484
PTRU: 123501259 123519945
ESN: 126980980
MNZ: 135213568
HAZT: 108670249
LSM: 121114334 121122242
TCF: 131876822 131882946
PPOI: 119089388
DSV: 119436082
RSAN: 119372661
RMP: 119185511
VDE: 111251320
VJA: 111272620
TUT: 107363859 107367509
DPTE: 113791828 113798730
DFR: 124490750 124491170
CSCU: 111623407 111638684
CVS: 136971609 136990270
PTEP: 107452662
ABRU: 129983791 129984531
UDV: 129223765 129224960
SDM: 118186485 118187008
LPOL: 106465222 106468404
LGI: LOTGIDRAFT_115371
PVUL: 126816269
PCAN: 112577004
BGT: 106067294
GAE: 121388686
HRF: 124135295
HRJ: 124266340
CRG: 105336030
CANU: 128188963
CVN: 111134509
OED: 125648179
MYI: 110458458
PMAX: 117337564
MMER: 123549315
RPHI: 132723392
DPOL: 127845643
MAEA: 128243159
LJP: 135465694
LAK: 106151524 106156374
LLON: 135495416
TAD: TRIADDRAFT_52497
AQU: 100636322 100636336
 » show all
Reference
PMID:1427768
  Authors
Stengel D, Parma J, Gannage MH, Roeckel N, Mattei MG, Barouki R, Hanoune J
  Title
Different chromosomal localization of two adenylyl cyclase genes expressed in human brain.
  Journal
Hum Genet 90:126-30 (1992)
DOI:10.1007/BF00210755
  Sequence
[hsa:108]
Reference
PMID:22461431
  Authors
Hardin M, Zielinski J, Wan ES, Hersh CP, Castaldi PJ, Schwinder E, Hawrylkiewicz I, Sliwinski P, Cho MH, Silverman EK
  Title
CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland.
  Journal
Am J Respir Cell Mol Biol 47:203-8 (2012)
DOI:10.1165/rcmb.2012-0011OC
LinkDB

KEGG   ORTHOLOGY: K08043
Entry
K08043                      KO                                     
Symbol
ADCY3
Name
adenylate cyclase 3 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04740  Olfactory transduction
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04962  Vasopressin-regulated water reabsorption
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05110  Vibrio cholerae infection
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Disease
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08043  ADCY3; adenylate cyclase 3
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04371 Apelin signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04020 Calcium signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04072 Phospholipase D signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04024 cAMP signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04022 cGMP-PKG signaling pathway
    K08043  ADCY3; adenylate cyclase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08043  ADCY3; adenylate cyclase 3
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08043  ADCY3; adenylate cyclase 3
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08043  ADCY3; adenylate cyclase 3
   04062 Chemokine signaling pathway
    K08043  ADCY3; adenylate cyclase 3
  09152 Endocrine system
   04911 Insulin secretion
    K08043  ADCY3; adenylate cyclase 3
   04923 Regulation of lipolysis in adipocytes
    K08043  ADCY3; adenylate cyclase 3
   04912 GnRH signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04913 Ovarian steroidogenesis
    K08043  ADCY3; adenylate cyclase 3
   04915 Estrogen signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04914 Progesterone-mediated oocyte maturation
    K08043  ADCY3; adenylate cyclase 3
   04921 Oxytocin signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04926 Relaxin signaling pathway
    K08043  ADCY3; adenylate cyclase 3
   04935 Growth hormone synthesis, secretion and action
    K08043  ADCY3; adenylate cyclase 3
   04918 Thyroid hormone synthesis
    K08043  ADCY3; adenylate cyclase 3
   04928 Parathyroid hormone synthesis, secretion and action
    K08043  ADCY3; adenylate cyclase 3
   04916 Melanogenesis
    K08043  ADCY3; adenylate cyclase 3
   04925 Aldosterone synthesis and secretion
    K08043  ADCY3; adenylate cyclase 3
   04927 Cortisol synthesis and secretion
    K08043  ADCY3; adenylate cyclase 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08043  ADCY3; adenylate cyclase 3
   04270 Vascular smooth muscle contraction
    K08043  ADCY3; adenylate cyclase 3
  09154 Digestive system
   04970 Salivary secretion
    K08043  ADCY3; adenylate cyclase 3
   04971 Gastric acid secretion
    K08043  ADCY3; adenylate cyclase 3
   04972 Pancreatic secretion
    K08043  ADCY3; adenylate cyclase 3
   04976 Bile secretion
    K08043  ADCY3; adenylate cyclase 3
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K08043  ADCY3; adenylate cyclase 3
  09156 Nervous system
   04724 Glutamatergic synapse
    K08043  ADCY3; adenylate cyclase 3
   04727 GABAergic synapse
    K08043  ADCY3; adenylate cyclase 3
   04725 Cholinergic synapse
    K08043  ADCY3; adenylate cyclase 3
   04723 Retrograde endocannabinoid signaling
    K08043  ADCY3; adenylate cyclase 3
  09157 Sensory system
   04740 Olfactory transduction
    K08043  ADCY3; adenylate cyclase 3
   04750 Inflammatory mediator regulation of TRP channels
    K08043  ADCY3; adenylate cyclase 3
  09149 Aging
   04211 Longevity regulating pathway
    K08043  ADCY3; adenylate cyclase 3
   04213 Longevity regulating pathway - multiple species
    K08043  ADCY3; adenylate cyclase 3
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08043  ADCY3; adenylate cyclase 3
   04714 Thermogenesis
    K08043  ADCY3; adenylate cyclase 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08043  ADCY3; adenylate cyclase 3
   05207 Chemical carcinogenesis - receptor activation
    K08043  ADCY3; adenylate cyclase 3
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08043  ADCY3; adenylate cyclase 3
   05163 Human cytomegalovirus infection
    K08043  ADCY3; adenylate cyclase 3
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K08043  ADCY3; adenylate cyclase 3
  09165 Substance dependence
   05032 Morphine addiction
    K08043  ADCY3; adenylate cyclase 3
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08043  ADCY3; adenylate cyclase 3
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08043  ADCY3; adenylate cyclase 3
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08043  ADCY3; adenylate cyclase 3
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08043  ADCY3; adenylate cyclase 3
Other DBs
GO: 0008294
Genes
HSA: 109(ADCY3)
PTR: 459070(ADCY3)
PPS: 100995134(ADCY3)
GGO: 101144031(ADCY3)
PON: 100431221(ADCY3)
PPYG: 129030192(ADCY3)
NLE: 100586735(ADCY3)
HMH: 116480405(ADCY3)
SSYN: 129468529(ADCY3)
MCC: 693523(ADCY3)
MCF: 101925741(ADCY3)
MTHB: 126933644
MNI: 105479810(ADCY3)
CSAB: 103220665(ADCY3)
CATY: 105578529(ADCY3)
PANU: 101006469(ADCY3)
TGE: 112604540(ADCY3)
MLEU: 105534027(ADCY3)
RRO: 104658457(ADCY3)
RBB: 108543021(ADCY3)
TFN: 117062665(ADCY3)
PTEH: 111554419(ADCY3)
CANG: 105518129(ADCY3)
CJC: 100415165(ADCY3)
SBQ: 101040601(ADCY3)
CIMI: 108303190(ADCY3)
ANAN: 105717935(ADCY3)
CSYR: 103262642(ADCY3)
MMUR: 105884349(ADCY3)
LCAT: 123636670(ADCY3)
PCOQ: 105816960(ADCY3)
OGA: 100942592(ADCY3)
MMU: 104111(Adcy3)
MCAL: 110306494(Adcy3)
MPAH: 110324646(Adcy3)
RNO: 64508(Adcy3)
MCOC: 116079663(Adcy3)
ANU: 117716811(Adcy3)
MUN: 110555185(Adcy3)
CGE: 100770498(Adcy3)
MAUA: 101844476(Adcy3)
PROB: 127220046(Adcy3)
PLEU: 114697107(Adcy3)
MORG: 121439713 121439725
MFOT: 126490736
AAMP: 119807554(Adcy3)
NGI: 103746460(Adcy3)
HGL: 101713887(Adcy3)
CPOC: 100725667(Adcy3)
CCAN: 109685686(Adcy3)
DORD: 105983683(Adcy3)
DSP: 122122500(Adcy3)
PLOP: 125356676(Adcy3)
NCAR: 124962927
MMMA: 107137043(Adcy3)
OCU: 100343958
OPI: 101529277(ADCY3)
TUP: 102477532(ADCY3)
GVR: 103588815(ADCY3)
CFA: 482994(ADCY3)
CLUD: 112664701(ADCY3)
VVP: 112908545(ADCY3)
VLG: 121491160(ADCY3)
NPO: 129510932(ADCY3)
AML: 100471164(ADCY3)
UMR: 103671685(ADCY3)
UAH: 113270586(ADCY3)
UAR: 123799951(ADCY3)
ELK: 111154044
LLV: 125108687
MPUF: 101671296(ADCY3)
MNP: 132021183(ADCY3)
MLK: 131807291(ADCY3)
NVS: 122915263(ADCY3)
ORO: 101368682(ADCY3)
EJU: 114205853(ADCY3)
ZCA: 113937275(ADCY3)
MLX: 118007652(ADCY3)
NSU: 110587205(ADCY3)
LWW: 102741598(ADCY3)
FCA: 101088157(ADCY3)
PYU: 121044199(ADCY3)
PCOO: 112864041(ADCY3)
PBG: 122497386(ADCY3)
PVIV: 125162135(ADCY3)
LRUF: 124503617
PPAD: 109267527(ADCY3)
PUC: 125937626
AJU: 106989109
HHV: 120235801(ADCY3)
BTA: 535603(ADCY3)
BOM: 102282732(ADCY3)
BIU: 109566330(ADCY3)
BBUB: 102407976(ADCY3)
BBIS: 104989034(ADCY3)
CHX: 102169019(ADCY3)
OAS: 101108203(ADCY3)
BTAX: 128056879(ADCY3)
ODA: 120851596(ADCY3)
CCAD: 122441999(ADCY3)
MBEZ: 129539229(ADCY3)
SSC: 100514402(ADCY3)
CFR: 102512950(ADCY3)
CBAI: 105063873(ADCY3)
CDK: 105100030(ADCY3)
VPC: 102536207(ADCY3)
BACU: 103020845(ADCY3)
BMUS: 118905966(ADCY3)
LVE: 103076182(ADCY3)
OOR: 101283651(ADCY3)
DLE: 111175000(ADCY3)
PCAD: 102989136(ADCY3)
PSIU: 116764233(ADCY3)
NASI: 112412774(ADCY3)
ECB: 100055961(ADCY3)
EPZ: 103547823(ADCY3)
EAI: 106841140(ADCY3)
MYB: 102261014(ADCY3)
MYD: 102757252(ADCY3)
MMYO: 118669221(ADCY3)
MLF: 102442682(ADCY3)
MDT: 132213586(ADCY3)
PKL: 118717241(ADCY3)
EFUS: 103305553(ADCY3)
MNA: 107534062(ADCY3)
DRO: 112297750(ADCY3)
SHON: 119001392(ADCY3)
AJM: 119050413(ADCY3)
PDIC: 114500049(ADCY3)
PHAS: 123822448(ADCY3)
MMF: 118630645(ADCY3)
PPAM: 129067273(ADCY3)
HAI: 109385186(ADCY3)
RFQ: 117032856(ADCY3)
PALE: 102886232(ADCY3)
PGIG: 120621545(ADCY3)
PVP: 105289813(ADCY3)
RAY: 107498506(ADCY3)
MJV: 108397345(ADCY3)
TOD: 119259500(ADCY3)
SARA: 101547055(ADCY3)
SETR: 126024026(ADCY3)
LAV: 100674724(ADCY3)
TMU: 101349290
ETF: 101646509(ADCY3)
DNM: 101411573(ADCY3)
MDO: 100025332(ADCY3)
GAS: 123235004(ADCY3)
SHR: 100925657(ADCY3)
AFZ: 127548786
PCW: 110206523(ADCY3)
TVP: 118841840(ADCY3)
OAA: 100085901(ADCY3)
GGA: 422013(ADCY3)
PCOC: 116235620(ADCY3)
MGP: 100538467(ADCY3)
CJO: 107312346(ADCY3)
TPAI: 128084684(ADCY3)
LMUT: 125689755(ADCY3)
NMEL: 110395965(ADCY3)
APLA: 101791112(ADCY3)
ACYG: 106038094(ADCY3)
CATA: 118256582(ADCY3)
AFUL: 116488201(ADCY3)
PMOA: 120504513(ADCY3)
OMA: 130251870(ADCY3)
ZLE: 135441349(ADCY3)
SVG: 106864351
MMEA: 130586630
FPG: 101921567(ADCY3)
FCH: 102047195(ADCY3)
SHAB: 115610050(ADCY3)
ACUN: 113478856(ADCY3)
TALA: 116958839(ADCY3)
ACHC: 115351414(ADCY3)
HLE: 104841476(ADCY3)
AGEN: 126046636
GCL: 127014701
DPUB: 104306755(ADCY3)
BRHI: 104500202(ADCY3)
EGZ: 104132021(ADCY3)
NNI: 104014763(ADCY3)
AFOR: 103902407(ADCY3)
CLV: 102092425(ADCY3)
CUCA: 104061819(ADCY3)
TEO: 104381100(ADCY3)
BREG: 104640852(ADCY3)
OHA: 104334752(ADCY3)
ACAR: 104522049(ADCY3)
CPEA: 104392793(ADCY3)
CVF: 104295685(ADCY3)
RTD: 128907497(ADCY3)
AROW: 112966650(ADCY3)
NPD: 112948757(ADCY3)
TGT: 104573744(ADCY3)
DNE: 112984267(ADCY3)
ASN: 102374249(ADCY3)
AMJ: 102566746(ADCY3)
CPOO: 109311539(ADCY3)
PSS: 102463305(ADCY3)
CMY: 102941584(ADCY3)
CCAY: 125634736(ADCY3)
DCC: 119852477(ADCY3)
CPIC: 101948171(ADCY3)
TST: 117875434(ADCY3)
CABI: 116830876(ADCY3)
MRV: 120401447(ADCY3)
ACS: 100558229(adcy3)
ASAO: 132761631(ADCY3)
PVT: 110089954(ADCY3)
SUND: 121919215(ADCY3)
PMUR: 107284867(ADCY3)
CTIG: 120309099(ADCY3)
TSR: 106555200(ADCY3)
PGUT: 117667701(ADCY3)
APRI: 131189019(ADCY3)
PTEX: 113446325(ADCY3)
NSS: 113414572(ADCY3)
PMUA: 114594931
PRAF: 128411458(ADCY3)
ZVI: 118082958(ADCY3)
HCG: 128324563(ADCY3)
GJA: 107124706(ADCY3)
STOW: 125444508(ADCY3)
EMC: 129335670(ADCY3)
XLA: 108717252(adcy3.L) 108718304
XTR: 100038110(dnajc27)
NPR: 108795542(ADCY3)
RTEM: 120936026(ADCY3)
BBUF: 120997161(ADCY3)
BGAR: 122935174(ADCY3)
MUO: 115467032(ADCY3)
GSH: 117357028(ADCY3)
DRE: 571825(adcy3a)
SRX: 107708319
SANH: 107685373 107688975 107703925
SGH: 107593287 107598935(adcy3)
CCAR: 109061725 109090165
CAUA: 113059808 113097331 113116527 113120648
CGIB: 127938084 127974391 127984289 128031089
PTET: 122323846 122324966 122359840 122360627(adcy3a)
LROH: 127178345(adcy3a) 127182895
OMC: 131522138(adcy3a) 131526673
PPRM: 120460244 120462680(adcy3a)
RKG: 130096565(adcy3a) 130103243
MAMB: 125243356(adcy3a) 125278498
CIDE: 127496915 127501758
CERY: 137018599 137029986(adcy3a)
MASI: 127409986 127452518 127454374
TROS: 130548258(adcy3a) 130565735
TDW: 130433023(adcy3a) 130434826
MANU: 129429917 129449272(adcy3a)
IPU: 108271861(adcy3a) 108275460
IFU: 128612717(adcy3a) 128616515
PHYP: 113526734(adcy3)
SMEO: 124385054(adcy3a)
TFD: 113644807(adcy3a) 113651668
TVC: 132845703(adcy3a) 132854706
TRN: 134310525(adcy3a) 134319793
AMEX: 103027936(adcy3a) 103034748
CMAO: 118816015 118819670(adcy3a)
EEE: 113583134(adcy3)
CHAR: 105899528 105905507(adcy3a)
TRU: 101066423(adcy3)
TFS: 130515968 130532052(adcy3a)
TNG: GSTEN00021989G001
LCO: 104938398
NCC: 104945720
TBEN: 117470747(adcy3a) 117493182
CGOB: 115003477 115021083
PGEO: 117440036 117460963(adcy3a)
GACU: 117538552 117554043(adcy3a)
EMAC: 134862007(adcy3a) 134877175
ELY: 117264741(adcy3a)
EFO: 125892836(adcy3a) 125896844
PLEP: 121945854(adcy3a)
SLUC: 116066597
ECRA: 117946038(adcy3a) 117961136
ESP: 116686433 116699442 116706561
PFLV: 114557128 114572936
GAT: 120810053(adcy3a)
PPUG: 119194580 119197445(adcy3a)
AFB: 129107005 129110257(adcy3a)
CLUM: 117727465 117728051(adcy3a)
PSWI: 130202530 130206457(adcy3a)
MSAM: 119896893(adcy3a)
SCHU: 122863563 122880946(adcy3a)
CUD: 121513070(adcy3a)
ALAT: 119006468(adcy3a) 119012484
MZE: 101468640
ONL: 100710007
OAU: 116316197(adcy3a)
OLA: 101167167 105355856(adcy3)
OML: 112151984
CSAI: 133424414 133440842 133464410
XMA: 102219355(adcy3)
XCO: 114152719(adcy3)
XHE: 116717093(adcy3)
PRET: 103478767(adcy3)
PFOR: 103139954(adcy3) 103144118
PLAI: 106937126(adcy3) 106957331
PMEI: 106920589(adcy3) 106920816
GAF: 122831106(adcy3a)
PPRL: 129353749(adcy3a) 129369253
CTUL: 119792159(adcy3a)
GMU: 124865677(adcy3a) 124882389
NFU: 107378974(adcy3)
KMR: 108247740(adcy3a)
ALIM: 106530667
NWH: 119410425 119418144
AOCE: 111578872 111588972
MCEP: 125017029(adcy3a)
CSEM: 103388741(adcy3)
POV: 109632037(adcy3)
SSEN: 122774154(adcy3a)
HHIP: 117758850 117777341(adcy3a)
HSP: 118099052 118113773(adcy3a)
PPLT: 128449895(adcy3a) 128460180
SMAU: 118284638(adcy3a) 118290427
LCF: 108886083(adcy3a)
SDU: 111227842 111236629
SLAL: 111664165 111672734
