KEGG   ORTHOLOGY: K09460
Entry
K09460            Tight     KO                                     
Symbol
auaEII
Name
anthranilate-CoA ligase [EC:6.2.1.32]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00848  Aurachin biosynthesis, anthranilate => aurachin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K09460  auaEII; anthranilate-CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.32  anthranilate---CoA ligase
     K09460  auaEII; anthranilate-CoA ligase
Other DBs
RN: R00982
COG: COG0365
GO: 0018860
Genes
AG: CCA65703(auaEII)
Reference
  Authors
Pistorius D, Li Y, Mann S, Muller R
  Title
Unprecedented anthranilate priming involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis.
  Journal
J Am Chem Soc 133:12362-5 (2011)
DOI:10.1021/ja203653w
  Sequence
LinkDB

KEGG   ENZYME: 6.2.1.32
Entry
EC 6.2.1.32                 Enzyme                                 
Name
anthranilate---CoA ligase;
anthraniloyl coenzyme A synthetase;
2-aminobenzoate---CoA ligase;
2-aminobenzoate---coenzyme A ligase;
2-aminobenzoate coenzyme A ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
anthranilate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + anthranilate + CoA = AMP + diphosphate + anthraniloyl-CoA [RN:R00982]
Reaction(KEGG)
R00982;
(other) R07416
Substrate
ATP [CPD:C00002];
anthranilate [CPD:C00108];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
anthraniloyl-CoA [CPD:C02247]
History
EC 6.2.1.32 created 1992
Pathway
ec00405  Phenazine biosynthesis
ec00627  Aminobenzoate degradation
ec00996  Biosynthesis of various alkaloids
ec00998  Biosynthesis of various antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K08295  2-aminobenzoate-CoA ligase
K09460  anthranilate-CoA ligase
K18000  anthranilate-CoA ligase
Genes
PAEPA0996(pqsA)
PAEVN297_1029
PAEIN296_1029
PAUPA14_51430(pqsA)
PAPPSPA7_4402
PAGPLES_43291(pqsA)
PAFPAM18_4052(pqsA)
PNCNCGM2_1850(pqsA)
PAEBNCGM1900_1672(pqsA)
PDKPADK2_20760
PSGG655_20320
PRPM062_05430
PAEPPA1S_20990
PAERPA1R_gp4593
PAEMU769_20835
PAELT223_22115
PAESSCV20265_4446
PAEUBN889_01048(pqsA)
PAEGAI22_12950
PAECM802_1026
PAEOM801_1029
GAIIMCC3135_14630(bclA)
HAKKO116_00942
HAMHALO3242
HOLHORIV_22230
HTTHZS52_20725
HCAMI4484_15205
HSXHNO51_15125
HSVHNO53_15635
HTXEKK97_17045
RSORSp0037
RSLRPSI07_mp0053
RSNRSPO_m00053(fadD2)
RSMCMR15_mp10039
RSEF504_3543
RSYRSUY_32590(bclA)
RPIRpic_3836
RPFRpic12D_3949
RPJN234_14070
RMNTK49_19425
RINACS15_5524
RPUCDC45_17770
RSGJK151_22795
REHH16_A2457(abmG)
CNCCNE_1c23660(abmG)
CUHBJN34_13175
REUReut_A2180
RMERmet_2198
CTIRALTA_A1988
CBWRR42_m2747
CGDCR3_1770(abmG)
CCUPBKK81_14235
CUPBKK80_15170
CUUBKK79_17835
CPAUEHF44_11770
COXE0W60_21735
BPSBPSS0481
BPMBURPS1710b_A2033
BPLBURPS1106A_A0653
