KEGG   ORTHOLOGY: K08977
Entry
K08977                      KO                                     
Symbol
cruF
Name
bisanhydrobacterioruberin hydratase [EC:4.2.1.161]
Pathway
map00906  Carotenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K08977  cruF; bisanhydrobacterioruberin hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.161  bisanhydrobacterioruberin hydratase
     K08977  cruF; bisanhydrobacterioruberin hydratase
Other DBs
RN: R12711 R12712
Genes
RMAR: GBA65_05160
MTH: MTH_1810
MMG: MTBMA_c03800
METC: MTCT_1650
MWO: MWSIV6_0343(cruF)
METE: tca_01748
METK: FVF72_02650
MTHM: FZP57_01595
METJ: FZP68_06610
MEME: HYG87_08520
HAL: VNG_1681C
HSL: OE_3377R
HHB: Hhub_3182
HALH: HTSR_0320
HHSR: HSR6_0306
HARA: AArcS_2864
HMA: rrnAC0318
HHI: HAH_1056
NPH: NP_4768A(cruF)
NMO: Nmlp_3028
HUT: Huta_2375
HTI: HTIA_2108
HMU: Hmuk_1362
HALL: LC1Hm_0583
HWA: HQ_2861A(cruF)
HWC: Hqrw_3255(cruF)
HVO: HVO_2526
HME: HFX_2548
HLA: Hlac_1899
HDF: AArcSl_1203(cruF)
HTU: Htur_2702
NMG: Nmag_1003
NAT: NJ7G_1610
SALI: L593_04755
AG: BAP82511(cruF)
 » show all
Reference
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
LinkDB

KEGG   ENZYME: 4.2.1.161
Entry
EC 4.2.1.161                Enzyme                                 
Name
bisanhydrobacterioruberin hydratase;
CruF;
C50 carotenoid 2'',3''-hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
bacterioruberin hydro-lyase (bisanhydrobacterioruberin-forming)
Reaction(IUBMB)
bacterioruberin = bisanhydrobacterioruberin + 2 H2O (overall reaction) [RN:R12710];
(1a) bacterioruberin = monoanhydrobacterioruberin + H2O [RN:R12711];
(1b) monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O [RN:R12712]
Reaction(KEGG)
Substrate
bacterioruberin [CPD:C22349];
monoanhydrobacterioruberin [CPD:C22348]
Product
bisanhydrobacterioruberin [CPD:C22347];
H2O [CPD:C00001];
monoanhydrobacterioruberin [CPD:C22348]
Comment
The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the introduction of hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin to generate bacterioruberin.
History
EC 4.2.1.161 created 2015
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08977  bisanhydrobacterioruberin hydratase
Genes
RMARGBA65_05160
MTHMTH_1810
MMGMTBMA_c03800
METCMTCT_1650
MWOMWSIV6_0343(cruF)
METEtca_01748
METKFVF72_02650
MTHMFZP57_01595
METJFZP68_06610
MEMEHYG87_08520
MZHMzhil_0945
MEMMemar_0115
HALVNG_1681C
HSLOE_3377R
HDLHALDL1_13220
HHBHhub_3182
HAGSJT689_08120
HABOJRZ79_06535
HNOLT974_11785
HLULT972_03125
HANRLJ422_06790
HJEHacjB3_05930
HALHHTSR_0320
HHSRHSR6_0306
HSUHLASF_0238
HSFHLASA_0238
SALRFQU85_06795
HALREFA46_012290
HARAAArcS_2864
HAADMW046_14470
HALXM0R89_12780
HMArrnAC0318
HHIHAH_1056
HHNHISP_05425
HABSG26_13095
HTABVU17_05170
HALJG9465_16505
HSINKDQ40_08210
NPHNP_4768A(cruF)
NMONmlp_3028
NHOHWV23_16735
NSALHWV07_18235
HUTHuta_2375
HTIHTIA_2108
HALAHrd1104_01375
HMUHmuk_1362
HALZE5139_09970
HALLLC1Hm_0583
HAZPGBQ70_09965
HALIBV210_13225
HSNDV733_06785
HDSHSR122_2628
HRRHZS55_20275
HPELHZS54_23760
HLTI7X12_14760
HARCHARCEL1_04570
HDOMUK72_08400
HWAHQ_2861A(cruF)
HWCHqrw_3255(cruF)
HVOHVO_2526
HMEHFX_2548
HGIABY42_12660
HALEG3A49_16055
HBOHbor_10670
HAQDU484_15080
HAJDU500_15110
HAERDU502_13070
HRAEI982_16635
HLMDV707_06365
HALMFCF25_03140
HLAHlac_1899
HALPDOS48_09175
HALBEKH57_01640
HEZZEO776_09990
HALQHrr1229_010275
HSSJ7656_06545
HSAIHPS36_12065
HAZZKI388_07980
SRUBC2R22_15230
HAEhalTADL_0467
HALNB4589_011170
HALGHUG10_00785
HALUHUG12_16795
HMPK6T50_14395
HREK6T36_14345
HRMK6T25_02460
HACBHbl1158_06190
HDFAArcSl_1203(cruF)
HAHHalar_2117
HTUHtur_2702
HDABB347_09715
HJTDVR14_14695
HALYHYG82_06620
HSALJMJ58_15360
HLOJ0X27_13910
HAKZJ0X25_02305
NMGNmag_1003
HXAHalxa_2220
NATNJ7G_1610
NPENatpe_1079
NPLFGF80_05285
NAYHYG81_05190
NGENatgr_2202
HRUHalru_1197
NOUNatoc_1919
SALIL593_04755
SAIMK0C01_06240
HLRHALLA_16015
HLCCHINAEXTREME08685
NAJB1756_18795
NAGAArcMg_2865
NANAArc1_0838
NBGDV706_10175
NASGCU68_01900
NACAQV86_03665
 » show all
Reference
1  [PMID:25712483]
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.161
IUBMB Enzyme Nomenclature: 4.2.1.161
ExPASy - ENZYME nomenclature database: 4.2.1.161
BRENDA, the Enzyme Database: 4.2.1.161
LinkDB

KEGG   REACTION: R12711
Entry
R12711                      Reaction                               
Definition
Bacterioruberin <=> Monoanhydrobacterioruberin + H2O
Equation
Comment
the first step of two-step reaction (see R12710, R12711+R12712)
Reaction class
RC00966  C22348_C22349
Enzyme
Pathway
rn00906  Carotenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K08977  bisanhydrobacterioruberin hydratase [EC:4.2.1.161]
LinkDB

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