KEGG   ORTHOLOGY: K08691
Entry
K08691                      KO                                     
Symbol
mcl
Name
malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map00660  C5-Branched dibasic acid metabolism
map00680  Methane metabolism
map00720  Other carbon fixation pathways
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00346  Formaldehyde assimilation, serine pathway
M00373  Ethylmalonyl pathway
M00376  3-Hydroxypropionate bi-cycle
Reaction
R00237  (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
R00473  L-malyl-CoA glyoxylate-lyase (acetyl-CoA-forming)
R00934  L-erythro-3-methylmalyl-CoA glyoxylate-lyase (propanoyl-CoA-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
   00660 C5-Branched dibasic acid metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
  09102 Energy metabolism
   00720 Other carbon fixation pathways
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
   00680 Methane metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.24  malyl-CoA lyase
     K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
    4.1.3.25  (S)-citramalyl-CoA lyase
     K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
Other DBs
COG: COG2301
GO: 0050083 0047777
Genes
SACZ: AOT14_23590(mcl1)
NJO: ABXT42_11330
TFT: RI844_14200
LLG: 44548918_02118(mcl1)
MCA: MCA1739
METU: GNH96_10430
MMEO: OOT43_04275
MEEF: JWZ97_01880
MMT: Metme_2695
MDN: JT25_000155
MDH: AYM39_08385
MKO: MKLM6_1752
METL: U737_10260
MPAD: KEF85_03350
MELL: IVG45_03090
MRP: NM686_005355
MMOT: QZJ86_13270
MEEP: JWZ98_13280
MEEC: PL263_02075
MEUP: QC632_17140
MAH: MEALZ_3217(mclA1)
MBUR: EQU24_04630
MPSY: CEK71_18035
MMAI: sS8_2223
MSZE: MSZNOR_4946(mcl)
MMOB: F6R98_20170
MEIN: methR_P0949
MOZ: MoryE10_14040
MISZ: MishRS11D_11830
MESL: KKZ03_00260
MECH: Q9L42_001115
MLAU: ACEPPP_17245
MEIY: MIN45_P1852
MCAU: MIT9_P1453
BLEP: AL038_08990
THIP: N838_00825
TSN: W908_06430
CBLY: IPM89_03270 IPM89_04980
RPJ: N234_12055
CNC: CNE_BB1p10140(mcl)
CUPP: CTP10_R46940
BGP: BGL_2c16890
BPLA: bpln_2g17560
BPH: Bphy_5924
BFN: OI25_5771 OI25_7353
BCAI: K788_0001579
PHS: C2L64_21705
PTER: C2L65_26290
PTRO: G5S35_34875
PACS: FAZ98_23740
PSAA: QEN71_12140 QEN71_33975
PKF: RW095_22000
PPAI: E1956_20570
BBRO: BAU06_24990
BFZ: BAU07_25025
BOH: AKI39_23800
APES: FOC84_30065
HYN: F9K07_00140
CBAB: SMCB_1586
MPT: Mpe_A3254
METP: C1M51_05895
XYK: GT347_12545
NEU: NE1809
NET: Neut_0607
NIT: NAL212_0420
NII: Nit79A3_0103
NCO: AAW31_08285
NUR: ATY38_03755
NST: Nstercoris_01831
NMU: Nmul_A1078
NLC: EBAPG3_012580
NIZ: NNRS527_01104
METR: BSY238_253
NIM: W01_13780
NARC: NTG6680_0561(mcl)
URU: DSM104443_00577(mcl1_1)
FMY: HO273_03895
APP: CAP2UW1_2508
ACOG: HWD57_21460
MLO: mlr1323
MLN: A9174_19865
MOP: Mesop_3793
MAM: Mesau_03584
MAMO: A6B35_22110
MESP: C1M53_18670
MHUA: MCHK_2942
MJR: EB229_19625
MERD: EB233_16970
MESJ: MJ8_41070
MESU: LHFGNBLO_003310
MEWS: QAZ47_17235
MEWM: QAZ22_17135
AAK: AA2016_5786
AMIH: CO731_05425(mcl1)
AMIS: Amn_pa02870
ANJ: AMD1_PA0303(mcl)
AMIO: N7E70_029070
PHT: BLM14_27150
AMAX: ABWH92_15240
PLA: Plav_3098
PMOB: HG718_00970
KMN: HW532_00815
PECT: BN1012_Phect939
RBS: RHODOSMS8_01011(mcl)
RHI: NGR_c26230
SFH: SFHH103_02474(cite1)
SFD: USDA257_c22030(mcl1)
SAME: SAMCFNEI73_pC0656(mcl)
SINO: SS05631_b61290
ESJ: SJ05684_b48780
EAK: EKH55_4315
ENU: PYH37_000576
EGI: PZN02_002069
STEG: QA637_13125
EAW: ACEP9W_26615
BRC: BCCGELA001_06950
BRAD: BF49_2901
BOT: CIT37_18285
BRQ: CIT40_04560
BGQ: X265_31260
BSYM: CIT39_02900
BEL: BE61_53460(citE)
BDG: LPJ38_11055
BCAN: BcanWSM471_32370
BAUT: QA635_20755
BBRA: QA636_21300
BPAH: QA639_24260
BRAY: ML401_05185
BRAI: FJV43_23055
BLUP: AB3L03_23160
BGEP: ACP2YO_42720
BRAN: RX330_06190
TARD: RSO67_10350
RHZ: RHPLAN_35810
BVV: BHK69_20015
BVES: QO058_01020
BOP: AXW83_07320
BOS: BSY19_2901
BOI: BLM15_06415
BOF: FQV39_02445
BOW: NWE53_06435
BOSE: RMR04_14015
XAU: Xaut_3870
XDI: EZH22_19265
AZC: AZC_1227
LNE: FZC33_08695
AQI: J5J86_17915
PTAW: DW352_05470
MEA: Mex_1p1733(mcl) Mex_1p4295
MDI: METDI2485(mcl) METDI4906
MEX: Mext_1802 Mext_3917
MCH: Mchl_2138 Mchl_4285
MPO: Mpop_1754 Mpop_4390
MZA: B2G69_01480 B2G69_16670
METQ: MSPGM_18400 MSPGM_39090
MRD: Mrad2831_1650 Mrad2831_3663
MET: M446_6315 M446_6559
MNO: Mnod_7119 Mnod_7178
MOR: MOC_2043 MOC_4185
META: Y590_08615 Y590_19480