XGL: 120783866(adcy3a)
HCQ: 109516699 109521893(adcy3)
SSCV: 125975266 125990480
SBIA: 133497022 133500609(adcy3a)
PEE: 133401105(adcy3a) 133417375
PTAO: 133468081 133479383(adcy3a)
BPEC: 110159121(adcy3)
MALB: 109952263
BSPL: 114842644(adcy3a) 114850163
SJO: 128366687(adcy3a) 128376826
SASA: 106584132 106605024 106607897
STRU: 115175579 115177411 115191681
OTW: 112217669 112223172 112234013
OMY: 110490105 110519325(adcy3a) 110522313
OGO: 123995167 123997492 124005714
ONE: 115106654 115139332 115141418
OKI: 109864829 109866597 109902225
OKE: 118364180 118367257 118386985
SALP: 111972593 112069658(adcy3)
SNH: 120019516 120031336 120048257
CCLU: 121543494(adcy3a) 121548712 121585903
ELS: 105005964(adcy3) 105017622
SFM: 108929094(adcy3)
PKI: 111851542
AANG: 118207103(adcy3a) 118228793
LOC: 102683703(adcy3)
PSPA: 121316002(adcy3a)
ARUT: 117403044(adcy3a)
PSEX: 120526110(adcy3a)
RTP: 109935189(adcy3a)
CPLA: 122552536(adcy3a)
HOC: 132819289(adcy3a)
LERI: 129699833
PMRN: 116941488 116945299
LRJ: 133344528(ADCY3) 133353274
BFO: 118404575
BBEL: 109476282
SPU: 582454
LPIC: 129255390
APLC: 110978247
ARUN: 117300756
AJC: 117109845
DME: Dmel_CG1506(Ac3)
DER: 6548790
DSE: 6619304
DSI: Dsimw501_GD29214(Dsim_GD29214)
DYA: Dyak_GE12923
DAN: 6498294
DSR: 110185021
DPO: 4817810
DPE: 6593540
DMN: 108163161
DWI: 6644450
DGR: 6562956
DMO: Dmoj_GI17441
DAZ: 108610471
DNV: 108658095
DHE: 111592509
DVI: 6628564
CCAT: 101452921
BOD: 106627089
BDR: 105222173
RZE: 108364620
AOQ: 129247717
TDA: 119661887
MDE: 101889515
SCAC: 106084968
LCQ: 111674541
LSQ: 119611456
GFS: 119633811
ECOE: 129939117
CLON: 129615862
HIS: 119652956
AGA: 4578014
ACOZ: 120955699
AARA: 120900035
AMER: 121595580
ASTE: 118510863
AFUN: 125763371
AMOU: 128302096
AALI: 118456237
AAG: 5571858
AALB: 115265620
ASUA: 134213289
CQU: CpipJ_CPIJ007058
CPII: 120422382
CNS: 116337149
BCOO: 119075649
AME: 408363(Ac3)
ACER: 107995067
ALAB: 122718105
ADR: 102677617
AFLR: 100866254
BIM: 100743487
BBIF: 117214055
BVK: 117236364
BVAN: 117161479
BTER: 100651573
BAFF: 126917737
BPYO: 122572716
BPAS: 132906654
FVI: 122537713
CCAL: 108626049
OBB: 114872430
OLG: 117601891
MGEN: 117225471
NMEA: 116434955
CGIG: 122404482
SOC: 105201589
MPHA: 105830745
AEC: 105143828
ACEP: 105620050
PBAR: 105427823
VEM: 105567376
HST: 105189653
DQU: 106743434
CFO: 105258159
FEX: 115245547
LHU: 105678451(Ac3)
PGC: 109856042
OBO: 105275628
PCF: 106784577
PFUC: 122517070
VPS: 122627953
VCRB: 124422992
VVE: 124947926
NVI: 100122644
CSOL: 105368022
TPRE: 106659602
LHT: 122501075
LBD: 127276842
MDL: 103570576
CGLO: 123262566
FAS: 105269461
DAM: 107048673
AGIF: 122853229
CINS: 118068472
VCAN: 122418080
CCIN: 107266397
DSM: 124411523
NPT: 124219635
NFB: 124183093
NLO: 107216989
NVG: 124305489
AROA: 105692401
TCA: 657568
DPA: 109540388
SOY: 115890718
AGRG: 126739042
ATD: 109599040
CSET: 123312147
AGB: 111692202
LDC: 111511084
DVV: 114331837
NVL: 108559187
APLN: 108740017
PPYR: 116170321
OTU: 111419645
BMOR: 105842081
BMAN: 114250981
MSEX: 115441032
DPL: KGM_214166
BANY: 112058553
MJU: 123867307
NIQ: 126780236
VCD: 124531281
MCIX: 123669765
PMAC: 106710670
PPOT: 106099456
PXU: 106127520
PRAP: 110998659
PBX: 123712606
PNAP: 125056935
ZCE: 119834210
CCRC: 123705887
AAGE: 121729059
HAW: 110375470
HZE: 124646154
TNL: 113501246
SLIU: 111352455
OFU: 114364732
ATRA: 106143008
GMW: 113517445
PGW: 126366300
CFEL: 113373271 113373274
CCRN: 123290745
API: 100163190
DNX: 107161386
AGS: 114126436
RMD: 113555842
ACOO: 126844952
DVT: 126897581
BTAB: 109035248
CLEC: 106670646
HHAL: 106679676(Ac3)
NLU: 111048874
HVI: 124364107
MQU: 129000902
PHU: Phum_PHUM149090
FOC: 113214623
TPAL: 117639687
ZNE: 110830923
CSEC: 117282028
SGRE: 126335781
BROR: 134540554
FCD: 110846307
DPX: DAPPUDRAFT_317298
DMK: 116928509
DPZ: 124310879
PJA: 122262922
PCHN: 125044069
HAME: 121867312
PCLA: 123764295
CQD: 128697076
PTRU: 123503561
ESN: 127002905
MNZ: 135222879
HAZT: 108664322
PPOI: 119096083
DSV: 119449210
RSAN: 119384145
RMP: 119169944
VDE: 111252385
VJA: 111263764
TUT: 107366670
DPTE: 113791730
DFR: 124494734
CSCU: 111621814
CVS: 136990679(Ac3)
PTEP: 107455365
ABRU: 129975033
UDV: 129227718
SDM: 118187632
LPOL: 106456994 106468917
PMEO: 129593277
PVUL: 126811878
BGT: 106067539
GAE: 121388074
HRF: 124147700
HRJ: 124282634
CRG: 105328828
LJP: 135464874
LLON: 135502700
NVE: 5514741
ATEN: 116286473
SPIS: 111343424
XEN: 124433348
HSY: 130647287 130648305
RES: 135689774
TAD: TRIADDRAFT_58375
 » show all
Reference
PMID:2255909
  Authors
Bakalyar HA, Reed RR
  Title
Identification of a specialized adenylyl cyclase that may mediate odorant detection.
  Journal
Science 250:1403-6 (1990)
DOI:10.1126/science.2255909
  Sequence
[rno:64508]
LinkDB

KEGG   ORTHOLOGY: K08044
Entry
K08044                      KO                                     
Symbol
ADCY4
Name
adenylate cyclase 4 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04742  Taste transduction
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08044  ADCY4; adenylate cyclase 4
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04371 Apelin signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04020 Calcium signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04072 Phospholipase D signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04024 cAMP signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04022 cGMP-PKG signaling pathway
    K08044  ADCY4; adenylate cyclase 4
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08044  ADCY4; adenylate cyclase 4
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08044  ADCY4; adenylate cyclase 4
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08044  ADCY4; adenylate cyclase 4
   04062 Chemokine signaling pathway
    K08044  ADCY4; adenylate cyclase 4
  09152 Endocrine system
   04911 Insulin secretion
    K08044  ADCY4; adenylate cyclase 4
   04923 Regulation of lipolysis in adipocytes
    K08044  ADCY4; adenylate cyclase 4
   04912 GnRH signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04913 Ovarian steroidogenesis
    K08044  ADCY4; adenylate cyclase 4
   04915 Estrogen signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04914 Progesterone-mediated oocyte maturation
    K08044  ADCY4; adenylate cyclase 4
   04921 Oxytocin signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04926 Relaxin signaling pathway
    K08044  ADCY4; adenylate cyclase 4
   04935 Growth hormone synthesis, secretion and action
    K08044  ADCY4; adenylate cyclase 4
   04918 Thyroid hormone synthesis
    K08044  ADCY4; adenylate cyclase 4
   04928 Parathyroid hormone synthesis, secretion and action
    K08044  ADCY4; adenylate cyclase 4
   04916 Melanogenesis
    K08044  ADCY4; adenylate cyclase 4
   04925 Aldosterone synthesis and secretion
    K08044  ADCY4; adenylate cyclase 4
   04927 Cortisol synthesis and secretion
    K08044  ADCY4; adenylate cyclase 4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08044  ADCY4; adenylate cyclase 4
   04270 Vascular smooth muscle contraction
    K08044  ADCY4; adenylate cyclase 4
  09154 Digestive system
   04970 Salivary secretion
    K08044  ADCY4; adenylate cyclase 4
   04971 Gastric acid secretion
    K08044  ADCY4; adenylate cyclase 4
   04972 Pancreatic secretion
    K08044  ADCY4; adenylate cyclase 4
   04976 Bile secretion
    K08044  ADCY4; adenylate cyclase 4
  09156 Nervous system
   04724 Glutamatergic synapse
    K08044  ADCY4; adenylate cyclase 4
   04727 GABAergic synapse
    K08044  ADCY4; adenylate cyclase 4
   04725 Cholinergic synapse
    K08044  ADCY4; adenylate cyclase 4
   04723 Retrograde endocannabinoid signaling
    K08044  ADCY4; adenylate cyclase 4
  09157 Sensory system
   04742 Taste transduction
    K08044  ADCY4; adenylate cyclase 4
   04750 Inflammatory mediator regulation of TRP channels
    K08044  ADCY4; adenylate cyclase 4
  09149 Aging
   04211 Longevity regulating pathway
    K08044  ADCY4; adenylate cyclase 4
   04213 Longevity regulating pathway - multiple species
    K08044  ADCY4; adenylate cyclase 4
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08044  ADCY4; adenylate cyclase 4
   04714 Thermogenesis
    K08044  ADCY4; adenylate cyclase 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08044  ADCY4; adenylate cyclase 4
   05207 Chemical carcinogenesis - receptor activation
    K08044  ADCY4; adenylate cyclase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08044  ADCY4; adenylate cyclase 4
   05163 Human cytomegalovirus infection
    K08044  ADCY4; adenylate cyclase 4
  09165 Substance dependence
   05032 Morphine addiction
    K08044  ADCY4; adenylate cyclase 4
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08044  ADCY4; adenylate cyclase 4
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08044  ADCY4; adenylate cyclase 4
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08044  ADCY4; adenylate cyclase 4
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08044  ADCY4; adenylate cyclase 4
Other DBs
GO: 0004016
Genes
HSA: 196883(ADCY4)
PTR: 452819(ADCY4)
PPS: 100978200(ADCY4)
GGO: 101125890(ADCY4)
PON: 100460806(ADCY4)
PPYG: 129012612(ADCY4)
NLE: 100603282(ADCY4)
HMH: 116484980(ADCY4)
SSYN: 129489292(ADCY4)
MCC: 714684(ADCY4)
MCF: 102123837(ADCY4)
MTHB: 126958798
MNI: 105477872(ADCY4)
CSAB: 103228726(ADCY4)
CATY: 105600225(ADCY4)
PANU: 101021139(ADCY4)
TGE: 112629482(ADCY4)
MLEU: 105532738(ADCY4)
RRO: 104662674(ADCY4)
RBB: 108540946(ADCY4)
TFN: 117069900(ADCY4)
PTEH: 111552878(ADCY4)
CANG: 105503715(ADCY4)
CJC: 100415141(ADCY4)
SBQ: 101044688(ADCY4)
CIMI: 108297937(ADCY4)
ANAN: 105727843(ADCY4)
CSYR: 103272228(ADCY4)
MMUR: 105866617(ADCY4)
LCAT: 123650680(ADCY4)
PCOQ: 105812764(ADCY4)
OGA: 100949638(ADCY4)
MMU: 104110(Adcy4)
MCAL: 110309267(Adcy4)
MPAH: 110325439(Adcy4)
RNO: 54223(Adcy4)
MCOC: 116084111(Adcy4)
ANU: 117704978(Adcy4)
MUN: 110556521(Adcy4)
CGE: 100768998(Adcy4)
MAUA: 101841504(Adcy4)
PROB: 127230359(Adcy4)
PLEU: 114708701(Adcy4)
MORG: 121434995(Adcy4)
MFOT: 126490851
AAMP: 119800380(Adcy4)
NGI: 103739411(Adcy4)
HGL: 101719464(Adcy4)
CPOC: 100715532(Adcy4)
CCAN: 109685852(Adcy4)
DORD: 105992475(Adcy4)
DSP: 122113375(Adcy4)
PLOP: 125345042 125363469(Adcy4)
NCAR: 124978229
MMMA: 107147463(Adcy4)
OCU: 100346742
OPI: 101527552(ADCY4)
TUP: 102490273(ADCY4)
GVR: 103590144(ADCY4)
CFA: 480271(ADCY4)
CLUD: 112657036(ADCY4)
VVP: 112926558(ADCY4)
VLG: 121493259(ADCY4)
NPO: 129499511(ADCY4)
AML: 100471940(ADCY4)
UMR: 103679331(ADCY4)
UAH: 113246056(ADCY4)
UAR: 123795737(ADCY4)
ELK: 111162403
LLV: 125104720
MPUF: 101676211(ADCY4)
MNP: 131999850(ADCY4)
MLK: 131836404(ADCY4)
NVS: 122893638(ADCY4)
ORO: 101374313(ADCY4)
EJU: 114217911(ADCY4)
ZCA: 113908984(ADCY4)
MLX: 118003693(ADCY4)
NSU: 110585498(ADCY4)
LWW: 102729355 102750941
FCA: 101097735(ADCY4)
PYU: 121031569(ADCY4)
PCOO: 112855238(ADCY4)
PBG: 122468944(ADCY4)
PVIV: 125167442(ADCY4)
LRUF: 124508863
PTG: 102965866(ADCY4)
PPAD: 109254969(ADCY4)
PUC: 125909634
AJU: 106987869
HHV: 120247005(ADCY4)
BTA: 788151(ADCY4)
BOM: 102286168(ADCY4)
BIU: 109564199(ADCY4)
BBUB: 102408103(ADCY4)
BBIS: 104982045(ADCY4)
CHX: 102185469(ADCY4)
OAS: 101119139(ADCY4)
BTAX: 128053854(ADCY4)
ODA: 120853482(ADCY4)
CCAD: 122443147(ADCY4)
MBEZ: 129562463(ADCY4)
SSC: 100152067(ADCY4)
CFR: 102524031(ADCY4)
CBAI: 105068818(ADCY4)
CDK: 105102432(ADCY4)
VPC: 102544207(ADCY4)
BACU: 103005549(ADCY4)
BMUS: 118891059(ADCY4)
LVE: 103075499(ADCY4)
OOR: 101289858(ADCY4)
DLE: 111164225(ADCY4)
PCAD: 102985820(ADCY4)
PSIU: 116749116(ADCY4)
NASI: 112405010(ADCY4)
ECB: 100054305(ADCY4)
EPZ: 103561050(ADCY4)
EAI: 106848607(ADCY4)
MYB: 102247996(ADCY4)
MYD: 102762536(ADCY4)
MMYO: 118678616(ADCY4)
MLF: 102417969(ADCY4)
MDT: 132241024(ADCY4)
PKL: 118725960(ADCY4)
EFUS: 103301470(ADCY4)
MNA: 107531740(ADCY4)
DRO: 112300586(ADCY4)
SHON: 118980863(ADCY4)
AJM: 119037286(ADCY4)
PDIC: 114492860(ADCY4)
PHAS: 123820487(ADCY4)
MMF: 118631458(ADCY4)
PPAM: 129074168(ADCY4)
HAI: 109393593(ADCY4)
RFQ: 117024169(ADCY4)
PALE: 102890575(ADCY4)
PGIG: 120608523(ADCY4)
PVP: 105309400(ADCY4)
RAY: 107498014(ADCY4)
MJV: 108410207(ADCY4)
TOD: 119238960(ADCY4)
SARA: 101539776(ADCY4)
SETR: 126001049(ADCY4)
LAV: 100675525(ADCY4)
TMU: 101350438
ETF: 101644952(ADCY4)
DNM: 101419332(ADCY4)
MDO: 100030872(ADCY4)
GAS: 123237960(ADCY4)
SHR: 100920243(ADCY4)
AFZ: 127551100
PCW: 110197384(ADCY4)
TVP: 118830153(ADCY4)
OAA: 103168714(ADCY4)
ASN: 102385636(ADCY4)
AMJ: 102558956(ADCY4)
PSS: 102451515
CMY: 102946725(ADCY4)
CCAY: 125622342(ADCY4)
DCC: 119841869(ADCY4)
CPIC: 101936524(ADCY4)
TST: 117886223
CABI: 116839023(ADCY4)
MRV: 120380361(ADCY4)
ACS: 100562762(adcy4)
ASAO: 132777697(ADCY4)
PVT: 110091692(ADCY4)
SUND: 121935289(ADCY4)
PBI: 103055695(ADCY4)
PMUR: 107286594(ADCY4)
CTIG: 120314849(ADCY4)
TSR: 106549385(ADCY4)
PGUT: 117662171(ADCY4)
APRI: 131197140(ADCY4)
PTEX: 113450840(ADCY4)
NSS: 113425496(ADCY4)
VKO: 123021770(ADCY4)
PMUA: 114581737(ADCY4)
PRAF: 128399744(ADCY4)
ZVI: 118078718(ADCY4)
HCG: 128331787(ADCY4)
GJA: 107111738(ADCY4)
STOW: 125445159(ADCY4)
EMC: 129340558(ADCY4)
XLA: 108707036 108715027(adcy4.L)
XTR: 100497212(adcy4)
NPR: 108788450(ADCY4)
RTEM: 120940456(ADCY4)
BBUF: 120988965(ADCY4)
BGAR: 122923965(ADCY4)
MUO: 115458109(ADCY4)
GSH: 117350558(ADCY4)
SRX: 107720483 107740771
SANH: 107693500 107698135
SGH: 107572836
CCAR: 109102764
CAUA: 113096274 113105408
MAMB: 125264290
IPU: 108260803
PHYP: 113544317
SMEO: 124381696
TFD: 113635544
AMEX: 103031621
EEE: 113591496
KMR: 108248619
ALIM: 106527078
CSEM: 103384541
LCF: 108890756
HCQ: 109516520
BPEC: 110158296
SASA: 106608969
OTW: 112215078
OMY: 110500394
ONE: 115131798
SALP: 111952465
ELS: 105030097
PKI: 111856451
PSPA: 121305249 121307360
ARUT: 117398126 117398838
PSEX: 120524043
HOC: 132807053
OVI: T265_02367
 » show all
Reference
PMID:12503609
  Authors
Ludwig MG, Seuwen K
  Title
Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.
