KEGG   ORTHOLOGY: K09065
Entry
K09065                      KO                                     
Symbol
argF
Name
N-acetylornithine carbamoyltransferase [EC:2.1.3.9]
Pathway
map00220  Arginine biosynthesis
map01100  Metabolic pathways
map01230  Biosynthesis of amino acids
Module
M00845  Arginine biosynthesis, glutamate => acetylcitrulline => arginine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K09065  argF; N-acetylornithine carbamoyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.9  N-acetylornithine carbamoyltransferase
     K09065  argF; N-acetylornithine carbamoyltransferase
Other DBs
RN: R07245
COG: COG0078
GO: 0043857
Genes
XFA: XF_0998
XFT: PD_0290(argF)
XFM: Xfasm12_0314
XFN: XfasM23_0284
XFF: XFLM_06825
XFL: P303_00885
XFS: D934_02520
XFH: XFHB_10450
XTW: AB672_01675
XCC: XCC2249(argF)
XCB: XC_1869
XCP: XCR_2518
XCV: XCV2551(argF)
XAX: XACM_2361(argF)
XAC: XAC2352(argF)
XCI: XCAW_02017(argF)
XFU: XFF4834R_chr23570(argF)
XOM: XOO2522(XOO2522)
XOO: XOO2676(argF)
XOP: PXO_00353
XOR: XOC_2751
XAL: XALC_1896(argF)
XPH: XppCFBP6546_01255(XppCFBP6546P_01255)
XHD: LMG31886_19220(argF')
SML: Smlt3302
SMT: Smal_2729
SMZ: SMD_2874
SACZ: AOT14_15980(pyrB_2)
SINC: DAIF1_28330(argF')
PSUW: WQ53_01270
PSD: DSC_08070
LAB: LA76x_3276(argF)
LAQ: GLA29479_4813(argF')
LCP: LC55x_3309(argF)
LGU: LG3211_1887(argF)
LEZ: GLE_1836
LEM: LEN_3148
LHX: LYSHEL_01260(argF')
LCAS: LYSCAS_01260(argF')
DKO: I596_2178
RBD: ALSL_1196
KKO: Kkor_0543
KGE: TQ33_1837
PPNO: DA70_13840
PPNM: LV28_25530
PPUL: RO07_10980
PSPU: NA29_06805
PAPI: SG18_11385
MXA: MXAN_5104(argF)
CCX: COCOR_02390(argF)
SUR: STAUR_5869(argF)
SCL: sce0074(argF1)
GAK: X907_2458
TEB: T8CH_1926
MTA: Moth_1996
MTHO: MOTHE_c20390(argF')
MTHZ: MOTHA_c21170(argF')
ATM: ANT_01250
BPO: BP951000_0722(argF)
BPW: WESB_2042(argF)
SRU: SRU_2218
SRM: SRM_02445(argF)
RMR: Rmar_0946
MARN: LN42_09080
BANA: BARAN1_1241(argF)
TAG: Tagg_0310
BARC: AOA65_0973(argF_2) AOA65_1786(argF_3)
 » show all
Reference
  Authors
Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M
  Title
Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis.
  Journal
J Bacteriol 188:2974-82 (2006)
DOI:10.1128/JB.188.8.2974-2982.2006
LinkDB

KEGG   ENZYME: 2.1.3.9
Entry
EC 2.1.3.9                  Enzyme                                 
Name
N-acetylornithine carbamoyltransferase;
acetylornithine transcarbamylase;
N-acetylornithine transcarbamylase;
AOTC;
carbamoyl-phosphate:2-N-acetyl-L-ornithine carbamoyltransferase;
AOTCase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
Sysname
carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + N2-acetyl-L-ornithine = phosphate + N-acetyl-L-citrulline [RN:R07245]
Reaction(KEGG)
R07245
Substrate
carbamoyl phosphate [CPD:C00169];
N2-acetyl-L-ornithine [CPD:C00437]
Product
phosphate [CPD:C00009];
N-acetyl-L-citrulline [CPD:C15532]
Comment
Differs from EC 2.1.3.3, ornithine carbamoyltransferase. This enzyme replaces EC 2.1.3.3 in the canonic arginine biosynthetic pathway of several Eubacteria and has no catalytic activity with L-ornithine as substrate.