MAQU: Maq22A_c18385(citE) Maq22A_c19250(mcl)
MPHY: MCBMB27_01298 MCBMB27_03145
MEE: DA075_20140 DA075_27160
METD: C0214_10380 C0214_21595
METX: A3862_13170 A3862_22625
METS: DK389_15360 DK389_27325
METI: DK427_15555 DK427_17480
MMES: MMSR116_01155 MMSR116_21315
MTEA: DK419_14290 DK419_26925
MIND: mvi_25720 mvi_28860
MOG: MMB17_01150 MMB17_19730
MTAD: M6G65_09600 M6G65_20420
MECL: CLZ_08145 CLZ_19310
MFUJ: ABC766_00780 ABC766_21045
MENI: GU700_08145 GU700_19315
MENS: LOK46_08880 LOK46_19385
MSL: Msil_1719
MTUN: MTUNDRAET4_3402(mcl)
MLG: CWB41_04715
MEHY: MHY1_02393(mcl1)
MEDK: QEV83_04540
MPOL: RZS28_09790
BBAR: RHAL1_03825(mcl_2)
BBAI: CU048_08565
RHJ: HZY79_12425
CHEL: AL346_17425
CDQ: BOQ54_08925
HDN: Hden_1659 Hden_3153
HDT: HYPDE_30183 HYPDE_38943
HMC: HYPMC_1941 HYPMC_4395(mcl)
HNI: W911_10365 W911_15805
RVA: Rvan_1682
RLAC: QMO75_10135
FIL: BN1229_v1_1240(mcl) BN1229_v1_2672
FIY: BN1229_v1_1238(mcl) BN1229_v1_3242
MCG: GL4_3371
METG: HT051_02845
BVR: BVIR_1803
BLAG: BLTE_09690(mclA)
MSC: BN69_1171 BN69_2035
MBRY: B1812_00060 B1812_17545
MROS: EHO51_12185 EHO51_15075
MHEY: H2LOC_011805 H2LOC_014625
MPAR: F7D14_06360 F7D14_09175
MIWA: SS37A_01470 SS37A_07190
MESZ: LNB28_12755
MECI: RVU70_04160 RVU70_07975
MEMC: OGR47_00410 OGR47_02520
MTW: CQW49_12235 CQW49_16215
MECQ: MSC49_04610 MSC49_35030(mclA)
MSPR: MSP5_002852 MSP5_003434
CMET: K6K41_15080 K6K41_22170
PLEO: OHA_1_00681(mcl) OHA_1_00777(citE)
HDI: HDIA_2217(mcl1_1) HDIA_2467(mcl1_2)
PSIN: CAK95_23545
NOH: G5V57_13010
RBM: TEF_05695
BRN: D1F64_11585
PSF: PSE_3192
PPHR: APZ00_18415
LAP: ACP90_14745
LABR: CHH27_05755
LABP: FJ695_18280
LABT: FIU93_20440(mcl2)
LAGG: B0E33_26575
RPOP: K1718_15345
RAGG: QUB73_15510
SIW: GH266_00855
PHR: C6569_07730
PSTG: E8M01_31685
PAQT: E8L99_17855
MFLG: ABS361_07945 ABS361_08810
CCR: CC_2999
CCS: CCNA_03094
CAK: Caul_0731
CSE: Cseg_3490
CHQ: AQ619_14395
CMB: CSW64_04970
CFH: C1707_10190
CAUF: CSW63_06460
CAUB: AMEJIAPC_03357(mcl)
CIW: ABOZ73_13520
BALB: M8231_03195
TSV: DSM104635_00778(mcl1)
SIL: SPO1565 SPO3608(mclA)
SIT: TM1040_3165
RUA: D1823_18170 D1823_20490
RUT: FIU92_13270(mcl2) FIU92_19865(mcl3)
RCON: K3740_00765 K3740_20040
RUY: NOR97_12580 NOR97_17625
JAN: Jann_0471
RDE: RD1_1001(citE) RD1_1160(mclA) RD1_4242(mclA)
RLI: RLO149_c002070(mcl1) RLO149_c036850(mcl2)
RPON: G3256_17055
RFU: ROLI_001060(mcl1_1) ROLI_003020(mcl1_2)
DSH: Dshi_2490(citE1) Dshi_3050(citE2)
PGA: PGA1_c30490
PGL: PGA2_c28380
PGD: Gal_00369
PHP: PhaeoP97_00458
PPIC: PhaeoP14_02820
PHQ: D1820_09925
PHAE: N1037_03410
OAT: OAN307_c02220
OAR: OA238_c37200
OTM: OSB_28710(mcl1)
OCT: FTO60_14185
LMD: METH_02340 METH_18390
LEJ: ETW24_03080 ETW24_17910
LAQU: R2C4_14570 R2C4_19790
LEV: ETW23_00250 ETW23_17075
LCAE: K3721_02490 K3721_16185
LEIM: K3557_01895
CID: P73_3958 P73_4243
CMAR: IMCC12053_1300
CEH: CEW89_10920
CBAK: DA792_18755
MALG: MALG_03008
CON: TQ29_15155
YPAC: CEW88_13335
YAN: AYJ57_18165
TPRO: Ga0080559_TMP1541
PABY: Ga0080574_TMP2641
SUAM: BOO69_01375
SULZ: C1J03_02230
SULI: C1J05_00980
SULD: B5M07_15575
SPOT: G6548_03345
SMED: JNX03_11790
SINL: DSM14862_03056(mcl1)
SFAV: PL335_14640
SUAL: KDD17_13110
SDUB: R1T39_09450
SULB: IV89_003044
SULY: ABM428_03160
SULP: AADW22_03465
SUSQ: K3756_01945
SPSE: SULPSESMR1_03496(mcl1)
TOM: BWR18_14535
TATE: ACMHLQ_14570
TATY: ACERHN_05795 ACERHN_07845
RMM: ROSMUCSMR3_02149(mcl1) ROSMUCSMR3_03455(mcl1)
ROK: RAK1035_1037 RAK1035_2340
RID: RIdsm_02779(mcl1_1) RIdsm_05011(mcl1_2)
ROM: EI983_00710 EI983_08270
ROH: FIU89_19925(mcl2)
RPEL: N7U68_03480 N7U68_09695
RPHC: RZ517_03050
RRL: RZS32_005725
AHT: ANTHELSMS3_00280(mcl1)
SAGU: CDO87_13335 CDO87_15505
SSTL: ABFK29_04820 ABFK29_06700
SAGZ: QNI11_16165 QNI11_18100
THAA: CFI11_04070
OCD: FHY55_18010
ROT: FIV09_13785(mcl2)
RMH: LVO79_03465
MALU: KU6B_08980(mcl1) KU6B_14460 KU6B_40050
TGL: HFZ77_14905
TMD: KUV46_04605
HAT: RC74_08495
PALX: GQA70_15345 GQA70_23220
LSAL: KBK07_02450
LALG: LentiSH36_02533
TRY: QF118_05630
MARU: FIU81_14310(mcl3)
RMAI: MACH21_17090 MACH21_30420(mcl1)
RED: roselon_01454 roselon_02260
ASCA: QEZ52_04645 QEZ52_19035
ACLD: ACIRQ6_01125 ACIRQ6_04170
SEOH: ACMUJL_09380
MATG: ACMVPR_21485
BOO: E2K80_13755
RPOH: ABWH90_15235
RSP: RSP_1771
RSH: Rsph17029_0417
RSQ: Rsph17025_2481
RSK: RSKD131_0071
CAZT: LV780_11350