BPDBURPS668_A0744
BPSEBDL_3707
BPSMBBQ_5715
BPSUBBN_3881
BPSDBBX_5544
BPZBP1026B_II0535
BPQBPC006_II0699
BPKBBK_5686
BPSHDR55_4871
BPSABBU_5566
BPSOX996_4621
BUTX994_4139
BTEBTH_II1935
BTQBTQ_5218
BTJBTJ_3849
BTZBTL_4703
BTDBTI_4297
BTVBTHA_5524
BTHEBTN_4342
BTHMBTRA_4608
BTHADR62_4391
BTHLBG87_4675
BOKDM82_4584
BOCBG90_6008
BUUWS70_19825
BSAVWS86_21080
BAMBamb_5763
BACBamMC406_5523
BCEPAPZ15_37345
BPYRABD05_31315
BCONNL30_31545
BUBBW23_4057
BSTGWT74_16985
BUGBC1001_4669
BGFBC1003_4829
BYIBYI23_D000260
BUEBRPE67_DCDS02290
BULBW21_3838
BUQAC233_26680
BUDAQ610_21715
BUMAXG89_31310
BXEBxe_B0275
BXBDR64_5616
BPHBphy_4075
BGEBC1002_4978
BPXBUPH_01244
BPYBphyt_7161
BUZAYM40_34360
BFNOI25_5786
BCAIK788_0001052
PSPWBJG93_22125
PARBCJU94_27910
PHSC2L64_18730
PTERC2L65_16565
PGPCUJ91_29555
PCJCUJ87_28530
PTSCUJ90_23205
PCAFDSC91_003271
PMEGFNZ07_03665
PTROG5S35_15765
PGISI6I06_27445
PACPFAZ97_19915
PACSFAZ98_15590
PDIOPDMSB3_3189.1
PPKU875_07410
PPNODA70_00055
PPNMLV28_06220
PRBX636_02170
PPULRO07_00210
PSPUNA29_11425
PAPISG18_00505
PVEUC34_16570
POXMB84_21355
PTXABW99_11400
PFGAB870_03395
PNRAT302_15610
PANDDRB87_15250
PFIBPI93_011465
CABASBC2_47200(bclA)
BUOBRPE64_DCDS01900
BPEBP0311
BPCBPTD_0306
BPERBN118_0336
BPETB1917_0313
BPEUQ425_35260
BPARBN117_4014
BPABPP3940
BBHBN112_4009
BBRBB4413
BBMBN115_4089
BBXBBS798_4190
BPTBpet0553
BAVBAV3020
BHOD560_1955
BHMD558_1940
BHZACR54_04139(bclA_2)
BTRMSAMEA390648700750(bclA_1)
BBROBAU06_22785
BFZBAU07_22925
BPDZBBN53_02400
BOHAKI39_02730
BGMCAL15_21100
BOJCBF45_04455
AXYAXYL_00588
AXONH44784_015911
AXNAX27061_0599
AXXERS451415_00591(bclA_1)
ADTAPT56_03080
AISBUW96_22905
ASWCVS48_03410
ACHRC2U31_07685
ACHBDVB37_02410
ADYHLG70_19150
PUTPT7_3494
PUSCKA81_11010
PUDG9Q38_05940
AKATKWG_20180
AMIMMIM_c32150
CDNBN940_15501
AFAUZ73_13670
AFQAFA_15750
AAQUD3M96_16870
AAMMFE795_14545
PIGEGT29_08560
PACRFXN63_07935
KGYEHF36_04840
PARKLSG25_12025
RSBRS694_10275
RHYRD110_19970
RHFEUB48_19340
RHGEXZ61_19435
POLBpro_0589
PNAPnap_3621
POSDT070_04455
AAVAave_3175
AAAAcav_2080
ACKC380_02640
ACRABSY15_1911
AMONH9L24_13505
ARADKI609_02655
DACDaci_4468
DELDelCs14_2336
DTSBI380_01285
DHKBO996_20215
DLAI6G47_02025
VAPVapar_5042
VPEVarpa_5752
VPDVAPA_1c52330
VAAAX767_08055
VBOCKY39_31205
VAMC4F17_20490
CTTCtCNB1_0394
CTESO987_02030
CODOLAD35_21545
RTARta_35050
LIML103DPR2_00578(bclA_1)
LIHL63ED372_00054(bclA_1)
HYRBSY239_228
HYBQ5W_17705
HYLLPB072_12050
HYCE5678_19565
HPSEHPF_03090(bclA1)
HYNF9K07_03705
HTNKI616_23980
DIHG7047_27130
DRGH9K76_22555
PBHAAW51_4170(abmG)
KIAG8A07_17965
JAGGJA_4017
JAZYQ44_19920
JALBZG29_08035
JSVCNX70_08490
JASFJQ89_24975
JLVG3257_08190
MNRACZ75_11820
MASWAM586_12350
MASSCR152_31490
MASZC9I28_09615
MTIMDIR46_05805
MASYDPH57_12380
