KEGG   ORTHOLOGY: K08093
Entry
K08093                      KO                                     
Symbol
hxlA
Name
3-hexulose-6-phosphate synthase [EC:4.1.2.43]
Pathway
map00030  Pentose phosphate pathway
map00680  Methane metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K08093  hxlA; 3-hexulose-6-phosphate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K08093  hxlA; 3-hexulose-6-phosphate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K08093  hxlA; 3-hexulose-6-phosphate synthase
Other DBs
RN: R05338
COG: COG0269
GO: 0043801
Genes
EUM: ECUMN_2963
STM: STM2755
SEO: STM14_3320
SEV: STMMW_27231
SEY: SL1344_2739(hxlA)
SEM: STMDT12_C28070
SEJ: STMUK_2743
SEB: STM474_2890
SEF: UMN798_2989(hxlA)
SETU: STU288_13940
SENI: CY43_14395
SEH: SeHA_C2929(hxlA)
SHB: SU5_03243
ECLZ: LI64_16165
ECAN: CWI88_05395(hxlA)
ECHG: FY206_18835(hxlA)
KPN: KPN_02957
KLW: DA718_10170(hxlA)
CITZ: E4Z61_22610(hxlA)
SOD: Sant_0061
METU: GNH96_02035(hxlA) GNH96_02065(hxlA)
METL: U737_21900(hxlA)
MPAD: KEF85_01965(hxlA) KEF85_12785(hxlA)
MELL: IVG45_20185(hxlA)
MAH: MEALZ_3953(hps1)
MPSY: CEK71_00435(hxlA)
MMAI: sS8_1135
MMOB: F6R98_00315(hxlA) F6R98_00325(hxlA)
MESL: KKZ03_07025(hxlA)
MEJ: Q7A_2498(hxlA) Q7A_2501(hxlA)
MPIN: LGT42_003280(hxlA) LGT42_003295(hxlA)
ORB: IPMB12_08420(hxlA)
MEP: MPQ_0281(sgbH) MPQ_1561
MBAC: BN1209_0202(rmpA) BN1209_0771(rmpA)
MBAT: BN1208_0845(hps)
SDO: SD1155_05640(hxlA)
ADO: A6F68_00105(proA_1)
BSU: BSU03460(hxlA)
BSR: I33_0397(hxlA)
BSL: A7A1_1851
BSH: BSU6051_03460(hxlA)
BSUT: BSUB_00396(hxlA)
BSUL: BSUA_00396(hxlA)
BSUS: Q433_02070
BSO: BSNT_06681(hxlA)
BSQ: B657_03460(hxlA)
BSX: C663_0338(hxlA)
BSS: BSUW23_01790(hxlA)
BST: GYO_0559(hxlA)
BLI: BL02045(hxlA)
BLD: BLi02805(hxlA)
BLH: BaLi_c29000(hxlA)
BAY: RBAM_003630(hxlA)
BAQ: BACAU_0303(hxlA)
BYA: BANAU_0305(hxlA)
BAMP: B938_01575
BQY: MUS_0325(hxlA)
BAML: BAM5036_0322(hxlA)
BAMA: RBAU_0337(hxlA)
BAMN: BASU_0321(hxlA)
BAMB: BAPNAU_0307(hxlA)
BAMT: AJ82_01980
BAMY: V529_03250(hxlA)
BMP: NG74_00345(hxlA)
BAO: BAMF_0310(hxlA)
BAZ: BAMTA208_01555(hxlA)
BQL: LL3_00318(hxlA)
BXH: BAXH7_00321(hxlA)
BAMI: KSO_017855
BAMC: U471_03230
BAMF: U722_01860
BSIA: CWD84_20190(hxlA)
BSON: S101395_01722(hxlA)
BHT: DIC78_08240(hxlA)
BMOJ: HC660_03860(hxlA)
BTEQ: G4P54_01945(hxlA)
BPU: BPUM_2333
BPUM: BW16_12650
BPUS: UP12_11780
BMET: BMMGA3_06845(hps)
BGY: BGLY_3090(hxlA)
BALT: CFN77_12450(hxlA)
BAER: BAE_00125(hxlA)
BFD: NCTC4823_01217(hxlA_1) NCTC4823_03793(hxlA_2)
BSHI: LGQ02_03485(hxlA)
BCAB: EFK13_02150(hxlA)
BRY: M0696_02000(hxlA)
BJS: MY9_0361
BACW: QR42_11740
BACP: SB24_07990
BACB: OY17_04480
BACY: QF06_00690
BACL: BS34A_04030(hxlA)
BALM: BsLM_0362
BACQ: DOE78_03635(hxlA)
BMQ: BMQ_0891(hxlA) BMQ_1538(hxlA) BMQ_2942(hxlA)
BMD: BMD_0891(hxlA) BMD_1519(hxlA) BMD_2971(hxlA)
BMEG: BG04_3186(hxlA) BG04_3830(hxlA) BG04_4896(hxlA) BG04_5472 BG04_5588(hxlA) BG04_5930(hxlA)
PKS: IE339_01975(hxlA)
BAG: Bcoa_0968
BCL: ABC3351(hxlA)
BKW: BkAM31D_07120(hxlA_1) BkAM31D_16315(hxlA_2)
OCN: CUC15_15170(hxlA)
GTN: GTNG_1490
GGH: GHH_c21400(hxlA)
GEA: GARCT_00704(hxlA_1) GARCT_02004(hxlA_2)
GZA: IC807_06470(hxlA)
PTB: DER53_08130(hxlA)
PARG: PspKH34_30140(hxlA)
ANM: GFC28_662
ANL: GFC29_964
HLI: HLI_12660
VNT: OLD84_16675(hxlA)
PPSR: I6J18_02975(hxlA) I6J18_08150(hxlA)
GRC: GI584_10025(hxlA)
NMK: CHR53_10820(hxlA)
NTM: BTDUT50_14180(hxlA)
MLIT: KDJ21_025570(hxlA) KDJ21_026155(hxlA)
BLEN: NCTC4824_00834(hxlA_1) NCTC4824_02164(hxlA_2)
RMF: D5E69_06120(hxlA)
BBEV: BBEV_0241(hxlA)
SAU: SA0528
SAV: SAV0570
SAW: SAHV_0568
SAM: MW0525
SAS: SAS0528
SAR: SAR0574
SAC: SACOL0617
SAE: NWMN_0533
SAD: SAAV_0533(hxlA)
SUU: M013TW_0558(hxlA)
SUE: SAOV_0605
SUJ: SAA6159_00524(hxlA)
SUK: SAA6008_00578(hxlA)
SUC: ECTR2_524(hxlA)
SUQ: HMPREF0772_12618(hxlA)
SUZ: MS7_0560(hxlA)
SUG: SAPIG0645(hxlA)
SAUA: SAAG_00991
SAUE: RSAU_000524(hps)
SAUS: SA40_0511
SAUU: SA957_0526
SAUG: SA268_0524
SAUF: X998_0612(hxlA)
SAB: SAB0520
SAUB: C248_0645
SAUM: BN843_5640
SAUC: CA347_586(hxlA)
SAUR: SABB_00621
SAUI: AZ30_02885
SAUD: CH52_02905
SAMS: NI36_02840
SER: SERP0216
SEP: SE_0341
SEPP: SEB_00262
SEPS: DP17_1647(hxlA)
SHA: SH2420
SHH: ShL2_02215(hxlA)
SDT: SPSE_2213(hxlA)
SDP: NCTC12225_02420(hxlA)
SPAS: STP1_1658
SHU: SHYC_10795(hxlA)
SSCH: LH95_10395
SSCZ: RN70_11130