RBL: B6K69_09750
FYT: QF092_14495 QF092_14520
PDE: Pden_0799
PAMI: JCM7686_2763 JCM7686_3168
PYE: A6J80_07835
PCON: B0A89_03920
PZH: CX676_04845 CX676_15565
PARO: CUV01_10870
PAMN: JCM7685_2683 pAMV1p0135(mcl) pAMV3p0611(mcal)
PMUT: DPM13_05940
PARR: EOJ32_05825
PAAK: FIU66_06855
PKD: F8A10_08855
PPAN: ESD82_17880
PLIA: E4191_12750
PSAN: HGN31_05715
PMAU: CP157_02398(mcl1)
PMEH: JWJ88_07325
PSEW: JHW44_10240
PSAP: JHX88_01975 JHX88_17895 JHX88_20315
PFIS: JHX87_05090
PAEX: JHW48_04005
PSTL: JHW45_12805
PALP: JHW40_15150 JHW40_18530
PVER: E3U25_16380
PFEO: E3U26_05025
PHOI: ACLISE_05020
PTP: RCA23_c05980(mclA)
RSU: NHU_02809
RHM: B5V46_11900
RHC: RGUI_3145
RHOV: ACK8CO_16750
RMB: K529_018960
TSCO: R1T40_18500
DAA: AKL17_3598
DON: BSK21_02035
MALC: QQG91_12775
RBZ: B9057_11515
THW: BMG03_17130
TEC: AKL02_016915
TLB: RPE78_05390
LVS: LOKVESSMR4R_02838(mcl1)
YAG: AABB28_11655
YRH: AABB31_07960
GEH: HYN69_16130 HYN69_16155
GFU: KM031_08955 KM031_11830
TAW: EI545_00080 EI545_09215
SALO: EF888_18940
SEDI: EBB79_18450 EBB79_24155
PPSO: QPJ95_09700
PSEB: EOK75_09010
PPRU: FDP22_10475
PAED: G5B38_01665 G5B38_14245
PAMO: BAR1_02110
POZ: I0K15_04605
MON: G8E03_06220
PALW: PSAL_024060(mcl1)
PSHQ: F3W81_17090
PGV: SL003B_2239
CACT: HZ995_04375
THAS: C6Y53_06905
HDH: G5B40_08975
CMAG: CBW24_04620
GCE: KYE46_00395
GYJ: AADW23_05035
NSM: JO391_00315 JO391_12675
ACRO: K3J57_12105
AALK: LGT41_0000610
AMYL: QBD29_03580 QBD29_08415
AMAQ: GO499_03725 GO499_18685
RHOC: QTA57_06920
PBAE: P8S53_01310
RBG: BG454_02060 BG454_05615
BOSG: GKR98_07030 GKR98_16035
MANH: LA6_000568(mcl1_1) LA6_004253(mcl1_2)
FAQ: G5B39_01155
SINR: O5O51_01720
RCP: RCAP_rcc03164(citE2)
RHP: LPB142_02980
RBX: I3V23_08345
HNE: HNE_0078(mclA)
HBA: Hbal_0778
CBOT: ATE48_06115
HBC: AEM38_14745
RDI: CMV14_07525
TFV: IDJ81_06845
GBE: GbCGDNIH1_0055
GBH: GbCGDNIH2_0055
GBC: GbCGDNIH3_0055
GBS: GbCGDNIH4_0055
RAP: RHOA_5783(mcl)
SKT: IGS68_03250
SMUC: JL100_003365
SROE: JL101_003125
RRU: Rru_A0217
RRF: F11_01090
RPM: RSPPHO_00107
MGY: MGMSRv2__3257
MGRY: MSR1_29830(mcl1)
MAGX: XM1_1373
MAGN: WV31_14965
FER: FNB15_09270
DEX: HWD60_03940
DVN: HQ394_01635
AALU: ABWI00_18075
MAG: amb3977
HTQ: FRZ44_44960
HADH: FRZ61_42590 FRZ61_45950
TXI: TH3_02680
THAC: CSC3H3_02980
TII: DY252_18625
THAI: IT893_02795
TLU: R1T41_11295
TTB: MACH01_05680
THGO: M9H61_10100
THAD: IT971_02425
MAGQ: MGMAQ_0659
VSU: P3M64_12025
TMO: TMO_0350(citE)
ECOG: FIV45_00610
SNEA: NBZ79_03900
MINW: ACMVY4_00965
DEO: CAY53_08885
DHG: EYB58_06030
DML: Dmul_11170
DAX: FDQ92_06220
TRO: trd_0455
STI: Sthe_2064
GGR: HKW67_06650
EUZ: DVS28_a0494
RANT: RHODO2019_08890
STRE: GZL_04819
SLD: T261_4311
SLC: SL103_17980
SNR: SNOUR_21930
SALU: DC74_4078
SALL: SAZ_21750
SGV: B1H19_20540
STRO: STRMOE7_00865
SPLA: CP981_36035
SDW: K7C20_34930
SAUH: SU9_032330
SANU: K7396_01540
SINE: KI385_01365
SNIG: HEK616_29400(citE_1)
STUD: STRTU_000263
SYUN: MOV08_22140
SRPA: HEP86_38235
SSIR: WAB15_00285
SEXP: SLV14_000560
STID: G7Z12_02250
SCT: SCAT_4364
SCY: SCATT_43520
ABRY: NYE86_27165
AGLA: OIE69_13955
AREV: RVR_7447
ICA: Intca_2587
ARS: ADJ73_02415
JTE: ASJ30_03525
JLI: EXU32_11365
JME: EEW87_011295
JAY: H7A72_03525
JCR: O9K63_16190
JAI: V1351_03505
JTR: V3C34_06460
TEH: GKE56_09880
PEI: H9L10_09525
TED: U5C87_20770
KNO: V6K52_05950
AUS: IPK37_13860
NCA: Noca_4393
NDK: I601_0974(mcl1)
NOY: EXE57_13540
NOI: FCL41_01330
NOO: FE634_19600
NSN: EXE58_09730
NBE: Back2_15770(citE_1)
NANO: G5V58_24335
NARO: CFH99_21490
NPI: G7071_06375
NAQU: ENKNEFLB_04247(mcl)
NRO: K8W59_01590
NOQ: LN652_11495
NCQ: K6T13_15930
NPC: KUV85_11405
NMAR: HPC71_19405
NFC: KG111_16475
NRN: SHK17_19420
NBI: SHK19_19515
NOF: MF408_11790
NOCR: OSR43_19690
NOCW: ABFU82_16405
NOCA: ncot_09650
NOCL: KM427_23805
NOCD: QJ852_03600
NOCQ: QI633_23365
NLB: P5P86_00340
PSIM: KR76_23920
AER: AERYTH_05645
AEZ: C3E78_04975
AEB: C6I20_10755
AEF: GEV26_04810
ASEZ: H9L21_04165
ADB: NP095_04110
AWN: NQV15_05020
NBT: KLP28_00560
FRA: Francci3_2805
FSY: FsymDg_0509
AMD: AMED_0079(citE)
AMN: RAM_00395
AMM: AMES_0076(citE)
AMZ: B737_0077(citE)
AOI: AORI_0068(mcl)
AJA: AJAP_00370
AMQ: AMETH_0090(citE)
AMYC: CU254_39710
AMYB: BKN51_34375
AAB: A4R43_28985
AMYY: YIM_00345(mcl2)
AORI: SD37_41460
AACD: LWP59_00255
APRT: MUY14_36265
AROO: NQK81_25995
ATHM: L1857_02835