  Journal
J Recept Signal Transduct Res 22:79-110 (2002)
DOI:10.1081/RRS-120014589
  Sequence
[hsa:196883]
LinkDB

KEGG   ORTHOLOGY: K08045
Entry
K08045                      KO                                     
Symbol
ADCY5
Name
adenylate cyclase 5 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05012  Parkinson disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05032  Morphine addiction
map05034  Alcoholism
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Disease
H02389  Familial dyskinesia with facial myokymia
H02397  Neurodevelopmental disorder with movement abnormalities or hypotonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08045  ADCY5; adenylate cyclase 5
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04371 Apelin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04072 Phospholipase D signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04024 cAMP signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04022 cGMP-PKG signaling pathway
    K08045  ADCY5; adenylate cyclase 5
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08045  ADCY5; adenylate cyclase 5
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08045  ADCY5; adenylate cyclase 5
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08045  ADCY5; adenylate cyclase 5
   04062 Chemokine signaling pathway
    K08045  ADCY5; adenylate cyclase 5
  09152 Endocrine system
   04911 Insulin secretion
    K08045  ADCY5; adenylate cyclase 5
   04923 Regulation of lipolysis in adipocytes
    K08045  ADCY5; adenylate cyclase 5
   04912 GnRH signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04913 Ovarian steroidogenesis
    K08045  ADCY5; adenylate cyclase 5
   04915 Estrogen signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04914 Progesterone-mediated oocyte maturation
    K08045  ADCY5; adenylate cyclase 5
   04921 Oxytocin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04926 Relaxin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04935 Growth hormone synthesis, secretion and action
    K08045  ADCY5; adenylate cyclase 5
   04918 Thyroid hormone synthesis
    K08045  ADCY5; adenylate cyclase 5
   04928 Parathyroid hormone synthesis, secretion and action
    K08045  ADCY5; adenylate cyclase 5
   04916 Melanogenesis
    K08045  ADCY5; adenylate cyclase 5
   04924 Renin secretion
    K08045  ADCY5; adenylate cyclase 5
   04925 Aldosterone synthesis and secretion
    K08045  ADCY5; adenylate cyclase 5
   04927 Cortisol synthesis and secretion
    K08045  ADCY5; adenylate cyclase 5
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08045  ADCY5; adenylate cyclase 5
   04270 Vascular smooth muscle contraction
    K08045  ADCY5; adenylate cyclase 5
  09154 Digestive system
   04970 Salivary secretion
    K08045  ADCY5; adenylate cyclase 5
   04971 Gastric acid secretion
    K08045  ADCY5; adenylate cyclase 5
   04972 Pancreatic secretion
    K08045  ADCY5; adenylate cyclase 5
   04976 Bile secretion
    K08045  ADCY5; adenylate cyclase 5
  09156 Nervous system
   04724 Glutamatergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04727 GABAergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04725 Cholinergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04728 Dopaminergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04726 Serotonergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04723 Retrograde endocannabinoid signaling
    K08045  ADCY5; adenylate cyclase 5
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08045  ADCY5; adenylate cyclase 5
  09149 Aging
   04211 Longevity regulating pathway
    K08045  ADCY5; adenylate cyclase 5
   04213 Longevity regulating pathway - multiple species
    K08045  ADCY5; adenylate cyclase 5
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08045  ADCY5; adenylate cyclase 5
   04714 Thermogenesis
    K08045  ADCY5; adenylate cyclase 5
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08045  ADCY5; adenylate cyclase 5
   05207 Chemical carcinogenesis - receptor activation
    K08045  ADCY5; adenylate cyclase 5
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08045  ADCY5; adenylate cyclase 5
   05163 Human cytomegalovirus infection
    K08045  ADCY5; adenylate cyclase 5
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08045  ADCY5; adenylate cyclase 5
  09165 Substance dependence
   05030 Cocaine addiction
    K08045  ADCY5; adenylate cyclase 5
   05031 Amphetamine addiction
    K08045  ADCY5; adenylate cyclase 5
   05032 Morphine addiction
    K08045  ADCY5; adenylate cyclase 5
   05034 Alcoholism
    K08045  ADCY5; adenylate cyclase 5
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08045  ADCY5; adenylate cyclase 5
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08045  ADCY5; adenylate cyclase 5
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08045  ADCY5; adenylate cyclase 5
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08045  ADCY5; adenylate cyclase 5
Other DBs
GO: 0004016
Genes
HSA: 111(ADCY5)
PTR: 470905(ADCY5)
PPS: 100989177(ADCY5)
GGO: 101150181(ADCY5)
PON: 100454138(ADCY5)
PPYG: 129032789(ADCY5)
NLE: 100580455(ADCY5)
HMH: 116466852(ADCY5)
SSYN: 129471707(ADCY5)
MCC: 715897(ADCY5)
MCF: 102135142(ADCY5)
MTHB: 126949094
MNI: 105470270(ADCY5)
CSAB: 103228169(ADCY5)
CATY: 105589787(ADCY5)
PANU: 101014828(ADCY5)
TGE: 112618524(ADCY5)
MLEU: 105533183(ADCY5)
RRO: 104668142(ADCY5)
RBB: 108517430(ADCY5)
TFN: 117083400(ADCY5)
PTEH: 111544335(ADCY5)
CANG: 105517990(ADCY5)
CJC: 100412782(ADCY5)
SBQ: 101049747(ADCY5)
CIMI: 108288965(ADCY5)
ANAN: 105733651(ADCY5)
CSYR: 103254816(ADCY5)
MMUR: 105879870(ADCY5)
LCAT: 123630472(ADCY5)
PCOQ: 105808688(ADCY5)
OGA: 100942320(ADCY5)
MMU: 224129(Adcy5)
MCAL: 110311373(Adcy5)
MPAH: 110329393(Adcy5)
RNO: 64532(Adcy5)
MCOC: 116085856(Adcy5)
ANU: 117717749(Adcy5)
MUN: 110547229(Adcy5)
CGE: 100765958(Adcy5)
MAUA: 101827234(Adcy5)
PROB: 127227112(Adcy5)
PLEU: 114704841(Adcy5)
MORG: 121461694(Adcy5)
MFOT: 126512151
AAMP: 119824190(Adcy5)
NGI: 103741989(Adcy5)
HGL: 101702436(Adcy5)
CPOC: 100714732(Adcy5)
CCAN: 109701078(Adcy5)
DORD: 105987907(Adcy5)
DSP: 122097950(Adcy5)
PLOP: 125351778(Adcy5)
NCAR: 124992559
MMMA: 107143106(Adcy5)
OCU: 100009315(ADCY5)
OPI: 101526286(ADCY5)
TUP: 102490639(ADCY5)
GVR: 103588664(ADCY5)
CFA: 403859(ADCY5)
CLUD: 112677166(ADCY5)
VVP: 112913504(ADCY5)
VLG: 121501047(ADCY5)
NPO: 129503910(ADCY5)
AML: 100482519(ADCY5)
UMR: 103678826(ADCY5)
UAH: 113252326(ADCY5)
UAR: 123802178(ADCY5)
ELK: 111155044
LLV: 125103305
MPUF: 101673819(ADCY5)
MNP: 132011863(ADCY5)
MLK: 131824632(ADCY5)
NVS: 122908870(ADCY5)
ORO: 101380824(ADCY5)
EJU: 114199416(ADCY5)
ZCA: 113917313(ADCY5)
MLX: 118007016(ADCY5)
NSU: 110582647(ADCY5)
FCA: 101100749(ADCY5)
PYU: 121036524(ADCY5)
PCOO: 112849881(ADCY5)
PBG: 122491521(ADCY5)
PVIV: 125174584(ADCY5)
LRUF: 124526579
PTG: 102969833(ADCY5)
PPAD: 109266493(ADCY5)
PUC: 125921018
AJU: 106984082
HHV: 120237362(ADCY5)
BTA: 505740(ADCY5)
BOM: 102276460(ADCY5)
BIU: 109555842(ADCY5)
BBUB: 102405387(ADCY5)
BBIS: 104984593(ADCY5)
CHX: 102189798(ADCY5)
OAS: 105602258(ADCY5)
BTAX: 128067499(ADCY5)
ODA: 120870754(ADCY5)
CCAD: 122444643(ADCY5)
MBEZ: 129536585(ADCY5)
SSC: 100155970(ADCY5)
CFR: 102503785(ADCY5)
CBAI: 105081635(ADCY5)
CDK: 105090284(ADCY5)
VPC: 102534219(ADCY5)
BACU: 103006764(ADCY5)
BMUS: 118894820(ADCY5)
LVE: 103091169(ADCY5)
OOR: 101283178(ADCY5)
DLE: 111171650(ADCY5)
PCAD: 102983319(ADCY5)
PSIU: 116753224(ADCY5)
NASI: 112407274(ADCY5)
ECB: 100070498(ADCY5)
EPZ: 103563830(ADCY5)
EAI: 106823728(ADCY5)
MYB: 102257731(ADCY5)
MYD: 102760678(ADCY5)
MMYO: 118676734(ADCY5)
MLF: 102425254(ADCY5)
MDT: 132230329(ADCY5)
PKL: 118722731(ADCY5)
EFUS: 103298761(ADCY5)
MNA: 107527242(ADCY5)
DRO: 112320488(ADCY5)
SHON: 118990736(ADCY5)
AJM: 119039523(ADCY5)
PDIC: 114490544(ADCY5)
PHAS: 123826843(ADCY5)
MMF: 118617134(ADCY5)
PPAM: 129071827(ADCY5)
HAI: 109387200(ADCY5)
RFQ: 117031053(ADCY5)
PALE: 102897495(ADCY5)
PGIG: 120586714(ADCY5)
PVP: 105288850(ADCY5)
RAY: 107518038(ADCY5)
MJV: 108396721(ADCY5)
TOD: 119257456(ADCY5)
SARA: 101551819(ADCY5)
SETR: 126026247(ADCY5)
LAV: 100670244(ADCY5)
TMU: 101346041
ETF: 101646822(ADCY5)
DNM: 101417345(ADCY5)
MDO: 100019274(ADCY5)
GAS: 123242354(ADCY5)
AFZ: 127554148
PCW: 110208122(ADCY5)
TVP: 118837516(ADCY5)
OAA: 114811232(ADCY5)
GGA: 395340(ADCY5)
PCOC: 116227376(ADCY5)
MGP: 100547372(ADCY5)
CJO: 107316827(ADCY5)
TPAI: 128077242(ADCY5)
LMUT: 125697126(ADCY5)
NMEL: 110399200(ADCY5)
APLA: 101794067(ADCY5)
ACYG: 106029894(ADCY5)
CATA: 118243131(ADCY5)
AFUL: 116490539(ADCY5)
TGU: 100220777(ADCY5)
LSR: 110468293(ADCY5)
SCAN: 103814312(ADCY5)
PMOA: 120497513(ADCY5)
OTC: 121337991(ADCY5)
PRUF: 121356628(ADCY5)
GFR: 102031760(ADCY5)
FAB: 101807084(ADCY5)
OMA: 130255812(ADCY5)
PHI: 102107286(ADCY5)
PMAJ: 107207500(ADCY5)
CCAE: 111932249(ADCY5)
CCW: 104694019(ADCY5)
CBRC: 103619683(ADCY5)
ETL: 114058103(ADCY5)
ZAB: 102071169(ADCY5)
ZLE: 135450684(ADCY5)
ACHL: 103808844(ADCY5)
SVG: 106850450(ADCY5)
MMEA: 130574988(ADCY5)
HRT: 120754848(ADCY5)
SATI: 136363660(ADCY5)
FPG: 101922323(ADCY5)
FCH: 102049855(ADCY5)
NNT: 104413857
SHAB: 115608320(ADCY5)
ACUN: 113482358(ADCY5)
TALA: 104360348(ADCY5)
ACHC: 115342497(ADCY5)
HALD: 104317582(ADCY5)
HLE: 104832562(ADCY5)
AGEN: 126040015
GCL: 127018137
LDI: 104350485(ADCY5)
DPUB: 104309833(ADCY5)
AVIT: 104270788(ADCY5)
BRHI: 104493718(ADCY5)
EGZ: 104128107(ADCY5)
NNI: 104018815(ADCY5)
PCRI: 104024554(ADCY5)
PCAO: 104050888(ADCY5)
PADL: 103919638(ADCY5)
AFOR: 103895406(ADCY5)
GSTE: 104253444(ADCY5)
CLV: 102085466(ADCY5)
PGUU: 104461391(ADCY5)
PLET: 104625212(ADCY5)
CMAC: 104476957(ADCY5)
CUCA: 104067688(ADCY5)
OHA: 104337463(ADCY5)
ACAR: 104526233(ADCY5)
CPEA: 104387452(ADCY5)
CVF: 104288498(ADCY5)
RTD: 128912369(ADCY5)
AAM: 106499045(ADCY5)
AROW: 112973826(ADCY5)
NPD: 112960094(ADCY5)
TGT: 104573965(ADCY5)
DNE: 112994245(ADCY5)
SCAM: 104151125(ADCY5)
ASN: 102387635
AMJ: 102562224(ADCY5)
CPOO: 109322645(ADCY5)
GGN: 109301418(ADCY5)
PSS: 102461993(ADCY5)
CMY: 102937309(ADCY5)
CCAY: 125644703(ADCY5)
DCC: 119863244(ADCY5)
CPIC: 101950146(ADCY5)
TST: 117885025(ADCY5)
CABI: 116834742(ADCY5)
MRV: 120374831(ADCY5)
ACS: 100558125(adcy5)
ASAO: 132774580(ADCY5)
PVT: 110083012(ADCY5)
SUND: 121918960(ADCY5)
PBI: 103060584(ADCY5)
PMUR: 107285748
CTIG: 120311904(ADCY5)
TSR: 106553086(ADCY5)
PGUT: 117668834(ADCY5)
APRI: 131204235(ADCY5)
PTEX: 113441153(ADCY5)
NSS: 113410757(ADCY5)
VKO: 123027333(ADCY5)
PMUA: 114603889(ADCY5)
PRAF: 128421318(ADCY5)
ZVI: 118091724(ADCY5)
HCG: 128322736(ADCY5)
GJA: 107113906
STOW: 125425933(ADCY5)
EMC: 129325033(ADCY5)
XLA: 108701255 108702898(adcy5.S)
XTR: 100490464(adcy5)
NPR: 108801019
RTEM: 120944286(ADCY5)
BBUF: 121007372(ADCY5)
BGAR: 122940041(ADCY5)
MUO: 115474547 115474650
GSH: 117360421(ADCY5)
DRE: 562619(adcy5)
SRX: 107714401 107722865
SANH: 107660638 107661140
SGH: 107555914 107596066
CCAR: 109052630 109073291
CAUA: 113053059 113069207 113108405
CGIB: 127964859 128020010
PTET: 122351186 122351883(adcy5)
LROH: 127170903(adcy5)
OMC: 131546935(adcy5)
PPRM: 120469763
RKG: 130096606(adcy5)
MAMB: 125270200(adcy5)
CIDE: 127518999
CERY: 137035387(adcy5)
MASI: 127446873 127448481
TROS: 130555467(adcy5)
TDW: 130427467(adcy5)
MANU: 129451616(adcy5)
IPU: 108266230
IFU: 128608656(adcy5)
PHYP: 113525981(adcy5)
SMEO: 124380150(adcy5)
TFD: 113654393(adcy5)
TVC: 132850110(adcy5)
TRN: 134324087(adcy5)
AMEX: 103026414(adcy5)
CMAO: 118823289(adcy5)
EEE: 113567484(adcy5)
CHAR: 105893374(adcy5)
TRU: 101070040(adcy5)
TFS: 130524813(adcy5)
TNG: GSTEN00029196G001
LCO: 104918228(adcy5)
TBEN: 117495159(adcy5)
PGEO: 117466775(adcy5)
GACU: 117539413 117549654(adcy5)
EMAC: 134867164(adcy5)
ELY: 117251312(adcy5)
EFO: 125899619(adcy5)
PLEP: 121948834(adcy5)
SLUC: 116067017(adcy5)
ECRA: 117952804(adcy5)
ESP: 116684799 116698375
PFLV: 114563925(adcy5)
GAT: 120834348(adcy5)
PPUG: 119228462(adcy5)
AFB: 129104443(adcy5)
CLUM: 117750304(adcy5)
PSWI: 130207209(adcy5)
MSAM: 119904436(adcy5)
SCHU: 122885099(adcy5)
CUD: 121522472(adcy5)
ALAT: 119026094(adcy5)
MZE: 101480556(adcy5)
ONL: 100698700(adcy5)
OAU: 116314774(adcy5)
OLA: 101174709(adcy5)
OML: 112154945(adcy5)
CSAI: 133445743(adcy5)
XMA: 102229859(adcy5)
XCO: 114147875(adcy5)
XHE: 116722709(adcy5)
PRET: 103478500(adcy5)
PFOR: 103134828
PLAI: 106936277
PMEI: 106925846(adcy5)
GAF: 122840426(adcy5)
PPRL: 129360965(adcy5)
CVG: 107101604(adcy5)
CTUL: 119778488(adcy5)
GMU: 124871401(adcy5)
NFU: 107389655(adcy5)
KMR: 108238863(adcy5)
NWH: 119419477(adcy5)
AOCE: 111573705(adcy5)
MCEP: 125017693(adcy5)
CSEM: 103391879(adcy5)
POV: 109637957
SSEN: 122765338(adcy5)
HHIP: 117754990(adcy5)
HSP: 118119955(adcy5)
PPLT: 128455938(adcy5)
SMAU: 118282943(adcy5)
LCF: 108897108
SDU: 111218374(adcy5)
SLAL: 111657529(adcy5)
XGL: 120801527(adcy5)
HCQ: 109521852
SSCV: 125973888
SBIA: 133511837(adcy5)
PEE: 133410263(adcy5)
PTAO: 133486486(adcy5)
BPEC: 110156638(adcy5)
MALB: 109974016(adcy5)
BSPL: 114846818(adcy5)
SJO: 128367522(adcy5)
SASA: 106582348(adcy5) 106586396
STRU: 115155606 115160940
OTW: 112224860 112238548(adcy5)
OMY: 110501809 110520268(adcy5)
OGO: 124017844 124043989(adcy5)
ONE: 115110765 115130118(adcy5)
OKI: 109868074 109870742
OKE: 118366914 118386422
SALP: 111959500 111977149
SNH: 120057913 120063767
CCLU: 121537021 121555154
ELS: 105016121(adcy5)
SFM: 108930060 108936601
PKI: 111851750(adcy5)
AANG: 118223221(adcy5)
LOC: 102689480(adcy5)
PSPA: 121322506 121322974
ARUT: 117408099 117426957
PSEX: 120530718(adcy5)
LCM: 102353581(ADCY5)
CMK: 103189036(adcy5)
CPLA: 122551792(adcy5)
HOC: 132817729(adcy5)
LERI: 129699122(adcy5)
PMRN: 116948627(ADCY5)
LRJ: 133349742
BFO: 118425098
BBEL: 109488308
CIN: 778532
SCLV: 120337426
SPU: 582776
LPIC: 129274407
APLC: 110979349
ARUN: 117300271
AJC: 117125272
SKO: 100376780
AME: 726514
ALAB: 122717101
BIM: 100747315
BBIF: 117216992
BVK: 117242346
BVAN: 117154408
BTER: 100645307
BAFF: 126925730
BPYO: 122576494
BPAS: 132914713
FVI: 122535726
CCAL: 108628661
OBB: 114879773
OLG: 117608931
MGEN: 117220940
NMEA: 116426026
CGIG: 122401699
SOC: 105204551
MPHA: 105838640
AEC: 105154476
ACEP: 105621266
PBAR: 105430765
VEM: 105563054
HST: 105191454
DQU: 106750327
CFO: 105258714
FEX: 115235810
LHU: 105679715
PGC: 109857578
OBO: 105275369
PCF: 106791020
PFUC: 122517485
VPS: 122629454
VCRB: 124423721
VVE: 124949970
MDL: 103580107
CGLO: 123261671
FAS: 105268525
DAM: 107035744
AGIF: 122858978
CINS: 118068103
VCAN: 122419518
CCIN: 107270651
DSM: 124410041
NPT: 124215870
NFB: 124179398
NLO: 107225651
NVG: 124301809
TCA: 659486
DPA: 109540307
AGRG: 126745931
ATD: 109594012
AGB: 108907225
DVV: 114330194
NVL: 108568296
BMOR: 101739615
BMAN: 114247436
DPL: KGM_200078
MJU: 123880070
NIQ: 126780709
VCD: 124542941
MCIX: 123668537
PMAC: 106715905
PPOT: 106099561
PXU: 106113903
PRAP: 111003341
PBX: 123718791
PNAP: 125062570
ZCE: 119835849
CCRC: 123705545
LSIN: 126978941
AAGE: 121738849
HAW: 110379459
ATRA: 106142307
GMW: 113517848
PXY: 105387103
PGW: 126379936
LGLY: 125240517
CFEL: 113368293
CCRN: 123304024
API: 100160451
DNX: 107169163
AGS: 114129527 114130853
RMD: 113549620
ACOO: 126846110
DVT: 126894686
BTAB: 109042497
HHAL: 106679834
HVI: 124359537
MQU: 128991800 128992407
TPAL: 117643971
ZNE: 110830589
CSEC: 111863049
SGRE: 126295328
BROR: 134532274
IEL: 124163709
FCD: 110843276
DPX: DAPPUDRAFT_39757(Adcy1)
DMK: 116923526
DPZ: 124342530
PVM: 113822760
PJA: 122251972
PMOO: 119595500
HAME: 121854629
PTRU: 123511448
ESN: 126984370
MNZ: 135223704
HAZT: 108683339
EAF: 111714019
PPOI: 119096346
ISC: 8038026
DSV: 119442339
RSAN: 119387173
RMP: 119159572
VDE: 111245001
VJA: 111265391
CSCU: 111624573
CVS: 136974092
PTEP: 107439050
ABRU: 129987880
UDV: 129225790
SDM: 118188448
PMEO: 129581533
LGI: LOTGIDRAFT_135033
PVUL: 126831735
PCAN: 112563595
BGT: 106061562
GAE: 121381879
HRF: 124151151
HRJ: 124280152
CRG: 105346394
CANU: 128162931
CVN: 111110751 111111874
OED: 125666582
MYI: 110463711
PMAX: 117343741
MCAF: 127730647
MMER: 123532329
RPHI: 132749184
OBI: 106882760
OSN: 115225862
LJP: 135477448
LAK: 106171289
LLON: 135500393
NVE: 5517880
EPA: 110245505
ADF: 107356750
AMIL: 114970122
PDAM: 113666552
SPIS: 111343062
DGT: 114520988
HMG: 100210301
TAD: TRIADDRAFT_21914
 » show all
Reference
PMID:12503609
  Authors
Ludwig MG, Seuwen K
  Title
Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.