MALIEYF70_20950
MUMFCL38_28070
MFLAGO485_23720
DUGHH213_19355
UPVEJN92_18655
PKTAT984_10480
MIUABE85_02400
SHDSUTH_01409
APETToN1_50470
AZOazo1996(acS1)
AOAdqs_2151
AZAAZKH_1850(abmG)
ACOMCEW83_03490
AZRCJ010_12950
DDZDSYM_08580
SATSYN_02417
DAODesac_1263
SFUSfum_2077
DAXFDQ92_13405
MLOmlr0619
MLNA9174_22525
MCIMesci_3963
MOPMesop_4279
MAMMesau_04043
MAMOA6B35_09665 A6B35_32735
MESWA9K65_022110
MESMEJ066_01845
MESPC1M53_03330
MHUAMCHK_2322
MJREB229_22550
MERDEB233_19450
MESRFGU64_16565
MESOBSQ44_12025
HOEIMCC20628_01400
AAKAA2016_5748
AMIHCO731_05547(bclA)
NIYFQ775_10895
NKIKW403_07885
KMNHW532_11095
SIXBSY16_4338
EADOV14_a0961
EAHFA04_32360
RTRRTCIAT899_CH14255
RJGCCGE525_16475
RHRCKA34_17160
NGLRG1141_CH41630
NGGRG540_CH42150
NEOCYG48_15555
RHTNT26_3982
RFVRFYW14_00009
ABAWD5400_21115
OANOant_4003
OAHDR92_4252
OCRHGK82_22770
OCLGTN27_15140
PSCQKHQ08_01220
BJAbll6076(bll6076)
BJUBJ6T_36330
BJPRN69_17615
BRABRADO2327
BBTBBta_2688
BRSS23_22000
AOLS58_52700
BRCBCCGELA001_25790
BRADBF49_5558
BICLMTR13_29955
BROBRAD285_5014
BRKCWS35_19425
BOTCIT37_23905
BRQCIT40_22355
BGQX265_12405
BGZXH91_11175
BSYMCIT39_21550
BBETF8237_26075
BARHWN72_33940
BVZBRAD3257_3054
BELBE61_67890
BDGLPJ38_32195
BSEPHAP48_0032180
BQBJ4P68_0033425
RPERPE_3227
RBKE0H22_08325
TRBHB776_01710
BOPAXW83_05470
BOSBSY19_2583
BVVBHK69_17900
BOIBLM15_06845
BOFFQV39_07720
AZCAZC_3184
MNOMnod_1201
MAQUMaq22A_c15010(acs)
MEEDA075_24335
METIDK427_23565
MTEADK419_08625
MINDmvi_06430
MOCBB934_20020
MIVC4E04_11000
MICOGDR74_09815
RHZRHPLAN_46610
MMYRMXMO3_02966
PLEOOHA_1_03143(bclA_2)
MMEDMame_00667(bclA)
PSINCAK95_09910 CAK95_17100
NOHG5V57_08200
RBMTEF_20615
PSFPSE_3152
PPHRAPZ00_22260
LAPACP90_18570
LABRCHH27_01645
LABPFJ695_03020
LABTFIU93_25230(bclA2)
LAGGB0E33_02340
SIWGH266_21610
PHRC6569_02065
PSTGE8M01_20655
ACUTMRB58_19430
TSVDSM104635_00125(bclA)
SILSPOA0401(badA-2)
SITTM1040_2238
JANJann_1328
RPONG3256_11240
PGAPGA1_c23440
PGLPGA2_c21390
PGDGal_01048
PHPPhaeoP97_02213
PPICPhaeoP14_02128
PHQD1820_06610
LMDMETH_05755
LEJETW24_06955
LAQUR2C4_11680
MALGMALG_04445
YPACCEW88_22255
SUAMBOO69_10910
SULZC1J03_14395
SULIC1J05_03640
SULDB5M07_07420
SMEDJNX03_02595
SINLDSM14862_01902(bclA)
SPSESULPSESMR1_00938(bclA)
TOMBWR18_13920
RIDRIdsm_02008(bclA_1)
THAACFI11_17575
ROTFIV09_19145(bclA)
PDEPden_5094
PZHCX676_10755
PAROCUV01_10705
PARUCYR75_10940
PARSDRW48_06115
PARREOJ32_00500
PKDF8A10_20340
PPANESD82_10155
PSANHGN31_04500
PMAUCP157_00365(bclA)
RMBK529_002670
GEHHYN69_13460
GFUKM031_16690
TAWEI545_11340
SEDIEBB79_22715
BOOE2K80_00540
PSEBEOK75_00185
PPRUFDP22_18960
PSHQF3W81_17830
PGVSL003B_1861
THASC6Y53_04990
HDHG5B40_19695
GCEKYE46_05200
MMRMmar10_2688
HYTHXX25_09870
CBOTATE48_08950
SECHB18_16610
SLUTH9L13_04570