AMOG: QRX60_11095
ACYN: ORV05_32440
ACOR: LCL61_06605
AMYZ: HUW46_03775(mcl)
ANW: QP939_13235
ABAR: AMYBAR_000058
AMYE: MJQ72_41465
AMYS: CVV72_28625
ARHI: AB5I40_26275
KAL: KALB_2473
KUT: JJ691_99900(citE_1)
KBR: Q4V65_36590
KPHY: AOZ06_42935
ALO: CRK61727
PMAD: BAY61_00315
ACTU: Actkin_00833(mcl1)
AAUR: V5P93_001000
EKE: EK0264_04565
JCY: M6B22_02735
JAT: SAMN05892883_1193
BSOL: FSW04_11520
BALA: DSM104299_01895(mcl)
PBAJ: LRS13_14185
CWO: Cwoe_4213
PARN: NBH00_07200
PARQ: DSM112329_01759(mcl)
SBAE: DSM104329_01824(mcl) DSM104329_03745(mcl1)
TALU: JDY09_03170
AYM: YM304_14270
ATQ: GH723_12970
AQZ: KSP35_02830
ADAE: ACE2AJ_02805
IAM: HC251_13125
IMA: PO878_12810
DHI: LH044_19160
AHAI: AB8619_07495
RRS: RoseRS_4173
RCA: Rcas_0912
CAU: Caur_0174
CHL: Chy400_0187
CAG: Cagg_1328
 » show all
Reference
PMID:6094488
  Authors
Fulton GL, Nunn DN, Lidstrom ME
  Title
Molecular cloning of a malyl coenzyme A lyase gene from Pseudomonas sp. strain AM1, a facultative methylotroph.
  Journal
J Bacteriol 160:718-23 (1984)
DOI:10.1128/JB.160.2.718-723.1984
Reference
PMID:17259315
  Authors
Friedmann S, Alber BE, Fuchs G
  Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 189:2906-14 (2007)
DOI:10.1128/JB.01620-06
Reference
PMID:12374834
  Authors
Herter S, Busch A, Fuchs G
  Title
L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:5999-6006 (2002)
DOI:10.1128/JB.184.21.5999-6006.2002
  Sequence
[cau:Caur_0174]
LinkDB

KEGG   ORTHOLOGY: K19281
Entry
K19281                      KO                                     
Symbol
mcl
Name
beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map00660  C5-Branched dibasic acid metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00740  Methylaspartate cycle
Reaction
R00934  L-erythro-3-methylmalyl-CoA glyoxylate-lyase (propanoyl-CoA-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K19281  mcl; beta-methylmalyl-CoA/(S)-malyl-CoA lyase
   00660 C5-Branched dibasic acid metabolism
    K19281  mcl; beta-methylmalyl-CoA/(S)-malyl-CoA lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.24  malyl-CoA lyase
     K19281  mcl; beta-methylmalyl-CoA/(S)-malyl-CoA lyase
Other DBs
COG: COG2301
GO: 0050083
Genes
HALX: M0R89_18090
HAXY: NGM07_04620
SALI: L593_04660
HMA: rrnAC0690(citE1)
HSIN: KDQ40_06765
HHI: HAH_1341(citE1)
HHN: HISP_06865
HAB: SG26_14710
HTA: BVU17_06535
HALJ: G9465_08585
HMU: Hmuk_2984
HALZ: E5139_02195
HALL: LC1Hm_2321(mcl)
HAZP: GBQ70_02195
HRR: HZS55_19985
HPEL: HZS54_23485
HTU: Htur_1590
HSAL: JMJ58_00685
HAKZ: J0X25_14760
NMG: Nmag_3338(mcl)
HXA: Halxa_3159
NAT: NJ7G_3289
NPE: Natpe_2590
NVR: FEJ81_11880
NPL: FGF80_10920
NAY: HYG81_14690
HALY: HYG82_17310
HJT: DVR14_02935
HLO: J0X27_02295
NGE: Natgr_3384
HLC: CHINAEXTREME16075
HRU: Halru_1548
SAWL: NGM29_08770
HALV: NGM15_00935
NOU: Natoc_1509
HLR: HALLA_10835
NAJ: B1756_12025
NAG: AArcMg_4138
NAN: AArc1_5073
NARA: QQ977_05700(citE)
NBG: DV706_12980
NAS: GCU68_13725
HDA: BB347_04010
 » show all
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
  Sequence
[hma:rrnAC0690]
LinkDB

KEGG   ENZYME: 4.1.3.24
Entry
EC 4.1.3.24                 Enzyme                                 
Name
malyl-CoA lyase;
malyl-coenzyme A lyase;
(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase;
mclA (gene name);
mcl1 (gene name);
(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming);
L-malyl-CoA lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(S)-malyl-CoA glyoxylate-lyase (acetyl-CoA-forming)
Reaction(IUBMB)
(1) (S)-malyl-CoA = acetyl-CoA + glyoxylate [RN:R00473];
(2) (2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate [RN:R00934]
Reaction(KEGG)
R00473 R00934
Substrate
(S)-malyl-CoA [CPD:C04348];
(2R,3S)-2-methylmalyl-CoA [CPD:C06027]
Product
acetyl-CoA [CPD:C00024];
glyoxylate [CPD:C00048];
propanoyl-CoA [CPD:C00100]
Comment
The enzymes from Rhodobacter species catalyse a step in the ethylmalonyl-CoA pathway for acetate assimilation [3,5]. The enzyme from halophilic bacteria participate in the methylaspartate cycle and catalyse the reaction in the direction of malyl-CoA formation [6]. The enzyme from the bacterium Chloroflexus aurantiacus, which participates in the 3-hydroxypropanoate cycle for carbon assimilation, also has the activity of EC 4.1.3.25, (3S)-citramalyl-CoA lyase [2,4].
