KEGG   ORTHOLOGY: K08691
Entry
K08691                      KO                                     
Symbol
mcl
Name
malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map00660  C5-Branched dibasic acid metabolism
map00680  Methane metabolism
map00720  Carbon fixation pathways in prokaryotes
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00346  Formaldehyde assimilation, serine pathway
M00373  Ethylmalonyl pathway
M00376  3-Hydroxypropionate bi-cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
   00660 C5-Branched dibasic acid metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
  09102 Energy metabolism
   00720 Carbon fixation pathways in prokaryotes
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
   00680 Methane metabolism
    K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.24  malyl-CoA lyase
     K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
    4.1.3.25  (S)-citramalyl-CoA lyase
     K08691  mcl; malyl-CoA/(S)-citramalyl-CoA lyase
Other DBs
RN: R00237 R00473 R00934
COG: COG2301
GO: 0050083 0047777
Genes
SACZ: AOT14_23590(mcl1)
LLG: 44548918_02118(mcl1)
MCA: MCA1739
METU: GNH96_10430
MMT: Metme_2695
MDN: JT25_000155
MDH: AYM39_08385
MKO: MKLM6_1752
METL: U737_10260
MPAD: KEF85_03350
MAH: MEALZ_3217(mclA1)
MMAI: sS8_2223
THIP: N838_00825
CNC: CNE_BB1p10140(mcl)
BPH: Bphy_5924
CBAB: SMCB_1586
MPT: Mpe_A3254
NET: Neut_0607
METR: BSY238_253
NIM: W01_13780
NARC: NTG6680_0561(mcl)
URU: DSM104443_00577(mcl1_1)
MHUA: MCHK_2942
AMIH: CO731_05425(mcl1)
PLA: Plav_3098
RBS: RHODOSMS8_01011(mcl)
SFH: SFHH103_02474(cite1)
SFD: USDA257_c22030(mcl1)
SAME: SAMCFNEI73_pC0656(mcl)
BRAD: BF49_2901
BEL: BE61_53460(citE)
XAU: Xaut_3870
AZC: AZC_1227
MDI: METDI2485(mcl) METDI4906
MAQU: Maq22A_c18385(citE) Maq22A_c19250(mcl)
MSL: Msil_1719
MTUN: MTUNDRAET4_3402(mcl)
BBAR: RHAL1_03825(mcl_2)
RVA: Rvan_1682
MCG: GL4_3371
BVR: BVIR_1803
BLAG: BLTE_09690(mclA)
PLEO: OHA_1_00681(mcl) OHA_1_00777(citE)
HDI: HDIA_2217(mcl1_1) HDIA_2467(mcl1_2)
RBM: TEF_05695
PSF: PSE_3192
LABT: FIU93_20440(mcl2)
CCR: CC_2999
CAK: Caul_0731
CSE: Cseg_3490
TSV: DSM104635_00778(mcl1)
SIL: SPO1565 SPO3608(mclA)
RUT: FIU92_13270(mcl2) FIU92_19865(mcl3)
JAN: Jann_0471
RDE: RD1_1001(citE) RD1_1160(mclA) RD1_4242(mclA)
RLI: RLO149_c002070(mcl1) RLO149_c036850(mcl2)
DSH: Dshi_3050(citE2)
PGD: Gal_00369
OTM: OSB_28710(mcl1)
MALG: MALG_03008
SINL: DSM14862_03056(mcl1)
SPSE: SULPSESMR1_03496(mcl1)
RID: RIdsm_02779(mcl1_1) RIdsm_05011(mcl1_2)
ROH: FIU89_19925(mcl2)
AHT: ANTHELSMS3_00280(mcl1)
MARU: FIU81_14310(mcl3)
ROT: FIV09_13785(mcl2)
RSP: RSP_1771
RCP: RCAP_rcc03164(citE2)
PDE: Pden_0799
PMAU: CP157_02398(mcl1)
PTP: RCA23_c05980(mclA)
RSU: NHU_02809
RHC: RGUI_3145
LVS: LOKVESSMR4R_02838(mcl1)
PAMO: BAR1_02110
PALW: PSAL_024060(mcl1)
HNE: HNE_0078(mclA)
HBA: Hbal_0778
RAP: RHOA_5783(mcl)
RRU: Rru_A0217
RRF: F11_01090
MAG: amb3977
MGRY: MSR1_29830(mcl1)
MAGX: XM1_1373
MAGN: WV31_14965
TMO: TMO_0350(citE)
TXI: TH3_02680
MAGQ: MGMAQ_0659
STRE: GZL_04819
SLD: T261_4311
SALU: DC74_4078
SALL: SAZ_21750
SAUH: SU9_032330
SCT: SCAT_4364
NCA: Noca_4393
NDK: I601_0974(mcl1)
NBE: Back2_15770(citE_1)
NAQU: ENKNEFLB_04247(mcl)
PSIM: KR76_23920
AMD: AMED_0079(citE)
AMN: RAM_00395
AMM: AMES_0076(citE)
AMZ: B737_0077(citE)
AOI: AORI_0068(mcl)
AMQ: AMETH_0090(citE)
AMYY: YIM_00345(mcl2)
AORI: SD37_41460
KAL: KALB_2473