SAGQ: EP23_11365(hxlA)
SSIF: AL483_08720(hxlA)
SPET: CEP67_09865(hxlA)
SKL: C7J89_12605(hxlA)
SFQ: C7J90_01805(hxlA)
SHOM: EGX58_03330(hxlA)
SMUS: C7J88_08345(hxlA)
SCAR: DWB96_11675(hxlA) DWB96_13070(hxlA)
SCHR: DWB92_10940(hxlA)
SARL: SAP2_21950
SDB: CNQ82_05285(hxlA) CNQ82_12845(hxlA)
SLLO: ISP08_10875(hxlA)
SAUL: I6G39_01920(hxlA)
SSAC: I6I31_05635(hxlA)
SRAI: LN051_10085(hxlA)
SPSD: JMB28_11605(hxlA)
STAS: HYI43_10895(hxlA)
SSCU: CEP64_01020(hxlA)
SFF: FOB90_09055(hxlA)
MLEN: H3V22_07285(hxlA)
MVT: I6J10_09650(hxlA)
MCL: MCCL_0037
MCAK: MCCS_00640
MBRU: MGG13_01510(hxlA)
MEPI: KFV12_00630(hxlA)
MEQU: KFV11_01600(hxlA)
ESI: Exig_2372
EAN: Eab7_2216
EACE: KKI46_12995(hxlA)
PPY: PPE_04673
PPM: PPSC2_24305(hxlA)
PPO: PPM_4826(hxlA)
PPOL: X809_40845
PPQ: PPSQR21_049250(sgbH)
PPOY: RE92_12975
PMS: KNP414_07885(hxlA)
PMW: B2K_37330
PRI: PRIO_3567 PRIO_6499(hxlA)
PSON: JI735_07210(hxlA)
PSWU: SY83_08105
PDH: B9T62_30300(hxlA)
PLW: D5F53_10835(hxlA)
PCHI: PC41400_00765(hxlA)
PPRT: ET464_10965(hxlA)
PBAC: HUB98_29030(hxlA)
PTRI: KDC22_31575(hxlA)
PALO: E6C60_2213
PCEL: HUB94_23390(hxlA)
PTJ: JRJ22_27900(hxlA)
CCHL: FPL14_29080(hxlA)
CHEB: HH215_35310(hxlA)
SACA: FFV09_02170(hxlA)
AACO: K1I37_20295(hxlA)
ADAU: NZD86_18890(hxlA) NZD86_23130(hxlA)
AFAS: NZD89_03510(hxlA) NZD89_05660(hxlA)
EFF: skT53_30650(hxlA)
PLX: CW734_09535(hxlA) CW734_13380(hxlA)
PDEC: H1Q58_12160(hxlA)
LPAP: LBPC_0348
LSN: LSA_03490
FIX: M8332_02210(hxlA)
LBN: LBUCD034_0077(hxlA)
LBR: LVIS_0442
AAPI: MOO46_01980(hxlA)
PCE: PECL_1750
OOE: OEOE_0131
LMM: MI1_09731
WSO: WSWS_00759(hxlA)
LBE: MOO44_01770(hxlA)
TOO: C7K38_07925(hxlA)
AUR: HMPREF9243_0240(hxlA)
CARN: FPV25_08815(hxlA)
CAC: CA_C0396
CAE: SMB_G0404(sgbH)
CAY: CEA_G0406
CBE: Cbei_4647
CBZ: Cbs_4647
CBEI: LF65_06885
CRW: CROST_007110(hxlA)
CFB: CLFE_041540(hxlA)
CAUN: CLAUR_022850(hxlA)
ROB: CK5_18950
ACAC: EYQ97_01665(hxlA) EYQ97_02425(hxlA) EYQ97_09120(hxlA)
PFT: JBW_00828
EUC: EC1_08720
ABSI: A9CBEGH2_06030(hxlA)
LCG: L3BBH23_22940(hxlA)
CDX: CDES_00570(rmpA)
CCYC: SCMU_00950 SCMU_40760(hxlA)
CMI: CMM_1123(sgaH)
CMS: CMS1443(hps)
CMC: CMN_01092(sgaH)
CZH: H9X71_05270(hxlA)
CPHA: FGI33_07660(hxlA)
CCAF: FGD68_07725(hxlA)
PLAP: EAO79_07240(hxlA)
AGX: AGREI_3079(hxlA)
ART: Arth_3708
ARR: ARUE_c04640(rmpA)
ARN: CGK93_01940(hxlA)
ARX: ARZXY2_3983(hxlA)
ARTH: C3B78_00800(hxlA)
ASUN: KG104_15075(hxlA)
AAU: AAur_0494(hps)
PUE: FV140_21525(hxlA)
PNV: JMY29_02270(hxlA)
PSEY: GU243_15480(hxlA)
AAI: AARI_06580(rmpA)
GLU: F0M17_03415(hxlA)
GMY: XH9_05400(hxlA)
PAUS: NCTC13651_01296(hxlA)
AMQ: AMETH_4519(hps) AMETH_4538(hps)
BDE: BDP_0013
BDN: BBDE_0013
BANG: BBAG_0932
TTR: Tter_2273
RBA: RB5319
PIR: VN12_13465(hxlA)
RUL: UC8_20370(hxlA)
RML: FF011L_43020(hxlA)
ROL: CA51_14720(hxlA)
AHEL: Q31a_23230(rmpA)
RLC: K227x_16680(hxlA)
GMR: GmarT_59230(hxlA)
GPN: Pan110_58500(hxlA)
ABAC: LuPra_03104(hxlA)
CPI: Cpin_5671
FLN: FLA_3348
FCR: HYN56_16620(hxlA)
ZPR: ZPR_1061
MARM: YQ22_17840
CBAL: M667_16185
CBAT: M666_16170
ZGA: ZOBELLIA_3942(hxlA)
AALG: AREALGSMS7_04556(hxlA)
CBEN: EG339_11265(hxlA)
DPB: BABL1_gene_664(hxlA)
MJA: MJ_0644
MAE: Maeo_1123
MTH: MTH_888
MWO: MWSIV6_1262(hpsA)
MTEE: MTTB_04920
METC: MTCT_0805
METE: tca_00853(proA)
MST: Msp_1358
MRU: mru_0712
MSI: Msm_0426
MEB: Abm4_0441
MMIL: sm9_0586
MEYE: TL18_02745
MOL: YLM1_0353
METH: MBMB1_0388
MFC: BRM9_1874
MFV: Mfer_0465
MKA: MK0153(sgbH) MK1449(menG)
APE: APE_0952.1(hxlA)
ACJ: ACAM_0624(hxlA)
SMR: Smar_0492
IHO: Igni_0269
IIS: EYM_01130
IPC: IPA_01560
DKA: DKAM_1456
TAG: Tagg_1068
IAG: Igag_1921
HBU: Hbut_0129
STO: STK_02380(hxlA)
SOH: D1869_00695(hxlA)
SSO: SSO0202(hpS-2)
SOL: Ssol_1184
SSOA: SULA_1220
SSOL: SULB_1221
SSOF: SULC_1219
SCAS: SACC_01190
SAI: Saci_0802
SID: M164_1939
SII: LD85_2191
SIH: SiH_1876
SIR: SiRe_1804
SIC: SiL_1785
SULL: EWF20_02130(hxlA)
MSE: Msed_0227
MEMJ: MJ1HA_0312
MCN: Mcup_1845
AHO: Ahos_0599
ACIH: HS5_20010
CSTY: KN1_17010
STEP: IC006_1852
SAHS: HS7_17030
PAI: PAE1679
PIS: Pisl_1686
PCL: Pcal_0568
PAS: Pars_1830
PYR: P186_0040
POG: Pogu_0300
TNE: Tneu_0708
CMA: Cmaq_1871
TTN: TTX_1521(hps)
TUZ: TUZN_2015
VDI: Vdis_1817
VMO: VMUT_0258
TPE: Tpen_0372
ASC: ASAC_0959
ACIA: SE86_04960
KCR: Kcr_1307
AG: BAA19967(rmpA)
 » show all
Reference
  Authors
Yasueda H, Kawahara Y, Sugimoto S.