History
EC 4.1.3.24 created 1972, modified 2014
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00660  C5-Branched dibasic acid metabolism
ec00680  Methane metabolism
ec00720  Other carbon fixation pathways
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08691  malyl-CoA/(S)-citramalyl-CoA lyase
K19281  beta-methylmalyl-CoA/(S)-malyl-CoA lyase
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase
Genes
SACZ: AOT14_23590(mcl1)
NJO: ABXT42_11330
TFT: RI844_14200
LLG: 44548918_02118(mcl1)
MCA: MCA1739
METU: GNH96_10430
MMEO: OOT43_04275
MEEF: JWZ97_01880
MMT: Metme_2695
MDN: JT25_000155
MDH: AYM39_08385
MKO: MKLM6_1752
METL: U737_10260
MPAD: KEF85_03350
MELL: IVG45_03090
MRP: NM686_005355
MMOT: QZJ86_13270
MEEP: JWZ98_13280
MEEC: PL263_02075
MEUP: QC632_17140
MAH: MEALZ_3217(mclA1)
MBUR: EQU24_04630
MPSY: CEK71_18035
MMAI: sS8_2223
MSZE: MSZNOR_4946(mcl)
MMOB: F6R98_20170
MEIN: methR_P0949
MOZ: MoryE10_14040
MISZ: MishRS11D_11830
MESL: KKZ03_00260
MECH: Q9L42_001115
MLAU: ACEPPP_17245
MEIY: MIN45_P1852
MCAU: MIT9_P1453
BLEP: AL038_08990
THIP: N838_00825
TSN: W908_06430
CBLY: IPM89_03270 IPM89_04980
RPJ: N234_12055
CNC: CNE_BB1p10140(mcl)
CUPP: CTP10_R46940
BGP: BGL_2c16890
BPLA: bpln_2g17560
BPH: Bphy_5924
BFN: OI25_5771 OI25_7353
BCAI: K788_0001579
PHS: C2L64_21705
PTER: C2L65_26290
PTRO: G5S35_34875
PACS: FAZ98_23740
PSAA: QEN71_12140 QEN71_33975
PKF: RW095_22000
PPAI: E1956_20570
BBRO: BAU06_24990
BFZ: BAU07_25025
BOH: AKI39_23800
APES: FOC84_30065
HYN: F9K07_00140
CBAB: SMCB_1586
MPT: Mpe_A3254
METP: C1M51_05895
XYK: GT347_12545
NEU: NE1809
NET: Neut_0607
NIT: NAL212_0420
NII: Nit79A3_0103
NCO: AAW31_08285
NUR: ATY38_03755
NST: Nstercoris_01831
NMU: Nmul_A1078
NLC: EBAPG3_012580
NIZ: NNRS527_01104
METR: BSY238_253
NIM: W01_13780
NARC: NTG6680_0561(mcl)
URU: DSM104443_00577(mcl1_1)
FMY: HO273_03895
APP: CAP2UW1_2508
ACOG: HWD57_21460
MLO: mlr1323
MLN: A9174_19865
MOP: Mesop_3793
MAM: Mesau_03584
MAMO: A6B35_22110
MESP: C1M53_18670
MHUA: MCHK_2942
MJR: EB229_19625
MERD: EB233_16970
MESJ: MJ8_41070
MESU: LHFGNBLO_003310
MEWS: QAZ47_17235
MEWM: QAZ22_17135
AAK: AA2016_5786
AMIH: CO731_05425(mcl1)
AMIS: Amn_pa02870
ANJ: AMD1_PA0303(mcl)
AMIO: N7E70_029070
PHT: BLM14_27150
AMAX: ABWH92_15240
PLA: Plav_3098
PMOB: HG718_00970
KMN: HW532_00815
PECT: BN1012_Phect939
RBS: RHODOSMS8_01011(mcl)
RHI: NGR_c26230
SFH: SFHH103_02474(cite1)
SFD: USDA257_c22030(mcl1)
SAME: SAMCFNEI73_pC0656(mcl)
SINO: SS05631_b61290
ESJ: SJ05684_b48780
EAK: EKH55_4315
ENU: PYH37_000576
EGI: PZN02_002069
STEG: QA637_13125
EAW: ACEP9W_26615
BRC: BCCGELA001_06950
BRAD: BF49_2901
BOT: CIT37_18285
BRQ: CIT40_04560
BGQ: X265_31260
BSYM: CIT39_02900
BEL: BE61_53460(citE)
BDG: LPJ38_11055
BCAN: BcanWSM471_32370
BAUT: QA635_20755
BBRA: QA636_21300
BPAH: QA639_24260
BRAY: ML401_05185
BRAI: FJV43_23055
BLUP: AB3L03_23160
BGEP: ACP2YO_42720
BRAN: RX330_06190
TARD: RSO67_10350
RHZ: RHPLAN_35810
BVV: BHK69_20015
BVES: QO058_01020
BOP: AXW83_07320
BOS: BSY19_2901
BOI: BLM15_06415
BOF: FQV39_02445
BOW: NWE53_06435
BOSE: RMR04_14015
XAU: Xaut_3870
XDI: EZH22_19265
AZC: AZC_1227
LNE: FZC33_08695
AQI: J5J86_17915
PTAW: DW352_05470
MEA: Mex_1p1733(mcl) Mex_1p4295
MDI: METDI2485(mcl) METDI4906
MEX: Mext_1802 Mext_3917
MCH: Mchl_2138 Mchl_4285
MPO: Mpop_1754 Mpop_4390
MZA: B2G69_01480 B2G69_16670
METQ: MSPGM_18400 MSPGM_39090
MRD: Mrad2831_1650 Mrad2831_3663
MET: M446_6315 M446_6559
MNO: Mnod_7119 Mnod_7178
MOR: MOC_2043 MOC_4185
META: Y590_08615 Y590_19480
MAQU: Maq22A_c18385(citE) Maq22A_c19250(mcl)
MPHY: MCBMB27_01298 MCBMB27_03145
MEE: DA075_20140 DA075_27160
METD: C0214_10380 C0214_21595
METX: A3862_13170 A3862_22625
METS: DK389_15360 DK389_27325
METI: DK427_15555 DK427_17480
MMES: MMSR116_01155 MMSR116_21315
MTEA: DK419_14290 DK419_26925
MIND: mvi_25720 mvi_28860
MOG: MMB17_01150 MMB17_19730
MTAD: M6G65_09600 M6G65_20420
MECL: CLZ_08145 CLZ_19310
MFUJ: ABC766_00780 ABC766_21045
MENI: GU700_08145 GU700_19315
MENS: LOK46_08880 LOK46_19385
MSL: Msil_1719
MTUN: MTUNDRAET4_3402(mcl)
MLG: CWB41_04715
MEHY: MHY1_02393(mcl1)
MEDK: QEV83_04540
MPOL: RZS28_09790
BBAR: RHAL1_03825(mcl_2)
BBAI: CU048_08565
RHJ: HZY79_12425
CHEL: AL346_17425
CDQ: BOQ54_08925
HDN: Hden_1659 Hden_3153
HDT: HYPDE_30183 HYPDE_38943
HMC: HYPMC_1941 HYPMC_4395(mcl)
HNI: W911_10365 W911_15805
RVA: Rvan_1682
RLAC: QMO75_10135
FIL: BN1229_v1_1240(mcl) BN1229_v1_2672