ALO: CRK61727
ACTU: Actkin_00833(mcl1)
CWO: Cwoe_4213
RCA: Rcas_0912
CAU: Caur_0174
CAG: Cagg_1328
TRO: trd_0455
STI: Sthe_2064
 » show all
Reference
PMID:6094488
  Authors
Fulton GL, Nunn DN, Lidstrom ME
  Title
Molecular cloning of a malyl coenzyme A lyase gene from Pseudomonas sp. strain AM1, a facultative methylotroph.
  Journal
J Bacteriol 160:718-23 (1984)
DOI:10.1128/JB.160.2.718-723.1984
Reference
  Authors
Friedmann S, Alber BE, Fuchs G
  Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 189:2906-14 (2007)
DOI:10.1128/JB.01620-06
Reference
  Authors
Herter S, Busch A, Fuchs G
  Title
L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:5999-6006 (2002)
DOI:10.1128/JB.184.21.5999-6006.2002
  Sequence
[cau:Caur_0174]
LinkDB

KEGG   ORTHOLOGY: K19282
Entry
K19282                      KO                                     
Symbol
aceB
Name
bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30]
Pathway
map00630  Glyoxylate and dicarboxylate metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01200  Carbon metabolism
Module
M00012  Glyoxylate cycle
M00740  Methylaspartate cycle
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K19282  aceB; bifunctional (S)-malyl-CoA lyase/thioesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.30  (3S)-malyl-CoA thioesterase
     K19282  aceB; bifunctional (S)-malyl-CoA lyase/thioesterase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.24  malyl-CoA lyase
     K19282  aceB; bifunctional (S)-malyl-CoA lyase/thioesterase
Other DBs
RN: R00473 R10612
GO: 0050083
Genes
HDL: HALDL1_15310
HHB: Hhub_3380(aceB)
HNO: LT974_13710
HLU: LT972_01030
HSU: HLASF_2007(aceB)
HSF: HLASA_1993(aceB)
SALR: FQU85_05715
HAAD: MW046_18245
HALX: M0R89_21245
SAIM: K0C01_12450
HMA: rrnAC1965(aceB)
HHI: HAH_2476(aceB)
NPH: NP_4430A(aceB)
NMO: Nmlp_2357(aceB)
HWA: HQ_1720A(aceB)
HWC: Hqrw_1842(aceB)
HVO: HVO_1983(aceB1) HVO_B0200(aceB2)
HME: HFX_2078(aceB)
HDF: AArcSl_1031(aceB)
HTU: Htur_4695
NMG: Nmag_3363(aceB)
 » show all
Reference
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
  Sequence
[hma:rrnAC1965]
LinkDB

KEGG   ENZYME: 4.1.3.24
Entry
EC 4.1.3.24                 Enzyme                                 
Name
malyl-CoA lyase;
malyl-coenzyme A lyase;
(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase;
mclA (gene name);
mcl1 (gene name);
(3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase (acetyl-CoA-forming);
L-malyl-CoA lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(S)-malyl-CoA glyoxylate-lyase (acetyl-CoA-forming)
Reaction(IUBMB)
(1) (S)-malyl-CoA = acetyl-CoA + glyoxylate [RN:R00473];
(2) (2R,3S)-2-methylmalyl-CoA = propanoyl-CoA + glyoxylate [RN:R00934]
Reaction(KEGG)
R00473 R00934
Substrate
(S)-malyl-CoA [CPD:C04348];
(2R,3S)-2-methylmalyl-CoA [CPD:C06027]
Product
acetyl-CoA [CPD:C00024];
glyoxylate [CPD:C00048];
propanoyl-CoA [CPD:C00100]
Comment
The enzymes from Rhodobacter species catalyse a step in the ethylmalonyl-CoA pathway for acetate assimilation [3,5]. The enzyme from halophilic bacteria participate in the methylaspartate cycle and catalyse the reaction in the direction of malyl-CoA formation [6]. The enzyme from the bacterium Chloroflexus aurantiacus, which participates in the 3-hydroxypropanoate cycle for carbon assimilation, also has the activity of EC 4.1.3.25, (3S)-citramalyl-CoA lyase [2,4].