  Title
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
  Journal
J Bacteriol 181:7154-60 (1999)
DOI:10.1128/JB.181.23.7154-7160.1999
LinkDB

KEGG   ORTHOLOGY: K13812
Entry
K13812                      KO                                     
Symbol
fae-hps
Name
bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]
Pathway
map00030  Pentose phosphate pathway
map00680  Methane metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13812  fae-hps; bifunctional enzyme Fae/Hps
  09102 Energy metabolism
   00680 Methane metabolism
    K13812  fae-hps; bifunctional enzyme Fae/Hps
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K13812  fae-hps; bifunctional enzyme Fae/Hps
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.147  5,6,7,8-tetrahydromethanopterin hydro-lyase
     K13812  fae-hps; bifunctional enzyme Fae/Hps
Other DBs
RN: R05338 R08058
COG: COG1795 COG0269
Genes
MJA: MJ_1447
MFE: Mefer_1012
MVU: Metvu_1176
MFS: MFS40622_0906
MIF: Metin_1286
MJH: JH146_0570
MESG: MLAUSG7_1449(fae-hps)
MESA: MLASG1_0987(fae-hps)
MIG: Metig_0664
MAE: Maeo_0614
MTH: MTH_1474
MMG: MTBMA_c00570(fae_hps)
MWO: MWSIV6_0011(fae-hps)
MTEE: MTTB_00460
METC: MTCT_1339
METE: tca_01421(fae)
MST: Msp_1498
MRU: mru_2131
MSI: Msm_1213
MEB: Abm4_0046
MMIL: sm9_0074
MEYE: TL18_10355
MOL: YLM1_1686
METH: MBMB1_0009(fae-hps)
MFC: BRM9_0060
MFI: DSM1535_1378(fae-hps)
MCUB: MCBB_0021(fae-hps_1)
METT: CIT01_05685(fae)
METO: CIT02_07030(fae)
MFV: Mfer_0572
AFU: AF_1305
FPL: Ferp_2129
GAC: GACE_2158
GAH: GAH_00575
MBAR: MSBR2_2313
MBAK: MSBR3_2375
MAC: MA_4608
MMA: MM_1279
MMAC: MSMAC_0037
METM: MSMTP_0040
MTHR: MSTHT_1787
MTHE: MSTHC_1499
MHOR: MSHOH_0037
MBU: Mbur_1994(fae-hps)
MMET: MCMEM_0222
MMH: Mmah_0234
MPY: Mpsy_1425
MTP: Mthe_0988
MCJ: MCON_1383
MHI: Mhar_0019
MHU: Mhun_1628
MLA: Mlab_0996
MEMA: MMAB1_1386(fae-hps)
MCHK: MchiMG62_12270(fae)
MPI: Mpet_0801
MAQE: RJ40_03655
MBN: Mboo_0772
MPL: Mpal_1036
MPD: MCP_2904(fae_hps)
MEZ: Mtc_0381(fae)
RCI: RCIX775(fae-hps)
HARA: AArcS_1663
MELU: MTLP_05990(fae_1)
CCAI: NAS2_0542
BARC: AOA65_1083(faeB-hpsB)
BARB: AOA66_1278
PSYT: DSAG12_03237(faeB-hpsB)
 » show all
Reference
  Authors
Grochowski LL, Xu H, White RH
  Title
Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway.
  Journal
J Bacteriol 187:7382-9 (2005)
DOI:10.1128/JB.187.21.7382-7389.2005
  Sequence
[mja:MJ_1447]
LinkDB

KEGG   ORTHOLOGY: K13831
Entry
K13831                      KO                                     
Symbol
hps-phi
Name
3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
Pathway
map00030  Pentose phosphate pathway
map00680  Methane metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
map01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
  09102 Energy metabolism
   00680 Methane metabolism
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.1  Interconverting aldoses and ketoses, and related compounds
    5.3.1.27  6-phospho-3-hexuloisomerase
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Other DBs
RN: R05338 R05339 R09780
COG: COG0269 COG0684
GO: 0043801 0043800
Genes
VSH: BSZ05_17120
MCA: MCA2738
METU: GNH96_04130(hxlA)
MAH: MEALZ_1912(hpsi2)
MBUR: EQU24_11340(hxlA)
MPSY: CEK71_18985
MMAI: sS8_1148
MOZ: MoryE10_06560
BPDZ: BBN53_16310
ACID: CBP33_16730
BPIT: BPIT_02080
MMP: MMP1270
MMD: GYY_07185
MMAD: MMJJ_15750(hxlA)
AFU: AF_0861
FPL: Ferp_2198
GAC: GACE_0250
GAH: GAH_00051
PFU: PF0220
PFI: PFC_00160
PHO: PH1938(PH1938)
PAB: PAB1222
PYN: PNA2_0868
PYS: Py04_0376
TKO: TK0475
TON: TON_0336
TGA: TGAM_1891(hps)
TSI: TSIB_0428
THE: GQS_03555
THA: TAM4_82
THM: CL1_0365
TLT: OCC_09933
THS: TES1_0756
TNU: BD01_0222
TEU: TEU_06790
TIC: FH039_04545(hxlA)
THEM: FPV09_04565(hxlA)
THEI: K1720_05250(hxlA)
PPAC: PAP_05755
MBAR: MSBR2_3345
MBAK: MSBR3_3372
MAC: MA_4504
MMA: MM_1215
MMAC: MSMAC_0105
METM: MSMTP_0201
MTHR: MSTHT_1664
MTHE: MSTHC_1625
MHOR: MSHOH_0117
MMET: MCMEM_0644
MMH: Mmah_1222
MPY: Mpsy_1396
MTP: Mthe_0455
MCJ: MCON_0429
MHI: Mhar_1869
MHU: Mhun_0647
MLA: Mlab_1453
MEMA: MMAB1_1456(hpsA)
MPI: Mpet_0679
MAQE: RJ40_11130
MBN: Mboo_0707
MPL: Mpal_2121
MPD: MCP_0861
MEZ: Mtc_1411
RCI: RCIX1492
MELU: MTLP_12130
MEAR: Mpt1_c14440(faeB)
MARC: AR505_0014
ABI: Aboo_0457
NCV: NCAV_0256
BARB: AOA66_0495
 » show all
Reference
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005
  Sequence
[pho:PH1938]
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
LinkDB

KEGG   ENZYME: 4.1.2.43
Entry
EC 4.1.2.43                 Enzyme                                 
Name
3-hexulose-6-phosphate synthase;
D-arabino-3-hexulose 6-phosphate formaldehyde-lyase;
3-hexulosephosphate synthase;
3-hexulose phosphate synthase;
HPS
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)
Reaction(IUBMB)
D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde [RN:R05338]
Reaction(KEGG)
R05338
Substrate
D-arabino-hex-3-ulose 6-phosphate [CPD:C06019]
Product
D-ribulose 5-phosphate [CPD:C00199];
formaldehyde [CPD:C00067]
Comment
Requires Mg2+ or Mn2+ for maximal activity [1]. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal [7]. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily [5].
