KEGG   ORTHOLOGY: K08260
Entry
K08260                      KO                                     
Symbol
cbiZ
Name
adenosylcobinamide hydrolase [EC:3.5.1.90]
Pathway
map00860  Porphyrin metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K08260  cbiZ; adenosylcobinamide hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.90  adenosylcobinamide hydrolase
     K08260  cbiZ; adenosylcobinamide hydrolase
Other DBs
RN: R05226
COG: COG1865
GO: 0043756
Genes
MMAI: sS8_1630
HAK: KO116_01845
HAG: BB497_14215
HVN: EI420_07430
GBI: PG2T_14225
BACI: B1NLA3E_01980
BACO: OXB_1391
BMQ: BMQ_1994
BMD: BMD_1950
BMH: BMWSH_3286
BMEG: BG04_4295
PMW: B2K_10005
PRI: PRIO_1520
PSWU: SY83_08810
ASOC: CB4_00867
SALQ: SYNTR_0853
PTH: PTH_1477
DRM: Dred_2681
DAE: Dtox_1956
HMO: HM1_1855
ELM: ELI_2045
AWO: Awo_c10360(cbiZ2)
TTE: TTE2426
TKI: TKV_c03070(cbiZ)
TPZ: Tph_c03470(cbiZ)
MIT: OCO_21870
MIA: OCU_22060
MID: MIP_03097
MYO: OEM_19770
MIR: OCQ_20980
MLP: MLM_1928A
MMM: W7S_10285
SERJ: SGUI_2139
SEN: SACE_6498
SESP: BN6_28070
KAL: KALB_7956
ACTI: UA75_27430
ACAD: UA74_26840
SAQ: Sare_4761
MIL: ML5_2591
ASE: ACPL_6861
ACTS: ACWT_6730
DEH: cbdbA637(rdhF) cbdbA87(rdhF)
DEV: DhcVS_591
DMC: btf_610(cbiZ)
DMD: dcmb_1046(cbiZ) dcmb_656(cbiZ)
DMG: GY50_0122(cbiZ) GY50_0246(cbiZ) GY50_0578(cbiZ) GY50_1354(cbiZ) GY50_1389(cbiZ)
DUC: UCH007_05720(cbiZ) UCH007_13440(rdhF)
TRA: Trad_0381
NDE: NIDE2660
NJA: NSJP_3530
MST: Msp_0437
MRU: mru_1218(cbiZ)
MSI: Msm_0825
MEB: Abm4_0754(cbiZ)
MMIL: sm9_1752(cbiZ)
MEYE: TL18_07800
MOL: YLM1_0611
MFC: BRM9_1712(cbiZ)
AFU: AF_1400
FPL: Ferp_2081
GAC: GACE_1857
GAH: GAH_01724
PFU: PF0305
PFI: PFC_00600
PHO: PH0814(PH0814)
PAB: PAB1708
PYN: PNA2_0142
TKO: TK0846
TON: TON_0689
TGA: TGAM_0516(cbiZ)
THE: GQS_01490
THA: TAM4_743
THM: CL1_2012
TLT: OCC_11919
THS: TES1_0965
TNU: BD01_0588
TEU: TEU_09185
PPAC: PAP_03150
MBAR: MSBR2_0417
MAC: MA_1623
MMA: MM_0173
MMAC: MSMAC_2488
METM: MSMTP_1142
MHOR: MSHOH_1351
MBU: Mbur_1001
MMET: MCMEM_1490
MMH: Mmah_1373
MPY: Mpsy_1883
MBG: BN140_2491(cbiZ)
MEMA: MMAB1_3351(cbiZ)
MBN: Mboo_0181
MPL: Mpal_0026
MPD: MCP_2916(cbiZ)
