KEGG   ORTHOLOGY: K08977
Entry
K08977                      KO                                     
Symbol
cruF
Name
bisanhydrobacterioruberin hydratase [EC:4.2.1.161]
Pathway
map00906  Carotenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R12711  
R12712  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00906 Carotenoid biosynthesis
    K08977  cruF; bisanhydrobacterioruberin hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.161  bisanhydrobacterioruberin hydratase
     K08977  cruF; bisanhydrobacterioruberin hydratase
Genes
ARTM: MN0502_25650
RMAR: GBA65_05160
MTH: MTH_1810
MMG: MTBMA_c03800
MWO: MWSIV6_0343(cruF)
METC: MTCT_1650
METE: tca_01748
METK: FVF72_02650
MTHM: FZP57_01595
METJ: FZP68_06610
MEME: HYG87_08520
MZH: Mzhil_0945
MEM: Memar_0115
MFK: E2N92_05460
HAL: VNG_1681C
HSL: OE_3377R
HANR: LJ422_06790
HDL: HALDL1_13220
HHB: Hhub_3182
HAGS: JT689_08120
HABO: JRZ79_06535
HNO: LT974_11785
HLU: LT972_03125
HALH: HTSR_0320
HHSR: HSR6_0306
HSU: HLASF_0238
HSF: HLASA_0238
HAHS: HSRCO_0375
SALR: FQU85_06795
HALR: EFA46_012290
HJE: HacjB3_05930
HDO: MUK72_08400
HALX: M0R89_12780
HAXZ: M0R88_12945
HAYC: NGM10_02420
HAXY: NGM07_00970
SALI: L593_04755
SAIM: K0C01_06240
HARA: AArcS_2864
HMA: rrnAC0318
HHI: HAH_1056
HHN: HISP_05425
HAB: SG26_13095
HTA: BVU17_05170
HALJ: G9465_16505
HSIN: KDQ40_08210
NPH: NP_4768A(cruF)
NMO: Nmlp_3028
NHO: HWV23_16735
NSAL: HWV07_18235
HUT: Huta_2375
HTI: HTIA_2108
HALA: Hrd1104_01375
HASV: SVXHr_2181(cruF)
HABN: HBNXHr_2177(cruF)
HMU: Hmuk_1362
HALZ: E5139_09970
HALL: LC1Hm_0583
HAZP: GBQ70_09965
HALI: BV210_13225
HSN: DV733_06785
HDS: HSR122_2628
HRR: HZS55_20275
HPEL: HZS54_23760
HLT: I7X12_14760
HARC: HARCEL1_04570
SSAI: N0B31_09230
HAAD: MW046_14470
HWA: HQ_2861A(cruF)
HWC: Hqrw_3255(cruF)
HVO: HVO_2526
HALE: G3A49_16055
HLN: SVXHx_2074(cruf)
HME: HFX_2548
HGI: ABY42_12660
HLS: KU306_00330
HBO: Hbor_10670
HAQ: DU484_15080
HAJ: DU500_15110
HAER: DU502_13070
HRA: EI982_16635
HLM: DV707_06365
HALM: FCF25_03140
HLA: Hlac_1899
HALP: DOS48_09175
HALB: EKH57_01640
HEZZ: EO776_09990
HALQ: Hrr1229_010275
HSS: J7656_06545
HSAI: HPS36_12065
HAZZ: KI388_07980
SRUB: C2R22_15230
HAE: halTADL_0467
HALN: B4589_011170
HALG: HUG10_00785
HALU: HUG12_16795
HMP: K6T50_14395
HRE: K6T36_14345
HRM: K6T25_02460
HACB: Hbl1158_06190
HDF: AArcSl_1203(cruF)
HAH: Halar_2117
HTU: Htur_2702
HSAL: JMJ58_15360
HAKZ: J0X25_02305
NMG: Nmag_1003
HXA: Halxa_2220
NAT: NJ7G_1610
NPE: Natpe_1079
NPL: FGF80_05285
NAY: HYG81_05190
HALY: HYG82_06620
HJT: DVR14_14695
HLO: J0X27_13910
NGE: Natgr_2202
HRU: Halru_1197
SAWL: NGM29_09960
HALV: NGM15_02165
NOU: Natoc_1919
HLR: HALLA_16015
HLC: CHINAEXTREME08685
NAJ: B1756_18795
NAG: AArcMg_2865
NAN: AArc1_0838
NARA: QQ977_09760(cruF)
NBG: DV706_10175
NAS: GCU68_01900
HDA: BB347_09715
NAC: AQV86_03665
AG: BAP82511(cruF)
 » show all
Reference
PMID:25712483
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
[ag:BAP82511]
LinkDB