History
EC 4.1.2.43 created 2008
Pathway
ec00030  Pentose phosphate pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08093  3-hexulose-6-phosphate synthase
K13812  bifunctional enzyme Fae/Hps
K13831  3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Genes
EUMECUMN_2963
STMSTM2755
SEOSTM14_3320
SEVSTMMW_27231
SEYSL1344_2739(hxlA)
SEMSTMDT12_C28070
SEJSTMUK_2743
SEBSTM474_2890
SEFUMN798_2989(hxlA)
SETUSTU288_13940
SETCCFSAN001921_03340
SENRSTMDT2_26611
SENDDT104_27571
SENICY43_14395
SEHSeHA_C2929(hxlA)
SHBSU5_03243
SENHCFSAN002069_18505
SEEHSEEH1578_22575
ECLZLI64_16165
ECANCWI88_05395(hxlA)
ECHGFY206_18835(hxlA)
KPNKPN_02957
KPYKPNIH31_18210
KMIVW41_11030
KOCAB185_13840
KLWDA718_10170(hxlA)
RTGNCTC13098_03929
CITZE4Z61_22610(hxlA)
PGELG71_08965
SODSant_0061
VSHBSZ05_17120
MCAMCA2738 MCA3043 MCA3049
METUGNH96_02035(hxlA) GNH96_02065(hxlA) GNH96_04130(hxlA)
MMTMetme_0742 Metme_4080
MDNJT25_012675 JT25_012930
MDHAYM39_02470 AYM39_02740
MKOMKLM6_0536 MKLM6_0590
METLU737_21900(hxlA)
MPADKEF85_01965(hxlA) KEF85_12785(hxlA)
MELLIVG45_20185(hxlA)
MAHMEALZ_1912(hpsi2) MEALZ_3953(hps1)
MBUREQU24_11340(hxlA)
MPSYCEK71_00435(hxlA) CEK71_18985
MMAIsS8_1135 sS8_1148
MMOBF6R98_00315(hxlA) F6R98_00325(hxlA)
MEINmethR_P2885
MOZMoryE10_01110 MoryE10_06560 MoryE10_07570
MISZMishRS11D_06510
MESLKKZ03_07025(hxlA)
MEJQ7A_2498(hxlA) Q7A_2501(hxlA)
MECQ7C_1679 Q7C_1682
MPINLGT42_003280(hxlA) LGT42_003295(hxlA)
ORBIPMB12_08420(hxlA)
BPDZBBN53_16310
ACIDCBP33_16730
CSERCCO03_04105
MFAMfla_0250 Mfla_1654
MMBMmol_0313 Mmol_1338
MEHM301_0304 M301_1547
MEIMsip34_0268
MEPMPQ_0281(sgbH) MPQ_1561
MBACBN1209_0202(rmpA) BN1209_0771(rmpA)
MBATBN1208_0845(hps)
MEUACJ67_02420 ACJ67_07420
MPAUZMTM_02460 ZMTM_11880
NSANitsa_1660
SLHYH65_04865
DAODesac_1176
MOHIHQ72_14040
XDIEZH22_21185
NOHG5V57_00560
ACUTMRB58_00780
SDOSD1155_05640(hxlA)
ADOA6F68_00105(proA_1)
GALA0U94_14275
GSPIGS75_14265
KBAA0U89_15345
BSUBSU03460(hxlA)
BSRI33_0397(hxlA)
BSLA7A1_1851
BSHBSU6051_03460(hxlA)
BSYI653_01730
BSUTBSUB_00396(hxlA)
BSULBSUA_00396(hxlA)
BSUSQ433_02070
BSOBSNT_06681(hxlA)
BSNBSn5_13315
BSQB657_03460(hxlA)
BSXC663_0338(hxlA)
BSPU712_01790
BSSBSUW23_01790(hxlA)
BSTGYO_0559(hxlA)
BLIBL02045(hxlA)
BLDBLi02805(hxlA)
BLHBaLi_c29000(hxlA)
BAYRBAM_003630(hxlA)
BAQBACAU_0303(hxlA)
BYABANAU_0305(hxlA)
BAMPB938_01575
BQYMUS_0325(hxlA)
BAMLBAM5036_0322(hxlA)
BAMARBAU_0337(hxlA)
BAMNBASU_0321(hxlA)
BAMBBAPNAU_0307(hxlA)
BAMTAJ82_01980
BAMYV529_03250(hxlA)
BMPNG74_00345(hxlA)
BAOBAMF_0310(hxlA)
BAZBAMTA208_01555(hxlA)
BQLLL3_00318(hxlA)
BXHBAXH7_00321(hxlA)
BAMIKSO_017855
BAMCU471_03230
BAMFU722_01860
BSIACWD84_20190(hxlA)
BAEBATR1942_20410
BVMB9C48_01845
BSONS101395_01722(hxlA)
BHTDIC78_08240(hxlA)
BMOJHC660_03860(hxlA)
BTEQG4P54_01945(hxlA)
BIQAN935_01795
BPUBPUM_2333
BPUMBW16_12650
BPUSUP12_11780
BIFN288_21395 N288_22430
BMETBMMGA3_06845(hps)
BSMBSM4216_0641
BGYBGLY_3090(hxlA)
BXIBK049_15320
BALTCFN77_12450(hxlA)
BAERBAE_00125(hxlA)
BSAFBSL056_12835
BITBIS30_12300
BFDNCTC4823_01217(hxlA_1) NCTC4823_03793(hxlA_2)
BSHILGQ02_03485(hxlA)
BCABEFK13_02150(hxlA)
BRYM0696_02000(hxlA)
BJSMY9_0361
GSTHW35_08370
BACWQR42_11740
BACPSB24_07990
BACBOY17_04480
BACYQF06_00690
BACLBS34A_04030(hxlA)
BALMBsLM_0362
BACSAUL54_09010
BACQDOE78_03635(hxlA)
BACAFAY30_22685 FAY30_23225(hxlA)
BHKB4U37_02010
BCIRC2I06_12975(hxlA) C2I06_17420
BMQBMQ_0891(hxlA) BMQ_1538(hxlA) BMQ_2942(hxlA)
BMDBMD_0891(hxlA) BMD_1519(hxlA) BMD_2971(hxlA)
BMHBMWSH_3691 BMWSH_4350(hxlA)
BMEGBG04_3186(hxlA) BG04_3830(hxlA) BG04_4896(hxlA) BG04_5472 BG04_5588(hxlA) BG04_5930(hxlA)
BEOBEH_06020 BEH_12940
BFXBC359_14510 BC359_19735
PKSIE339_01975(hxlA)
BAGBcoa_0968
BCLABC3351(hxlA)
BKWBkAM31D_07120(hxlA_1) BkAM31D_16315(hxlA_2)
BGIBGM20_16795
BONA361_15685 A361_15780 A361_26060
CGOTJ1899_06860 J1899_20250 J1899_21665(hxlA)
CFIRNAF01_02050 NAF01_14215(hxlA)
OIHOB2697 OB2806
OCNCUC15_15170(hxlA)
GTKGT3570_09830
GLIGLN3_03390
GTNGTNG_1490
GMCGY4MC1_3093
GGHGHH_c21400(hxlA)
GJFM493_16830
GEAGARCT_00704(hxlA_1) GARCT_02004(hxlA_2)
GELIB49_02240
GSRGS3922_12380
GEJA0V43_08225
GZAIC807_06470(hxlA)
GTHGeoth_3109
PTLAOT13_07080
