KEGG   ORTHOLOGY: K08690
Entry
K08690                      KO                                     
Symbol
bphB
Name
cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56]
Pathway
map00621  Dioxin degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
Reaction
R05239  cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase
R05241  cis-2,3-dihydro-2,3-dihydroxy-4'-chlorobiphenyl:NAD+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00621 Dioxin degradation
    K08690  bphB; cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.56  cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
     K08690  bphB; cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K08690
Other DBs
GO: 0018509
Genes
PSD: DSC_09350
PFUW: KF707C_16280(bphB)
PCAV: D3880_02400
PALL: UYA_07075
ABOU: ACBO_15320
FCE: JN531_005645(hcaB)
BMEC: WJ16_19980
BPLA: bpln_1g12660
BXE: Bxe_C1192(bphB)
BXB: DR64_8613(bphB)
PANX: OYT13_24875(bphB)
PNA: Pnap_4147
ACK: C380_15940(bphB)
CTES: O987_08240
ABRE: pbN1_20540(bphB)
NPM: QEO92_31470(hcaB)
CID: P73_0349
SPFD: SPYCA_3466
SPCA: GL174_19460(hcaB)
NDT: L1999_23270(hcaB)
MMAN: MMAN_22960(hcaB)
MBRD: MBRA_22550(hcaB)
RHA: RHA1_ro08054(bphB) RHA1_ro10126(bphB2)
ROP: ROP_pROB02-01630(bnzB)
RPSK: JWS13_01625(hcaB)
RHOU: KZJ41_10525(hcaB)
RHOY: QNA09_06875(hcaB)
SSOI: I1A49_46005(hcaB)
OCP: NF557_09240(hcaB)
AACD: LWP59_27020(hcaB)
AMOG: QRX60_29010(hcaB)
ANW: QP939_26525(hcaB)
DFU: Dfulv_20790(hcaB)
HLS: KU306_03855(hcaB)
MEMJ: MJ1HA_1405
AG: AAB18304(bphB)
 » show all
Reference
PMID:8702262
  Authors
Sylvestre M, Hurtubise Y, Barriault D, Bergeron J, Ahmad D
  Title
Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB).
  Journal
Appl Environ Microbiol 62:2710-5 (1996)
DOI:10.1128/AEM.62.8.2710-2715.1996
  Sequence
Reference
PMID:8344527
  Authors
Hofer B, Eltis LD, Dowling DN, Timmis KN
  Title
Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation.
  Journal
Gene 130:47-55 (1993)
DOI:10.1016/0378-1119(93)90345-4
  Sequence
[bxe:Bxe_C1192]
Reference
  Authors
Vezina J, Barriault D, Sylvestre M
  Title
Family shuffling of soil DNA to change the regiospecificity of Burkholderia xenovorans LB400 biphenyl dioxygenase.
  Journal
J Bacteriol 189:779-88 (2007)
DOI:10.1128/JB.01267-06
LinkDB

KEGG   ORTHOLOGY: K22676
Entry
K22676            Tight     KO                                     
Symbol
bphB
Name
cis-2,3-dihydrobiphenyl-2,3-diol/cis-2,3-dihydrodiol-DDE dehydrogenase [EC:1.3.1.-]
Pathway
map00621  Dioxin degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Reaction
R12025  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00621 Dioxin degradation
    K22676  bphB; cis-2,3-dihydrobiphenyl-2,3-diol/cis-2,3-dihydrodiol-DDE dehydrogenase
Other DBs
COG: COG1028
Genes
AG: BAM76240(bphB)
Reference
  Authors
Nguyen PA, Trinh TH, Fukumitsu Y, Shimodaira J, Miyauchi K, Tokuda M, Kasai D, Masai E, Fukuda M
  Title
Gene cluster and regulation system for 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE) degradation in Janibacter sp.  TYM3221.
  Journal
J Biosci Bioeng 116:91-100 (2013)
DOI:10.1016/j.jbiosc.2013.01.007
  Sequence
LinkDB