  Journal
J Recept Signal Transduct Res 22:79-110 (2002)
DOI:10.1081/RRS-120014589
  Sequence
[hsa:111]
Reference
PMID:15385642
  Authors
Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD
  Title
Raf kinase activation of adenylyl cyclases: isoform-selective regulation.
  Journal
Mol Pharmacol 66:921-8 (2004)
DOI:10.1124/mol.66.4.921
LinkDB

KEGG   ORTHOLOGY: K08046
Entry
K08046                      KO                                     
Symbol
ADCY6
Name
adenylate cyclase 6 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04742  Taste transduction
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04961  Endocrine and other factor-regulated calcium reabsorption
map04962  Vasopressin-regulated water reabsorption
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Disease
H00865  Lethal congenital contractural syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08046  ADCY6; adenylate cyclase 6
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04371 Apelin signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04072 Phospholipase D signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04024 cAMP signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04022 cGMP-PKG signaling pathway
    K08046  ADCY6; adenylate cyclase 6
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08046  ADCY6; adenylate cyclase 6
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08046  ADCY6; adenylate cyclase 6
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08046  ADCY6; adenylate cyclase 6
   04062 Chemokine signaling pathway
    K08046  ADCY6; adenylate cyclase 6
  09152 Endocrine system
   04911 Insulin secretion
    K08046  ADCY6; adenylate cyclase 6
   04923 Regulation of lipolysis in adipocytes
    K08046  ADCY6; adenylate cyclase 6
   04912 GnRH signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04913 Ovarian steroidogenesis
    K08046  ADCY6; adenylate cyclase 6
   04915 Estrogen signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04914 Progesterone-mediated oocyte maturation
    K08046  ADCY6; adenylate cyclase 6
   04921 Oxytocin signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04926 Relaxin signaling pathway
    K08046  ADCY6; adenylate cyclase 6
   04935 Growth hormone synthesis, secretion and action
    K08046  ADCY6; adenylate cyclase 6
   04918 Thyroid hormone synthesis
    K08046  ADCY6; adenylate cyclase 6
   04928 Parathyroid hormone synthesis, secretion and action
    K08046  ADCY6; adenylate cyclase 6
   04916 Melanogenesis
    K08046  ADCY6; adenylate cyclase 6
   04924 Renin secretion
    K08046  ADCY6; adenylate cyclase 6
   04925 Aldosterone synthesis and secretion
    K08046  ADCY6; adenylate cyclase 6
   04927 Cortisol synthesis and secretion
    K08046  ADCY6; adenylate cyclase 6
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08046  ADCY6; adenylate cyclase 6
   04270 Vascular smooth muscle contraction
    K08046  ADCY6; adenylate cyclase 6
  09154 Digestive system
   04970 Salivary secretion
    K08046  ADCY6; adenylate cyclase 6
   04971 Gastric acid secretion
    K08046  ADCY6; adenylate cyclase 6
   04972 Pancreatic secretion
    K08046  ADCY6; adenylate cyclase 6
   04976 Bile secretion
    K08046  ADCY6; adenylate cyclase 6
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K08046  ADCY6; adenylate cyclase 6
   04961 Endocrine and other factor-regulated calcium reabsorption
    K08046  ADCY6; adenylate cyclase 6
  09156 Nervous system
   04724 Glutamatergic synapse
    K08046  ADCY6; adenylate cyclase 6
   04727 GABAergic synapse
    K08046  ADCY6; adenylate cyclase 6
   04725 Cholinergic synapse
    K08046  ADCY6; adenylate cyclase 6
   04723 Retrograde endocannabinoid signaling
    K08046  ADCY6; adenylate cyclase 6
  09157 Sensory system
   04742 Taste transduction
    K08046  ADCY6; adenylate cyclase 6
   04750 Inflammatory mediator regulation of TRP channels
    K08046  ADCY6; adenylate cyclase 6
  09149 Aging
   04211 Longevity regulating pathway
    K08046  ADCY6; adenylate cyclase 6
   04213 Longevity regulating pathway - multiple species
    K08046  ADCY6; adenylate cyclase 6
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08046  ADCY6; adenylate cyclase 6
   04714 Thermogenesis
    K08046  ADCY6; adenylate cyclase 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08046  ADCY6; adenylate cyclase 6
   05207 Chemical carcinogenesis - receptor activation
    K08046  ADCY6; adenylate cyclase 6
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08046  ADCY6; adenylate cyclase 6
   05163 Human cytomegalovirus infection
    K08046  ADCY6; adenylate cyclase 6
  09165 Substance dependence
   05032 Morphine addiction
    K08046  ADCY6; adenylate cyclase 6
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08046  ADCY6; adenylate cyclase 6
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08046  ADCY6; adenylate cyclase 6
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08046  ADCY6; adenylate cyclase 6
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08046  ADCY6; adenylate cyclase 6
Other DBs
GO: 0004016
Genes
HSA: 112(ADCY6)
PTR: 451866(ADCY6)
PPS: 100991116(ADCY6)
GGO: 101139873(ADCY6)
PON: 100438178(ADCY6)
PPYG: 129009382(ADCY6)
NLE: 100589304(ADCY6)
HMH: 116461805(ADCY6)
SSYN: 129491141(ADCY6)
MCC: 707978(ADCY6)
MCF: 102116122(ADCY6)
MTHB: 126930150
MNI: 105492900(ADCY6)
CSAB: 103238242(ADCY6)
CATY: 105580404(ADCY6)
PANU: 101008785(ADCY6)
TGE: 112635149(ADCY6)
MLEU: 105544918(ADCY6)
RRO: 104654871(ADCY6)
RBB: 108543933(ADCY6)
TFN: 117090196(ADCY6)
PTEH: 111542054(ADCY6)
CANG: 105507648(ADCY6)
CJC: 100406617(ADCY6)
SBQ: 101037803(ADCY6)
CIMI: 108316024(ADCY6)
ANAN: 105709451(ADCY6)
CSYR: 103273462(ADCY6)
MMUR: 105867497(ADCY6)
LCAT: 123640442(ADCY6)
PCOQ: 105818188(ADCY6)
OGA: 100963748(ADCY6)
MMU: 11512(Adcy6)
MCAL: 110310126(Adcy6)
MPAH: 110334500(Adcy6)
RNO: 25289(Adcy6)
MCOC: 116079067(Adcy6)
ANU: 117718589(Adcy6)
MUN: 110559444(Adcy6)
CGE: 100768368(Adcy6)
MAUA: 101835563(Adcy6)
PROB: 127226028(Adcy6)
PLEU: 114708522(Adcy6)
MORG: 121441427(Adcy6)
MFOT: 126493775
AAMP: 119822579(Adcy6)
NGI: 103750558(Adcy6)
HGL: 101698189(Adcy6)
CPOC: 100731224(Adcy6)
CCAN: 109686365(Adcy6)
DORD: 105987548(Adcy6)
DSP: 122106258(Adcy6)
PLOP: 125365347(Adcy6)
NCAR: 124983776
MMMA: 107148587(Adcy6)
OCU: 100354934
OPI: 101528764(ADCY6)
TUP: 102468478(ADCY6)
GVR: 103588863(ADCY6)
CFA: 477625(ADCY6)
CLUD: 112678267(ADCY6)
VVP: 112921089(ADCY6)
VLG: 121479760(ADCY6)
NPO: 129517234(ADCY6)
AML: 100476922(ADCY6)
UMR: 103675618(ADCY6)
UAH: 113257671(ADCY6)
UAR: 123794794(ADCY6)
ELK: 111157825
LLV: 125106490
MPUF: 101676713(ADCY6)
MNP: 132019632(ADCY6)
MLK: 131838820(ADCY6)
NVS: 122892410(ADCY6)
ORO: 101373816(ADCY6)
EJU: 114225777(ADCY6)
ZCA: 113922228(ADCY6)
MLX: 118008901(ADCY6)
NSU: 110593651(ADCY6)
LWW: 102734024(ADCY6)
FCA: 101091211(ADCY6)
PYU: 121038647(ADCY6)
PCOO: 112867731(ADCY6)
PBG: 122472335(ADCY6)
PVIV: 125171196(ADCY6)
LRUF: 124501854
PTG: 102949044(ADCY6)
PPAD: 109249043(ADCY6)
PUC: 125919005
AJU: 106969297
HHV: 120223032(ADCY6)
BTA: 509936(ADCY6)
BOM: 102265325(ADCY6)
BIU: 109559159(ADCY6)
BBUB: 102407637(ADCY6)
BBIS: 105001683(ADCY6)
CHX: 102169557(ADCY6)
OAS: 101105735(ADCY6)
BTAX: 128047362(ADCY6)
ODA: 120858160 120861292
CCAD: 122427399(ADCY6)
MBEZ: 129535859(ADCY6)
SSC: 100522613(ADCY6)
CFR: 102519611(ADCY6)
CBAI: 105076187(ADCY6)
CDK: 105103816(ADCY6)
VPC: 102532587(ADCY6)
BACU: 103014094(ADCY6)
BMUS: 118902170(ADCY6)
LVE: 103075153(ADCY6)
OOR: 101273023(ADCY6)
DLE: 111174035(ADCY6)
PCAD: 102986152(ADCY6)
PSIU: 116760787(ADCY6)
NASI: 112394265(ADCY6)
ECB: 100051295(ADCY6)
EPZ: 103563634(ADCY6)
EAI: 106836825(ADCY6)
MYB: 102248773(ADCY6)
MYD: 102766123(ADCY6)
MMYO: 118650262(ADCY6)
MLF: 102433159(ADCY6)
MDT: 132227516(ADCY6)
PKL: 118730217(ADCY6)
EFUS: 103285248(ADCY6)
MNA: 107528232(ADCY6)
DRO: 112318673(ADCY6)
SHON: 118976509(ADCY6)
AJM: 119042160(ADCY6)
PDIC: 114512738(ADCY6)
PHAS: 123812947(ADCY6)
MMF: 118623920(ADCY6)
PPAM: 129084881(ADCY6)
HAI: 109393238(ADCY6)
RFQ: 117028303(ADCY6)
PALE: 102890588(ADCY6)
PGIG: 120618216(ADCY6)
PVP: 105297518(ADCY6)
RAY: 107514224(ADCY6)
MJV: 108383520(ADCY6)
TOD: 119247875(ADCY6)
SARA: 101549131(ADCY6)
SETR: 126022668(ADCY6)
LAV: 100653532(ADCY6)
TMU: 101349243
ETF: 101650470(ADCY6)
DNM: 101442950(ADCY6)
GAS: 123250524(ADCY6)
SHR: 100932634(ADCY6)
AFZ: 127564773
PCW: 110201474(ADCY6)
TVP: 118850104(ADCY6)
OAA: 100081118(ADCY6)
GGA: 107050028
CJO: 107307087(ADCY6)
APLA: 119715289(ADCY6)
ACYG: 125181599(ADCY6)
CATA: 118261359(ADCY6)
AFUL: 116499930(ADCY6)
TGU: 100223723(ADCY6)
LSR: 110480398(ADCY6)
SCAN: 103824610(ADCY6)
PMOA: 120499475(ADCY6)
OTC: 121334293(ADCY6)
PRUF: 121356310(ADCY6)
GFR: 102033025(ADCY6)
FAB: 101810909(ADCY6)
OMA: 130265763(ADCY6)
PHI: 102101002(ADCY6)
PMAJ: 107198603(ADCY6)
CCAE: 111940536(ADCY6)
CBRC: 103611920(ADCY6)
ETL: 114071073
ZAB: 102068664(ADCY6)
ZLE: 135459172(ADCY6)
SVG: 106862685(ADCY6)
MMEA: 130584143(ADCY6)
HRT: 120764420(ADCY6)
SATI: 136372800(ADCY6)
FPG: 101916278(ADCY6)
FCH: 102050328(ADCY6)
SHAB: 115618663(ADCY6)
TALA: 116960680(ADCY6)
ACHC: 115351035(ADCY6)
HLE: 104831174(ADCY6)
AGEN: 126046312
NNI: 104019883(ADCY6)
AFOR: 103903427(ADCY6)
CLV: 102092552(ADCY6)
CUCA: 104055011(ADCY6)
CVF: 104284823(ADCY6)
RTD: 128901258(ADCY6)
AROW: 112975226(ADCY6)
NPD: 112950312(ADCY6)
ASN: 102388125(ADCY6)
AMJ: 102573402(ADCY6)
CPOO: 109324447(ADCY6)
PSS: 102448834(ADCY6)
CMY: 102942183(ADCY6)
CCAY: 125627429(ADCY6)
DCC: 119845889(ADCY6)
CPIC: 101948443(ADCY6)
TST: 117889271(ADCY6)
CABI: 116827794(ADCY6)
MRV: 120391118(ADCY6)
ACS: 100558069(adcy6)
ASAO: 132768345(ADCY6)
PVT: 110074939(ADCY6)
SUND: 121921728(ADCY6)
PBI: 103050190(ADCY6)
PMUR: 107290979
CTIG: 120302331(ADCY6)
TSR: 106539925
PGUT: 117662735(ADCY6)
APRI: 131191081(ADCY6)
PTEX: 113445503(ADCY6)
NSS: 113422719(ADCY6)
VKO: 123019207(ADCY6)
PMUA: 114592965(ADCY6)
PRAF: 128405141(ADCY6)
ZVI: 118077506(ADCY6)
HCG: 128347937(ADCY6)
GJA: 107120916(ADCY6)
STOW: 125428400(ADCY6)
EMC: 129327435(ADCY6)
XLA: 108708542(adcy6.L) 414728(adcy6.S)
XTR: 100493933(adcy6)
NPR: 108802250
RTEM: 120929589(ADCY6)
BBUF: 120995950(ADCY6)
BGAR: 122931129(ADCY6)
MUO: 115465941(ADCY6)
GSH: 117357774(ADCY6)
DRE: 560807(adcy6b) 570652(adcy6a)
SRX: 107705664 107716189 107723117 107745452
SANH: 107668560 107693540 107695824 107696932
SGH: 107568450 107571464 107594095 107601336
CCAR: 109056841 109066789 109092711
CAUA: 113041064 113065498 113070523 113093005
CGIB: 127944560 127944783 128011259 128011825
PTET: 122328457(adcy6a) 122328824(adcy6b)
LROH: 127154638(adcy6a) 127154831(adcy6b)
OMC: 131531959(adcy6b) 131532212(adcy6a)
PPRM: 120463384(adcy6b) 120488223(adcy6a)
RKG: 130070785(adcy6a) 130073174(adcy6b)
MAMB: 125259558(adcy6a) 125260716(adcy6b)
CIDE: 127504834 127504871
CERY: 137008930(adcy6b) 137009886(adcy6a)
MASI: 127419028 127419228 127419596 127419944
TROS: 130544987(adcy6b) 130545212(adcy6a)
TDW: 130409182(adcy6a) 130409222(adcy6b)
MANU: 129430536(adcy6b) 129430578(adcy6a)
IPU: 108276068(adcy6b)
IFU: 128618901(adcy6b)
PHYP: 113530428(adcy6)
TFD: 113658129(adcy6b)
TVC: 132861842(adcy6b)
TRN: 134333243(adcy6a) 134333774(adcy6b)
AMEX: 103041051(adcy6a) 103042747(adcy6b)
CMAO: 118822502(adcy6b) 118823077(adcy6a)
EEE: 113583096(adcy6) 113591158
CHAR: 105894115 105897272(adcy6b)
TRU: 101067605 101077549(adcy6) 115248177
TFS: 130529878 130530663
TNG: GSTEN00028124G001
LCO: 104919645(adcy6) 104933400
NCC: 104952766 104967529
TBEN: 117479566 117494413
CGOB: 115010615 115010702(adcy6)
PGEO: 117449024 117449293
GACU: 117541907 117542997
EMAC: 134864347 134865591
ELY: 117258192(adcy6b) 117258226
EFO: 125891083 125891397
PLEP: 121946801
SLUC: 116039341 116062169
ECRA: 117947096 117947753(adcy6b)
ESP: 116692318 116692820(adcy6)
PFLV: 114558670(adcy6) 114558853
GAT: 120829083 120829551
PPUG: 119222278 119223640
AFB: 129099361 129099971
CLUM: 117732987 117733644
PSWI: 130199141 130200154
MSAM: 119905272 119905502
SCHU: 122882904 122883618
CUD: 121517286 121517296
ALAT: 119022541 119023298
MZE: 101473262 101483853(adcy6)
ONL: 100702460 100704485(adcy6)
OAU: 116310917 116325822(adcy6b)
OLA: 101158108(adcy6) 101169035
OML: 112158993 112159026
CSAI: 133456804 133457215
XMA: 102232614(adcy6) 102235040
XCO: 114140049 114160600
XHE: 116726440(adcy6) 116726867
PRET: 103467316 103467625(adcy6)
PFOR: 103141167 103141208 103147813 103147814
PLAI: 106938827 106938828 106961467(adcy6)
PMEI: 106906069 106910254 106914961
GAF: 122837578 122839097
PPRL: 129370281 129372396
CVG: 107094831 107095164
CTUL: 119782213 119799168
GMU: 124870631 124871149
NFU: 107390847 107391215(adcy6)
KMR: 108232105 108244602
ALIM: 106524252 106525241 106530128(adcy5)
NWH: 119417525 119417632
AOCE: 111567033 111576524
MCEP: 125015099 125019197
CSEM: 103384589 103385410(adcy6)
POV: 109630770 109635053
SSEN: 122777042 122777458
HHIP: 117764056 117764768
HSP: 118110500 118110721
PPLT: 128442375 128442933
SMAU: 118316417(adcy6b) 118316907
LCF: 108876515 108900204
SDU: 111217291 111219014
SLAL: 111670684 111671536(adcy6)
XGL: 120803470 120803484
HCQ: 109528420 109528542
SSCV: 125989179 125989322
SBIA: 133505046 133513104
PEE: 133409526 133412062
PTAO: 133477406 133487993(adcy6a)
BPEC: 110164760(adcy6) 110164822
MALB: 109966043(adcy6) 109968886
BSPL: 114858207(adcy6a) 114858479
SJO: 128356916 128357787
SASA: 106566714 106567013 106571946 106572701
STRU: 115165462 115166185 115167808 115168355
OTW: 112215797 112221668 112222161 112232722
OMY: 110491936 110492371 110531246 110532031(adcy6a)
OGO: 124031731(adcy6a) 124032309 124046119
ONE: 115102673 115131919
OKI: 109869150 109869860 109907076 109907793
OKE: 118359667 118360139 118360499 118361366(adcy6a)
SALP: 111976437 111976578
SNH: 120059091 120059480(adcy6a) 120061001 120061300
CCLU: 121537863 121538102 121545441 121545889
ELS: 105010241 105026316
SFM: 108918490(adcy6) 108939304
PKI: 111837572(adcy6)
AANG: 118208186
LOC: 102693411(adcy6)
PSPA: 121309011(adcy6a)
ARUT: 117400918 117966951
PSEX: 120524822(adcy6a)
LCM: 102366154(ADCY6)
AGIF: 122847527
CLEC: 106671898
NLU: 111044161
HVI: 124360204
PCHN: 125032896
PCLA: 123756565
LPOL: 106465707 106478879
DPOL: 127854424
MAEA: 128206627
ATEN: 116306816
XEN: 124439835
HSY: 130621182
RES: 135682492
 » show all
Reference
PMID:10978539
  Authors
Wicker R, Catalan AG, Cailleux A, Starenki D, Stengel D, Sarasin A, Suarez HG
  Title
Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues.