PTBDER53_08130(hxlA)
PARGPspKH34_30140(hxlA)
ANMGFC28_662
ANLGFC29_964
ANDGRQ40_09545
ACAIISX45_01330(hxlA) ISX45_06735
LAGRFJQ98_01550
HMNHM131_14425
HLIHLI_12660
VIGBKP57_09220
VNECFK40_05180
VPTKBP50_20725
VNTOLD84_16675(hxlA)
VIKKFZ58_14350
FARABE41_010275
SJEAAV35_011130
APAKAP3564_06145
PBUTDTO10_07700
PPSRI6J18_02975(hxlA) I6J18_08150(hxlA)
PFRIL8956_21565
GRCGI584_10025(hxlA)
NMKCHR53_10820(hxlA)
NTMBTDUT50_14180(hxlA)
NDTL1999_02995 L1999_22990(hxlA)
MEKUHUW50_04030(hxlA) HUW50_16935
MSEMGMB29_08440
MDGK8L98_13980(hxlA) K8L98_15450
MLITKDJ21_025570(hxlA) KDJ21_026155(hxlA)
AIAAWH56_012125
BLENNCTC4824_00834(hxlA_1) NCTC4824_02164(hxlA_2)
SEDDERJ70_14580 ERJ70_18455(hxlA)
BVQFHE72_04710 FHE72_17335(hxlA)
RMFD5E69_06120(hxlA)
BBEVBBEV_0241(hxlA)
STEAC0679_04045
SAUSA0528
SAVSAV0570
SAWSAHV_0568
SAHSaurJH1_0607 SaurJH1_2812
SAJSaurJH9_0593 SaurJH9_2736
SAMMW0525
SASSAS0528
SARSAR0574
SACSACOL0617
SAXUSA300HOU_0564
SAASAUSA300_0555
SAOSAOUHSC_00553
SAENWMN_0533
SADSAAV_0533(hxlA)
SUUM013TW_0558(hxlA)
SUVSAVC_02440
SUESAOV_0605
SUJSAA6159_00524(hxlA)
SUKSAA6008_00578(hxlA)
SUCECTR2_524(hxlA)
SUTSAT0131_00631
SUQHMPREF0772_12618(hxlA)
SUZMS7_0560(hxlA)
SUDST398NM01_0645
SUXSAEMRSA15_04970
SUWSATW20_06400
SUGSAPIG0645(hxlA)
SUFSARLGA251_05060
SAUASAAG_00991
SAUERSAU_000524(hps)
SAUNSAKOR_00559
SAUSSA40_0511
SAUUSA957_0526
SAUGSA268_0524
SAUZSAZ172_0572
SAUTSAI1T1_2004400
SAUJSAI2T2_1004420
SAUKSAI3T3_1004410
SAUQSAI4T8_1004400
SAUVSAI7S6_1004410
SAUWSAI5S5_1004370
SAUXSAI6T6_1004380
SAUYSAI8T7_1004410
SAUFX998_0612(hxlA)
SABSAB0520
SUYSA2981_0547
SAUBC248_0645
SAUMBN843_5640
SAUCCA347_586(hxlA)
SAURSABB_00621
SAUIAZ30_02885
SAUDCH52_02905
SAMSNI36_02840
SUHSAMSHR1132_05140
SERSERP0216
SEPSE_0341
SEPPSEB_00262
SEPSDP17_1647(hxlA)
SHASH2420
SHHShL2_02215(hxlA)
SSPSSP1619 SSP1626 SSP2148
SCASCA_0226 SCA_0711
SLGSLGD_02315
SLNSLUG_22330
SSDSPSINT_0249
SDTSPSE_2213(hxlA)
SDPNCTC12225_02420(hxlA)
SWAA284_00525 A284_10445 A284_12317
SPASSTP1_1658
SXYBE24_00590
SXLSXYLSMQ121_2137
SXOSXYL_02291
SHUSHYC_10795(hxlA)
SCAPAYP1020_2319
SSCHLH95_10395
SSCZRN70_11130
SAGQEP23_11365(hxlA)
SEQOSE1039_03970
SSIFAL483_08720(hxlA)
SCVA4G25_06550
SPETCEP67_09865(hxlA)
SCOHBZ166_02680
SNLBJD96_12035
SKLC7J89_12605(hxlA)
SFQC7J90_01805(hxlA)
SHOMEGX58_03330(hxlA)
SMUSC7J88_08345(hxlA)
SCARDWB96_11675(hxlA) DWB96_13070(hxlA)
SCHRDWB92_10940(hxlA)
SARLSAP2_21950
SPICSAMEA4384060_1853 SAMEA4384060_2297
SSHNCTC13712_00522
SSIMSAMEA4384339_0522
SDBCNQ82_05285(hxlA) CNQ82_12845(hxlA)
SLLOISP08_10875(hxlA)
SAULI6G39_01920(hxlA)
SSACI6I31_05635(hxlA)
SRAILN051_10085(hxlA)
SPSDJMB28_11605(hxlA)
STASHYI43_10895(hxlA)
SSCUCEP64_01020(hxlA)
SFFFOB90_09055(hxlA)
MLENH3V22_07285(hxlA)
MVTI6J10_09650(hxlA)
MCLMCCL_0037
MCAKMCCS_00640
MACRBHM04_10305
MBRUMGG13_01510(hxlA)
MEPIKFV12_00630(hxlA)
MEQUKFV11_01600(hxlA)
SHVAAT16_06530 AAT16_11280
ESIExig_2372
EANEab7_2216
EXMU719_13055
EXUESP131_15165
EACEKKI46_12995(hxlA)
PJDPjdr2_1185
GYMGYMC10_3885
PPYPPE_04673
PPMPPSC2_24305(hxlA)
PPOPPM_4826(hxlA)
PPOLX809_40845
PPQPPSQR21_049250(sgbH)
PPOYRE92_12975
PMSKNP414_07885(hxlA)
PMQPM3016_7402
PMWB2K_37330
PTAHPL003_05880
PSABPSAB_01345 PSAB_23295
PDUPDUR_01610 PDUR_26635
PBDPBOR_34755
PGMPGRAT_31065
PODPODO_29415
PAENP40081_36070
PAEFR50345_29525
PAEQR50912_32680
PSTEPSTEL_02005 PSTEL_26045
PAEAR70723_31470
PAEER70331_30230
PAEHH70357_33735
PAEJH70737_29170
PBJVN24_01055 VN24_04705
PRIPRIO_3567 PRIO_6499(hxlA)
PSONJI735_07210(hxlA)
PPEOABE82_24515
PNPIJ22_01440 IJ22_02540 IJ22_02590 IJ22_07980
POWIJ21_08240
PBVAR543_06015 AR543_17150
PXLBS614_16300
PYGAWM70_20320
PSWUSY83_08105
PDHB9T62_30300(hxlA)
PIBBBD41_28040
PCXLPB68_19235
PKBB4V02_00905
PAIHASL14_13410
PVOPVOR_20959
PLWD5F53_10835(hxlA)
PALBEJC50_17680 EJC50_19855(hxlA)
PCHIPC41400_00765(hxlA)
PPRTET464_10965(hxlA)
PBACHUB98_29030(hxlA)
PRZGZH47_09140(hxlA) GZH47_10845
PLYCGXP70_05785 GXP70_07130(hxlA)
PSOPKP014_02000(hxlA) KP014_04755
PTRIKDC22_31575(hxlA)
PALOE6C60_2213
PCELHUB94_23390(hxlA)
PTJJRJ22_27900(hxlA)
COHNKCTCHS21_15480
CCHLFPL14_29080(hxlA)
CHEBHH215_35310(hxlA)
SACAFFV09_02170(hxlA)
AFXJZ786_23545