FIY: BN1229_v1_1238(mcl) BN1229_v1_3242
MCG: GL4_3371
METG: HT051_02845
BVR: BVIR_1803
BLAG: BLTE_09690(mclA)
MSC: BN69_1171 BN69_2035
MBRY: B1812_00060 B1812_17545
MROS: EHO51_12185 EHO51_15075
MHEY: H2LOC_011805 H2LOC_014625
MPAR: F7D14_06360 F7D14_09175
MIWA: SS37A_01470 SS37A_07190
MESZ: LNB28_12755
MECI: RVU70_04160 RVU70_07975
MEMC: OGR47_00410 OGR47_02520
MTW: CQW49_12235 CQW49_16215
MECQ: MSC49_04610 MSC49_35030(mclA)
MSPR: MSP5_002852 MSP5_003434
CMET: K6K41_15080 K6K41_22170
PLEO: OHA_1_00681(mcl) OHA_1_00777(citE)
HDI: HDIA_2217(mcl1_1) HDIA_2467(mcl1_2)
PSIN: CAK95_23545
NOH: G5V57_13010
RBM: TEF_05695
BRN: D1F64_11585
PSF: PSE_3192
PPHR: APZ00_18415
LAP: ACP90_14745
LABR: CHH27_05755
LABP: FJ695_18280
LABT: FIU93_20440(mcl2)
LAGG: B0E33_26575
RPOP: K1718_15345
RAGG: QUB73_15510
SIW: GH266_00855
PHR: C6569_07730
PSTG: E8M01_31685
PAQT: E8L99_17855
MFLG: ABS361_07945 ABS361_08810
CCR: CC_2999
CCS: CCNA_03094
CAK: Caul_0731
CSE: Cseg_3490
CHQ: AQ619_14395
CMB: CSW64_04970
CFH: C1707_10190
CAUF: CSW63_06460
CAUB: AMEJIAPC_03357(mcl)
CIW: ABOZ73_13520
BALB: M8231_03195
TSV: DSM104635_00778(mcl1)
SIL: SPO1565 SPO3608(mclA)
SIT: TM1040_3165
RUA: D1823_18170 D1823_20490
RUT: FIU92_13270(mcl2) FIU92_19865(mcl3)
RCON: K3740_00765 K3740_20040
RUY: NOR97_12580 NOR97_17625
JAN: Jann_0471
RDE: RD1_1001(citE) RD1_1160(mclA) RD1_4242(mclA)
RLI: RLO149_c002070(mcl1) RLO149_c036850(mcl2)
RPON: G3256_17055
RFU: ROLI_001060(mcl1_1) ROLI_003020(mcl1_2)
DSH: Dshi_2490(citE1) Dshi_3050(citE2)
PGA: PGA1_c30490
PGL: PGA2_c28380
PGD: Gal_00369
PHP: PhaeoP97_00458
PPIC: PhaeoP14_02820
PHQ: D1820_09925
PHAE: N1037_03410
OAT: OAN307_c02220
OAR: OA238_c37200
OTM: OSB_28710(mcl1)
OCT: FTO60_14185
LMD: METH_02340 METH_18390
LEJ: ETW24_03080 ETW24_17910
LAQU: R2C4_14570 R2C4_19790
LEV: ETW23_00250 ETW23_17075
LCAE: K3721_02490 K3721_16185
LEIM: K3557_01895
CID: P73_3958 P73_4243
CMAR: IMCC12053_1300
CEH: CEW89_10920
CBAK: DA792_18755
MALG: MALG_03008
CON: TQ29_15155
YPAC: CEW88_13335
YAN: AYJ57_18165
TPRO: Ga0080559_TMP1541
PABY: Ga0080574_TMP2641
SUAM: BOO69_01375
SULZ: C1J03_02230
SULI: C1J05_00980
SULD: B5M07_15575
SPOT: G6548_03345
SMED: JNX03_11790
SINL: DSM14862_03056(mcl1)
SFAV: PL335_14640
SUAL: KDD17_13110
SDUB: R1T39_09450
SULB: IV89_003044
SULY: ABM428_03160
SULP: AADW22_03465
SUSQ: K3756_01945
SPSE: SULPSESMR1_03496(mcl1)
TOM: BWR18_14535
TATE: ACMHLQ_14570
TATY: ACERHN_05795 ACERHN_07845
RMM: ROSMUCSMR3_02149(mcl1) ROSMUCSMR3_03455(mcl1)
ROK: RAK1035_1037 RAK1035_2340
RID: RIdsm_02779(mcl1_1) RIdsm_05011(mcl1_2)
ROM: EI983_00710 EI983_08270
ROH: FIU89_19925(mcl2)
RPEL: N7U68_03480 N7U68_09695
RPHC: RZ517_03050
RRL: RZS32_005725
AHT: ANTHELSMS3_00280(mcl1)
SAGU: CDO87_13335 CDO87_15505
SSTL: ABFK29_04820 ABFK29_06700
SAGZ: QNI11_16165 QNI11_18100
THAA: CFI11_04070
OCD: FHY55_18010
ROT: FIV09_13785(mcl2)
RMH: LVO79_03465
MALU: KU6B_08980(mcl1) KU6B_14460 KU6B_40050
TGL: HFZ77_14905
TMD: KUV46_04605
HAT: RC74_08495
PALX: GQA70_15345 GQA70_23220
LSAL: KBK07_02450
LALG: LentiSH36_02533
TRY: QF118_05630
MARU: FIU81_14310(mcl3)
RMAI: MACH21_17090 MACH21_30420(mcl1)
RED: roselon_01454 roselon_02260
ASCA: QEZ52_04645 QEZ52_19035
ACLD: ACIRQ6_01125 ACIRQ6_04170
SEOH: ACMUJL_09380
MATG: ACMVPR_21485
BOO: E2K80_13755
RPOH: ABWH90_15235
RSP: RSP_1771
RSH: Rsph17029_0417
RSQ: Rsph17025_2481
RSK: RSKD131_0071
CAZT: LV780_11350
RBL: B6K69_09750
FYT: QF092_14495 QF092_14520
PDE: Pden_0799
PAMI: JCM7686_2763 JCM7686_3168
PYE: A6J80_07835
PCON: B0A89_03920
PZH: CX676_04845 CX676_15565
PARO: CUV01_10870
PAMN: JCM7685_2683 pAMV1p0135(mcl) pAMV3p0611(mcal)
PMUT: DPM13_05940
PARR: EOJ32_05825
PAAK: FIU66_06855
PKD: F8A10_08855
PPAN: ESD82_17880
PLIA: E4191_12750
PSAN: HGN31_05715
PMAU: CP157_02398(mcl1)
PMEH: JWJ88_07325
PSEW: JHW44_10240
PSAP: JHX88_01975 JHX88_17895 JHX88_20315
PFIS: JHX87_05090
PAEX: JHW48_04005
PSTL: JHW45_12805
PALP: JHW40_15150 JHW40_18530
PVER: E3U25_16380
PFEO: E3U26_05025
PHOI: ACLISE_05020
PTP: RCA23_c05980(mclA)
RSU: NHU_02809
RHM: B5V46_11900
RHC: RGUI_3145
RHOV: ACK8CO_16750
RMB: K529_018960
TSCO: R1T40_18500
DAA: AKL17_3598
DON: BSK21_02035
MALC: QQG91_12775
RBZ: B9057_11515
THW: BMG03_17130
TEC: AKL02_016915
TLB: RPE78_05390
LVS: LOKVESSMR4R_02838(mcl1)
YAG: AABB28_11655
YRH: AABB31_07960
GEH: HYN69_16130 HYN69_16155
GFU: KM031_08955 KM031_11830