SRHIH9L12_00165
SXAFMM02_07360
SPAIFPZ24_12950
SSING7078_07250
SSAUH8M03_09320
SMICSmB9_25160
SPHSETR14_04615
ELQGa0102493_111588
ERKCD351_08195
AZLAZL_a03650(acs)
ALIAZOLI_p10337
ABSAZOBR_p1170010
ABQABAZ39_18115
ABFAMK58_18200
ATIAL072_20705
AZTTSH58p_29320
AZMDM194_16095
AZZDEW08_04215 DEW08_27915
AOZHUE56_27380
SKTIGS68_14660
SMUCJL100_011505
SROEJL101_014190
MAGamb2262
MAGXXM1_3084 XM1_3863
MAGNWV31_07975 WV31_20530
FERFNB15_14040
TXITH3_14035
THACCSC3H3_21305
TIIDY252_07830
ECOGFIV45_00665
DKUDesku_2922
THEFE1B22_00625
MFJMFLOJ_23640(acs)
MGORH0P51_02480
CCYCSCMU_02020(acs_1)
NFANFA_12430
NFRERS450000_02867(bclA_1)
NBRO3I_025355
NTPCRH09_09690 CRH09_29855
NOZDMB37_35720
NAHF5544_00280 F5544_18265
NIEKV110_14365
REBXU06_29665
ROAPd630_LPD04668
RHUA3Q40_02701(bclA)
TOYFO059_01145
SCOSCO5983(StBAC16H6.18c)
SMASAVERM_2307
SGRSGR_1564
SGBWQO_27525
SCBSCAB_87851
SVLStrvi_6040
SHYSHJG_7045
SHOSHJGH_6805
SRCM271_00730
SMALSMALA_0964
SSOII1A49_08310
SCTSCAT_p1530
SCYSCATT_p01940
SFASfla_1376
SBHSBI_03204
SVESVEN_5804
SDVBN159_2442
SALSSLNWT_4227
STRPF750_5507
SFISFUL_5894
SCIB446_27830
SALUDC74_5984
SALLSAZ_31000
SLVSLIV_08700
SGUSGLAU_25625
SVTSVTN_29055
STREGZL_02810
SCWTU94_25315
SLDT261_2063
SLCSL103_26320
STRMM444_26260
STRCAA958_27720
SAMBSAM23877_5697
SPRISPRI_1834
SCZABE83_06700
SCXAS200_12495
SRWTUE45_06578(bclA)
STRFASR50_27050
SLEsle_17290(sle_17290)
SPAVSpa2297_25145
STRTA8713_24950
SCLFBB341_04820
SGSAVL59_11230
STSIA4E84_30605
SALWCP975_27805
SGMGCM10017557_77660(acs)
SCADDN051_11005
SLSSLINC_6364
SNRSNOUR_12075
SPLULK06_026020
SNWBBN63_06915
SAUOBV401_08615
SSIAA7J05_09095
SVUB1H20_28110
SPUNBFF78_11515
SGVB1H19_30390
SLAUSLA_5842
SALFSMD44_06591(abmG)
SALJSMD11_1625(abmG)
SLXSLAV_10175(bclA)
STROSTRMOE7_29315
SFKKY5_6124c
SNZDC008_26840
SGEDWG14_02130(bclA)
SRJSRO_1857
SLKSLUN_30220
SDXC4B68_09720
SGDELQ87_09960
SQZFQU76_26770
SCYAEJ357_35065
SASTCD934_06860
STIRDDW44_24145
SKACP970_10315
SGZC0216_08435
SVNCP980_07910
SHAWCEB94_31195
SRKFGW37_25080
SFICEIZ62_06950
SGALCP966_27710
SSPODDQ41_25825
SFYGFH48_11310
SAQUEJC51_35685
SGFHEP81_02105
SCAVCVT27_27065
SBYH7H31_06620
SRIMCP984_08910
SSUBCP968_08530
SPHVF9278_37230
SCINCP977_26405
SFUGCNQ36_25195
SPACB1H29_08955
STSUB7R87_27230
SCHACP983_10685
SGXH4W23_30130
SCOECP976_32725
SBATG4Z16_06345
SSPBCP982_31390
SNFJYK04_01136(bclA_1) JYK04_06353(bclA_2)
SPLACP981_29495
SBROGQF42_32410
STUIGCM10017668_54560
SATAC5746_31710
SCHFIPT68_28095
SHUNDWB77_01871(bclA)
SCYGS1361_29690(bclA)
SFEUIM697_33320
SDWK7C20_28280
SVDCP969_28665
SCALI6J39_27975
SAUHSU9_026900
SMOBJ7W19_24815
SPEUCGZ69_28470
SROIIAG44_09420
SXNIAG42_08185
SGJIAG43_25340
SHKJ2N69_28735
SANUK7396_08740
STRYEQG64_28295
SDDD9753_08220
SACTDMT42_29485