MEZ: Mtc_0313
RCI: RCIX826
HAL: VNG_1583C
HSL: OE_3261F(cbiZ)
HHB: Hhub_2918(cbiZ)
HAGS: JT689_07770(cbiZ)
HABO: JRZ79_06185(cbiZ)
HANR: LJ422_06430(cbiZ)
HALH: HTSR_1763(cbiZ)
HHSR: HSR6_1829(cbiZ)
HSU: HLASF_0298(cbiZ)
HSF: HLASA_0297(cbiZ)
HARA: AArcS_2275(cbiZ)
HMA: rrnAC1935
HHI: HAH_2444
NPH: NP_5300A(cbiZ)
NMO: Nmlp_2452(cbiZ)
HUT: Huta_2500
HMU: Hmuk_0140
HALL: LC1Hm_2696(cbiZ)
HDS: HSR122_2341(cbiZ)
HWA: HQ_1406A(cbiZ)
HWC: Hqrw_1482(cbiZ)
HVO: HVO_0592(cbiZ)
HME: HFX_0579(cbiZ)
HLA: Hlac_0236
HDF: AArcSl_2193(cbiZ)
HTU: Htur_2838
NMG: Nmag_0992(cbiZ)
NAT: NJ7G_1620
MELU: MTLP_08190
TVO: TVG0808276(TVG0808276)
PTO: PTO0124
MARC: AR505_1296
STO: STK_02670
SOL: Ssol_2424
SSOA: SULA_2449
SSOL: SULB_2450
SSOF: SULC_2447
SID: M164_0544
SII: LD85_0555
SIH: SiH_0832
SIR: SiRe_0518
SIC: SiL_0543
MSE: Msed_1086
AHO: Ahos_1964
CMA: Cmaq_1368
TTN: TTX_1465
TUZ: TUZN_1652
VDI: Vdis_1065
VMO: VMUT_1904
 » show all
Reference
  Authors
Woodson JD, Escalante-Semerena JC
  Title
CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.
  Journal
Proc Natl Acad Sci U S A 101:3591-6 (2004)
DOI:10.1073/pnas.0305939101
  Sequence
[mma:MM_0173] [hal:VNG_1583C]
LinkDB

KEGG   ENZYME: 3.5.1.90
Entry
EC 3.5.1.90                 Enzyme                                 
Name
adenosylcobinamide hydrolase;
CbiZ;
AdoCbi amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
adenosylcobinamide amidohydrolase
Reaction(IUBMB)
adenosylcobinamide + H2O = adenosylcobyric acid + (R)-1-aminopropan-2-ol [RN:R05226]
Reaction(KEGG)
R05226
Substrate
adenosylcobinamide [CPD:C06508];
H2O [CPD:C00001]
Product
adenosylcobyric acid [CPD:C06507];
(R)-1-aminopropan-2-ol [CPD:C03194]
Comment
Involved in the salvage pathway of cobinamide in archaea. Archaea convert adenosylcobinamide (AdoCbi) into adenosylcobinamide phosphate (AdoCbi-P) in two steps. First, the amidohydrolase activity of CbiZ cleaves off the aminopropanol moiety of AdoCbi yielding adenosylcobyric acid (AdoCby); second, AdoCby is converted into AdoCbi-P by the action of EC 6.3.1.10, adenosylcobinamide-phosphate synthase (CbiB).
