KEGG   ORTHOLOGY: K09758
Entry
K09758                      KO                                     
Symbol
asdA
Name
aspartate 4-decarboxylase [EC:4.1.1.12]
Pathway
map00250  Alanine, aspartate and glutamate metabolism
map00270  Cysteine and methionine metabolism
map01100  Metabolic pathways
map01230  Biosynthesis of amino acids
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K09758  asdA; aspartate 4-decarboxylase
   00270 Cysteine and methionine metabolism
    K09758  asdA; aspartate 4-decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.12  aspartate 4-decarboxylase
     K09758  asdA; aspartate 4-decarboxylase
Other DBs
RN: R00397 R00863
GO: 0047688
Genes
PGE: LG71_16775
SGOE: A8O29_009805
EBI: EbC_05500(asdA)
EGE: EM595_p0259(asD)
PAGC: BEE12_19545
XCZ: EBN15_14105
DCS: ISN74_02670
VPF: M634_10470
VAG: N646_0788
VOW: A9237_22760
ABX: ABK1_1281
ABH: M3Q_2677
ACC: BDGL_001724(asdA)
AGU: AS4_34620
AUG: URS_3215
ABOU: ACBO_17400(asdA)
SPSW: Sps_02671
FTQ: RO31_0955
FTW: FTW_1358
FTL: FTL_0320
FTH: FTH_0320(aspD)
FTA: FTA_0339
FTS: F92_01720
FTI: FTS_0320(aspD)
FTC: DA46_389(aspD)
FTV: CH67_605(aspD)
FTZ: CH68_339(aspD)
FTM: FTM_0420
FTN: FTN_0343
FTX: AW25_1696(aspD)
FTD: AS84_347(aspD)
FTY: CH70_1724(aspD)
FPH: Fphi_0481
FPT: BZ13_1555(aspD)
FPI: BF30_676(aspD)
FPM: LA56_1696(aspD)
FPX: KU46_878(aspD)
FPZ: LA55_350(aspD)
FPJ: LA02_93(aspD)
RIN: ACS15_4642(aspD)
REH: H16_A3009(asdA)
RME: Rmet_1984(asdA)
BDL: AK34_5158(aspD)
BGU: KS03_1969(aspD)
BGO: BM43_966(aspD)
BXE: Bxe_A3891
BXB: DR64_1567(aspD)
BFN: OI25_910(aspD)
PDIO: PDMSB3_0651(asD)
PPNO: DA70_08515
PPNM: LV28_22125
PPUL: RO07_16525
PSPU: NA29_20650
PAPI: SG18_15360
CABA: SBC2_59080(asD)
AXY: AXYL_01733(asdA)
DAC: Daci_3914
CTES: O987_14975
MMS: mma_1084(asdA)
CFU: CFU_0143(asdA)
CARE: LT85_0123
CPRA: CPter91_0121(aspD)
SUN: SUN_0877
DAS: Daes_0274
PLA: Plav_0095
SMER: DU99_31685
RHL: LPU83_pLPU83c0641(asdA)
KAI: K32_37910
OAN: Oant_3483
OAH: DR92_3003(aspD)
BJA: blr3477(blr3477)
BRS: S23_35870
BSEP: HAP48_0009735(aspD)
MET: M446_1557
RUT: FIU92_18350(asD)
ZMO: ZMO1682
ZMN: Za10_1537
ZMM: Zmob_1458
ZMB: ZZ6_1435
ZMI: ZCP4_1480
KSC: CD178_01686(asD)
ASZ: ASN_851
PRD: F7984_03280(aspD)
AAD: TC41_0858
AFX: JZ786_08480(aspD)
AACO: K1I37_06695(aspD)
LGR: LCGT_1281
LGV: LCGL_1302
LAC: LBA1695
LAD: LA14_1696
LAF: SD55_1697
LHL: LBHH_1710
LCA: LSEI_2747
LCS: LCBD_2960
LCE: LC2W_2934
LCB: LCABL_29320(asdA)
LPZ: Lp16_F030
LSA: LCA_0306(aspD)
EFA: EF1037
EFL: EF62_1474
EFS: EFS1_0865(asdA)
EFQ: DR75_96(aspD)
ENE: ENT_30620
ERAF: J9537_19820(aspD)
THL: TEH_22060(aspD)
DPM: FNV33_08145(aspD)
CPF: CPF_0325 CPF_1258(aspD)