History
EC 2.1.3.9 created 2005
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K09065  N-acetylornithine carbamoyltransferase
Genes
XFAXF_0998
XFTPD_0290(argF)
XFMXfasm12_0314
XFNXfasM23_0284
XFFXFLM_06825
XFLP303_00885
XFSD934_02520
XFHXFHB_10450
XTWAB672_01675
XCCXCC2249(argF)
XCBXC_1869
XCAxcc-b100_1930
XCPXCR_2518
XCVXCV2551(argF)
XAXXACM_2361(argF)
XACXAC2352(argF)
XCIXCAW_02017(argF)
XCTJ151_02525
XCJJ158_02515
XCUJ159_02513
XCNJ169_02522
XCWJ162_02514
XCRJ163_02509
XCMJ164_02511
XCFJ172_02516
XFUXFF4834R_chr23570(argF)
XAOXAC29_11920
XOMXOO2522(XOO2522)
XOOXOO2676(argF)
XOPPXO_00353
XOYAZ54_10760
XORXOC_2751
XOZBE73_13320
XALXALC_1896(argF)
XSASB85_18590
XTNFD63_07480
XFRBER92_11890
XVEBJD12_02825
XPEBJD13_04640
XHRXJ27_05360
XGABI317_11400
XPHXppCFBP6546_01255(XppCFBP6546P_01255)
XVAC7V42_10385
XANAC801_12100
XARXB05_06835
XHYFZ025_17105
XCZEBN15_10550
XTHG4Q83_12335
XEUXSP_002367
XHDLMG31886_19220(argF')
SMLSmlt3302
SMTSmal_2729
BUJBurJV3_2745
SMZSMD_2874
SACZAOT14_15980(pyrB_2)
STEKAXG53_02270
SRHBAY15_2472
SLMBIZ42_03290
STENCCR98_14170
STEMCLM74_14470
STESMG068_14130
SINCDAIF1_28330(argF')
SPAQSTNY_R29170
PSUPsesu_1224
PSUWWQ53_01270
PSDDSC_08070
PMEXH4W19_02430
PJPLAG73_09600
PDDMNQ95_00280
LABLA76x_3276(argF)
LAQGLA29479_4813(argF')
LCPLC55x_3309(argF)
LGULG3211_1887(argF)
LEZGLE_1836
LEMLEN_3148
LMBC9I47_1932
LYTDWG18_08150
LUEDCD74_05345
LYJFKV23_10185
LSOLGOY17_12170
LSXH8B22_13445
LAREHIV01_002490
LHXLYSHEL_01260(argF')
LCASLYSCAS_01260(argF')
LCICINQ41_05280
LUMCNR27_08000
LUSE5843_08625
LUGFPZ22_11925
THESFHQ07_02595
THEHG7079_09315
TCNH9L16_14845
TBVH9L17_14625
XBCELE36_07715
FAUFraau_2115
RHDR2APBS1_1203
RGLCS053_06175
RTHLRK53_07530
DJICH75_03530
DJAHY57_09525
DTXATSB10_16390
DYEEO087_06265
DCSISN74_04865
DTLH8F01_16010
DKOI596_2178
LRZBJI69_00695
LPYFIV34_14315
XBAC7S18_05955
RBDALSL_1196
WMAWM2015_184
WOCBA177_02135
KKOKkor_0543
KGETQ33_1837
KSDKS2013_1901
SDFACG33_14155
PPKU875_26890
PPNODA70_13840
PPNMLV28_25530
PRBX636_13010
PPULRO07_10980
PSPUNA29_06805
PAPISG18_11385
PVEUC34_02680
POXMB84_07165
PFGAB870_13895
PNRAT302_10830
PANDDRB87_02540
PFIBPI93_002425
MXAMXAN_5104(argF)
MSDMYSTI_05593
MYMA176_001781
MFBMFUL124B02_30515
CCXCOCOR_02390(argF)
MFULILAB_33450
MMASMYMAC_004986
SURSTAUR_5869(argF)
SCLsce0074(argF1)
SCUSCE1572_00430
CCROCMC5_043050
LLUAKJ09_05863