History
EC 3.5.1.90 created 2004
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
Orthology
K08260  adenosylcobinamide hydrolase
Genes
MMAIsS8_1630
HAKKO116_01845
HAGBB497_14215
HVNEI420_07430
GBIPG2T_14225
BACIB1NLA3E_01980
BACOOXB_1391
BMQBMQ_1994
BMDBMD_1950
BMHBMWSH_3286
BMEGBG04_4295
BFXBC359_13235
PKSIE339_16055
LGYT479_13115
LFUHR49_14080
LYSLBYS11_09285
BLRBRLA_c021790
BRWGOP56_03695
PJDPjdr2_3347
GYMGYMC10_5189
PMSKNP414_01665
PMQPM3016_1972
PMWB2K_10005
PLVERIC2_c32630
PODPODO_06000
PAEFR50345_06380
PAEER70331_06075
PAEJH70737_06230
PBJVN24_21395
PIHUB51_16105
PRIPRIO_1520
PXLBS614_11210
PSWUSY83_08810
PDHB9T62_01465
PIBBBD41_19985
PCXLPB68_07845
PVOPVOR_27914
PLWD5F53_04055
PLENEIM92_20635
PLUTEI981_21615
PBKBack11_13150
PPRTET464_04125
PBACHUB98_23890
PRZGZH47_03420
PTRIKDC22_06225
PCELHUB94_18215
PTJJRJ22_05325
ANXACH33_02990
ASOCCB4_00867
ATHEK3F53_15945
CCHLFPL14_25275
AFXJZ786_00050 JZ786_07515
TUMCBW65_11160
TABCIG75_16875
LFBC1X05_13255
TVUAB849_007595
KPULGXN76_03665
KEBGXN75_03785
PABSJIR001_25000
BPROPMF13cell1_01394
EHLEHLA_0566 EHLA_2015
SALQSYNTR_0853
DEDDHBDCA_p2629
DECDCF50_p2640
DRSDEHRE_01430 DEHRE_12855
PTHPTH_1477
DRMDred_2681
DAEDtox_1956
DKUDesku_2191
FWADCMF_24995 DCMF_25050
TJRTherJR_1261
HMOHM1_1855
ELMELI_2045
ELIMB2M23_17005
AWOAwo_c10360(cbiZ2)
ALKAJ0B03_06030
TTETTE2426
TKITKV_c03070(cbiZ)
TPZTph_c03470(cbiZ)
DHODia5BBH33_05930
SSGSelsp_1207
SELEADJ74_07590
MANAMAMMFC1_02847
STEDSPTER_03330
PFACPFJ30894_01782
MITOCO_21870
MIAOCU_22060
MIDMIP_03097
MYOOEM_19770
MCHIAN480_11320
MIROCQ_20980
MMALCKJ54_09785
MLPMLM_1928A
MMMW7S_10285
MGORH0P51_08660
SERJSGUI_2139
SERWFY030_15580
ORNDV701_11620
NMESH9L09_19745
NPIG7071_14490
SENSACE_6498
SACGFDZ84_07375
SESPBN6_28070
KALKALB_7956
KPHYAOZ06_28410
LEDBBK82_07075
AHMTL08_23590
ACTIUA75_27430
ACADUA74_26840
AHGAHOG_24745
PMADBAY61_12190
SACEGIY23_08780
STPStrop_4321
SAQSare_4761
MAUMicau_5904
MILML5_2591
MICBMicB006_1949
MTUACSH63_27810
MICHFJK98_30665
MTEMGCE86_24130
MCABHXZ27_29450
MSAGGCM10017556_21530
VMAVAB18032_02945
ASEACPL_6861
ACTSACWT_6730
PLABC6361_10000
PLATC6W10_07100
PFLAPflav_067840
PSUUPsuf_029930
VERHUT12_30530
ATLAthai_58250
ASERAsera_16770
PRYPrubr_29620
AEYCDG81_03860
AYMYM304_06580
ATQGH723_09265
AQZKSP35_12315
DETDET0653 DET0687
DEHcbdbA637(rdhF) cbdbA87(rdhF)
DEBDehaBAV1_0102 DehaBAV1_0623
DEVDhcVS_591
DEGDehalGT_0585
DMCbtf_610(cbiZ)
DMDdcmb_1046(cbiZ) dcmb_656(cbiZ)
DMGGY50_0122(cbiZ) GY50_0246(cbiZ) GY50_0578(cbiZ) GY50_1354(cbiZ) GY50_1389(cbiZ)