  Journal
Biochim Biophys Acta 1493:279-83 (2000)
DOI:10.1016/S0167-4781(00)00187-1
  Sequence
[hsa:112]
Reference
PMID:15385642
  Authors
Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD
  Title
Raf kinase activation of adenylyl cyclases: isoform-selective regulation.
  Journal
Mol Pharmacol 66:921-8 (2004)
DOI:10.1124/mol.66.4.921
LinkDB

KEGG   ORTHOLOGY: K08047
Entry
K08047                      KO                                     
Symbol
ADCY7
Name
adenylate cyclase 7 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08047  ADCY7; adenylate cyclase 7
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04371 Apelin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04020 Calcium signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04072 Phospholipase D signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04024 cAMP signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04022 cGMP-PKG signaling pathway
    K08047  ADCY7; adenylate cyclase 7
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08047  ADCY7; adenylate cyclase 7
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08047  ADCY7; adenylate cyclase 7
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08047  ADCY7; adenylate cyclase 7
   04062 Chemokine signaling pathway
    K08047  ADCY7; adenylate cyclase 7
  09152 Endocrine system
   04911 Insulin secretion
    K08047  ADCY7; adenylate cyclase 7
   04923 Regulation of lipolysis in adipocytes
    K08047  ADCY7; adenylate cyclase 7
   04912 GnRH signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04913 Ovarian steroidogenesis
    K08047  ADCY7; adenylate cyclase 7
   04915 Estrogen signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04914 Progesterone-mediated oocyte maturation
    K08047  ADCY7; adenylate cyclase 7
   04921 Oxytocin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04926 Relaxin signaling pathway
    K08047  ADCY7; adenylate cyclase 7
   04935 Growth hormone synthesis, secretion and action
    K08047  ADCY7; adenylate cyclase 7
   04918 Thyroid hormone synthesis
    K08047  ADCY7; adenylate cyclase 7
   04928 Parathyroid hormone synthesis, secretion and action
    K08047  ADCY7; adenylate cyclase 7
   04916 Melanogenesis
    K08047  ADCY7; adenylate cyclase 7
   04925 Aldosterone synthesis and secretion
    K08047  ADCY7; adenylate cyclase 7
   04927 Cortisol synthesis and secretion
    K08047  ADCY7; adenylate cyclase 7
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08047  ADCY7; adenylate cyclase 7
   04270 Vascular smooth muscle contraction
    K08047  ADCY7; adenylate cyclase 7
  09154 Digestive system
   04970 Salivary secretion
    K08047  ADCY7; adenylate cyclase 7
   04971 Gastric acid secretion
    K08047  ADCY7; adenylate cyclase 7
   04972 Pancreatic secretion
    K08047  ADCY7; adenylate cyclase 7
   04976 Bile secretion
    K08047  ADCY7; adenylate cyclase 7
  09156 Nervous system
   04724 Glutamatergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04727 GABAergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04725 Cholinergic synapse
    K08047  ADCY7; adenylate cyclase 7
   04723 Retrograde endocannabinoid signaling
    K08047  ADCY7; adenylate cyclase 7
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08047  ADCY7; adenylate cyclase 7
  09149 Aging
   04211 Longevity regulating pathway
    K08047  ADCY7; adenylate cyclase 7
   04213 Longevity regulating pathway - multiple species
    K08047  ADCY7; adenylate cyclase 7
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08047  ADCY7; adenylate cyclase 7
   04714 Thermogenesis
    K08047  ADCY7; adenylate cyclase 7
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08047  ADCY7; adenylate cyclase 7
   05207 Chemical carcinogenesis - receptor activation
    K08047  ADCY7; adenylate cyclase 7
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08047  ADCY7; adenylate cyclase 7
   05163 Human cytomegalovirus infection
    K08047  ADCY7; adenylate cyclase 7
  09165 Substance dependence
   05032 Morphine addiction
    K08047  ADCY7; adenylate cyclase 7
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08047  ADCY7; adenylate cyclase 7
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08047  ADCY7; adenylate cyclase 7
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08047  ADCY7; adenylate cyclase 7
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08047  ADCY7; adenylate cyclase 7
Other DBs
GO: 0004016
Genes
HSA: 113(ADCY7)
PTR: 473278(ADCY7)
PPS: 100984225(ADCY7)
GGO: 101126268(ADCY7)
PON: 100436577(ADCY7)
PPYG: 129015265(ADCY7)
NLE: 100587036(ADCY7)
HMH: 116471246(ADCY7)
SSYN: 129492521(ADCY7)
MCC: 694730(ADCY7)
MCF: 102125718(ADCY7)
MTHB: 126944901
MNI: 105492251(ADCY7)
CSAB: 103232667(ADCY7)
CATY: 105588901(ADCY7)
PANU: 101000833(ADCY7)
TGE: 112613998(ADCY7)
MLEU: 105545643(ADCY7)
RRO: 104672569(ADCY7)
RBB: 108522948(ADCY7)
TFN: 117087765(ADCY7)
PTEH: 111541238(ADCY7)
CANG: 105514953(ADCY7)
CJC: 100404620(ADCY7)
SBQ: 101032672(ADCY7)
CIMI: 108305477(ADCY7)
ANAN: 105730804(ADCY7)
CSYR: 103259338(ADCY7)
MMUR: 105884745(ADCY7)
LCAT: 123625466(ADCY7)
PCOQ: 105808848(ADCY7)
OGA: 100956925(ADCY7)
MMU: 11513(Adcy7)
MCAL: 110299719(Adcy7)
MPAH: 110337453(Adcy7)
RNO: 84420(Adcy7)
MCOC: 116069817(Adcy7)
ANU: 117723273(Adcy7)
MUN: 110560723(Adcy7)
CGE: 100756132(Adcy7)
MAUA: 101839314(Adcy7)
PROB: 127229980(Adcy7)
PLEU: 114708501(Adcy7)
MORG: 121446853(Adcy7)
MFOT: 126487138
AAMP: 119801694(Adcy7)
NGI: 103730120(Adcy7)
HGL: 101712483(Adcy7)
CPOC: 100726699(Adcy7)
CCAN: 109698373(Adcy7)
DORD: 105994440(Adcy7)
DSP: 122119361(Adcy7)
PLOP: 125358478(Adcy7)
NCAR: 124966834
MMMA: 107144878(Adcy7)
OCU: 100357357
OPI: 101519430(ADCY7)
TUP: 102496578(ADCY7)
GVR: 103583204 103594947(ADCY7)
CFA: 487289(ADCY7)
CLUD: 112660528(ADCY7)
VVP: 112929565(ADCY7)
VLG: 121497930(ADCY7)
NPO: 129513386(ADCY7)
AML: 100466965(ADCY7)
UMR: 103673916(ADCY7)
UAH: 113252223(ADCY7)
UAR: 123798393(ADCY7)
ELK: 111157326
LLV: 125088705
MPUF: 101684190(ADCY7)
MNP: 132005324(ADCY7)
MLK: 131818734(ADCY7)
NVS: 122911463(ADCY7)
ORO: 101377421(ADCY7)
EJU: 114202960 114202963
ZCA: 113935770(ADCY7)
MLX: 118023800(ADCY7)
NSU: 110593510(ADCY7)
LWW: 102732736(ADCY7)
FCA: 101094148(ADCY7)
PYU: 121045271(ADCY7)
PCOO: 112857348(ADCY7)
PBG: 122494184(ADCY7)
PVIV: 125153013(ADCY7)
LRUF: 124511307
PTG: 102972917(ADCY7)
PPAD: 109270953(ADCY7)
PUC: 125915408
AJU: 106985835
HHV: 120238226(ADCY7)
BTA: 281603(ADCY7)
BOM: 102266966(ADCY7)
BIU: 109572478(ADCY7)
BBUB: 102410456(ADCY7)
BBIS: 104999563(ADCY7)
CHX: 102185858(ADCY7)
OAS: 101112667(ADCY7)
BTAX: 128063240(ADCY7)
ODA: 120872811(ADCY7)
CCAD: 122421548(ADCY7)
MBEZ: 129547117(ADCY7)
SSC: 100620994(ADCY7)
CFR: 102524614(ADCY7)
CBAI: 105074271(ADCY7)
CDK: 105097528(ADCY7)
VPC: 102529498(ADCY7)
BACU: 102997912(ADCY7)
BMUS: 118884739(ADCY7)
LVE: 103078677(ADCY7)
OOR: 101273592(ADCY7)
DLE: 111164991(ADCY7)
PCAD: 102985075(ADCY7)
PSIU: 116744731(ADCY7)
NASI: 112401228(ADCY7)
ECB: 100058891(ADCY7)
EPZ: 103556685(ADCY7)
EAI: 106824126(ADCY7)
MYB: 102253549(ADCY7)
MYD: 102764043(ADCY7)
MMYO: 118674005(ADCY7)
MDT: 132217592(ADCY7)
PKL: 118720641(ADCY7)
EFUS: 103295862(ADCY7)
MNA: 107531029(ADCY7)
DRO: 112296774(ADCY7)
SHON: 119001137(ADCY7)
AJM: 119046468(ADCY7)
PDIC: 114488191(ADCY7)
PHAS: 123805699(ADCY7)
MMF: 118639510(ADCY7)
PPAM: 129068161(ADCY7)
HAI: 109383261(ADCY7)
RFQ: 117034378(ADCY7)
PALE: 102881535(ADCY7)
PGIG: 120617254(ADCY7)
PVP: 105292087(ADCY7)
RAY: 107512248(ADCY7)
MJV: 108407296(ADCY7)
TOD: 119249160(ADCY7)
SARA: 101543858(ADCY7)
SETR: 126027080(ADCY7)
LAV: 100653771(ADCY7)
TMU: 101341715
ETF: 101640587(ADCY7)
DNM: 101427927(ADCY7)
MDO: 100013823(ADCY7)
GAS: 123233664(ADCY7)
SHR: 100929278(ADCY7)
AFZ: 127550695
PCW: 110207473(ADCY7)
TVP: 118844654(ADCY7)
OAA: 100076221(ADCY7)
GGA: 415732(ADCY7)
PCOC: 116243930(ADCY7)
MGP: 100548914
CJO: 107319017(ADCY7)
TPAI: 128082547(ADCY7)
LMUT: 125699136(ADCY7)
NMEL: 110404374(ADCY7)
APLA: 101794076(ADCY7)
ACYG: 106039584(ADCY7)
CATA: 118246350(ADCY7)
AFUL: 116494191(ADCY7)
TGU: 100225700(ADCY7)
LSR: 110473537(ADCY7)
SCAN: 103816806(ADCY7)
PMOA: 120507978(ADCY7)
OTC: 121333986(ADCY7)
PRUF: 121348916(ADCY7)
GFR: 102043194(ADCY7)
FAB: 101816007(ADCY7)
OMA: 130257686(ADCY7)
PHI: 102106688(ADCY7)
PMAJ: 107209841(ADCY7)
CCAE: 111934618(ADCY7)
CCW: 104687454(ADCY7)
CBRC: 103620194(ADCY7)
ETL: 114055552(ADCY7)
ZAB: 102073757(ADCY7)
ZLE: 135452721(ADCY7)
ACHL: 103800785(ADCY7)
SVG: 106856945(ADCY7)
MMEA: 130579119(ADCY7)
HRT: 120757744(ADCY7)
SATI: 136366652(ADCY7)
FPG: 101914615(ADCY7)
FCH: 102052224(ADCY7)
CCRI: 104157350(ADCY7)
NNT: 104406202(ADCY7)
SHAB: 115601291(ADCY7)
ACUN: 113484440(ADCY7)
TALA: 104368104(ADCY7)
ACHC: 115345521(ADCY7)
HALD: 104320370(ADCY7)
HLE: 104842584(ADCY7)
AGEN: 126041284
GCL: 127021006
CSTI: 104553421
LDI: 104345595(ADCY7)
MNB: 103770738(ADCY7)
DPUB: 104303154(ADCY7)
AVIT: 104269827
EGZ: 104125176(ADCY7)
NNI: 104011289(ADCY7)
PCRI: 104031527(ADCY7)
PCAO: 104042414(ADCY7)
PADL: 103913801(ADCY7)
AFOR: 103896863(ADCY7)
FGA: 104077549(ADCY7)
GSTE: 104256338(ADCY7)
CLV: 102090470(ADCY7)
MUI: 104533950(ADCY7)
PGUU: 104464269(ADCY7)
PLET: 104617349(ADCY7)
EHS: 104509139(ADCY7)
CMAC: 104479655(ADCY7)
CUCA: 104068389(ADCY7)
TEO: 104371518(ADCY7)
BREG: 104638310(ADCY7)
OHA: 104338983(ADCY7)
ACAR: 104532959(ADCY7)
CPEA: 104388571(ADCY7)
CVF: 104286482(ADCY7)
RTD: 128908370(ADCY7)
AAM: 106483289(ADCY7)
AROW: 112967538(ADCY7)
NPD: 112944957(ADCY7)
TGT: 104566596(ADCY7)
DNE: 112984414(ADCY7)
SCAM: 104146325(ADCY7)
ASN: 102368976(ADCY7)
AMJ: 102566330(ADCY7)
CPOO: 109310532(ADCY7)
GGN: 109289593(ADCY7)
PSS: 102449192(ADCY7)
CMY: 102946407(ADCY7)
CCAY: 125645349(ADCY7)
DCC: 119841199(ADCY7)
CPIC: 101938536(ADCY7)
TST: 117886819(ADCY7)
CABI: 116826976(ADCY7)
MRV: 120384768(ADCY7)
ACS: 100558751(adcy7)
ASAO: 132783079(ADCY7)
PVT: 110086573(ADCY7)
SUND: 121914489(ADCY7)
PBI: 103060035(ADCY7)
PMUR: 107290046(ADCY7)
CTIG: 120312119(ADCY7)
TSR: 106554339(ADCY7)
PGUT: 117670935(ADCY7)
APRI: 131184024(ADCY7)
PTEX: 113444984(ADCY7)
NSS: 113417526(ADCY7)
VKO: 123022135(ADCY7)
PMUA: 114602227(ADCY7)
PRAF: 128419465(ADCY7)
ZVI: 118085993(ADCY7)
HCG: 128334274(ADCY7)
GJA: 107117185(ADCY7)
STOW: 125443684(ADCY7)
EMC: 129344146(ADCY7)
XLA: 399055(adcy7.L)
XTR: 100127741(adcy7)
NPR: 108794932(ADCY7)
RTEM: 120917430(ADCY7)
BBUF: 120981193(ADCY7)
BGAR: 122920478(ADCY7)
MUO: 115470804(ADCY7)
GSH: 117359545(ADCY7)
DRE: 568726(adcy7)
SRX: 107742778 107750233
SANH: 107657123 107696709
SGH: 107551487 107554606
CCAR: 109080760 109091999
CAUA: 113051418 113106060
CGIB: 127961582 128016846
PTET: 122349408(adcy7)
LROH: 127167860(adcy7)
OMC: 131544254(adcy7)
PPRM: 120468737(adcy7)
RKG: 130069752(adcy7)
MAMB: 125265058(adcy7)
CIDE: 127515179
CERY: 137031340(adcy7)
MASI: 127444080 127453675
TROS: 130557119(adcy7)
TDW: 130418420(adcy7)
MANU: 129444859(adcy7)
IPU: 108259218
IFU: 128602846(adcy7)
PHYP: 113540899(adcy7)
SMEO: 124379641(adcy7)
TFD: 113648472(adcy7)
TVC: 132838932(adcy7)
TRN: 134303947(adcy7)
AMEX: 103025161(adcy7)
CMAO: 118817411(adcy7)
EEE: 113581231
CHAR: 105899759(adcy7)
TRU: 101066272(adcy7)
TFS: 130521879(adcy7)
LCO: 104940647(adcy7)
TBEN: 117496670(adcy7)
CGOB: 115005259(adcy7)
PGEO: 117441125(adcy7)
GACU: 117549142(adcy7)
EMAC: 134863119(adcy7)
ELY: 117253092(adcy7)
EFO: 125878880(adcy7)
PLEP: 121939187(adcy7)
SLUC: 116037616(adcy7)
ECRA: 117949494(adcy7)
ESP: 116693865(adcy7)
PFLV: 114555545(adcy7)
GAT: 120811617(adcy7)
PPUG: 119226484(adcy7)
AFB: 129105651(adcy7)
CLUM: 117726078(adcy7)
PSWI: 130192880(adcy7)
MSAM: 119889811(adcy7)
SCHU: 122863875(adcy7)
CUD: 121509307(adcy7)
ALAT: 119018820(adcy7)
MZE: 101480238(adcy7)
ONL: 100703488(adcy7)
OAU: 116325574(adcy7)
OLA: 101164967(adcy7)
OML: 112160437(adcy7)
CSAI: 133463928(adcy7)
XMA: 102223009(adcy7)
XCO: 114142861(adcy7)
XHE: 116718405(adcy7)
PRET: 103462645(adcy7)
PFOR: 103138067(adcy7)
PLAI: 106957719
PMEI: 106927339
GAF: 122825208(adcy7)
PPRL: 129364417(adcy7)
CVG: 107088499(adcy7)
CTUL: 119781951(adcy7)
GMU: 124867163(adcy7)
NFU: 107381237(adcy7)
KMR: 108243337(adcy7)
ALIM: 106527041
NWH: 119426404(adcy7)
AOCE: 111572244(adcy7)
MCEP: 125005160(adcy7)
CSEM: 103398552
POV: 109625125(adcy7)
SSEN: 122772187(adcy7)
HHIP: 117759592(adcy7)
HSP: 118106353(adcy7)
PPLT: 128441980(adcy7)
SMAU: 118302966(adcy7)
LCF: 108876970
SDU: 111217971(adcy7)
SLAL: 111672304(adcy7)
XGL: 120789257(adcy7)
HCQ: 109513976(adcy7)
SSCV: 125967608
SBIA: 133498167(adcy7)
PEE: 133397769(adcy7)
PTAO: 133474155(adcy7)
BPEC: 110175272(adcy7)
MALB: 109955816(adcy7)
BSPL: 114852640(adcy7)
SJO: 128358809(adcy7)
SASA: 106562384 106587576
STRU: 115167552 115203287
OTW: 112249333 112249354
OMY: 110506731 110526596
OGO: 124033586 124035566
ONE: 115112487 115113769
OKI: 109881364 109881656
OKE: 118362652 118365705
SALP: 111974474
SNH: 120024860 120048037
CCLU: 121534524 121562328
ELS: 105025700(adcy7)
SFM: 108932972
PKI: 111832687 111848207
AANG: 118215074(adcy7) 118227441
LOC: 102689559(adcy7)
PSPA: 121296167 121325516
ARUT: 117424464(adcy7) 117425878
PSEX: 120535204(adcy7)
LCM: 102351065(ADCY7)
CMK: 103176081(adcy7)
RTP: 109935305(adcy7)
CPLA: 122558411(adcy7)
HOC: 132823957(adcy7)
LERI: 129705029(adcy7)
DMK: 116929418
DFR: 124491502
UDV: 129223995
 » show all
Reference
PMID:7961850
  Authors
Watson PA, Krupinski J, Kempinski AM, Frankenfield CD
  Title
Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells.