KABB7C62_29195
KAUB6264_27665
KITCFP65_1369
LEBG7066_03625
LDNH9L06_07570
LVIG7068_12765
ARRARUE_113p00220 ARUE_c41730
ARLAFL94_05005
AREAL755_03285 AL755_04020
AAQAOC05_11120
ARZAUT26_09950
ARNCGK93_22615
ARXARZXY2_1967(abmG)
AAUAAur_4030
PUEFV140_10225
PNVJMY29_19340
PSULAU252_00120
PSEYGU243_00260
GLUF0M17_05310
GPRJQN66_05440
TEHGKE56_05410
ORNDV701_11185
NAROCFH99_00735
PSIMKR76_09700
NALB005_0469
NGVCDO52_13240
SAIUJ4H86_05720
AGRAAGRA3207_002230
BSDBLASA_2568
SENSACE_3131
AMDAMED_3360(acs)
AMNRAM_17085
AMMAMES_3321(acs)
AMZB737_3321(acs)
AOIAORI_3474(abmG)
AJAAJAP_21795
AMQAMETH_3668(acs)
AMYCCU254_13360
AMYBBKN51_15135
AORISD37_17980
PDXPsed_4246
PAUTPdca_55330(acs_4)
SESPBN6_40590
SSYIEKG83_10175
KALKALB_3448
KPHYAOZ06_34255
LEDBBK82_33830
AHGAHOG_16420(bclA)
SACEGIY23_11620
ATLAthai_10140(acs_1)
ASERAsera_63130(acs_2)
CAICaci_5524
SNASnas_6454
EKEEK0264_06025
RXYRxyl_2279
RMARGBA65_17945
EUZDVS28_a0081
DPHEHF33_19000
MRBMrub_2116
MREK649_11955
GAUGAU_3271
GPHGEMMAAP_16735
GGRHKW67_13060
GBAJ421_5580
COYHF329_06230
FPSZAMR72_01565
FINKQS_01625
FATDVK85_10680
FPALHYN49_11400
FMGHYN48_11315
FALBHYN59_11920
FSNGS03_02244(bclA)
FAKFUA48_13800
TTKTST_0306 TST_1126
MOXDAMO_2031
AFGAFULGI_00010660
ASTAsulf_00270
FPLFerp_2180
GAHGAH_01124
HNOLT974_08145
HJEHacjB3_15636
HALJG9465_21875
SRUBC2R22_17760
HALUHUG12_20070
HACBHbl1158_15350
HTUHtur_4177
HRUHalru_2525
NOUNatoc_0740
HLRHALLA_02630
NAJB1756_07220
 » show all
Reference
1  [PMID:2176602]
  Authors
Altenschmidt U, Eckerskorn C, Fuchs G.
  Title
Evidence that enzymes of a novel aerobic 2-amino-benzoate metabolism in denitrifying Pseudomonas are coded on a small plasmid.
  Journal
Eur J Biochem 194:647-53 (1990)
DOI:10.1111/j.1432-1033.1990.tb15664.x
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.32
IUBMB Enzyme Nomenclature: 6.2.1.32
ExPASy - ENZYME nomenclature database: 6.2.1.32
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.32
BRENDA, the Enzyme Database: 6.2.1.32
CAS: 112692-58-7
LinkDB

KEGG   REACTION: R00982
Entry
R00982                      Reaction                               
Name
Anthranilate:CoA ligase (AMP-forming)
Definition
ATP + Anthranilate + CoA <=> AMP + Diphosphate + Anthraniloyl-CoA
Equation
Reaction class
RC00004  C00010_C02247
RC00174  C00108_C02247
Enzyme
Pathway
rn00405  Phenazine biosynthesis
rn00627  Aminobenzoate degradation
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00848  Aurachin biosynthesis, anthranilate => aurachin A
Orthology
K08295  2-aminobenzoate-CoA ligase [EC:6.2.1.32]
K09460  anthranilate-CoA ligase [EC:6.2.1.32]
K18000  anthranilate-CoA ligase [EC:6.2.1.32]
Other DBs
RHEA: 10831
LinkDB

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