KEGG   ORTHOLOGY: K08690
Entry
K08690                      KO                                     
Symbol
bphB
Name
cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56]
Pathway
map00621  Dioxin degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00621 Dioxin degradation
    K08690  bphB; cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.56  cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
     K08690  bphB; cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K08690
Other DBs
RN: R05239 R05241
GO: 0018509
Genes
PSD: DSC_09350
PFUW: KF707C_16280(bphB)
PALL: UYA_07075
ABOU: ACBO_15320
FCE: JN531_005645(hcaB)
BXE: Bxe_C1192(bphB)
BXB: DR64_8613(bphB)
PNA: Pnap_4147
ACK: C380_15940(bphB)
CTES: O987_08240
PGV: SL003B_4098
MMAN: MMAN_22960(hcaB)
MBRD: MBRA_22550(hcaB)
RHA: RHA1_ro08054(bphB) RHA1_ro10126(bphB2)
ROP: ROP_pROB02-01630(bnzB)
SSOI: I1A49_46005(hcaB)
GYU: FE374_10380
AACD: LWP59_27020(hcaB)
HAAD: MW046_15100
AG: AAB18304(bphB)
 » show all
Reference
PMID:8702262
  Authors
Sylvestre M, Hurtubise Y, Barriault D, Bergeron J, Ahmad D
  Title
Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB).
  Journal
Appl Environ Microbiol 62:2710-5 (1996)
DOI:10.1128/AEM.62.8.2710-2715.1996
  Sequence
[ag:AAB18304]
Reference
PMID:8344527
  Authors
Hofer B, Eltis LD, Dowling DN, Timmis KN
  Title
Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation.
  Journal
Gene 130:47-55 (1993)
DOI:10.1016/0378-1119(93)90345-4
  Sequence
[bxe:Bxe_C1192]
Reference
PMID:17142386
  Authors
Vezina J, Barriault D, Sylvestre M
  Title
Family shuffling of soil DNA to change the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase.
  Journal
J Bacteriol 189:779-88 (2007)
DOI:10.1128/JB.01267-06
LinkDB

KEGG   ENZYME: 1.3.1.56
Entry
EC 1.3.1.56                 Enzyme                                 
Name
cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase;
2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase
Reaction(IUBMB)
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+ [RN:R05239]
Reaction(KEGG)
R05239;
(other) R05241
Substrate
cis-3-phenylcyclohexa-3,5-diene-1,2-diol [CPD:C06589];
NAD+ [CPD:C00003]
Product
biphenyl-2,3-diol [CPD:C02526];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Catalyses the second step in the biphenyl degradation pathway in bacteria.
History
EC 1.3.1.56 created 2000
Pathway
ec00621  Dioxin degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08690  cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Genes
PSD: DSC_09350
PFUW: KF707C_16280(bphB)
PALL: UYA_07075
ABOU: ACBO_15320
FCE: JN531_005645(hcaB)
BXE: Bxe_C1192(bphB)
BXB: DR64_8613(bphB)
PNA: Pnap_4147
ACK: C380_15940(bphB)
CTES: O987_08240
PGV: SL003B_4098
MMAN: MMAN_22960(hcaB)
MBRD: MBRA_22550(hcaB)
RHA: RHA1_ro08054(bphB) RHA1_ro10126(bphB2)
ROP: ROP_pROB02-01630(bnzB)
SSOI: I1A49_46005(hcaB)
GYU: FE374_10380
AACD: LWP59_27020(hcaB)
HAAD: MW046_15100
 » show all
Reference
1  [PMID:8702262]
  Authors
Sylvestre M, Hurtubise Y, Barriault D, Bergeron J, Ahmad D
  Title
Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB).
  Journal
Appl Environ Microbiol 62:2710-5 (1996)
DOI:10.1128/AEM.62.8.2710-2715.1996
  Sequence
[ag:AAB18304]
Reference
2  [PMID:8048958]
  Authors
Fukuda M, Yasukochi Y, Kikuchi Y, Nagata Y, Kimbara K, Horiuchi H, Takagi M, Yano K.
  Title
Identification of the bphA and bphB genes of Pseudomonas sp. strains KKS102 involved in degradation of biphenyl and polychlorinated biphenyls.
  Journal
Biochem Biophys Res Commun 202:850-6 (1994)
DOI:10.1006/bbrc.1994.2008
Reference
3  [PMID:8344527]
  Authors
Hofer B, Eltis LD, Dowling DN, Timmis KN
  Title
Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation.
  Journal
Gene 130:47-55 (1993)
DOI:10.1016/0378-1119(93)90345-4
  Sequence
[bxe:Bxe_C1192]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.56
IUBMB Enzyme Nomenclature: 1.3.1.56
ExPASy - ENZYME nomenclature database: 1.3.1.56
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.56
BRENDA, the Enzyme Database: 1.3.1.56
LinkDB

KEGG   REACTION: R05241
Entry
R05241                      Reaction                               
Name
cis-2,3-dihydro-2,3-dihydroxy-4'-chlorobiphenyl:NAD+ oxidoreductase
Definition
cis-2,3-Dihydro-2,3-dihydroxy-4'-chlorobiphenyl + NAD+ <=> 2,3-Dihydroxy-4'-chlorobiphenyl + NADH + H+
Equation
C06585 + C00003 <=> C06586 + C00004 + C00080
Reaction class
RC00001  C00003_C00004
RC00534  C06585_C06586
Enzyme
1.3.1.56
Pathway
rn00621  Dioxin degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
Orthology
K08690  cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56]
LinkDB

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