  Journal
J Biol Chem 269:28893-8 (1994)
  Sequence
[hsa:113]
Reference
PMID:22264442
  Authors
Joeyen-Waldorf J, Nikolova YS, Edgar N, Walsh C, Kota R, Lewis DA, Ferrell R, Manuck SB, Hariri AR, Sibille E
  Title
Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry.
  Journal
Biol Psychiatry 71:627-32 (2012)
DOI:10.1016/j.biopsych.2011.11.029
LinkDB

KEGG   ORTHOLOGY: K08048
Entry
K08048                      KO                                     
Symbol
ADCY8
Name
adenylate cyclase 8 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04720  Long-term potentiation
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04742  Taste transduction
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08048  ADCY8; adenylate cyclase 8
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04371 Apelin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04020 Calcium signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04072 Phospholipase D signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04024 cAMP signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04022 cGMP-PKG signaling pathway
    K08048  ADCY8; adenylate cyclase 8
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08048  ADCY8; adenylate cyclase 8
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08048  ADCY8; adenylate cyclase 8
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08048  ADCY8; adenylate cyclase 8
   04062 Chemokine signaling pathway
    K08048  ADCY8; adenylate cyclase 8
  09152 Endocrine system
   04911 Insulin secretion
    K08048  ADCY8; adenylate cyclase 8
   04923 Regulation of lipolysis in adipocytes
    K08048  ADCY8; adenylate cyclase 8
   04912 GnRH signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04913 Ovarian steroidogenesis
    K08048  ADCY8; adenylate cyclase 8
   04915 Estrogen signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04914 Progesterone-mediated oocyte maturation
    K08048  ADCY8; adenylate cyclase 8
   04921 Oxytocin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04926 Relaxin signaling pathway
    K08048  ADCY8; adenylate cyclase 8
   04935 Growth hormone synthesis, secretion and action
    K08048  ADCY8; adenylate cyclase 8
   04918 Thyroid hormone synthesis
    K08048  ADCY8; adenylate cyclase 8
   04928 Parathyroid hormone synthesis, secretion and action
    K08048  ADCY8; adenylate cyclase 8
   04916 Melanogenesis
    K08048  ADCY8; adenylate cyclase 8
   04925 Aldosterone synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
   04927 Cortisol synthesis and secretion
    K08048  ADCY8; adenylate cyclase 8
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08048  ADCY8; adenylate cyclase 8
   04270 Vascular smooth muscle contraction
    K08048  ADCY8; adenylate cyclase 8
  09154 Digestive system
   04970 Salivary secretion
    K08048  ADCY8; adenylate cyclase 8
   04971 Gastric acid secretion
    K08048  ADCY8; adenylate cyclase 8
   04972 Pancreatic secretion
    K08048  ADCY8; adenylate cyclase 8
   04976 Bile secretion
    K08048  ADCY8; adenylate cyclase 8
  09156 Nervous system
   04724 Glutamatergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04727 GABAergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04725 Cholinergic synapse
    K08048  ADCY8; adenylate cyclase 8
   04720 Long-term potentiation
    K08048  ADCY8; adenylate cyclase 8
   04723 Retrograde endocannabinoid signaling
    K08048  ADCY8; adenylate cyclase 8
  09157 Sensory system
   04742 Taste transduction
    K08048  ADCY8; adenylate cyclase 8
   04750 Inflammatory mediator regulation of TRP channels
    K08048  ADCY8; adenylate cyclase 8
  09149 Aging
   04211 Longevity regulating pathway
    K08048  ADCY8; adenylate cyclase 8
   04213 Longevity regulating pathway - multiple species
    K08048  ADCY8; adenylate cyclase 8
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08048  ADCY8; adenylate cyclase 8
   04714 Thermogenesis
    K08048  ADCY8; adenylate cyclase 8
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08048  ADCY8; adenylate cyclase 8
   05207 Chemical carcinogenesis - receptor activation
    K08048  ADCY8; adenylate cyclase 8
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08048  ADCY8; adenylate cyclase 8
   05163 Human cytomegalovirus infection
    K08048  ADCY8; adenylate cyclase 8
  09165 Substance dependence
   05032 Morphine addiction
    K08048  ADCY8; adenylate cyclase 8
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08048  ADCY8; adenylate cyclase 8
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08048  ADCY8; adenylate cyclase 8
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08048  ADCY8; adenylate cyclase 8
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08048  ADCY8; adenylate cyclase 8
Other DBs
GO: 0008294
Genes
HSA: 114(ADCY8)
PTR: 464400(ADCY8)
PPS: 100994715(ADCY8)
GGO: 101142672(ADCY8)
PON: 100461383(ADCY8)
PPYG: 129043074(ADCY8)
NLE: 100592592(ADCY8)
HMH: 116813595(ADCY8)
SSYN: 129486826(ADCY8)
MCC: 695792(ADCY8)
MCF: 102144854(ADCY8)
MTHB: 126961343
MNI: 105492815(ADCY8)
CSAB: 103237447(ADCY8)
CATY: 105588369(ADCY8)
PANU: 101007115(ADCY8)
TGE: 112630332(ADCY8)
MLEU: 105530895(ADCY8)
RRO: 104675683(ADCY8)
RBB: 108514094(ADCY8)
TFN: 117079299(ADCY8)
PTEH: 111549769(ADCY8)
CANG: 105509064(ADCY8)
CJC: 100404484(ADCY8)
SBQ: 101034552(ADCY8)
CIMI: 108283815(ADCY8)
ANAN: 105723783(ADCY8)
CSYR: 103267869(ADCY8)
MMUR: 105882731(ADCY8)
LCAT: 123644339(ADCY8)
PCOQ: 105813348(ADCY8)
OGA: 100952034(ADCY8)
MMU: 11514(Adcy8)
MCAL: 110310371(Adcy8)
MPAH: 110334612(Adcy8)
RNO: 29241(Adcy8)
MCOC: 116082049(Adcy8)
ANU: 117718712(Adcy8)
MUN: 110561696(Adcy8)
CGE: 113837458
MAUA: 101827170(Adcy8)
PROB: 127235293(Adcy8)
PLEU: 114697724(Adcy8)
MORG: 121461516(Adcy8)
MFOT: 126503596
AAMP: 119823121(Adcy8)
NGI: 103743923(Adcy8)
HGL: 101698293(Adcy8)
CPOC: 100722340(Adcy8)
CCAN: 109678665(Adcy8)
DORD: 105992323(Adcy8)
DSP: 122125337(Adcy8)
PLOP: 125360503(Adcy8)
NCAR: 124965096
MMMA: 107143016(Adcy8)
OCU: 100337882
OPI: 101523667(ADCY8)
TUP: 102472317(ADCY8)
GVR: 103591872(ADCY8)
CFA: 482045(ADCY8)
CLUD: 112662113(ADCY8)
VVP: 112915982(ADCY8)
VLG: 121498514(ADCY8)
NPO: 129502672(ADCY8)
AML: 100474121(ADCY8)
UMR: 103661704(ADCY8)
UAH: 113252717(ADCY8)
UAR: 123801897(ADCY8)
ELK: 111146667
LLV: 125098951
MPUF: 101693988(ADCY8)
MNP: 132014306(ADCY8)
MLK: 131826395(ADCY8)
NVS: 122904294(ADCY8)
ORO: 101370350(ADCY8)
EJU: 114211178(ADCY8)
ZCA: 113934371(ADCY8)
MLX: 118015219(ADCY8)
NSU: 110578940(ADCY8)
LWW: 102733005
FCA: 101087555(ADCY8)
PYU: 121042990(ADCY8)
PCOO: 112859389(ADCY8)
PBG: 122495819(ADCY8)
PVIV: 125156381(ADCY8)
LRUF: 124507481
PTG: 102948581(ADCY8)
PPAD: 109273118(ADCY8)
PUC: 125924401
AJU: 106976879
HHV: 120221853(ADCY8)
BTA: 535017(ADCY8)
BOM: 102272964(ADCY8)
BIU: 109568647(ADCY8)
BBUB: 102395302(ADCY8)
BBIS: 104991731(ADCY8)
CHX: 102184919(ADCY8)
OAS: 101121944(ADCY8)
BTAX: 128059256(ADCY8)
ODA: 120878868(ADCY8)
CCAD: 122451315(ADCY8)
MBEZ: 129560440(ADCY8)
SSC: 100622999(ADCY8)
CFR: 102521259(ADCY8)
CBAI: 105082946(ADCY8)
CDK: 105096450(ADCY8)
VPC: 102543885(ADCY8)
BACU: 103019172(ADCY8)
BMUS: 118883477(ADCY8)
LVE: 103085845(ADCY8)
OOR: 101273171(ADCY8)
DLE: 111164400(ADCY8)
PCAD: 102975211(ADCY8)
PSIU: 116742406(ADCY8)
NASI: 112397114(ADCY8)
ECB: 100057796(ADCY8)
EPZ: 103565019 103567623(ADCY8)
EAI: 106824833(ADCY8)
MYB: 102249345(ADCY8)
MYD: 102765722(ADCY8)
MMYO: 118670715(ADCY8)
MLF: 102423495(ADCY8)
MDT: 132219755(ADCY8)
PKL: 118718663(ADCY8)
EFUS: 103302409(ADCY8)
MNA: 107539500(ADCY8)
DRO: 112315487(ADCY8)
SHON: 118988683(ADCY8)
AJM: 119064806(ADCY8)
PDIC: 114514654(ADCY8)
PHAS: 123833093(ADCY8)
MMF: 118631528(ADCY8)
PPAM: 129084082(ADCY8)
HAI: 109372359(ADCY8)
RFQ: 117033942(ADCY8)
PALE: 102896789(ADCY8)
PGIG: 120588721(ADCY8)
PVP: 105301250(ADCY8)
RAY: 107497689(ADCY8)
MJV: 108397669(ADCY8)
TOD: 119237825(ADCY8)
SARA: 101550559(ADCY8)
SETR: 125997104(ADCY8)
LAV: 100661616(ADCY8)
TMU: 101350704
ETF: 101652236(ADCY8)
DNM: 101422732
MDO: 100026554(ADCY8)
GAS: 123241596(ADCY8)
SHR: 100923926(ADCY8)
AFZ: 127544457
PCW: 110216073(ADCY8)
TVP: 118854947(ADCY8)
OAA: 100077908(ADCY8)
GGA: 420328(ADCY8)
PCOC: 116227752(ADCY8)
MGP: 100548951(ADCY8)
CJO: 107310566(ADCY8)
TPAI: 128091225(ADCY8)
LMUT: 125690991(ADCY8)
NMEL: 110394336(ADCY8)
APLA: 101794043(ADCY8)
ACYG: 106046364(ADCY8)
CATA: 118252699(ADCY8)
AFUL: 116486321(ADCY8)
TGU: 100230277(ADCY8)
LSR: 110476995(ADCY8)
SCAN: 103816719(ADCY8)
PMOA: 120505202(ADCY8)
OTC: 121337449(ADCY8)
PRUF: 121364662(ADCY8)
GFR: 102037430(ADCY8)
FAB: 101809046(ADCY8)
OMA: 130249345(ADCY8)
PHI: 102108193(ADCY8)
PMAJ: 107200813(ADCY8)
CCAE: 111925137 111925138
CCW: 104692638(ADCY8)
CBRC: 103623540(ADCY8)
ETL: 114065892(ADCY8)
ZAB: 102061077(ADCY8)
ZLE: 135444676(ADCY8)
ACHL: 103803525(ADCY8)
SVG: 106856647(ADCY8)
MMEA: 130574389(ADCY8)
HRT: 120751558(ADCY8)
SATI: 136371854(ADCY8)
FPG: 101921528(ADCY8)
FCH: 102056487(ADCY8)
CCRI: 104162029(ADCY8)
SHAB: 115616417(ADCY8)
ACUN: 113476386(ADCY8)
TALA: 104358260(ADCY8)
ACHC: 115340454(ADCY8)
HALD: 104318994(ADCY8)
HLE: 104837657(ADCY8)
AGEN: 126050151
GCL: 127013867
LDI: 104348640(ADCY8)
MNB: 103772687(ADCY8)
DPUB: 104302935(ADCY8)
AVIT: 104279107(ADCY8)
EGZ: 104134444(ADCY8)
NNI: 104016868(ADCY8)
PCRI: 104028976(ADCY8)
PADL: 103916382(ADCY8)
AFOR: 103894564(ADCY8)
GSTE: 104259822(ADCY8)
CLV: 102086133(ADCY8)
MUI: 104548250(ADCY8)
PLET: 104619139(ADCY8)
EHS: 104512940(ADCY8)
CUCA: 104058511(ADCY8)
TEO: 104376345(ADCY8)
BREG: 104636567(ADCY8)
OHA: 104335886(ADCY8)
ACAR: 104528708(ADCY8)
CPEA: 104392847(ADCY8)
CVF: 104282884(ADCY8)
RTD: 128906210(ADCY8)
AAM: 106496221(ADCY8)
AROW: 112971840(ADCY8)
NPD: 112959414(ADCY8)
TGT: 104574302(ADCY8)
DNE: 112991309(ADCY8)
SCAM: 104153703(ADCY8)
ASN: 102369910(ADCY8)
AMJ: 102562540(ADCY8)
CPOO: 109322048(ADCY8)
GGN: 109305202(ADCY8)
PSS: 102448969(ADCY8)
CMY: 102930804(ADCY8)
CCAY: 125632845(ADCY8)
DCC: 119851950(ADCY8)
CPIC: 101947738(ADCY8)
TST: 117873819(ADCY8)
CABI: 116823168(ADCY8)
MRV: 120399258(ADCY8)
ACS: 100556578(adcy8)
ASAO: 132775114(ADCY8)
PVT: 110090751(ADCY8)
SUND: 121929803(ADCY8)
PBI: 103049018(ADCY8)
PMUR: 107289979(ADCY8)
CTIG: 120304822(ADCY8)
TSR: 106542281
PGUT: 117668453(ADCY8)
APRI: 131195285(ADCY8)
PTEX: 113438325(ADCY8)
NSS: 113419248
VKO: 123033688(ADCY8)
PMUA: 114600245(ADCY8)
PRAF: 128417072(ADCY8)
ZVI: 118089989(ADCY8)
HCG: 128322803(ADCY8)
GJA: 107119214(ADCY8)
EMC: 129333839(ADCY8)
XLA: 108719413(adcy8.L) 414729(adcy8.S)
XTR: 549366
NPR: 108788952(ADCY8)
RTEM: 120941534(ADCY8)
BBUF: 121001129(ADCY8)
MUO: 115480506(ADCY8)
GSH: 117355125(ADCY8)
DRE: 100148976(adcy8) 560410(si:ch211-132f19.7) 560719(si:dkey-206f10.1)
SRX: 107721761 107726739 107733159 107743294 107749169
SANH: 107659784 107663336 107674102 107697672
SGH: 107549698 107557810 107569488 107592799 107594777 107603098
CCAR: 109049343 109053960 109078891 109108520(adcy8)
CAUA: 113045049 113060337 113092585 113120779 113120872
CGIB: 127934466 127938090 127950475 127983755 128031463(si:ch211-132f19.7)
PTET: 122324789(adcy8) 122324933(si:dkey-206f10.1) 122361619(si:ch211-132f19.7)
LROH: 127175788(adcy8) 127179900(si:ch211-132f19.7) 127182519(si:dkey-206f10.1)
OMC: 131523720(si:ch211-132f19.7) 131526680(si:dkey-206f10.1) 131551343(adcy8)
PPRM: 120481867(si:ch211-132f19.7) 120494248(si:dkey-206f10.1) 120495233(adcy8)
RKG: 130070253(adcy8) 130076940(si:ch211-132f19.7) 130103218(si:dkey-206f10.1)
MAMB: 125250700(adcy8) 125269091(si:ch211-132f19.7) 125278420(si:dkey-206f10.1)
CIDE: 127495274 127499075(si:ch211-132f19.7) 127502320(si:dkey-206f10.1)
CERY: 137002583(adcy8) 137006192(si:ch211-132f19.7) 137018534(si:dkey-206f10.1)
MASI: 127410295 127411253 127415639 127440439 127443123 127455482
TROS: 130554045(adcy8) 130560791(si:ch211-132f19.7) 130565478(si:dkey-206f10.1)
TDW: 130417495(adcy8) 130433977(si:dkey-206f10.1) 130437020(si:ch211-132f19.7)
MANU: 129417181(si:ch211-132f19.7) 129429475(si:dkey-206f10.1) 129442933(adcy8)
IPU: 108257757(si:dkey-206f10.1) 108280230
IFU: 128601169(si:dkey-206f10.1) 128624010(adcy8)
PHYP: 113532110 113543309(adcy8)
SMEO: 124376502(si:dkey-206f10.1) 124403016(adcy8)
TFD: 113637307(adcy8) 113648313(si:dkey-206f10.1)
TVC: 132843077(si:dkey-206f10.1) 132864121(adcy8)
TRN: 134302923(adcy8) 134320903(si:dkey-206f10.1)
AMEX: 103023616(si:dkey-206f10.1) 103024991(adcy8) 103031589(si:ch211-132f19.7)
CMAO: 118803042(adcy8) 118803172(si:ch211-132f19.7) 118816110(si:dkey-206f10.1)
EEE: 113584128(adcy8)
CHAR: 105901592(si:dkey-206f10.1) 105908162(si:ch211-132f19.7)
TRU: 101073369 101073390 101076392(adcy8)
TFS: 130516250(si:dkey-206f10.1) 130523019 130538837(adcy8)
TNG: GSTEN00012568G001 GSTEN00015280G001 GSTEN00030377G001
LCO: 104922014 104938356(adcy8)
NCC: 104955036(adcy8)
TBEN: 117487284(adcy8) 117493083(si:dkey-206f10.1)
CGOB: 115022284(adcy8) 115028833
PGEO: 117439994(si:dkey-206f10.1) 117462673(adcy8)
GACU: 117533794(si:dkey-206f10.1) 117541104(adcy8)
EMAC: 134866626(adcy8) 134876514(si:dkey-206f10.1)
ELY: 117250016 117270489(si:dkey-206f10.1) 117272061(adcy8)
EFO: 125885131 125896955(si:dkey-206f10.1) 125902262(adcy8)