DMXX792_03165 X792_07260
DMYX793_02910
DMZX794_00335 X794_02655 X794_04905 X794_06655
DUCUCH007_05720(cbiZ) UCH007_13440(rdhF)
DEWDGWBC_1178
DFODform_01406
TRATrad_0381
FVAFV113G1_31850
FNFBSQ88_02390
PCAGNCTC12856_00133
DYSG7050_13770
NDENIDE2660
NJANSJP_3530
MSTMsp_0437
METBAW729_04920
MRUmru_1218(cbiZ)
MSIMsm_0825
MEBAbm4_0754(cbiZ)
MMILsm9_1752(cbiZ)
MEYETL18_07800
MOLYLM1_0611
MFCBRM9_1712(cbiZ)
METNBK008_08620
METTCIT01_00970
METOCIT02_04050
AFUAF_1400
AFGAFULGI_00015110
APOArcpr_0307
AVEArcve_1003
ASTAsulf_00935
FPLFerp_2081
GACGACE_1857
GAHGAH_01724
PFUPF0305
PFIPFC_00600
PHOPH0814(PH0814)
PABPAB1708
PYNPNA2_0142
PYAPYCH_17420
PYCTQ32_02265
TKOTK0846
TONTON_0689
TGATGAM_0516(cbiZ)
TBATERMP_00560
THEGQS_01490
THATAM4_743
THMCL1_2012
TLTOCC_11919
THSTES1_0965
TNUBD01_0588
TEUTEU_09185
TGYX802_07720
THVADU37_CDS15850
TCHCHITON_1275
TPEPA0127_02010
TPIEA7C91_09565
TGGA3K92_03405
TCEA3L02_03895
TBSA3L01_04215
THHCDI07_04105
TTDA3L14_06110
TPRFA3L09_09540
TRLA3L10_02380
TPAFA3L08_05950
THYA3L12_04860
TICFH039_07865
TCQTIRI35C_1092
THEMFPV09_01550
PPACPAP_03150
MBAMbar_A3636
MBYMSBRM_1999
MBWMSBRW_1096
MBARMSBR2_0417
MACMA_1623
MMAMM_0173
MMAZMmTuc01_0181
MMJMSMAS_1128
MMACMSMAC_2488
MVCMSVAZ_1368
MEKMSKOL_1311
MLSMSLAZ_1097
METMMSMTP_1142
MEFMSWH1_1025
MEQMSWHS_1096
MSJMSSAC_1600
MSZMSSIH_1189
MSWMSSIT_1256
MHORMSHOH_1351
MBUMbur_1001
MMETMCMEM_1490
MELOJ7W08_06240
MMHMmah_1373
MHAZBHR79_06795
MEVMetev_2213
MZHMzhil_0770
MPYMpsy_1883
MZIHWN40_12760
MHZMetho_0085
MHUMhun_0271 Mhun_2543
MRTJKHC33_03965
MLAMlab_0705 Mlab_1672
MEMMemar_2352
MBGBN140_2491(cbiZ)
MEMAMMAB1_3351(cbiZ)
MCHKMchiMG62_00820
MPIMpet_0148 Mpet_2230
MBNMboo_0181
MFOMetfor_0011 Metfor_0922
MPLMpal_0026
MPDMCP_2916(cbiZ)
MEZMtc_0313
RCIRCIX826
HALVNG_1583C
HSLOE_3261F(cbiZ)
HDLHALDL1_05020
HHBHhub_2918(cbiZ)
HAGSJT689_07770(cbiZ)
HABOJRZ79_06185(cbiZ)
HNOLT974_11365
HANRLJ422_06430(cbiZ)
HJEHacjB3_12800
HALHHTSR_1763(cbiZ)
HHSRHSR6_1829(cbiZ)
HSUHLASF_0298(cbiZ)
HSFHLASA_0297(cbiZ)
HALREFA46_013440
HARAAArcS_2275(cbiZ)
HAADMW046_07560
HALXM0R89_09965
HMArrnAC1935
HHIHAH_2444
HHNHISP_12440
HABSG26_04755
HTABVU17_11895
HALJG9465_06600
HSINKDQ40_01205
NPHNP_5300A(cbiZ)
NMONmlp_2452(cbiZ)
NHOHWV23_10035
NSALHWV07_14455
HUTHuta_2500
HALAHrd1104_08195
HMUHmuk_0140
HALZE5139_03990
HALLLC1Hm_2696(cbiZ)
HAZPGBQ70_03990
HALIBV210_04730
HDSHSR122_2341(cbiZ)
HRRHZS55_07810
HPELHZS54_08475
HLTI7X12_06205
HARCHARCEL1_07210
HDOMUK72_06640