CPR: CPR_0327
CBO: CBO1166(asdA)
CBA: CLB_1197(asdA)
CBH: CLC_1209(asdA)
CBY: CLM_1317
CBL: CLK_0601
CBB: CLD_3403
CBI: CLJ_B1207(aspD)
CBF: CLI_1247(aspD)
CBE: Cbei_1924
CBZ: Cbs_1924
CBEI: LF65_02091
CKL: CKL_0699
CKR: CKR_0621
CBV: U729_1867(aspD)
CSQ: CSCA_1714
CLD: CLSPO_c11660(asd1)
CTYK: CTK_C07120
CSEP: CP523_01580(aspD)
CDY: F3K33_09545(aspD)
CFER: D4Z93_01615(aspD)
CLOS: DMR38_16645(aspD)
CCAA: KQH81_05490(aspD)
CMAH: C1I91_23255(aspD)
SARJ: HH195_05955(aspD)
PBIF: KXZ80_04485(aspD)
CEW: EKH84_13810(aspD)
PDC: CDIF630_02764(aspD)
CDC: CD196_2360(aspD)
CDL: CDR20291_2407(aspD)
EAC: EAL2_c09600(aspD)
ROC: HF520_07485(aspD)
PHX: KGNDJEFE_01911(asD)
TEM: JW646_15505(aspD)
AMIC: Ami3637_00175(aspD)
ABUT: Ami103574_04740(aspD)
MANA: MAMMFC1_00109(asD)
TSG: HLK68_09170(aspD) HLK68_11245(aspD)
MBOK: MBOE_49860(asdA)
SALB: XNR_4167
SGR: SGR_4732
SGB: WQO_11875
SVE: SVEN_2588
SFI: SFUL_2397
SFK: KY5_2946
KSK: KSE_63100
SESP: BN6_36290
CAI: Caci_1946
SNA: Snas_3840
AEQ: AEQU_1726
LBA: Lebu_0659
BTH: BT_0735
BTHO: Btheta7330_02355(asD)
BFR: BF1517
BXY: BXY_02850
BOA: Bovatus_00911(asD)
BCEL: BcellWH2_01068(asD)
BCAC: CGC64_12685(aspD)
BIS: DXK01_019955(aspD)
BEG: INE88_00537(asd_1)
BSTE: K6V31_16075(aspD)
BFE: K6V30_15685(aspD)
BNO: K8P02_11205(aspD)
BVU: BVU_2264
PDI: BDI_1073
PMER: INE87_00972(asd_1)
COY: HF329_12145(aspD)
PGO: FSB84_29235(aspD)
FJG: BB050_04015(asD)
APIB: G8C43_08895(aspD)
THA: TAM4_1721
THM: CL1_0496
ABI: Aboo_0621
 » show all
Reference
  Authors
Abe K, Ohnishi F, Yagi K, Nakajima T, Higuchi T, Sano M, Machida M, Sarker RI, Maloney PC
  Title
Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction.
  Journal
J Bacteriol 184:2906-13 (2002)
DOI:10.1128/JB.184.11.2906-2913.2002
LinkDB

KEGG   ENZYME: 4.1.1.12
Entry
EC 4.1.1.12                 Enzyme                                 
Name
aspartate 4-decarboxylase;
desulfinase;
aminomalonic decarboxylase;
aspartate beta-decarboxylase;
aspartate omega-decarboxylase;
aspartic omega-decarboxylase;
aspartic beta-decarboxylase;
L-aspartate beta-decarboxylase;
cysteine sulfinic desulfinase;
L-cysteine sulfinate acid desulfinase;
L-aspartate 4-carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
L-aspartate 4-carboxy-lyase (L-alanine-forming)
Reaction(IUBMB)
L-aspartate = L-alanine + CO2 [RN:R00397]
Reaction(KEGG)
R00397;
(other) R00863
Substrate
L-aspartate [CPD:C00049]
Product
L-alanine [CPD:C00041];
CO2 [CPD:C00011]
Comment
A pyridoxal-phosphate protein. Also catalyses the decarboxylation of aminomalonate (formerly listed as EC 4.1.1.10), and the desulfination of 3-sulfino-L-alanine to sulfite and alanine.