History
EC 4.1.3.24 created 1972, modified 2014
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00660  C5-Branched dibasic acid metabolism
ec00680  Methane metabolism
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08691  malyl-CoA/(S)-citramalyl-CoA lyase
K19281  beta-methylmalyl-CoA/(S)-malyl-CoA lyase
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase
Genes
SACZAOT14_23590(mcl1)
LLG44548918_02118(mcl1)
MCAMCA1739
METUGNH96_10430
MMTMetme_2695
MDNJT25_000155
MDHAYM39_08385
MKOMKLM6_1752
METLU737_10260
MPADKEF85_03350
MELLIVG45_03090
MAHMEALZ_3217(mclA1)
MBUREQU24_04630
MPSYCEK71_18035
MMAIsS8_2223
MMOBF6R98_20170
MEINmethR_P0949
MOZMoryE10_14040
MISZMishRS11D_11830
MESLKKZ03_00260
BLEPAL038_08990
THIPN838_00825
TSNW908_06430
RPJN234_12055
CNCCNE_BB1p10140(mcl)
BGPBGL_2c16890
BPLAbpln_2g17560
BPHBphy_5924
BFNOI25_5771 OI25_7353
BCAIK788_0001579
PHSC2L64_21705
PTERC2L65_26290
PTROG5S35_34875
PACSFAZ98_23740
BBROBAU06_24990
BFZBAU07_25025
BOHAKI39_23800
HYNF9K07_00140
CBABSMCB_1586
MPTMpe_A3254
METPC1M51_05895
XYKGT347_12545
NETNeut_0607
NITNAL212_0420
NIINit79A3_0103
NCOAAW31_08285
NURATY38_03755
NSTNstercoris_01831
NLCEBAPG3_012580
METRBSY238_253
NIMW01_13780
NARCNTG6680_0561(mcl)
URUDSM104443_00577(mcl1_1)
FMYHO273_03895
APPCAP2UW1_2508
DEOCAY53_08885
DMLDmul_11170
DAXFDQ92_06220
MLNA9174_19865
MOPMesop_3793
MAMMesau_03584
MAMOA6B35_22110
MESPC1M53_18670
MHUAMCHK_2942
MJREB229_19625
MERDEB233_16970
AAKAA2016_5786
AMIHCO731_05425(mcl1)
PHTBLM14_27150
PLAPlav_3098
PMOBHG718_00970
KMNHW532_00815
RBSRHODOSMS8_01011(mcl)
RHINGR_c26230
SFHSFHH103_02474(cite1)
SFDUSDA257_c22030(mcl1)
SAMESAMCFNEI73_pC0656(mcl)
SINOSS05631_b61290
ESJSJ05684_b48780
EAKEKH55_4315
BRCBCCGELA001_06950
BRADBF49_2901
BOTCIT37_18285
BRQCIT40_04560
BGQX265_31260
BSYMCIT39_02900
BELBE61_53460(citE)
BDGLPJ38_11055
BOPAXW83_07320
BOSBSY19_2901
BVVBHK69_20015
BOIBLM15_06415
BOFFQV39_02445
XAUXaut_3870
XDIEZH22_19265
AZCAZC_1227
LNEFZC33_08695
MEAMex_1p1733(mcl) Mex_1p4295
MDIMETDI2485(mcl) METDI4906
MEXMext_1802 Mext_3917
MCHMchl_2138 Mchl_4285
MPOMpop_1754 Mpop_4390
MZAB2G69_01480 B2G69_16670
MRDMrad2831_1650 Mrad2831_3663
METM446_6315 M446_6559
MNOMnod_7119 Mnod_7178
MORMOC_2043 MOC_4185
METAY590_08615 Y590_19480
MAQUMaq22A_c18385(citE) Maq22A_c19250(mcl)
MPHYMCBMB27_01298 MCBMB27_03145
MEEDA075_20140 DA075_27160
METDC0214_10380 C0214_21595
METXA3862_13170 A3862_22625