AACOK1I37_20295(hxlA)
ACURJZ785_20925
ADAUNZD86_18890(hxlA) NZD86_23130(hxlA)
AFASNZD89_03510(hxlA) NZD89_04475 NZD89_05660(hxlA)
EFFskT53_30650(hxlA)
PRTAUC31_15190
PANABBH88_04830 BBH88_17520
PMARB0X71_02090
PLXCW734_09535(hxlA) CW734_13380(hxlA)
PMATBBI11_12880
PDECH1Q58_12160(hxlA)
JEOJMA_08740 JMA_29170
SPSYAZE41_09415
PANCE2636_12245
PLAYDNR44_005605
TVUAB849_007475
LKLDKL58_01400 DKL58_07350
LCZLCAZH_0412
LCSLCBD_0422 LCBD_0453
LCELC2W_0417 LC2W_0448
LCWBN194_04270 BN194_04560
LCLLOCK919_0475
LPQAF91_01140
LPILBPG_03035
LPAPLBPC_0348
LCBLCABL_04190 LCABL_04490(hps)
LCXLCA12A_2395
LCHIKG086_13075
LZEKG087_13955
LMULBLM1_00435
LSNLSA_03490
LLEAYR59_00780
FIXM8332_02210(hxlA)
LBNLBUCD034_0077(hxlA)
LCUPL11_004190
LKFDNL43_05240
LHILG8J22_00758
LLAOLHL71_06165
LBRLVIS_0442
LBKLVISKB_0449
LCYLC20004_14635
AAPIMOO46_01980(hxlA)
LPDAYR62_06120
PCEPECL_1750
PACIA4V11_00360
LROSLROSL1_0262
LALWBTM29_04245
LALILA20249_07465
LHBD1010_15415
OOEOEOE_0131
OENDSM07_06150
LMMMI1_09731
LGCA9176_08390
WCBAO080_07995 AO080_11070
WJOFOL01_0737
WCFC6P13_08480
WSOWSWS_00759(hxlA)
WHEEFA59_09465
WEIEQG49_01015
LBEMOO44_01770(hxlA)
EGVEGCR1_00760(hxlA) EGCR1_06790
EAVEH197_05785(hxlA) EH197_09440(hxlA) EH197_17130
ESGEsVE80_07410
ERAFJ9537_02595(hxlA) J9537_09055
TOOC7K38_07925(hxlA)
VCPH9L18_04415
VHYG7082_07465
AURHMPREF9243_0240(hxlA)
CARNFPV25_08815(hxlA)
CACCA_C0396
CAESMB_G0404(sgbH)
CAYCEA_G0406
CBECbei_4647
CBZCbs_4647
CBEILF65_06885
CSRCspa_c49610
CDYF3K33_23655
CRWCROST_007110(hxlA)
CFBCLFE_041540(hxlA)
CAUNCLAUR_022850(hxlA)
CGELpsyc5s11_51560
ACOLK5I23_04770
ROBCK5_18950
ARFAR1Y2_1706 AR1Y2_3086 AR1Y2_3232
ACACEYQ97_01665(hxlA) EYQ97_02425(hxlA) EYQ97_09120(hxlA)
SINTK5I26_01765
CMIUB1H56_12255
HALSD7D81_05785
IFNGM661_03240
PFTJBW_00828
EUCEC1_08720
FROAALO17_19710
AARGAargi30884_01890 Aargi30884_03610 Aargi30884_04650(hxlA)
ABSIA9CBEGH2_06030(hxlA)
CIUG4D55_04125(hxlA) G4D55_16760(hxlA) G4D55_20095
LCGL3BBH23_22940(hxlA)
ERBA4V01_02795 A4V01_05815 A4V01_19475
MDXBTO20_03345 BTO20_30245
MAUBMAUB_30940 MAUB_31120
MMATMMAGJ_12220 MMAGJ_74070(hxlA)
CDXCDES_00570(rmpA)
CCYCSCMU_00950 SCMU_40760(hxlA)
RHARHA1_ro11329
ROAPd630_LPD04589
RKOJWS14_16845 JWS14_41255
ROZCBI38_29950
RPSKJWS13_28030
SRCM271_24320
SXNIAG42_32240
PSICJ4E96_11815
CMICMM_1123(sgaH)
CMSCMS1443(hps)
CMCCMN_01092(sgaH)
CMHVO01_04530
CCAPAES38_05195
CZHH9X71_05270(hxlA)
CPHAFGI33_07660(hxlA)
CCAFFGD68_07725(hxlA)
MIMAKG07_11695
MIHBJP65_05205
MICRBMW26_14455 BMW26_16485
MCHNHCR76_15235
RIAC7V51_11565
RFSC1I64_17210
RTEGSU10_14405
CUMNI26_12475
CUBBJK06_08985
CUGC1N91_12860
CQFGBG65_05940
AGYATC03_10775
AGMDCE93_00160
CARTPA27867_0095
MYLC3E77_13395
MSPOKXZ72_11835
SALCC2138_08145
SALAESZ53_12315
PLAPEAO79_07240(hxlA)
FRNF1C15_08050
AGXAGREI_3079(hxlA)
ARTArth_3708
ARRARUE_c04640(rmpA)
AREAL755_02190 AL755_14010
ARHAHiyo8_33930
ARZAUT26_19920
ARUASPU41_06005
ARQBWQ92_06605 BWQ92_09770 BWQ92_12695
ARNCGK93_01940(hxlA)
ARXARZXY2_3983(hxlA)
ARTHC3B78_00800(hxlA)
ASUNKG104_15075(hxlA)
AAUAAur_0494(hps)
PUEFV140_21525(hxlA)
PNVJMY29_02270(hxlA)
APNAsphe3_02200
PSULAU252_12865
PSEYGU243_15480(hxlA)
AAIAARI_06580(rmpA)
GARAOZ07_14970
GLUF0M17_03415(hxlA)
GMYXH9_05400(hxlA)
KPLKPaMU14_03840
SATKSA2016_1326 SA2016_3449 SA2016_3840 SA2016_3841
BRXBH708_07835
BRRC1N80_12905
BKIM4486_00580
BHHBra3105_16385
PAUSNCTC13651_01296(hxlA)
NOWGBF35_26640
AMQAMETH_4519(hps) AMETH_4538(hps)
PSEEFRP1_13235 FRP1_13275
PSEQAD006_20915 AD006_20955
PECQAD017_00495 AD017_00535
MCRAID554_09635 ID554_24760
VERHUT12_22585
PFLAPflav_052080
BDEBDP_0013
BDNBBDE_0013
BANGBBAG_0932
BGXESN35_00230
BLEMBL8807_07050
BEUBE0216_04560
AEYCDG81_05575
ABAMB1s21122_01895
NHIB1s21160_01650
OLOADJ70_05660
ABAOBEQ56_09840
TTRTter_2273
ROOG5S37_04785
RBARB5319
PIRVN12_13465(hxlA)
RULUC8_20370(hxlA)
RMLFF011L_43020(hxlA)
ROLCA51_14720(hxlA)
AHELQ31a_23230(rmpA)
RLCK227x_16680(hxlA)
LPAVPLANPX_2556
GMRGmarT_59230(hxlA)
GIMF1728_15900
GPNPan110_58500(hxlA)
TIMGMBLW1_21350
KSTKSMBR1_1055
BROCIPI25_12570
BPITBPIT_02080
JETL3J17_12540
HBSIPV69_02725
UAMUABAM_03098
BHCJFL75_16590
TRSTerro_1472
TALBFTW19_05085
EDAGWR55_03245