PLEP: 121951261(adcy8) 121955835(si:dkey-206f10.1)
SLUC: 116044740(adcy8) 116066255(si:dkey-206f10.1)
ECRA: 117953964(adcy8) 117961123(si:dkey-206f10.1)
ESP: 116698871(adcy8) 116705853
PFLV: 114564992(adcy8) 114572973
GAT: 120808486
PPUG: 119194976(si:dkey-206f10.1) 119209002(adcy8)
AFB: 129107575(si:dkey-206f10.1) 129112315(adcy8)
CLUM: 117727096(si:dkey-206f10.1) 117746031(adcy8)
PSWI: 130190901(adcy8)
MSAM: 119901661(adcy8) 119908444 119908457(si:dkey-206f10.1) 119915897
SCHU: 122862945(si:dkey-206f10.1) 122887074(adcy8)
CUD: 121506508 121519638(adcy8) 121521629(si:dkey-206f10.1)
ALAT: 119010641(adcy8) 119012449(si:dkey-206f10.1) 119015111(si:ch211-132f19.7)
MZE: 101465620(adcy8) 101468839 101473876
ONL: 100705805 100706035 100708106(adcy8)
OAU: 116310796(si:dkey-206f10.1) 116316516(adcy8) 116325033
OLA: 101161086(adcy8) 101162414 101162988
OML: 112144246(adcy8) 112156739 112158536(si:dkey-206f10.1)
CSAI: 133452395(adcy8) 133464639(si:dkey-206f10.1)
XMA: 102218852(adcy8) 102231024 102236399
XCO: 114140665 114146247(adcy8) 114158148
XHE: 116715629 116720923(adcy8) 116734023
PRET: 103457562 103480038(adcy8) 103481184
PFOR: 103138590 103150940 103156017(adcy8)
PLAI: 106949201 106950379 106955875
PMEI: 106905188 106910104 106928777(adcy8)
GAF: 122825293(si:dkey-206f10.1) 122826983(si:ch211-132f19.7) 122841663(adcy8)
PPRL: 129351152(si:dkey-206f10.1) 129351773 129352689(adcy8) 129354678
CVG: 107083338 107086997(adcy8) 107104317
CTUL: 119784215(adcy8) 119785063(si:dkey-206f10.1) 119791543
GMU: 124861404 124870367(adcy8) 124881823(si:dkey-206f10.1)
NFU: 107377600 107383681(adcy8) 107384598
KMR: 108229092(si:ch211-132f19.7) 108246168(adcy8)
ALIM: 106527219(adcy8) 106531266
NWH: 119415271(adcy8) 119428743(si:ch211-132f19.7)
AOCE: 111566062 111568870(adcy8) 111584658
MCEP: 124999026 125000626 125010885(adcy8)
CSEM: 103380838 103396830(adcy8)
POV: 109636103 109646927
SSEN: 122762475(adcy8) 122783786(si:dkey-206f10.1)
HHIP: 117758266(si:dkey-206f10.1) 117778572(adcy8) 117778677
HSP: 118099234(si:dkey-206f10.1) 118103313(si:ch211-132f19.7) 118118361(adcy8)
PPLT: 128454464(adcy8) 128459715(si:dkey-206f10.1)
SMAU: 118289860(si:dkey-206f10.1) 118310811(adcy8)
LCF: 108877174(si:ch211-132f19.7) 108882439 108895615(si:dkey-206f10.1)
SDU: 111233908(adcy8) 111235549 111236701
SLAL: 111646845 111647103(adcy8) 111650568
XGL: 120788729(si:dkey-206f10.1) 120798356 120799361(adcy8)
HCQ: 109518125 109518881(adcy8)
SSCV: 125985406 125989815(si:dkey-206f10.1)
SBIA: 133497007(si:dkey-206f10.1) 133510369(adcy8)
PEE: 133411300(adcy8) 133417224(si:dkey-206f10.1)
PTAO: 133468434(si:dkey-206f10.1) 133488497(adcy8)
BPEC: 110155800 110165875(adcy8)
MALB: 109970259(adcy8) 109971087
BSPL: 114844148(adcy8) 114849216(si:dkey-206f10.1) 114850565(si:ch211-132f19.7)
SJO: 128354596 128376834(si:dkey-206f10.1)
SASA: 106568630(adcy8) 106611404
STRU: 115156513(adcy8) 115161910
OTW: 112250071(adcy8) 112255820(si:ch211-132f19.7)
OMY: 110504263(si:ch211-132f19.7) 110529931(adcy8)
OGO: 124009784(adcy8) 124045363(si:ch211-132f19.7)
ONE: 115114051(adcy8) 115123485
OKI: 109875096(adcy8) 109881906
OKE: 118402417(adcy8) 127915572(si:ch211-132f19.7)
SALP: 111957123(adcy8) 112076728
SNH: 120022998(si:ch211-132f19.7) 120056232(adcy8)
CCLU: 121534863(adcy8) 121544568(si:ch211-132f19.7) 121548808(si:dkey-206f10.1)
ELS: 105023619(adcy8) 105031560
SFM: 108918520 108937764(adcy8)
PKI: 111845896(adcy8)
AANG: 118229366(si:dkey-206f10.1) 118234492(adcy8)
LOC: 102685748(adcy8) 102694194
PSPA: 121309014(adcy8)
ARUT: 117399547(adcy8)
PSEX: 120529809(adcy8)
LCM: 102346737(ADCY8)
CMK: 103183440(adcy8)
RTP: 109914598(adcy8)
CPLA: 122549061(adcy8) 122553148
HOC: 132815436(adcy8) 132819266
LERI: 129696342(adcy8) 129699829
PMRN: 116942605(ADCY8)
LRJ: 133349154(ADCY8)
BFO: 118405038
BBEL: 109476272
CIN: 100181005
SCLV: 120336024
SKO: 100370378
DME: Dmel_CG10564(Ac78C)
DER: 6546178
DSE: 6616399
DSI: Dsimw501_GD12142(Dsim_GD12142)
DYA: Dyak_GE22718
DAN: 6493061
DSR: 110189946
DPO: 4814005
DPE: 6602992
DMN: 108152936
DWI: 6645098
DGR: 6558351
DMO: Dmoj_GI13820
DNV: 108652084
DHE: 111599815
DVI: 6623758
CCAT: 101449938
BOD: 106622843
BDR: 105225020
RZE: 108373107
AOQ: 129241834
TDA: 119663367 119679124
MDE: 101893364
SCAC: 106093569 106094892
LCQ: 111677112
LSQ: 119606237
ECOE: 129946747
CLON: 129606790
HIS: 119648927
AGA: 1269297
ACOZ: 120949475
AARA: 120894424
AMER: 121588750
ASTE: 118506685
AFUN: 125765759
AMOU: 128301920
AALI: 118457036
AAG: 5563558
AALB: 109414810
ASUA: 134226589
CQU: CpipJ_CPIJ015189
CPII: 120415895
CNS: 116342455
BCOO: 119084184
AME: 726262
ACER: 107993030
ALAB: 122714062
ADR: 102674292
AFLR: 100872128
BIM: 100741339
BBIF: 117209501
BVK: 117233726
BVAN: 117158627
BTER: 100650732
BAFF: 126926809
BPYO: 122571917
BPAS: 132908902
FVI: 122530523
CCAL: 108626074
OBB: 114874916
OLG: 117605938
MGEN: 117228046
NMEA: 116426288
CGIG: 122401165
SOC: 105208160
MPHA: 105831878
AEC: 105145442
ACEP: 105621896
PBAR: 105425253
VEM: 105566125
HST: 105185447
DQU: 106740959
CFO: 105247922
FEX: 115242516
LHU: 105672367
PGC: 109856473
OBO: 105279868
PCF: 106787929
PFUC: 122513875
VPS: 122633833
VCRB: 124429199
VVE: 124953420
NVI: 100679362
CSOL: 105367908
TPRE: 106651649
MDL: 103569316
CGLO: 123261994
FAS: 105267081
DAM: 107039258
VCAN: 122417909
CCIN: 107268305
AROA: 105683907
TCA: 107397949 655273
DPA: 109539855
SOY: 115891600
CSET: 123310733
AGB: 108912049
LDC: 111504846
DVV: 126881536
NVL: 108558843
PPYR: 116169542
OTU: 111419609
BMOR: 101744252
BMAN: 114249948
MSEX: 115448811
DPL: KGM_202174
BANY: 112058332
MJU: 123864362
NIQ: 126776308
VCD: 124542556
MCIX: 123667163
PMAC: 106707822
PPOT: 106111023
PXU: 106114758
PRAP: 110992313
PBX: 123708464
PNAP: 125051233
ZCE: 119829857
LSIN: 126979377
AAGE: 121729741
HAW: 110376572 110376583 110376590
HZE: 124636209 124643961 124645100
TNL: 113492944 113492945
SLIU: 111354485 111355801 111356866
OFU: 114355374
ATRA: 106139315
GMW: 113523060
PXY: 105382561
PGW: 126382062
LGLY: 125241211
CCRN: 123291544
API: 100161699
DNX: 107163062
AGS: 114123034
RMD: 113561352
ACOO: 126842289
DVT: 126896987
BTAB: 109032361
DCI: 103516636
CLEC: 106663679
NLU: 111044266
HVI: 124359305
MQU: 128991511
PHU: Phum_PHUM176700
FOC: 113211545
ZNE: 110834851
CSEC: 111865456
BROR: 134531985
DPX: DAPPUDRAFT_247897(Adcy6) DAPPUDRAFT_318338
DMK: 116932776
DPZ: 124313537 124343581 124350944
PVM: 113803537
PJA: 122251535
PCHN: 125043001
HAME: 121876217
PCLA: 123766907
PTRU: 123515821
HAZT: 108672252
EAF: 111704198
LSM: 121118136
PPOI: 119099816
DSV: 119448858
RSAN: 119381807
RMP: 119170587
TUT: 107365159
DPTE: 113796993
DFR: 124494863
PTEP: 107439048
ABRU: 129965976
UDV: 129217055
SDM: 118184219
LPOL: 106459888
PMAX: 117316821
LAK: 106153878
AQU: 100637659
DFA: DFA_04345(acaA)
SPAR: SPRG_05070
 » show all
Reference
PMID:8076676
  Authors
Defer N, Marinx O, Stengel D, Danisova A, Iourgenko V, Matsuoka I, Caput D, Hanoune J
  Title
Molecular cloning of the human type VIII adenylyl cyclase.
  Journal
FEBS Lett 351:109-13 (1994)
DOI:10.1016/0014-5793(94)00836-1
  Sequence
[hsa:114]
Reference
PMID:21046358
  Authors
Roger B, Papin J, Vacher P, Raoux M, Mulot A, Dubois M, Kerr-Conte J, Voy BH, Pattou F, Charpentier G, Jonas JC, Moustaid-Moussa N, Lang J
  Title
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells.
  Journal
Diabetologia 54:390-402 (2011)
DOI:10.1007/s00125-010-1955-x
LinkDB

KEGG   ORTHOLOGY: K08049
Entry
K08049                      KO                                     
Symbol
ADCY9
Name
adenylate cyclase 9 [EC:4.6.1.1]
Pathway
map00230  Purine metabolism
map01100  Metabolic pathways
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04114  Oocyte meiosis
map04211  Longevity regulating pathway
map04213  Longevity regulating pathway - multiple species
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04361  Axon regeneration
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04727  GABAergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04961  Endocrine and other factor-regulated calcium reabsorption
map04962  Vasopressin-regulated water reabsorption
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05032  Morphine addiction
map05110  Vibrio cholerae infection
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Reaction
R00089  ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming)
R00434  GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08049  ADCY9; adenylate cyclase 9
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04371 Apelin signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04020 Calcium signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04072 Phospholipase D signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04024 cAMP signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04022 cGMP-PKG signaling pathway
    K08049  ADCY9; adenylate cyclase 9
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08049  ADCY9; adenylate cyclase 9
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08049  ADCY9; adenylate cyclase 9
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08049  ADCY9; adenylate cyclase 9
   04062 Chemokine signaling pathway
    K08049  ADCY9; adenylate cyclase 9
  09152 Endocrine system
   04911 Insulin secretion
    K08049  ADCY9; adenylate cyclase 9
   04923 Regulation of lipolysis in adipocytes
    K08049  ADCY9; adenylate cyclase 9
   04912 GnRH signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04913 Ovarian steroidogenesis
    K08049  ADCY9; adenylate cyclase 9
   04915 Estrogen signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04914 Progesterone-mediated oocyte maturation
    K08049  ADCY9; adenylate cyclase 9
   04921 Oxytocin signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04926 Relaxin signaling pathway
    K08049  ADCY9; adenylate cyclase 9
   04935 Growth hormone synthesis, secretion and action
    K08049  ADCY9; adenylate cyclase 9
   04918 Thyroid hormone synthesis
    K08049  ADCY9; adenylate cyclase 9
   04928 Parathyroid hormone synthesis, secretion and action
    K08049  ADCY9; adenylate cyclase 9
   04916 Melanogenesis
    K08049  ADCY9; adenylate cyclase 9
   04925 Aldosterone synthesis and secretion
    K08049  ADCY9; adenylate cyclase 9
   04927 Cortisol synthesis and secretion
    K08049  ADCY9; adenylate cyclase 9
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08049  ADCY9; adenylate cyclase 9
   04270 Vascular smooth muscle contraction
    K08049  ADCY9; adenylate cyclase 9
  09154 Digestive system
   04970 Salivary secretion
    K08049  ADCY9; adenylate cyclase 9
   04971 Gastric acid secretion
    K08049  ADCY9; adenylate cyclase 9
   04972 Pancreatic secretion
    K08049  ADCY9; adenylate cyclase 9
   04976 Bile secretion
    K08049  ADCY9; adenylate cyclase 9
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K08049  ADCY9; adenylate cyclase 9
   04961 Endocrine and other factor-regulated calcium reabsorption
    K08049  ADCY9; adenylate cyclase 9
  09156 Nervous system
   04724 Glutamatergic synapse
    K08049  ADCY9; adenylate cyclase 9
   04727 GABAergic synapse
    K08049  ADCY9; adenylate cyclase 9
   04725 Cholinergic synapse
    K08049  ADCY9; adenylate cyclase 9
   04723 Retrograde endocannabinoid signaling
    K08049  ADCY9; adenylate cyclase 9
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08049  ADCY9; adenylate cyclase 9
  09158 Development and regeneration
   04361 Axon regeneration
    K08049  ADCY9; adenylate cyclase 9
  09149 Aging
   04211 Longevity regulating pathway
    K08049  ADCY9; adenylate cyclase 9
   04213 Longevity regulating pathway - multiple species
    K08049  ADCY9; adenylate cyclase 9
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08049  ADCY9; adenylate cyclase 9
   04714 Thermogenesis
    K08049  ADCY9; adenylate cyclase 9
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08049  ADCY9; adenylate cyclase 9
   05207 Chemical carcinogenesis - receptor activation
    K08049  ADCY9; adenylate cyclase 9
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08049  ADCY9; adenylate cyclase 9
   05163 Human cytomegalovirus infection
    K08049  ADCY9; adenylate cyclase 9
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K08049  ADCY9; adenylate cyclase 9
  09165 Substance dependence
   05032 Morphine addiction
    K08049  ADCY9; adenylate cyclase 9
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08049  ADCY9; adenylate cyclase 9
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08049  ADCY9; adenylate cyclase 9
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08049  ADCY9; adenylate cyclase 9
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08049  ADCY9; adenylate cyclase 9
Other DBs
GO: 0004016
Genes
HSA: 115(ADCY9)
PTR: 453869(ADCY9)
PPS: 100972356(ADCY9)
GGO: 101145410(ADCY9)
PON: 103889530(ADCY9)
PPYG: 129016354(ADCY9)
NLE: 100599484(ADCY9)
HMH: 116462297(ADCY9)
SSYN: 129462674(ADCY9)
MCC: 706789(ADCY9)
MCF: 102135923(ADCY9)
MTHB: 126944580
MNI: 105467851(ADCY9)
CSAB: 103227576(ADCY9)
CATY: 105572097(ADCY9)
PANU: 101004325(ADCY9)
TGE: 112614524(ADCY9)
MLEU: 105541508(ADCY9)
RRO: 104672288(ADCY9)