METSDK389_15360 DK389_27325
METIDK427_15555 DK427_17480
MMESMMSR116_01155 MMSR116_21315
MTEADK419_14290 DK419_26925
MINDmvi_25720 mvi_28860
MOGMMB17_01150 MMB17_19730
MTADM6G65_09600 M6G65_20420
MSLMsil_1719
MTUNMTUNDRAET4_3402(mcl)
MLGCWB41_04715
RHJHZY79_12425
BBARRHAL1_03825(mcl_2)
CHELAL346_17425
CDQBOQ54_08925
HDNHden_1659 Hden_3153
HDTHYPDE_30183 HYPDE_38943
HMCHYPMC_1941 HYPMC_4395(mcl)
HNIW911_10365 W911_15805
RVARvan_1682
FILBN1229_v1_1240(mcl) BN1229_v1_2672
FIYBN1229_v1_1238(mcl) BN1229_v1_3242
RHZRHPLAN_35810
MCGGL4_3371
METGHT051_02845
BVRBVIR_1803
BLAGBLTE_09690(mclA)
MSCBN69_1171 BN69_2035
MBRYB1812_00060 B1812_17545
MROSEHO51_12185 EHO51_15075
MHEYH2LOC_011805 H2LOC_014625
MPARF7D14_06360 F7D14_09175
MTWCQW49_12235 CQW49_16215
CMETK6K41_15080 K6K41_22170
PLEOOHA_1_00681(mcl) OHA_1_00777(citE)
HDIHDIA_2217(mcl1_1) HDIA_2467(mcl1_2)
BRND1F64_11585
PSINCAK95_23545
NOHG5V57_13010
RBMTEF_05695
PSFPSE_3192
PPHRAPZ00_18415
LAPACP90_14745
LABRCHH27_05755
LABPFJ695_18280
LABTFIU93_20440(mcl2)
LAGGB0E33_26575
SIWGH266_00855
PHRC6569_07730
PSTGE8M01_31685
CCRCC_2999
CCSCCNA_03094
CAKCaul_0731
CSECseg_3490
CHQAQ619_14395
CMBCSW64_04970
CFHC1707_10190
CAUFCSW63_06460
BALBM8231_03195
TSVDSM104635_00778(mcl1)
SILSPO1565 SPO3608(mclA)
SITTM1040_3165
RUAD1823_18170 D1823_20490
RUTFIU92_13270(mcl2) FIU92_19865(mcl3)
RCONK3740_00765 K3740_20040
JANJann_0471
RDERD1_1001(citE) RD1_1160(mclA) RD1_4242(mclA)
RLIRLO149_c002070(mcl1) RLO149_c036850(mcl2)
RPONG3256_17055
DSHDshi_3050(citE2)
PGAPGA1_c30490
PGLPGA2_c28380
PGDGal_00369
PHPPhaeoP97_00458
PPICPhaeoP14_02820
PHQD1820_09925
OATOAN307_c02220
OAROA238_c37200
OTMOSB_28710(mcl1)
OCTFTO60_14185
LMDMETH_02340 METH_18390
LEJETW24_03080 ETW24_17910
LAQUR2C4_14570 R2C4_19790
LEVETW23_00250 ETW23_17075
LCAEK3721_02490 K3721_16185
REDroselon_01454 roselon_02260
CIDP73_3958 P73_4243
CMARIMCC12053_1300
CEHCEW89_10920
MALGMALG_03008
CONTQ29_15155
YPACCEW88_13335
YANAYJ57_18165
TPROGa0080559_TMP1541
PABYGa0080574_TMP2641
SUAMBOO69_01375
SULZC1J03_02230
SULIC1J05_00980
SULDB5M07_15575
SPOTG6548_03345
SMEDJNX03_11790
SINLDSM14862_03056(mcl1)
SPSESULPSESMR1_03496(mcl1)
TOMBWR18_14535
RMMROSMUCSMR3_02149(mcl1) ROSMUCSMR3_03455(mcl1)
ROKRAK1035_1037 RAK1035_2340
RIDRIdsm_02779(mcl1_1) RIdsm_05011(mcl1_2)
ROMEI983_00710 EI983_08270
ROHFIU89_19925(mcl2)
AHTANTHELSMS3_00280(mcl1)
SAGUCDO87_13335 CDO87_15505