TAW: EI545_00080 EI545_09215
SALO: EF888_18940
SEDI: EBB79_18450 EBB79_24155
PPSO: QPJ95_09700
PSEB: EOK75_09010
PPRU: FDP22_10475
PAED: G5B38_01665 G5B38_14245
PAMO: BAR1_02110
POZ: I0K15_04605
MON: G8E03_06220
PALW: PSAL_024060(mcl1)
PSHQ: F3W81_17090
PGV: SL003B_2239
CACT: HZ995_04375
THAS: C6Y53_06905
HDH: G5B40_08975
CMAG: CBW24_04620
GCE: KYE46_00395
GYJ: AADW23_05035
NSM: JO391_00315 JO391_12675
ACRO: K3J57_12105
AALK: LGT41_0000610
AMYL: QBD29_03580 QBD29_08415
AMAQ: GO499_03725 GO499_18685
RHOC: QTA57_06920
PBAE: P8S53_01310
RBG: BG454_02060 BG454_05615
BOSG: GKR98_07030 GKR98_16035
MANH: LA6_000568(mcl1_1) LA6_004253(mcl1_2)
FAQ: G5B39_01155
SINR: O5O51_01720
RCP: RCAP_rcc03164(citE2)
RHP: LPB142_02980
RBX: I3V23_08345
HNE: HNE_0078(mclA)
HBA: Hbal_0778
CBOT: ATE48_06115
HBC: AEM38_14745
RDI: CMV14_07525
TFV: IDJ81_06845
GBE: GbCGDNIH1_0055
GBH: GbCGDNIH2_0055
GBC: GbCGDNIH3_0055
GBS: GbCGDNIH4_0055
RAP: RHOA_5783(mcl)
SKT: IGS68_03250
SMUC: JL100_003365
SROE: JL101_003125
RRU: Rru_A0217
RRF: F11_01090
RPM: RSPPHO_00107
MGY: MGMSRv2__3257
MGRY: MSR1_29830(mcl1)
MAGX: XM1_1373
MAGN: WV31_14965
FER: FNB15_09270
DEX: HWD60_03940
DVN: HQ394_01635
AALU: ABWI00_18075
MAG: amb3977
HTQ: FRZ44_44960
HADH: FRZ61_42590 FRZ61_45950
TXI: TH3_02680
THAC: CSC3H3_02980
TII: DY252_18625
THAI: IT893_02795
TLU: R1T41_11295
TTB: MACH01_05680
THGO: M9H61_10100
THAD: IT971_02425
MAGQ: MGMAQ_0659
VSU: P3M64_12025
TMO: TMO_0350(citE)
ECOG: FIV45_00610
SNEA: NBZ79_03900
MINW: ACMVY4_00965
DEO: CAY53_08885
DHG: EYB58_06030
DML: Dmul_11170
DAX: FDQ92_06220
TRO: trd_0455
STI: Sthe_2064
GGR: HKW67_06650
EUZ: DVS28_a0494
RANT: RHODO2019_08890
STRE: GZL_04819
SLD: T261_4311
SLC: SL103_17980
SNR: SNOUR_21930
SALU: DC74_4078
SALL: SAZ_21750
SGV: B1H19_20540
STRO: STRMOE7_00865
SPLA: CP981_36035
SDW: K7C20_34930
SAUH: SU9_032330
SANU: K7396_01540
SINE: KI385_01365
SNIG: HEK616_29400(citE_1)
STUD: STRTU_000263
SYUN: MOV08_22140
SRPA: HEP86_38235
SSIR: WAB15_00285
SEXP: SLV14_000560
STID: G7Z12_02250
SCT: SCAT_4364
SCY: SCATT_43520
ABRY: NYE86_27165
AGLA: OIE69_13955
AREV: RVR_7447
ICA: Intca_2587
ARS: ADJ73_02415
JTE: ASJ30_03525
JLI: EXU32_11365
JME: EEW87_011295
JAY: H7A72_03525
JCR: O9K63_16190
JAI: V1351_03505
JTR: V3C34_06460
TEH: GKE56_09880
PEI: H9L10_09525
TED: U5C87_20770
KNO: V6K52_05950
AUS: IPK37_13860
NCA: Noca_4393
NDK: I601_0974(mcl1)
NOY: EXE57_13540
NOI: FCL41_01330
NOO: FE634_19600
NSN: EXE58_09730
NBE: Back2_15770(citE_1)
NANO: G5V58_24335
NARO: CFH99_21490
NPI: G7071_06375
NAQU: ENKNEFLB_04247(mcl)
NRO: K8W59_01590
NOQ: LN652_11495
NCQ: K6T13_15930
NPC: KUV85_11405
NMAR: HPC71_19405
NFC: KG111_16475
NRN: SHK17_19420
NBI: SHK19_19515
NOF: MF408_11790
NOCR: OSR43_19690
NOCW: ABFU82_16405
NOCA: ncot_09650
NOCL: KM427_23805
NOCD: QJ852_03600
NOCQ: QI633_23365
NLB: P5P86_00340
PSIM: KR76_23920
AER: AERYTH_05645
AEZ: C3E78_04975
AEB: C6I20_10755
AEF: GEV26_04810
ASEZ: H9L21_04165
ADB: NP095_04110
AWN: NQV15_05020
NBT: KLP28_00560
FRA: Francci3_2805
FSY: FsymDg_0509
AMD: AMED_0079(citE)
AMN: RAM_00395
AMM: AMES_0076(citE)
AMZ: B737_0077(citE)
AOI: AORI_0068(mcl)
AJA: AJAP_00370
AMQ: AMETH_0090(citE)
AMYC: CU254_39710
AMYB: BKN51_34375
AAB: A4R43_28985
AMYY: YIM_00345(mcl2)
AORI: SD37_41460
AACD: LWP59_00255
APRT: MUY14_36265
AROO: NQK81_25995
ATHM: L1857_02835
AMOG: QRX60_11095
ACYN: ORV05_32440
ACOR: LCL61_06605
AMYZ: HUW46_03775(mcl)
ANW: QP939_13235
ABAR: AMYBAR_000058
AMYE: MJQ72_41465
AMYS: CVV72_28625
ARHI: AB5I40_26275
KAL: KALB_2473
KUT: JJ691_99900(citE_1)
KBR: Q4V65_36590
KPHY: AOZ06_42935
ALO: CRK61727
PMAD: BAY61_00315
ACTU: Actkin_00833(mcl1)
AAUR: V5P93_001000
EKE: EK0264_04565
JCY: M6B22_02735
JAT: SAMN05892883_1193
BSOL: FSW04_11520
BALA: DSM104299_01895(mcl)
PBAJ: LRS13_14185
CWO: Cwoe_4213
PARN: NBH00_07200
PARQ: DSM112329_01759(mcl)
SBAE: DSM104329_01824(mcl) DSM104329_03745(mcl1)
TALU: JDY09_03170
AYM: YM304_14270
ATQ: GH723_12970
AQZ: KSP35_02830
ADAE: ACE2AJ_02805
IAM: HC251_13125
IMA: PO878_12810
DHI: LH044_19160
AHAI: AB8619_07495
RRS: RoseRS_4173
RCA: Rcas_0912
CAU: Caur_0174
CHL: Chy400_0187
CAG: Cagg_1328
HDL: HALDL1_15310
HHB: Hhub_3380(aceB)
HNO: LT974_13710
HLU: LT972_01030
HANX: ABSL23_02875(aceB)
HSU: HLASF_2007(aceB)
HSF: HLASA_1993(aceB)
HAHS: HSRCO_2658(mcl2)
SALR: FQU85_05715
HDO: MUK72_12480
HALX: M0R89_18090 M0R89_21245
HAXY: NGM07_04620
SALI: L593_04660
SAIM: K0C01_12450