HWAHQ_1406A(cbiZ)
HWCHqrw_1482(cbiZ)
HVOHVO_0592(cbiZ)
HMEHFX_0579(cbiZ)
HGIABY42_02770
HALEG3A49_03000
HBOHbor_26120
HAQDU484_05755
HAJDU500_06225
HAERDU502_03885
HRAEI982_09780
HLMDV707_12480
HALMFCF25_09780
HLAHlac_0236
HALPDOS48_01140
HALBEKH57_09575
HEZZEO776_02820
HALQHrr1229_005290
HSSJ7656_13950
HSAIHPS36_04800
HAZZKI388_00455
SRUBC2R22_02855
HAEhalTADL_2184
HALGHUG10_16670
HALUHUG12_19730
HMPK6T50_10895
HREK6T36_10680
HRMK6T25_05350
HACBHbl1158_02665
HDFAArcSl_2193(cbiZ)
HTUHtur_2838
HDABB347_09760
HJTDVR14_14760
HALYHYG82_06025
HSALJMJ58_14240
HLOJ0X27_15055
HAKZJ0X25_02365
NMGNmag_0992(cbiZ)
HXAHalxa_2231
NATNJ7G_1620
NPENatpe_1092
NVRFEJ81_05680
NPLFGF80_05325
NAYHYG81_05245
NGENatgr_2766
HRUHalru_2358
NOUNatoc_1890
SAIMK0C01_07375
HLRHALLA_15860
HLCCHINAEXTREME08775
NAJB1756_03160
NAGAArcMg_2763
NANAArc1_0943
NBGDV706_10225
NASGCU68_01840
MELUMTLP_08190
TVOTVG0808276(TVG0808276)
PTOPTO0124
FACFACI_IFERC01G1896
TARTALC_01123 TALC_01134
MAXMMALV_11630
MARCAR505_1296
STOSTK_02670
SOHD1869_00840
SOLSsol_2424
SSOASULA_2449
SSOLSULB_2450
SSOFSULC_2447
SSHIJ5U23_01464
SISLS215_1134
SIAM1425_0519
SIMM1627_0528
SIDM164_0544
SIYYG5714_0493
SINYN1551_2515
SIILD85_0555
SIHSiH_0832
SIRSiRe_0518
SICSiL_0543
SULEGFS03_05375
SULOGFS33_10665
MSEMsed_1086
MPRUDFR88_01090
MJNMjAS7_2093
AHOAhos_1964
AMANB6F84_09305
ABRIDFR85_05730
ASULDFR86_07995
AAMBD1866_04820
SACDHS1genome_1561
SAZOD1868_06740
CMACmaq_1368
TTNTTX_1465
TUZTUZN_1652
VDIVdis_1065
VMOVMUT_1904
FFOFFONT_0055
 » show all
Reference
1  [PMID:14990804]
  Authors
Woodson JD, Escalante-Semerena JC
  Title
CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.
  Journal
Proc Natl Acad Sci U S A 101:3591-6 (2004)
DOI:10.1073/pnas.0305939101
  Sequence
[mma:MM_0173] [hal:VNG_1583C]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.90
IUBMB Enzyme Nomenclature: 3.5.1.90
ExPASy - ENZYME nomenclature database: 3.5.1.90
BRENDA, the Enzyme Database: 3.5.1.90
CAS: 905988-16-1
LinkDB

KEGG   REACTION: R05226
Entry
R05226                      Reaction                               
Name
adenosylcobinamide amidohydrolase
Definition
Adenosyl cobyrinate hexaamide + (R)-1-Aminopropan-2-ol <=> Adenosyl cobinamide + H2O
Equation
Reaction class
RC00090  C06507_C06508
RC00096  C03194_C06508
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01100  Metabolic pathways
Orthology
K08260  adenosylcobinamide hydrolase [EC:3.5.1.90]
Other DBs
RHEA: 23507
LinkDB

DBGET integrated database retrieval system