THAACFI11_04070
OCDFHY55_18010
MARUFIU81_14310(mcl3)
ROTFIV09_13785(mcl2)
RMHLVO79_03465
MALUKU6B_08980(mcl1) KU6B_14460 KU6B_40050
TGLHFZ77_14905
TMDKUV46_04605
HATRC74_08495
PALXGQA70_15345 GQA70_23220
LSALKBK07_02450
RSPRSP_1771
RSHRsph17029_0417
RSQRsph17025_2481
RSKRSKD131_0071
CAZTLV780_11350
RCPRCAP_rcc03164(citE2)
RHPLPB142_02980
RBLB6K69_09750
PDEPden_0799
PAMIJCM7686_2763 JCM7686_3168
PYEA6J80_07835
PCONB0A89_03920
PZHCX676_04845 CX676_15565
PAROCUV01_10870
PAMNJCM7685_2683 pAMV1p0135(mcl) pAMV3p0611(mcal)
PMUTDPM13_05940
PARREOJ32_05825
PAAKFIU66_06855
PKDF8A10_08855
PPANESD82_17880
PLIAE4191_12750
PSANHGN31_05715
PMAUCP157_02398(mcl1)
PMEHJWJ88_07325
PTPRCA23_c05980(mclA)
RSUNHU_02809
RHMB5V46_11900
RHCRGUI_3145
RMBK529_018960
DAAAKL17_3598
DONBSK21_02035
RBZB9057_11515
THWBMG03_17130
TECAKL02_016915
LVSLOKVESSMR4R_02838(mcl1)
RBGBG454_02060 BG454_05615
GEHHYN69_16130 HYN69_16155
GFUKM031_08955 KM031_11830
TAWEI545_00080 EI545_09215
SALOEF888_18940
SEDIEBB79_18450 EBB79_24155
BOOE2K80_13755
PSEBEOK75_09010
PPRUFDP22_10475
PAEDG5B38_01665 G5B38_14245
MONG8E03_06220
PAMOBAR1_02110
PSHQF3W81_17090
POZI0K15_04605
PALWPSAL_024060(mcl1)
PGVSL003B_2239
CACTHZ995_04375
THASC6Y53_06905
HDHG5B40_08975
CMAGCBW24_04620
GCEKYE46_00395
NSMJO391_00315 JO391_12675
ACROK3J57_12105
SINRO5O51_01720
FAQG5B39_01155
AMAQGO499_03725 GO499_18685
HNEHNE_0078(mclA)
HBAHbal_0778
CBOTATE48_06115
HBCAEM38_14745
RDICMV14_07525
TFVIDJ81_06845
GBEGbCGDNIH1_0055
GBHGbCGDNIH2_0055
GBCGbCGDNIH3_0055
GBSGbCGDNIH4_0055
RAPRHOA_5783(mcl)
SKTIGS68_03250
SMUCJL100_003365
SROEJL101_003125
RRURru_A0217
RRFF11_01090
RPMRSPPHO_00107
MAGamb3977
MGYMGMSRv2__3257
MGRYMSR1_29830(mcl1)
MAGXXM1_1373
MAGNWV31_14965
TMOTMO_0350(citE)
FERFNB15_09270
HTQFRZ44_44960
HADHFRZ61_42590 FRZ61_45950
DEXHWD60_03940
DVNHQ394_01635
TXITH3_02680
THACCSC3H3_02980
TIIDY252_18625
THAIIT893_02795
MAGQMGMAQ_0659
ECOGFIV45_00610
SNEANBZ79_03900
STREGZL_04819
SLDT261_4311
SLCSL103_17980
SNRSNOUR_21930
SALUDC74_4078
SALLSAZ_21750
SGVB1H19_20540
STROSTRMOE7_00865
SPLACP981_36035
SDWK7C20_34930
SAUHSU9_032330
SANUK7396_01540
SINEKI385_01365
SCTSCAT_4364
SCYSCATT_43520
ABRYNYE86_27165
ICAIntca_2587
ARSADJ73_02415
JTEASJ30_03525
JLIEXU32_11365
JMEEEW87_011295
JAYH7A72_03525
TEHGKE56_09880
PEIH9L10_09525
AUSIPK37_13860
NCANoca_4393
NDKI601_0974(mcl1)
NOYEXE57_13540
NOIFCL41_01330
NOOFE634_19600