History
EC 4.1.1.12 created 1961, modified 1976 (EC 4.1.1.10 created 1961, incorporated 1972)
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K09758  aspartate 4-decarboxylase
Genes
PGELG71_16775
SGOEA8O29_009805
EBIEbC_05500(asdA)
EGEEM595_p0259(asD)
PAGCBEE12_19545
XCZEBN15_14105
DCSISN74_02670
VPFM634_10470
VAGN646_0788
VOWA9237_22760
VBRA6E01_18540
VSHBSZ05_17320
VNLD3H41_09020
VCCFAZ90_22230
VASGT360_19455
PORAPT59_06490
PPSLBJP27_21240
ABCACICU_02407
ABXABK1_1281
ABRABTJ_01313
ABDABTW07_2602
ABHM3Q_2677
ABJBJAB07104_02567
ABAJBJAB0868_02449
ABKLX00_11905
ABWBL01_18405
ACCBDGL_001724(asdA)
ANORR32_06650
ALCOTEC02_06155
ACALBUM88_12690
ASEII8T81_06570
ACDAOLE_05980
ACWA0J50_05920
ARJDOM24_06685
AGUAS4_34620
AUGURS_3215
ADSFPL17_02705
ABERBSR55_16730
ABOUACBO_17400(asdA)
SJASJ2017_0934
SPSWSps_02671
SAESHBH39_15210
SPSHFM037_05185
AGZM0C34_10675 M0C34_15950
FTQRO31_0955
FTWFTW_1358
FTLFTL_0320
FTHFTH_0320(aspD)
FTAFTA_0339
FTSF92_01720
FTIFTS_0320(aspD)
FTCDA46_389(aspD)
FTVCH67_605(aspD)
FTZCH68_339(aspD)
FTMFTM_0420
FTNFTN_0343
FTXAW25_1696(aspD)
FTDAS84_347(aspD)
FTYCH70_1724(aspD)
FCFFNFX1_0347
FCNFN3523_0319
FHIFSC454_01590
FPHFphi_0481
FPTBZ13_1555(aspD)
FPIBF30_676(aspD)
FPMLA56_1696(aspD)
FPXKU46_878(aspD)
FPZLA55_350(aspD)
FPJLA02_93(aspD)
FNLM973_02125
FRXF7310_01935
FMIF0R74_00170
FSRKQR59_01715
TBOGLT988_20810
GAPGAPWK_0604
FPPFPB0191_01217
SALVSALWKB2_1178
JEUBJP62_06550
RMNTK49_17160
RINACS15_4642(aspD)
REHH16_A3009(asdA)
CUHBJN34_16100
REUReut_A2709
RMERmet_1984(asdA)
CTIRALTA_A2486
CPAUEHF44_03735 EHF44_08790
BDLAK34_5158(aspD)
BGLbglu_1g10380
BGUKS03_1969(aspD)
BUGBC1001_0495
BGFBC1003_0509
BGDbgla_1g34720
BGOBM43_966(aspD)
BYIBYI23_B001880 BYI23_B009610
BUEBRPE67_BCDS04300 BRPE67_BCDS13690
BUQAC233_02730 AC233_21280
BGPBGL_1c10730
BPLAbpln_1g10290
BUIAX768_27835
BXEBxe_A3891
BXBDR64_1567(aspD)
BPXBUPH_04382
BPYBphyt_0790
BUZAYM40_02735
BFNOI25_910(aspD)
BCAIK788_0004943
PARABTO02_16975
PARBCJU94_02295
PTERC2L65_12530
PGPCUJ91_02890 CUJ91_22250
PCJCUJ87_02565
PTROG5S35_02720
PGISI6I06_08795
PACPFAZ97_02760
PACSFAZ98_02735
PEWKZJ38_05240
PDIOPDMSB3_0651(asD)
PPKU875_16620
PPNODA70_08515
PPNMLV28_22125
PRBX636_17850
PPULRO07_16525
PSPUNA29_20650
PAPISG18_15360
PVEUC34_07725
POXMB84_12100
PFGAB870_18430
PNRAT302_26280
PFIBPI93_020105
CABASBC2_59080(asD)
BUOBRPE64_BCDS03460
BGMCAL15_04880
AXYAXYL_01733(asdA)
AXONH44784_003501
AXNAX27061_1634
AXXERS451415_01627
ADTAPT56_07650
AISBUW96_17710
ASWCVS48_27420
ACHBDVB37_06875 DVB37_19495
ADYHLG70_14320
PIGEGT29_14105
PACRFXN63_11900
AANTHUK68_19395
DACDaci_3914
DELDelCs14_2898
DTSBI380_05570