ABACLuPra_03104(hxlA)
STRSterm_1849 Sterm_3212
RBARAWN76_010760
CPICpin_5671
CHIHGWR21_16300
ARACE0W69_006905
FLNFLA_3348
FLCKJS93_07410
PEPAQ505_07150
PCMAY601_4886
PSTYBFS30_16375
PROEH9L23_01690
PMUOLOK61_01885
MUPA0256_03165
MRUBDEO27_000305
MGOSDIU38_016630
AGDFRZ59_01495
CMRCycma_4041
CAMUCA2015_3993
EVIEchvi_3532
EMAIKZP23_17980
ALMAO498_04580
SPIKEXU85_08270
SPIBG8759_32855
RHOZGXP67_03990
ALSDJ013_10535
MAQALAG90_17715
PKOPKOR_19965
ADDHUW48_11525
ASWUHUW51_20280
FCRHYN56_16620(hxlA)
ZPRZPR_1061
MARMYQ22_17840
CAOCelal_3937
CBALM667_16185
CBATM666_16170
ZGAZOBELLIA_3942(hxlA)
AALGAREALGSMS7_04556(hxlA)
LPALLDL79_02280
CBENEG339_11265(hxlA)
MPGTheba_2591
ALAMRT761_00648
DPBBABL1_gene_664(hxlA)
CDESC0J27_01395
VPMKG892_00070
MJAMJ_0644 MJ_1447
MFEMefer_0259 Mefer_1012
MVUMetvu_0541 Metvu_1176
MFSMFS40622_0906 MFS40622_1056
MIFMetin_1286 Metin_1445
MJHJH146_0570 JH146_0865
MESGMLAUSG7_0043 MLAUSG7_1449(fae-hps)
MESAMLASG1_0987(fae-hps) MLASG1_1223
MIGMetig_0604 Metig_0664
MMPMMP1270
MMQMmarC5_0321
MMXMmarC6_1403
MMZMmarC7_0516
MMDGYY_07185
MMAKMMKA1_14950
MMAOMMOS7_13770
MMADMMJJ_15750(hxlA)
MAEMaeo_0614 Maeo_1123
MVNMevan_0582
MOKMetok_0605 Metok_1249
METFCFE53_02965 CFE53_04300
MTHMTH_1474 MTH_888
MMGMTBMA_c00570(fae_hps) MTBMA_c12830
MWOMWSIV6_0011(fae-hps) MWSIV6_1262(hpsA)
MTEEMTTB_00460 MTTB_04920
METCMTCT_0805 MTCT_1339
METEtca_00853(proA) tca_01421(fae)
METZMETMT2_0957 METMT2_1368
METKFVF72_04250 FVF72_07115
MTHMFZP57_00015 FZP57_06005
METJFZP68_01675
MSTMsp_1358 Msp_1498
METBAW729_07875 AW729_08735
MRUmru_0712 mru_2131
MSIMsm_0426 Msm_1213
MEBAbm4_0046 Abm4_0441
MMILsm9_0074 sm9_0586
MEYETL18_02745 TL18_10355
MOLYLM1_0353 YLM1_1686
MAROMarbSA_11880 MarbSA_18020
METVK4897_02645 K4897_05320
MELMetbo_0071 Metbo_2333
MEWMSWAN_0017 MSWAN_0326
METHMBMB1_0009(fae-hps) MBMB1_0388
MFCBRM9_0060 BRM9_1874
MFIDSM1535_0057 DSM1535_1378(fae-hps)
MCUBMCBB_0021(fae-hps_1)
MSUBBK009_09760 BK009_12115
METNBK008_05430 BK008_07745
METTCIT01_02340 CIT01_05685(fae)
METOCIT02_04870 CIT02_07030(fae)
MEMEHYG87_03735 HYG87_06650
MFVMfer_0465 Mfer_0572
MKAMK0153(sgbH) MK1449(menG)
AFUAF_0861 AF_1305
AFGAFULGI_00009430 AFULGI_00014160
APOArcpr_1052 Arcpr_1797
AVEArcve_1411 Arcve_1683
ASTAsulf_00326 Asulf_01087
FPLFerp_2129 Ferp_2198
GACGACE_0250 GACE_2158
GAHGAH_00051 GAH_00575
PFUPF0220
PFIPFC_00160
PHOPH1938(PH1938)
PABPAB1222
PYNPNA2_0868
PYAPYCH_13020
PYSPy04_0376
PYCTQ32_01240
TKOTK0475
TONTON_0336
TGATGAM_1891(hps)
TSITSIB_0428
TBATERMP_00758
THEGQS_03555
THATAM4_82
THMCL1_0365
TLTOCC_09933
THSTES1_0756
TNUBD01_0222
TEUTEU_06790
TGYX802_02210
THVADU37_CDS03570
TPEPA0127_02350
TPIEA7C91_07685
TGGA3K92_01750
TCEA3L02_00185
TBSA3L01_02370
THHCDI07_02325
TSLA3L11_06255
TTDA3L14_03835
TPRFA3L09_00545
TRLA3L10_04210
TPAFA3L08_04625
THYA3L12_06325
TICFH039_04545(hxlA)
TCQTIRI35C_0698
THEMFPV09_04565(hxlA)
THEIK1720_05250(hxlA)
PPACPAP_05755
MBAMbar_A0935 Mbar_A1170
MBYMSBRM_0067 MSBRM_3392
MBWMSBRW_0061 MSBRW_3553
MBARMSBR2_2313 MSBR2_3345
MBAKMSBR3_2375 MSBR3_3372
MACMA_4504 MA_4608
MMAMM_1215 MM_1279
MMAZMmTuc01_1255 MmTuc01_1325
MMJMSMAS_0037 MSMAS_0097
MMACMSMAC_0037 MSMAC_0105
MVCMSVAZ_0074 MSVAZ_0103
MEKMSKOL_0070 MSKOL_0099
MLSMSLAZ_0035 MSLAZ_3053
METMMSMTP_0040 MSMTP_0201
MEFMSWH1_0036 MSWH1_3047
MEQMSWHS_0037 MSWHS_1919
MSJMSSAC_0046 MSSAC_4300
MSZMSSIH_0039 MSSIH_3802
MSWMSSIT_0039 MSSIT_3879
MTHRMSTHT_1664 MSTHT_1787
MTHEMSTHC_1499 MSTHC_1625
MHORMSHOH_0037 MSHOH_0117
MFZAOB57_007440 AOB57_008160
MBUMbur_1994(fae-hps)
MMETMCMEM_0222 MCMEM_0644
MELOJ7W08_01295 J7W08_11180
MMHMmah_0234 Mmah_1222
MHAZBHR79_02340 BHR79_07435
MEVMetev_0697 Metev_1698
MZHMzhil_0262 Mzhil_0311
MPYMpsy_1396 Mpsy_1425
MZIHWN40_01665 HWN40_01805
MHZMetho_0261 Metho_0283
MTPMthe_0455 Mthe_0988
MCJMCON_0429 MCON_1383
MHIMhar_0019 Mhar_1869
MHUMhun_0647 Mhun_1628
MRTJKHC33_06360 KHC33_10130
MLAMlab_0996 Mlab_1453
MEMMemar_0744 Memar_1085
MBGBN140_1075 BN140_1140
MEMAMMAB1_1386(fae-hps) MMAB1_1456(hpsA)
MCHKMchiMG62_08670 MchiMG62_12270(fae)
MSUMOH143_10440 OH143_12150
MPIMpet_0679 Mpet_0801
MENDL6E24_05200 L6E24_11130
MAQERJ40_03655 RJ40_11130