NSNEXE58_09730
NBEBack2_15770(citE_1)
NANOG5V58_24335
NAROCFH99_21490
NPIG7071_06375
NAQUENKNEFLB_04247(mcl)
NROK8W59_01590
NOQLN652_11495
NCQK6T13_15930
NPCKUV85_11405
PSIMKR76_23920
AERAERYTH_05645
AEZC3E78_04975
AEBC6I20_10755
AEFGEV26_04810
FRAFrancci3_2805
FSYFsymDg_0509
AMDAMED_0079(citE)
AMNRAM_00395
AMMAMES_0076(citE)
AMZB737_0077(citE)
AOIAORI_0068(mcl)
AJAAJAP_00370
AMQAMETH_0090(citE)
AMYCCU254_39710
AMYBBKN51_34375
AABA4R43_28985
AMYYYIM_00345(mcl2)
AORISD37_41460
AACDLWP59_00255
APRTMUY14_36265
AROONQK81_25995
ATHML1857_02835
KALKALB_2473
KPHYAOZ06_42935
ALOCRK61727
PMADBAY61_00315
ACTUActkin_00833(mcl1)
EKEEK0264_04565
BSOLFSW04_11520
CWOCwoe_4213
PARNNBH00_07200
SBAEDSM104329_01824(mcl) DSM104329_03745(mcl1)
AYMYM304_14270
ATQGH723_12970
AQZKSP35_02830
IAMHC251_13125
EUZDVS28_a0494
RRSRoseRS_4173
RCARcas_0912
CAUCaur_0174
CHLChy400_0187
CAGCagg_1328
TROtrd_0455
STISthe_2064
GGRHKW67_06650
HDLHALDL1_15310
HHBHhub_3380(aceB)
HNOLT974_13710
HLULT972_01030
HSUHLASF_2007(aceB)
HSFHLASA_1993(aceB)
SALRFQU85_05715
HAADMW046_18245
HALXM0R89_18090 M0R89_21245
SALIL593_04660
SAIMK0C01_12450
HMArrnAC0690(citE1) rrnAC1965(aceB)
HHIHAH_1341(citE1) HAH_2476(aceB)
HHNHISP_06865 HISP_12605
HABSG26_04910 SG26_14710
HTABVU17_06535 BVU17_12045
HALJG9465_08585
HSINKDQ40_00995 KDQ40_06765
NPHNP_4430A(aceB)
NMONmlp_2357(aceB)
NHOHWV23_13655
NSALHWV07_07395
HMUHmuk_2984
HALZE5139_02195
HALLLC1Hm_2321(mcl)
HAZPGBQ70_02195
HALIBV210_07645
HRRHZS55_19985
HPELHZS54_23485
HDOMUK72_12480
SSAIN0B31_16615
HWAHQ_1720A(aceB)
HWCHqrw_1842(aceB)
HVOHVO_1983(aceB1) HVO_B0200(aceB2)
HMEHFX_2078(aceB)
HGIABY42_09665 ABY42_16600
HALEG3A49_07690 G3A49_12900
HLSKU306_02605
HBOHbor_30530
HLMDV707_13970
SRUBC2R22_21540
HALGHUG10_03375
HALUHUG12_13540
HMPK6T50_01580
HREK6T36_01385
HRMK6T25_15035
HACBHbl1158_08495
HDFAArcSl_1031(aceB)
HTUHtur_1590 Htur_4695
HDABB347_04010
HSALJMJ58_00685 JMJ58_24075
HLOJ0X27_02295
HAKZJ0X25_14760
NMGNmag_3338(mcl) Nmag_3363(aceB)
HXAHalxa_3159
NATNJ7G_3289
NPENatpe_2590
NVRFEJ81_11880
NPLFGF80_10920
NAYHYG81_14690
HALYHYG82_17310
HJTDVR14_02935
NGENatgr_3384
HRUHalru_1548
HALVNGM15_00935
NOUNatoc_1509 Natoc_4308
HLRHALLA_10835
HLCCHINAEXTREME16075
NAJB1756_06555 B1756_12025
NAGAArcMg_4138
NANAArc1_5073
NBGDV706_12980 DV706_17910
NASGCU68_13725 GCU68_18820
SAWLNGM29_08770
 » show all
Reference
1  [PMID:14285256]
  Authors
TUBOI S, KIKUCHI G.