DHKBO996_17860
DLAI6G47_04575
VBOCKY39_13670
CTTCtCNB1_2315
CTESO987_14975
OTKC6570_11340
MMSmma_1084(asdA)
JAZYQ44_16560
JALBZG29_11315
JSVCNX70_11725
JASFJQ89_00355
JLVG3257_11780
HEEhmeg3_11990
CFUCFU_0143(asdA)
CARELT85_0123
CPRACPter91_0121(aspD)
RGUA4W93_20110
SUNSUN_0877
DSDGD606_11240
DASDaes_0274
PSELGM415_11140
MSDMYSTI_04286
MFBMFUL124B02_23065
CCXCOCOR_02790
LLUAKJ09_07676
PLAPlav_0095
SMERDU99_31685
EAHFA04_09150
ATAAWN88_07440
AGTEYD00_17740
RIRBN877_II0817
RPUSCFBP5875_17910
RHLLPU83_pLPU83c0641(asdA)
KAIK32_37910
OANOant_3483
OAHDR92_3003(aspD)
OCRHGK82_19905
OCLGTN27_17960
BJAblr3477(blr3477)
BRSS23_35870
BELBE61_65300
BSEPHAP48_0009735(aspD)
BOIBLM15_13525
BOFFQV39_12980
METM446_1557
AALAIGS74_01595
NOHG5V57_02800
CMBCSW64_14790
RUAD1823_08915
RUTFIU92_18350(asD)
PSHQF3W81_02265
HDHG5B40_15560
ZMOZMO1682
ZMNZa10_1537
ZMMZmob_1458
ZMBZZ6_1435
ZMIZCP4_1480
ZMCA265_01479
ZMRA254_01478
KSCCD178_01686(asD)
APTAPA01_04430 APA01_15490
APWAPA42C_04430 APA42C_15490
APFAPA03_04430 APA03_15490
APUAPA07_04430 APA07_15490
APGAPA12_04430 APA12_15490
APQAPA22_04430 APA22_15490
APXAPA26_04430 APA26_15490
APZAPA32_04430 APA32_15490
APKAPA386B_1928(asdA) APA386B_482
ASZASN_851
ASVWG31_02660 WG31_08065
AACEA0U92_00615
APERA0U91_10830
APOMCPF11_05090 CPF11_12475
ATOCIW82_07840
AASCA4S02_09960
ACETDS739_02335 DS739_07955
AOTAcetOri_orf02602 AcetOri_orf04014
AOYEOV40_002210 EOV40_007185
ACEKFLP30_02220
KBAA0U89_15935
RGIRGI145_16190
ROSCTJ15_14925
RMUCFOB66_04270
BOMBGT348_07755
ABSAZOBR_p430032
ABQABAZ39_32690
ABFAMK58_23540
AZTTSH58p_19950
BDCDOE51_04330
BDZDOM22_15740
PRDF7984_03280(aspD)
AADTC41_0858
AFXJZ786_08480(aspD)
AACOK1I37_06695(aspD)
LGRLCGT_1281
LGVLCGL_1302
LACLBA1695
LADLA14_1696
LAFSD55_1697
LHLLBHH_1710
LTAH1A07_02740
LCALSEI_2747
LCZLCAZH_2752
LCSLCBD_2960
LCELC2W_2934
LCWBN194_28750
LCLLOCK919_3003
LPILBPG_01343
LCBLCABL_29320(asdA)
LCXLCA12A_0440
LPRLBP_p3g040
LPZLp16_F030
LORAYI71_02915
LHOLOOC260_121710
LSALCA_0306(aspD)
LCVFBA2_01670
LGMLG542_07710
EFAEF1037
EFLEF62_1474
EFIOG1RF_10770
EFDEFD32_0849
EFSEFS1_0865(asdA)
EFNDENG_01170
EFQDR75_96(aspD)
ENEENT_30620
EGVEGCR1_11780 EGCR1_18225(aspD)
EAVEH197_06745(aspD) EH197_21350
ERAFJ9537_19820(aspD)
MPSMPTP_0441 MPTP_0995
MPXMPD5_0951 MPD5_1465
THLTEH_22060(aspD)
VTEBHY08_01720 BHY08_05240
VPIBW732_03295
MARRBKP56_00640
DPMFNV33_08145(aspD)
CPECPE0341 CPE1001
CPFCPF_0325 CPF_1258(aspD)
CPRCPR_0327
CBOCBO1166(asdA)
CBACLB_1197(asdA)
CBHCLC_1209(asdA)
CBYCLM_1317
CBLCLK_0601
CBBCLD_3403
CBICLJ_B1207(aspD)
CBFCLI_1247(aspD)
CBJH04402_01235
CBECbei_1924
CBZCbs_1924
CBEILF65_02091