KEGG   ENZYME: 4.2.1.161
Entry
EC 4.2.1.161                Enzyme                                 
Name
bisanhydrobacterioruberin hydratase;
CruF;
C50 carotenoid 2'',3''-hydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
bacterioruberin hydro-lyase (bisanhydrobacterioruberin-forming)
Reaction(IUBMB)
bacterioruberin = bisanhydrobacterioruberin + 2 H2O (overall reaction) [RN:R12710];
(1a) bacterioruberin = monoanhydrobacterioruberin + H2O [RN:R12711];
(1b) monoanhydrobacterioruberin = bisanhydrobacterioruberin + H2O [RN:R12712]
Reaction(KEGG)
R12710 R12711 R12712
Substrate
bacterioruberin [CPD:C22349];
monoanhydrobacterioruberin [CPD:C22348]
Product
bisanhydrobacterioruberin [CPD:C22347];
H2O [CPD:C00001];
monoanhydrobacterioruberin [CPD:C22348]
Comment
The enzyme, isolated from the archaeon Haloarcula japonica, is involved in the biosynthesis of the C50 carotenoid bacterioruberin. In this pathway it catalyses the introduction of hydroxyl groups to C3'' and C3''' of bisanhydrobacterioruberin to generate bacterioruberin.
History
EC 4.2.1.161 created 2015
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K08977  bisanhydrobacterioruberin hydratase
Genes
ARTM: MN0502_25650
RMAR: GBA65_05160
MTH: MTH_1810
MMG: MTBMA_c03800
MWO: MWSIV6_0343(cruF)
METC: MTCT_1650
METE: tca_01748
METK: FVF72_02650
MTHM: FZP57_01595
METJ: FZP68_06610
MEME: HYG87_08520
MZH: Mzhil_0945
MEM: Memar_0115
MFK: E2N92_05460
HAL: VNG_1681C
HSL: OE_3377R
HANR: LJ422_06790
HDL: HALDL1_13220
HHB: Hhub_3182
HAGS: JT689_08120
HABO: JRZ79_06535
HNO: LT974_11785
HLU: LT972_03125
HALH: HTSR_0320
HHSR: HSR6_0306
HSU: HLASF_0238
HSF: HLASA_0238
HAHS: HSRCO_0375
SALR: FQU85_06795
HALR: EFA46_012290
HJE: HacjB3_05930
HDO: MUK72_08400
HALX: M0R89_12780
HAXZ: M0R88_12945
HAYC: NGM10_02420
HAXY: NGM07_00970
SALI: L593_04755
SAIM: K0C01_06240
HARA: AArcS_2864
HMA: rrnAC0318
HHI: HAH_1056
HHN: HISP_05425
HAB: SG26_13095
HTA: BVU17_05170
HALJ: G9465_16505
HSIN: KDQ40_08210
NPH: NP_4768A(cruF)
NMO: Nmlp_3028
NHO: HWV23_16735
NSAL: HWV07_18235
HUT: Huta_2375
HTI: HTIA_2108
HALA: Hrd1104_01375
HASV: SVXHr_2181(cruF)
HABN: HBNXHr_2177(cruF)
HMU: Hmuk_1362
HALZ: E5139_09970
HALL: LC1Hm_0583
HAZP: GBQ70_09965
HALI: BV210_13225
HSN: DV733_06785
HDS: HSR122_2628
HRR: HZS55_20275
HPEL: HZS54_23760
HLT: I7X12_14760
HARC: HARCEL1_04570
SSAI: N0B31_09230
HAAD: MW046_14470
HWA: HQ_2861A(cruF)
HWC: Hqrw_3255(cruF)
HVO: HVO_2526
HALE: G3A49_16055
HLN: SVXHx_2074(cruf)
HME: HFX_2548
HGI: ABY42_12660
HLS: KU306_00330
HBO: Hbor_10670
HAQ: DU484_15080
HAJ: DU500_15110
HAER: DU502_13070
HRA: EI982_16635
HLM: DV707_06365
HALM: FCF25_03140
HLA: Hlac_1899
HALP: DOS48_09175
HALB: EKH57_01640
HEZZ: EO776_09990
HALQ: Hrr1229_010275
HSS: J7656_06545
HSAI: HPS36_12065
HAZZ: KI388_07980
SRUB: C2R22_15230
HAE: halTADL_0467
HALN: B4589_011170
HALG: HUG10_00785
HALU: HUG12_16795
HMP: K6T50_14395
HRE: K6T36_14345
HRM: K6T25_02460
HACB: Hbl1158_06190
HDF: AArcSl_1203(cruF)
HAH: Halar_2117
HTU: Htur_2702
HSAL: JMJ58_15360
HAKZ: J0X25_02305
NMG: Nmag_1003
HXA: Halxa_2220
NAT: NJ7G_1610
NPE: Natpe_1079
NPL: FGF80_05285
NAY: HYG81_05190
HALY: HYG82_06620
HJT: DVR14_14695
HLO: J0X27_13910
NGE: Natgr_2202
HRU: Halru_1197
SAWL: NGM29_09960
HALV: NGM15_02165
NOU: Natoc_1919
HLR: HALLA_16015
HLC: CHINAEXTREME08685
NAJ: B1756_18795
NAG: AArcMg_2865
NAN: AArc1_0838
NARA: QQ977_09760(cruF)
NBG: DV706_10175
NAS: GCU68_01900
HDA: BB347_09715
NAC: AQV86_03665
 » show all
Reference
1  [PMID:25712483]
  Authors
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S
  Title
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
  Journal
J Bacteriol 197:1614-23 (2015)
DOI:10.1128/JB.02523-14
  Sequence
[ag:BAP82511]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.161
IUBMB Enzyme Nomenclature: 4.2.1.161
ExPASy - ENZYME nomenclature database: 4.2.1.161
BRENDA, the Enzyme Database: 4.2.1.161
LinkDB

KEGG   REACTION: R12711
Entry
R12711                      Reaction                               
Definition
Bacterioruberin <=> Monoanhydrobacterioruberin + H2O
Equation
C22349 <=> C22348 + C00001
Comment
the first step of two-step reaction (see R12710, R12711+R12712)
Reaction class
RC00966  C22348_C22349
Enzyme
4.2.1.161
Pathway
rn00906  Carotenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.161
     R12711  Bacterioruberin <=> Monoanhydrobacterioruberin + H2O
Orthology
K08977  bisanhydrobacterioruberin hydratase [EC:4.2.1.161]
LinkDB

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