RBB: 108538326(ADCY9)
TFN: 117097725(ADCY9)
PTEH: 111551667(ADCY9)
CANG: 105525627(ADCY9)
CJC: 100405403(ADCY9)
SBQ: 101052034(ADCY9)
CIMI: 108286553(ADCY9)
ANAN: 105709814(ADCY9)
CSYR: 103273680(ADCY9)
MMUR: 105859653(ADCY9)
LCAT: 123632319(ADCY9)
PCOQ: 105813177(ADCY9)
OGA: 100943767(ADCY9)
MMU: 11515(Adcy9)
MCAL: 110311555(Adcy9)
MPAH: 110329624(Adcy9)
RNO: 302950(Adcy9)
MCOC: 116084214(Adcy9)
ANU: 117710708(Adcy9)
MUN: 110545944(Adcy9)
CGE: 100751372(Adcy9)
MAUA: 101842546(Adcy9)
PROB: 127219617(Adcy9)
PLEU: 114710615(Adcy9)
MORG: 121463621(Adcy9)
MFOT: 126492532
AAMP: 119811771(Adcy9)
NGI: 103744458(Adcy9)
HGL: 101714605(Adcy9)
CPOC: 100717226(Adcy9)
CCAN: 109681681 109681696
DORD: 105981874(Adcy9)
DSP: 122123783(Adcy9)
PLOP: 125340976(Adcy9)
NCAR: 124970113
MMMA: 107146665(Adcy9)
OCU: 100340877
OPI: 101517485(ADCY9)
TUP: 102477344(ADCY9)
GVR: 103591384(ADCY9)
CFA: 490031(ADCY9)
CLUD: 112640443(ADCY9)
VVP: 112923266(ADCY9)
VLG: 121486234(ADCY9)
NPO: 129519450(ADCY9)
AML: 100476495(ADCY9)
UMR: 103668547(ADCY9)
UAH: 113270857(ADCY9)
UAR: 123783548(ADCY9)
ELK: 111156133
LLV: 125091072
MPUF: 101680942(ADCY9)
MNP: 132026955(ADCY9)
MLK: 131819927(ADCY9)
NVS: 122895879(ADCY9)
ORO: 101364108(ADCY9)
EJU: 114219898(ADCY9)
ZCA: 113932237(ADCY9)
MLX: 118021775(ADCY9)
NSU: 110588085(ADCY9)
LWW: 102728665
FCA: 101095942(ADCY9)
PYU: 121019600(ADCY9)
PCOO: 112853291(ADCY9)
PBG: 122471737(ADCY9)
PVIV: 125154541(ADCY9)
LRUF: 124517827
PTG: 102969003(ADCY9)
PPAD: 109278247(ADCY9)
PUC: 125926198
AJU: 106978803
HHV: 120236476(ADCY9)
BTA: 525482(ADCY9)
BOM: 102285642(ADCY9)
BIU: 109578364(ADCY9)
BBUB: 102404282(ADCY9)
BBIS: 104988909(ADCY9)
CHX: 102188104(ADCY9)
OAS: 101122401(ADCY9)
BTAX: 128043555(ADCY9)
ODA: 120874335(ADCY9)
CCAD: 122432769(ADCY9)
MBEZ: 129545325(ADCY9)
SSC: 100625423(ADCY9)
CFR: 102505261(ADCY9)
CBAI: 105064797(ADCY9)
CDK: 105099828(ADCY9)
VPC: 102535401(ADCY9)
BACU: 103016058(ADCY9)
BMUS: 118881054(ADCY9)
LVE: 103070451(ADCY9)
OOR: 101281654(ADCY9)
DLE: 111185250(ADCY9)
PCAD: 102995803(ADCY9)
PSIU: 116740403(ADCY9)
NASI: 112409457(ADCY9)
ECB: 100066046(ADCY9)
EPZ: 103553014(ADCY9)
EAI: 106826021(ADCY9)
MYB: 102248953(ADCY9)
MYD: 102760324(ADCY9)
MMYO: 118656939(ADCY9)
MLF: 102422477(ADCY9)
MDT: 132233026(ADCY9)
PKL: 118703343(ADCY9)
EFUS: 103286155(ADCY9)
MNA: 107535777(ADCY9)
DRO: 112298360(ADCY9)
SHON: 118975805(ADCY9)
AJM: 119056281(ADCY9)
PDIC: 114503776 114505902(ADCY9)
PHAS: 123807136(ADCY9)
MMF: 118642221(ADCY9)
PPAM: 129083643(ADCY9)
HAI: 109392133(ADCY9)
RFQ: 117019474(ADCY9)
PALE: 102885676(ADCY9)
PGIG: 120620331(ADCY9)
PVP: 105303095(ADCY9)
RAY: 107521680(ADCY9)
MJV: 108388549(ADCY9)
TOD: 119241983(ADCY9)
SARA: 101551730(ADCY9)
SETR: 126001221(ADCY9)
LAV: 100663448(ADCY9)
TMU: 101344705
ETF: 101662031(ADCY9)
DNM: 101442901(ADCY9)
MDO: 100013831(ADCY9)
GAS: 123231736(ADCY9)
SHR: 100926025(ADCY9)
AFZ: 127542142
PCW: 110214660(ADCY9)
TVP: 118830945(ADCY9)
OAA: 100080569(ADCY9)
GGA: 395339(ADCY9)
PCOC: 116230251(ADCY9)
MGP: 100542393 104913356
CJO: 107320968(ADCY9)
TPAI: 128078941(ADCY9)
LMUT: 125700673(ADCY9)
NMEL: 110405807(ADCY9)
APLA: 101800617(ADCY9)
ACYG: 106033354(ADCY9)
CATA: 118249301(ADCY9)
AFUL: 116495186(ADCY9)
TGU: 100231171(ADCY9)
LSR: 110476108(ADCY9)
SCAN: 103817765(ADCY9)
PMOA: 120513041(ADCY9)
OTC: 121338477(ADCY9)
PRUF: 121350906(ADCY9)
GFR: 102043312(ADCY9)
FAB: 101818533(ADCY9)
OMA: 130259051(ADCY9)
PHI: 102103610(ADCY9)
PMAJ: 107211136(ADCY9)
CCAE: 111935874(ADCY9)
CCW: 104684954(ADCY9)
CBRC: 103620492(ADCY9)
ETL: 114057021(ADCY9)
ZAB: 102065721(ADCY9)
ZLE: 135454379(ADCY9)
ACHL: 103811434(ADCY9)
SVG: 106862893(ADCY9)
MMEA: 130577218(ADCY9)
HRT: 120759456(ADCY9)
SATI: 136368107(ADCY9)
FPG: 101921768(ADCY9)
FCH: 102047847(ADCY9)
CCRI: 104168626(ADCY9)
SHAB: 115607555(ADCY9)
ACUN: 113485514(ADCY9)
TALA: 104366998(ADCY9)
ACHC: 115336030(ADCY9)
HALD: 104320863(ADCY9)
HLE: 104838567(ADCY9)
AGEN: 126033989
GCL: 127022660
CSTI: 104562692(ADCY9)
LDI: 104344596(ADCY9)
MNB: 103775660(ADCY9)
DPUB: 104300295(ADCY9)
AVIT: 104273239(ADCY9)
BRHI: 104495892(ADCY9)
EGZ: 104121973(ADCY9)
NNI: 104023465(ADCY9)
PCRI: 104028600(ADCY9)
PCAO: 104052519(ADCY9)
PADL: 103917604(ADCY9)
AFOR: 103897456(ADCY9)
FGA: 104073483(ADCY9)
GSTE: 104254777(ADCY9)
CLV: 102095574(ADCY9)
MUI: 104544861(ADCY9)
PGUU: 104462066(ADCY9)
PLET: 104620463(ADCY9)
EHS: 104506918(ADCY9)
CMAC: 104477171(ADCY9)
CUCA: 104068131(ADCY9)
TEO: 104373465(ADCY9)
BREG: 104643838(ADCY9)
OHA: 104331018(ADCY9)
CPEA: 104386813(ADCY9)
CVF: 104283743(ADCY9)
RTD: 128913706(ADCY9)
AAM: 106482327(ADCY9)
AROW: 112965855(ADCY9)
NPD: 112955683(ADCY9)
TGT: 104569769(ADCY9)
DNE: 112986919(ADCY9)
SCAM: 104143916(ADCY9)
ASN: 102370673 102373860(ADCY9)
AMJ: 102574362(ADCY9)
CPOO: 109313447(ADCY9)
GGN: 109290787(ADCY9)
PSS: 102448197(ADCY9)
CMY: 102945804(ADCY9)
CCAY: 125643636(ADCY9)
DCC: 119862420(ADCY9)
CPIC: 101940138(ADCY9)
TST: 117883930(ADCY9)
CABI: 116825535(ADCY9)
MRV: 120373164(ADCY9)
ACS: 100556223(adcy9)
ASAO: 132782057(ADCY9)
PVT: 110089110(ADCY9)
SUND: 121914170(ADCY9)
PBI: 103051661(ADCY9)
PMUR: 107283963(ADCY9)
CTIG: 120315776(ADCY9)
TSR: 106551564(ADCY9)
PGUT: 117679454(ADCY9)
APRI: 131184956(ADCY9)
PTEX: 113438988(ADCY9)
NSS: 113422381(ADCY9)
VKO: 123025128(ADCY9)
PMUA: 114584296(ADCY9)
PRAF: 128401275(ADCY9)
ZVI: 118092905(ADCY9)
HCG: 128336385(ADCY9)
GJA: 107109291(ADCY9)
STOW: 125431155(ADCY9)
EMC: 129338722(ADCY9)
XLA: 108703189(adcy9.S) 378610(adcy9.L)
XTR: 100126441(adcy9)
NPR: 108790811(ADCY9)
RTEM: 120943333(ADCY9)
BBUF: 121008967(ADCY9)
BGAR: 122944479(ADCY9)
MUO: 115476156(ADCY9)
GSH: 117369434(ADCY9)
DRE: 100333702(adcy9) 101884360
SRX: 107715643 107718568 107742090 107755348
SANH: 107655369 107659321 107661757 107695715
SGH: 107553626 107566051 107566672 107601541(adcy9)
CCAR: 109046870 109046899(adcy9)
CAUA: 113039957 113051739 113065061 113067623
CGIB: 127943078 127953286 127955411 127988423
PTET: 122327661(adcy9) 122340527
LROH: 127153464(adcy9) 127161786
OMC: 131529841(adcy9) 131534865
PPRM: 120489506 120495239(adcy9)
RKG: 130095060 130103524(adcy9)
MAMB: 125262387 125263713(adcy9)
CIDE: 127507826 127520673
CERY: 137017251 137027823(adcy9)
MASI: 127438523 127439009 127450214 127451971
TROS: 130548376(adcy9) 130561860
TDW: 130426035 130426037 130430588(adcy9)
MANU: 129436653 129453161(adcy9)
IPU: 108259388
IFU: 128603018(adcy9)
PHYP: 113547577
SMEO: 124379699(adcy9)
TFD: 113657013(adcy9)
TVC: 132838603(adcy9)
TRN: 134300309 134304069(adcy9)
AMEX: 103022434
CMAO: 118804604(adcy9) 118821634
EEE: 113576829 113580690
CHAR: 105896883(adcy9)
TRU: 101074204 101078598(adcy9)
TFS: 130515478 130527581
TNG: GSTEN00026314G001 GSTEN00026315G001
LCO: 104925375 104925703(adcy9)
NCC: 104952968 104960152 104960179
TBEN: 117474577(adcy9) 117492576
CGOB: 115011853(adcy9) 115019777
PGEO: 117450787 117466152(adcy9)
GACU: 117548476 117561607(adcy9)
EMAC: 134864843(adcy9) 134878335
ELY: 117255130(adcy9) 117268794
EFO: 125879469 125883662(adcy9)
PLEP: 121941820(adcy9) 121956605
SLUC: 116042792(adcy9) 116059342
ECRA: 117954726(adcy9) 117958663
ESP: 116702848(adcy9) 116706628
PFLV: 114565456 114569437(adcy9)
GAT: 120825138(adcy9) 120827674
PPUG: 119218113(adcy9) 119220190
AFB: 129095336(adcy9) 129098413
CLUM: 117735526 117737161(adcy9)
PSWI: 130188722 130189473(adcy9)
MSAM: 119889816 119899433(adcy9)
SCHU: 122868809 122873932(adcy9)
CUD: 121507894(adcy9) 121529451
ALAT: 119007440(adcy9) 119014314
MZE: 101466373 101477119(adcy9)
ONL: 100703903(adcy9) 100710254
OAU: 116310579(adcy9) 116321439
OLA: 101155516(adcy9) 101163149
OML: 112137465(adcy9) 112146809
CSAI: 133421617 133443967(adcy9)
XMA: 102230840(adcy9) 102231255
XCO: 114144541 114160082(adcy9)
XHE: 116719875 116735712(adcy9)
PRET: 103464021 103469190(adcy9)
PFOR: 103131040 103141004 103154140
PLAI: 106942578(adcy9) 106945964
PMEI: 106915777 106922027 106933946
GAF: 122821683 122829319(adcy9)
PPRL: 129363211 129367296(adcy9)
CVG: 107083431 107095220(adcy9)
CTUL: 119773188 119798032
GMU: 124862755 124864776 124867768(adcy9)
NFU: 107376487(adcy9) 107390534
KMR: 108241462(adcy9) 108247648
ALIM: 106518708(adcy9) 106532502
NWH: 119420989 119423075(adcy9)
AOCE: 111569892 111582512
MCEP: 124997289 125004196(adcy9)
CSEM: 103384091 103393051(adcy9)
POV: 109627430 109638721
SSEN: 122771216(adcy9) 122784928
HHIP: 117761437(adcy9) 117766860
HSP: 118120272(adcy9) 118123534
PPLT: 128436831(adcy9) 128458945
SMAU: 118288986 118312152(adcy9)
LCF: 108885408 108886159
SDU: 111227004(adcy9) 111229246
SLAL: 111665544 111667563(adcy9)
XGL: 120783409 120799900(adcy9)
HCQ: 109527326 109532550(adcy9)
SSCV: 125969246 125983468
SBIA: 133505982(adcy9) 133514777
PEE: 133403587(adcy9) 133414441
PTAO: 133466128 133476287(adcy9)
BPEC: 110166178 110168281(adcy9)
MALB: 109972278 109972902(adcy9)
BSPL: 114851174(adcy9) 114861051
SJO: 128378456 128379339(adcy9)
SASA: 106564461 106564466 106590289 106590466 106601887 106601890 106606489(adcy9)
STRU: 115147400 115171775 115178829 115206444
OTW: 112238377(adcy9) 112240731
OMY: 110485545 110516720 110539056 118938426
OGO: 123999196 124016520(adcy9)
OKI: 109878239(adcy9) 109880859 109880861
OKE: 118376346 118380107(adcy9)
SALP: 112074752
SNH: 120017568 120032464 120044084
CCLU: 121551797 121553821(adcy9) 121570729
ELS: 105012108 105021646
SFM: 108928849(adcy9) 108930202
PKI: 111843208(adcy9) 111860576
AANG: 118217014 118219851
LOC: 102695743(adcy9)
PSPA: 121300452 121330489
ARUT: 117418288 117431652(adcy9)
PSEX: 120543008(adcy9)
LCM: 102363182(ADCY9)
CMK: 103178726(adcy9)
CPLA: 122560628(adcy9)
HOC: 132825408(adcy9)
LERI: 129706900(adcy9)
PMRN: 116951471(ADCY9)
LRJ: 133340728(ADCY9)
BFO: 118419128
BBEL: 109470759
CIN: 100176999
SCLV: 120340982
SPU: 115918037
LPIC: 129261030
APLC: 110976938
ARUN: 117294031
DME: Dmel_CG9210(Ac13E)
DER: 6550781
DSE: 6620492
DSI: Dsimw501_GD27717(Dsim_GD27717)
DYA: Dyak_GE16042
DAN: 6504918
DSR: 110179465
DPO: 4815863
DPE: 6600185
DMN: 108162824
DWI: 6641108
DGR: 6565535
DMO: Dmoj_GI15443
DAZ: 108618258
DNV: 108657257
DHE: 111593022
DVI: 6632141
CCAT: 101454975
BOD: 106627061
BDR: 105225576
RZE: 108358500
AOQ: 129237003
TDA: 119667110 119671505
MDE: 101898652
SCAC: 106094127
LCQ: 111674878
LSQ: 119604677
GFS: 119645377
ECOE: 129947428
CLON: 129605341
HIS: 119656638
AGA: 1272181
ACOZ: 120960963
AARA: 120905622
AMER: 121595522
ASTE: 118509964
AFUN: 125764604
AMOU: 128306395
AAG: 23687681
AALB: 109401910
ASUA: 134206900
CQU: CpipJ_CPIJ017308
CPII: 120416886
CNS: 116347550
BCOO: 119070332
AME: 552535
ACER: 107997752
ALAB: 122716251
ADR: 102680532
AFLR: 100872672
BIM: 100746561
BBIF: 117208810
BVK: 117231486
BVAN: 117156886
BTER: 100651494
BAFF: 126918007
BPYO: 122572676
BPAS: 132907230
FVI: 122539040
CCAL: 108624324
OBB: 114880536
OLG: 117602094
MGEN: 117225285
NMEA: 116429546
CGIG: 122404520
SOC: 105198643
MPHA: 105838352
AEC: 105150701
ACEP: 105627205
PBAR: 105427028
VEM: 105564754
HST: 105181099
DQU: 106747283
CFO: 105256088
FEX: 115243591
LHU: 105677518(Ac13E)
PGC: 109854881
PCF: 106790513
PFUC: 122521303
VPS: 122637861
VCRB: 124432936
VVE: 124954122
NVI: 100119583
CSOL: 105363461
TPRE: 106651218
MDL: 103571696
CGLO: 123272289
FAS: 105268508
DAM: 107042438
AGIF: 122859433
CCIN: 107272739
TCA: 663450
DPA: 109540821
SOY: 115888190
AGRG: 126744753 126749384
ATD: 109602330
CSET: 123308982
AGB: 108914929
LDC: 111503657
DVV: 114327121
NVL: 108565010
APLN: 108738447
PPYR: 116177917
OTU: 111422488 111423681
BMOR: 101739269
BMAN: 114241715
MSEX: 115445816 119190145
DPL: KGM_211881
BANY: 112054500
MJU: 123866325
NIQ: 126781819
VCD: 124544454
MCIX: 123670230
PMAC: 106721760
PPOT: 106103338
PXU: 106123447
PRAP: 110992828
PBX: 123714841
PNAP: 125061353
ZCE: 119833421
CCRC: 123691575
LSIN: 126973794
AAGE: 121729092
HAW: 110378429
HZE: 124632530
TNL: 113507970
SLIU: 111358257
OFU: 114361142
ATRA: 106131314
GMW: 113509148
PGW: 126366191
LGLY: 125228627
CCRN: 123292957
BTAB: 109032478
CLEC: 106670008
HHAL: 106686877(Ac13E)
NLU: 111052708
HVI: 124372766
MQU: 128988972
PHU: Phum_PHUM155150
FOC: 113214351
TPAL: 117647999
ZNE: 110827835
CSEC: 111861375
BROR: 134532089
IEL: 124161893
DPX: DAPPUDRAFT_302912
DMK: 116915808
DPZ: 124314399
PVM: 113829994
PJA: 122250771
PCHN: 125046997
PMOO: 119593112
HAME: 121871881
PCLA: 123760662
CQD: 128703399
PTRU: 123506767
ESN: 126983793
HAZT: 108673638
EAF: 111705863
LSM: 121114776
PPOI: 119108067 119108069
ISC: 8035824
DSV: 119449545
RSAN: 119382569
RMP: 119179607
VDE: 111243249
VJA: 111263474 111267788
CSCU: 111635808
CVS: 136982231(Ac13E)
LPOL: 106463976
CEL: CELE_F17C8.1(acy-1)
CBR: CBG_18000(Cbr-acy-1)
NAI: NECAME_02871
BMY: BM_BM3414(Bma-acy-1)
LOA: LOAG_11276
TSP: Tsp_06467 Tsp_06476
LGI: LOTGIDRAFT_136233
PVUL: 126830910
PCAN: 112558934
BGT: 106058937
GAE: 121375216
HRF: 124139610
HRJ: 124280216
CRG: 105335675
CANU: 128191474
CVN: 111123748
OED: 125681099
MYI: 110461839
PMAX: 117329864
MCAF: 127714109
MMER: 123556748
DPOL: 127879231
MAEA: 128227031
LJP: 135472736
LAK: 106155533 106170328
SMM: Smp_102340.1
OVI: T265_02194 T265_02366 T265_04534 T265_06551
EGL: EGR_00868 EGR_01141 EGR_01447
LLON: 135493181
NVE: 5519173
EPA: 110248954
ATEN:&