MRMA7982_00311
BSEDDN745_16955
PCAYFRD00_19420
MMRMmar10_0364
GAKX907_2458
HYTHXX25_09465
PBRPB2503_11074
TEBT8CH_1926
MTAMoth_1996
MTHOMOTHE_c20390(argF')
MTHZMOTHA_c21170(argF')
ETTAZF37_03130
MANRMPAN_016160
TBKHF295_01000
ATMANT_01250
PSUBPelsub_P2113 Pelsub_P2197
ABAOBEQ56_08645
CAPCLDAP_10970
KBSEPA93_12415
PMETG4Y79_17675
UAMUABAM_06584
SSMSpirs_2731
BPOBP951000_0722(argF)
BPJB2904_orf2101
BPIPBPP43_11545
BPWWESB_2042(argF)
CTMCabther_B0219
CVLJ8C06_12710
CHLOJ8C02_13765
SRUSRU_2218
SRMSRM_02445(argF)
RMRRmar_0946
RMGRhom172_1920
RBARAWN76_002220
TFEJYK00_08370
MPZMarpi_1704
MARNLN42_09080
BANABARAN1_1241(argF)
BIHBIP78_0906
SHCShell_0591
DFDDesfe_0193
DMUDesmu_0309
TAGTagg_0310
THGTCELL_1366
CSUCSUB_C1718 CSUB_C1723
BARCAOA65_0973(argF_2) AOA65_1786(argF_3)
 » show all
Reference
1  [PMID:15731101]
  Authors
Shi D, Morizono H, Yu X, Roth L, Caldovic L, Allewell NM, Malamy MH, Tuchman M.
  Title
Crystal structure of N-acetylornithine transcarbamylase from Xanthomonas campestris: a novel enzyme in a new arginine biosynthetic pathway found in several eubacteria.
  Journal
J Biol Chem 280:14366-9 (2005)
DOI:10.1074/jbc.C500005200
  Sequence
[xcc:XCC2249]
Reference
2  [PMID:16585758]
  Authors
Morizono H, Cabrera-Luque J, Shi D, Gallegos R, Yamaguchi S, Yu X, Allewell NM, Malamy MH, Tuchman M
  Title
Acetylornithine transcarbamylase: a novel enzyme in arginine biosynthesis.
  Journal
J Bacteriol 188:2974-82 (2006)
DOI:10.1128/JB.188.8.2974-2982.2006
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.9
IUBMB Enzyme Nomenclature: 2.1.3.9
ExPASy - ENZYME nomenclature database: 2.1.3.9
BRENDA, the Enzyme Database: 2.1.3.9
CAS: 890853-54-0
LinkDB

KEGG   REACTION: R07245
Entry
R07245                      Reaction                               
Name
carbamoyl-phosphate:N2-acetyl-L-ornithine carbamoyltransferase
Definition
Carbamoyl phosphate + N-Acetylornithine <=> Orthophosphate + N-Acetyl-L-citrulline
Equation
Reaction class
RC00096  C00437_C15532
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn01100  Metabolic pathways
rn01230  Biosynthesis of amino acids
Module
M00845  Arginine biosynthesis, glutamate => acetylcitrulline => arginine
Orthology
K09065  N-acetylornithine carbamoyltransferase [EC:2.1.3.9]
Other DBs
RHEA: 18612
LinkDB

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