KEGG   ENZYME: 1.3.1.56
Entry
EC 1.3.1.56                 Enzyme                                 
Name
cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase;
2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase
Reaction(IUBMB)
cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+ [RN:R05239]
Reaction(KEGG)
R05239;
(other) R05241
Substrate
cis-3-phenylcyclohexa-3,5-diene-1,2-diol [CPD:C06589];
NAD+ [CPD:C00003]
Product
biphenyl-2,3-diol [CPD:C02526];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Catalyses the second step in the biphenyl degradation pathway in bacteria.
History
EC 1.3.1.56 created 2000
Pathway
ec00621  Dioxin degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08690  cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Genes
PSDDSC_09350
PFUWKF707C_16280(bphB)
PCAVD3880_02400
PALLUYA_07075
ABOUACBO_15320
FCEJN531_005645(hcaB)
BMECWJ16_19980
BPLAbpln_1g12660
BXEBxe_C1192(bphB)
BXBDR64_8613(bphB)
PANXOYT13_24875(bphB)
PNAPnap_4147
ACKC380_15940(bphB)
ACIDCBP33_05310
ACIPCBP36_05760
ACINCBP34_05145
ACISCBP35_13185
DELDelCs14_1742
CTESO987_08240
MASWAM586_27560
ABREpbN1_20540(bphB)
AZIAzCIB_4413
AZDCDA09_21450
NPMQEO92_31470(hcaB)
MAADAZF01_18215
CIDP73_0349
CONTQ29_19185
PGVSL003B_4098
SPFDSPYCA_3466
SPCAGL174_19460(hcaB)
SPHYCHN51_18350
BACAFAY30_11685
BKOCKF48_07585
NDTL1999_23270(hcaB)
MMANMMAN_22960(hcaB)
MLWMJO58_22505
MBRDMBRA_22550(hcaB)
RHARHA1_ro08054(bphB) RHA1_ro10126(bphB2)
ROPROP_pROB02-01630(bnzB)
ROZCBI38_14165
RPSKJWS13_01625(hcaB)
RHOUKZJ41_10525(hcaB)
RHOWA4U64_15220
RHOYQNA09_06875(hcaB)
SSOII1A49_46005(hcaB)
OCPNF557_09240(hcaB)
GYUFE374_10380
AACDLWP59_27020(hcaB)
ARHDVSH64_15730 VSH64_15755 VSH64_21255(hcaB) VSH64_25880
AMOGQRX60_29010(hcaB)
ANWQP939_26525(hcaB)
PPELH6H00_04700
PSDSK1T35_34225
DFUDfulv_20790(hcaB)
HAADMW046_15100
HLSKU306_03855(hcaB)
MEMJMJ1HA_1405
 » show all
Reference
1  [PMID:8702262]
  Authors
Sylvestre M, Hurtubise Y, Barriault D, Bergeron J, Ahmad D
  Title
Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB).
  Journal
Appl Environ Microbiol 62:2710-5 (1996)
DOI:10.1128/AEM.62.8.2710-2715.1996
  Sequence
Reference
2  [PMID:8048958]
  Authors
Fukuda M, Yasukochi Y, Kikuchi Y, Nagata Y, Kimbara K, Horiuchi H, Takagi M, Yano K.
  Title
Identification of the bphA and bphB genes of Pseudomonas sp. strains KKS102 involved in degradation of biphenyl and polychlorinated biphenyls.
  Journal
Biochem Biophys Res Commun 202:850-6 (1994)
DOI:10.1006/bbrc.1994.2008
Reference
3  [PMID:8344527]
  Authors
Hofer B, Eltis LD, Dowling DN, Timmis KN
  Title
Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation.
  Journal
Gene 130:47-55 (1993)
DOI:10.1016/0378-1119(93)90345-4
  Sequence
[bxe:Bxe_C1192]
Other DBs
ExplorEnz - The Enzyme Database: 1.3.1.56
IUBMB Enzyme Nomenclature: 1.3.1.56
ExPASy - ENZYME nomenclature database: 1.3.1.56
UM-BBD (Biocatalysis/Biodegradation Database): 1.3.1.56
BRENDA, the Enzyme Database: 1.3.1.56
LinkDB

KEGG   REACTION: R05239
Entry
R05239                      Reaction                               
Name
cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase
Definition
cis-2,3-Dihydro-2,3-dihydroxybiphenyl + NAD+ <=> Biphenyl-2,3-diol + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00534  C02526_C06589
Enzyme
Pathway
rn00621  Dioxin degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.56
     R05239  cis-2,3-Dihydro-2,3-dihydroxybiphenyl + NAD+ <=> Biphenyl-2,3-diol + NADH + H+
Orthology
K08690  cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56]
Other DBs
RHEA: 17036
LinkDB

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