MOUOU421_09050 OU421_12595
MBNMboo_0707 Mboo_0772
MFOMetfor_2057 Metfor_2503
MPLMpal_1036 Mpal_2121
MPDMCP_0861 MCP_2904(fae_hps)
MEZMtc_0381(fae) Mtc_1411
RCIRCIX1492 RCIX775(fae-hps)
HARAAArcS_1663
MELUMTLP_05990(fae_1) MTLP_12130
MEAMMU439_01845 MU439_06385
TARTALC_01565
MAXMMALV_16840
MERMMINT_19420
MEARMpt1_c14440(faeB)
MEUZKRP56_00255
MARCAR505_0014
ABIAboo_0457
ACFAciM339_0590
APEAPE_0952.1(hxlA)
ACJACAM_0624(hxlA)
SMRSmar_0492
SHCShell_0310
IHOIgni_0269
IISEYM_01130
IPCIPA_01560
DKADKAM_1456
DFDDesfe_0079
DMUDesmu_0149
TAGTagg_1068
IAGIgag_1921
THGTCELL_0740
HBUHbut_0129
PFMPyrfu_0648
PDLPyrde_0680
STOSTK_02380(hxlA)
SOHD1869_00695(hxlA)
SSOSSO0202(hpS-2)
SOLSsol_1184
SSOASULA_1220
SSOLSULB_1221
SSOFSULC_1219
SSHIJ5U23_00054
SCASSACC_01190
SAISaci_0802
SACNSacN8_03890
SACRSacRon12I_03880
SACSSUSAZ_03625
SISLS215_2094
SIAM1425_1931
SIMM1627_2009
SIDM164_1939
SIYYG5714_2053
SINYN1551_0865
SIILD85_2191
SIHSiH_1876
SIRSiRe_1804
SICSiL_1785
SULABFU36_04900
SULEGFS03_10600
SULOGFS33_02415
SULLEWF20_02130(hxlA)
MSEMsed_0227
MEMJMJ1HA_0312
MCNMcup_1845
MHKDFR87_05610
MPRUDFR88_05485
MTENGWK48_05945
MJNMjAS7_0813
AHOAhos_0599
AMANB6F84_07975
ABRIDFR85_06830
ASULDFR86_07010
AAMBD1866_10735
ACIHHS5_20010
SACDHS1genome_0892
SAZOD1868_00970
CSTYKN1_17010
STEPIC006_1852
SAHSHS7_17030
PAIPAE1679
PISPisl_1686
PCLPcal_0568
PASPars_1830
PYRP186_0040
POGPogu_0300
TNETneu_0708
PYWPYWP30_00751
CMACmaq_1871
TTNTTX_1521(hps)
TUZTUZN_2015
VDIVdis_1817
VMOVMUT_0258
VSOVsou_02140
TPETpen_0372
THBN186_02880
TCBTCARB_1644
THELIG193_05685
ASCASAC_0959
ACIASE86_04960
CLGCalag_0067
FFOFFONT_0403
NCVNCAV_0256
CCAINAS2_0542
KCRKcr_1307
BARCAOA65_1083(faeB-hpsB)
BARBAOA66_0495 AOA66_1278
FLTSv326_0214 Sv326_0884
LOKILokiarch_06870 Lokiarch_17920 Lokiarch_47420
PSYTDSAG12_03237(faeB-hpsB)
 » show all
Reference
1  [PMID:4219834]
  Authors
Ferenci T, Strom T, Quayle JR
  Title
Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus.
  Journal
Biochem J 144:477-86 (1974)
DOI:10.1042/bj1440477
Reference
2  [PMID:564713]
  Authors
Kato N, Ohashi H, Tani Y, Ogata K
  Title
3-Hexulosephosphate synthase from Methylomonas aminofaciens 77a. Purification, properties and kinetics.
  Journal
Biochim Biophys Acta 523:236-44 (1978)
DOI:10.1016/0005-2744(78)90026-8
Reference
3  [PMID:8595859]
  Authors
Yanase H, Ikeyama K, Mitsui R, Ra S, Kita K, Sakai Y, Kato N
  Title
Cloning and sequence analysis of the gene encoding 3-hexulose-6-phosphate synthase from the methylotrophic bacterium, Methylomonas aminofaciens 77a, and its expression in Escherichia coli.
  Journal
FEMS Microbiol Lett 135:201-5 (1996)
DOI:10.1111/j.1574-6968.1996.tb07990.x
  Sequence
Reference
4  [PMID:16278835]
  Authors
Yurimoto H, Kato N, Sakai Y
  Title
Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism.
  Journal
Chem Rec 5:367-75 (2005)
DOI:10.1002/tcr.20056
Reference
5  [PMID:16428816]
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
6  [PMID:15901685]
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005
  Sequence
[pho:PH1938]
Reference
7
  Authors
Kato, N., Miyamoto, N., Shimao, M. and Sakazawa, C.
  Title
3-Hexulose phosphate pynthase from a new facultative methylotroph, Mycobacterium gastri MB19.
  Journal
Agric Biol Chem 52:2659-2661 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.43
IUBMB Enzyme Nomenclature: 4.1.2.43
ExPASy - ENZYME nomenclature database: 4.1.2.43
BRENDA, the Enzyme Database: 4.1.2.43
LinkDB

KEGG   REACTION: R05338
Entry
R05338                      Reaction                               
Name
D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)
Definition
D-Ribulose 5-phosphate + Formaldehyde <=> D-arabino-Hex-3-ulose 6-phosphate
Equation
Reaction class
RC00421  C00067_C06019
RC00422  C00199_C06019
Enzyme
Pathway
rn00030  Pentose phosphate pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Orthology
K08093  3-hexulose-6-phosphate synthase [EC:4.1.2.43]
K13812  bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]
K13831  3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
Other DBs
RHEA: 25204
LinkDB

DBGET integrated database retrieval system