HMA: rrnAC0690(citE1) rrnAC1965(aceB)
HSIN: KDQ40_00995 KDQ40_06765
HHI: HAH_1341(citE1) HAH_2476(aceB)
HHN: HISP_06865 HISP_12605
HAB: SG26_04910 SG26_14710
HTA: BVU17_06535 BVU17_12045
HALJ: G9465_08585
HMU: Hmuk_2984
HALZ: E5139_02195
HALL: LC1Hm_2321(mcl)
HAZP: GBQ70_02195
HALI: BV210_07645
HRR: HZS55_19985
HPEL: HZS54_23485
SSAI: N0B31_16615
HAAD: MW046_18245
NPH: NP_4430A(aceB)
NMO: Nmlp_2357(aceB)
NHO: HWV23_13655
NSAL: HWV07_07395
HWA: HQ_1720A(aceB)
HWC: Hqrw_1842(aceB)
HVO: HVO_1983(aceB1) HVO_B0200(aceB2)
HALE: G3A49_07690 G3A49_12900
HLN: SVXHx_2637(aceb) SVXHx_3054(aceb)
HME: HFX_2078(aceB)
HGI: ABY42_09665 ABY42_16600
HLS: KU306_02605
HBO: Hbor_30530
HLM: DV707_13970
SRUB: C2R22_21540
HALG: HUG10_03375
HALU: HUG12_13540
HMP: K6T50_01580
HRE: K6T36_01385
HRM: K6T25_15035
HACB: Hbl1158_08495
HDF: AArcSl_1031(aceB)
HAAA: AArcCO_0901(mcl)
HTU: Htur_1590 Htur_4695
HSAL: JMJ58_00685 JMJ58_24075
HAKZ: J0X25_14760
NMG: Nmag_3338(mcl) Nmag_3363(aceB)
HXA: Halxa_3159
NAT: NJ7G_3289
NPE: Natpe_2590
NVR: FEJ81_11880
NPL: FGF80_10920
NAY: HYG81_14690
HALY: HYG82_17310
HJT: DVR14_02935
HLO: J0X27_02295
NGE: Natgr_3384
HLC: CHINAEXTREME16075
HRU: Halru_1548
SAWL: NGM29_08770
HALV: NGM15_00935
NOU: Natoc_1509 Natoc_4308
HLR: HALLA_10835
NAJ: B1756_06555 B1756_12025
NAG: AArcMg_4138
NAN: AArc1_5073
NARA: QQ977_05700(citE)
NBG: DV706_12980 DV706_17910
NAS: GCU68_13725 GCU68_18820
HDA: BB347_04010
 » show all
Reference
1  [PMID:14285256]
  Authors
TUBOI S, KIKUCHI G.
  Title
ENZYMIC CLEAVAGE OF MALYTL-COENZYME A INTO ACETYL-COENZYME A AND GLYOXYLIC ACID.
  Journal
Biochim Biophys Acta 96:148-53 (1965)
DOI:10.1016/0005-2787(65)90618-0
Reference
2  [PMID:12374834]
  Authors
Herter S, Busch A, Fuchs G
  Title
L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:5999-6006 (2002)
DOI:10.1128/JB.184.21.5999-6006.2002
  Sequence
[cau:Caur_0174]
Reference
3  [PMID:15687206]
  Authors
Meister M, Saum S, Alber BE, Fuchs G
  Title
L-malyl-coenzyme A/beta-methylmalyl-coenzyme A lyase is involved in acetate assimilation of the isocitrate lyase-negative bacterium Rhodobacter capsulatus.
  Journal
J Bacteriol 187:1415-25 (2005)
DOI:10.1128/JB.187.4.1415-1425.2005
  Sequence
[rcp:RCAP_rcc03164]
Reference
4  [PMID:17259315]
  Authors
Friedmann S, Alber BE, Fuchs G
  Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 189:2906-14 (2007)
DOI:10.1128/JB.01620-06
Reference
5  [PMID:20047909]
  Authors
Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE
  Title
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase.
  Journal
J Bacteriol 192:1249-58 (2010)
DOI:10.1128/JB.01267-09
  Sequence
[rsp:RSP_1771]
Reference
6  [PMID:27920298]
  Authors
Borjian F, Han J, Hou J, Xiang H, Zarzycki J, Berg IA.
  Title
Malate Synthase and beta-Methylmalyl Coenzyme A Lyase Reactions in the Methylaspartate Cycle in Haloarcula hispanica.
  Journal
J Bacteriol 199:e00657-16 (2017)
DOI:10.1128/JB.00657-16
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.24
IUBMB Enzyme Nomenclature: 4.1.3.24
ExPASy - ENZYME nomenclature database: 4.1.3.24
BRENDA, the Enzyme Database: 4.1.3.24
CAS: 37290-67-8
LinkDB

KEGG   REACTION: R00934
Entry
R00934                      Reaction                               
Name
L-erythro-3-methylmalyl-CoA glyoxylate-lyase (propanoyl-CoA-forming)
Definition
Propanoyl-CoA + Glyoxylate <=> L-erythro-3-Methylmalyl-CoA
Equation
C00100 + C00048 <=> C06027
Reaction class
RC00311  C00048_C06027
RC00407  C00100_C06027
Enzyme
4.1.3.24
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00660  C5-Branched dibasic acid metabolism
rn00720  Other carbon fixation pathways
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00373  Ethylmalonyl pathway
M00376  3-Hydroxypropionate bi-cycle
M00740  Methylaspartate cycle
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.24
     R00934  Propanoyl-CoA + Glyoxylate <=> L-erythro-3-Methylmalyl-CoA
Overall reaction [br08210.html]
 Carbon fixation
  R00934
Orthology
K08691  malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
K19281  beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24]
Reference
1  [PMID:12374834]
  Authors
Herter S, Busch A, Fuchs G
  Title
L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:5999-6006 (2002)
DOI:10.1128/JB.184.21.5999-6006.2002
Other DBs
RHEA: 38262
LinkDB

DBGET integrated database retrieval system