  Title
ENZYMIC CLEAVAGE OF MALYTL-COENZYME A INTO ACETYL-COENZYME A AND GLYOXYLIC ACID.
  Journal
Biochim Biophys Acta 96:148-53 (1965)
DOI:10.1016/0005-2787(65)90618-0
Reference
2  [PMID:12374834]
  Authors
Herter S, Busch A, Fuchs G
  Title
L-Malyl-coenzyme A lyase/beta-methylmalyl-coenzyme A lyase from Chloroflexus aurantiacus, a bifunctional enzyme involved in autotrophic CO(2) fixation.
  Journal
J Bacteriol 184:5999-6006 (2002)
DOI:10.1128/JB.184.21.5999-6006.2002
  Sequence
[cau:Caur_0174]
Reference
3  [PMID:15687206]
  Authors
Meister M, Saum S, Alber BE, Fuchs G
  Title
L-malyl-coenzyme A/beta-methylmalyl-coenzyme A lyase is involved in acetate assimilation of the isocitrate lyase-negative bacterium Rhodobacter capsulatus.
  Journal
J Bacteriol 187:1415-25 (2005)
DOI:10.1128/JB.187.4.1415-1425.2005
  Sequence
Reference
4  [PMID:17259315]
  Authors
Friedmann S, Alber BE, Fuchs G
  Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
  Journal
J Bacteriol 189:2906-14 (2007)
DOI:10.1128/JB.01620-06
Reference
5  [PMID:20047909]
  Authors
Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE
  Title
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase.
  Journal
J Bacteriol 192:1249-58 (2010)
DOI:10.1128/JB.01267-09
  Sequence
[rsp:RSP_1771]
Reference
6  [PMID:27920298]
  Authors
Borjian F, Han J, Hou J, Xiang H, Zarzycki J, Berg IA.
  Title
Malate Synthase and beta-Methylmalyl Coenzyme A Lyase Reactions in the Methylaspartate Cycle in Haloarcula hispanica.
  Journal
J Bacteriol 199:e00657-16 (2017)
DOI:10.1128/JB.00657-16
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.24
IUBMB Enzyme Nomenclature: 4.1.3.24
ExPASy - ENZYME nomenclature database: 4.1.3.24
BRENDA, the Enzyme Database: 4.1.3.24
CAS: 37290-67-8
LinkDB

KEGG   REACTION: R00473
Entry
R00473                      Reaction                               
Name
L-malyl-CoA glyoxylate-lyase (acetyl-CoA-forming)
Definition
L-Malyl-CoA <=> Acetyl-CoA + Glyoxylate
Equation
Reaction class
RC00307  C00024_C04348
RC00308  C00048_C04348
Enzyme
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn00720  Carbon fixation pathways in prokaryotes
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00012  Glyoxylate cycle
M00346  Formaldehyde assimilation, serine pathway
M00373  Ethylmalonyl pathway
M00376  3-Hydroxypropionate bi-cycle
M00740  Methylaspartate cycle
Orthology
K08691  malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25]
K19282  bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30]
Other DBs
RHEA: 16632
LinkDB

DBGET integrated database retrieval system