CKLCKL_0699
CKRCKR_0621
CLJCLJU_c33270
CSBCLSA_c16110
CAHCAETHG_1226
CBVU729_1867(aspD)
CSQCSCA_1714
CLDCLSPO_c11660(asd1)
CCKCcar_06140
CTYKCTK_C07120
CEUA7L45_04535
CDRKB9W14_10705
CSEPCP523_01580(aspD)
CDYF3K33_09545(aspD)
CFERD4Z93_01615(aspD)
CLOSDMR38_16645(aspD)
CCAAKQH81_05490(aspD)
CMAHC1I91_23255(aspD)
SARJHH195_05955(aspD)
PBIFKXZ80_04485(aspD)
CLEClole_2227
CEWEKH84_13810(aspD)
CDFCD630_25150
PDCCDIF630_02764(aspD)
CDCCD196_2360(aspD)
CDLCDR20291_2407(aspD)
PDFCD630DERM_25150
EACEAL2_c09600(aspD)
PSORRSJ16_04440
ROCHF520_07485(aspD)
PHXKGNDJEFE_01911(asD)
TEMJW646_15505(aspD)
DMTDESME_09070
DORDesor_4048
DAIDesaci_1009
AMICAmi3637_00175(aspD)
ABUTAmi103574_04740(aspD)
HHLHalha_1158
MANAMAMMFC1_00109(asD)
TURAT726_09355 AT726_11740
TSGHLK68_09170(aspD) HLK68_11245(aspD)
MBOKMBOE_49860(asdA)
NNONONO_c61950
SALBXNR_4167
SGRSGR_4732
SGBWQO_11875
SVESVEN_2588
SFISFUL_2397
SVTSVTN_13840
SCZABE83_23965
SVUB1H20_11125
SFKKY5_2946
SKACP970_27805
SVNCP980_06000
SNKCP967_32090
SCAVCVT27_10565
SSUBCP968_06530
SCALI6J39_11340
SGJIAG43_26770
STRYEQG64_11000
KSKKSE_63100
KABB7C62_10775
KITCFP65_6286
SALAESZ53_11080
AAQAOC05_08165
SESPBN6_36290
PMADBAY61_13710
CAICaci_1946
SNASnas_3840
AEQAEQU_1726
AHATADCFC_06340
LSCKIK02_20220
TRMJO41_09340
LBALebu_0659
CPORBED41_13885
BTHBT_0735
BTHOBtheta7330_02355(asD)
BFRBF1517
BFSBF9343_1378
BFGBF638R_1530
BFBVU15_06365
BXYBXY_02850
BOABovatus_00911(asD)
BCELBcellWH2_01068(asD)
BCACCGC64_12685(aspD)
BISDXK01_019955(aspD)
BUNBun01g_20960
BEGINE88_00537(asd_1)
BSTEK6V31_16075(aspD)
BFEK6V30_15685(aspD)
BNOK8P02_11205(aspD)
BVUBVU_2264
BDOEL88_04250
BDHGV66_11835
PDIBDI_1073
PARCCI960_09080
PMERINE87_00972(asd_1)
PGOLK6V26_07070
PJOLK449_08285
COPRCop2CBH44_09800
COYHF329_12145(aspD)
PGOFSB84_29235(aspD)
SCNSolca_2046
FJGBB050_04015(asD)
CAOCelal_4230
OLLCW732_12970
PSYNE9099_16455
APIBG8C43_08895(aspD)
MELMetbo_1835
THATAM4_1721
THMCL1_0496
ABIAboo_0621
ACFAciM339_0098
 » show all
Reference
1  [PMID:5773301]
  Authors
Kakimoto T, Kato J, Shibatani T, Nishimura N, Chibata I.
  Title
Crystalline L-aspartate beta-decarboxylase of Pseudomonas dacunhae. I. Crystallization and some physiocochemical properties.
  Journal
J Biol Chem 244:353-8 (1969)
Reference
2  [PMID:14154469]
  Authors
NOVOGRODSKY A, MEISTER A.
  Title
CONTROL OF ASPARTATE BETA-DECARBOXYLASE ACTIVITY BY TRANSAMINATION.
  Journal
J Biol Chem 239:879-88 (1964)
Reference
3  [PMID:5424207]
  Authors
Palekar AG, Tate SS, Meister A.
  Title
Inhibition of aspartate beta-decarboxylase by aminomalonate. Stereospecific decarboxylation of aminomalonate to glycine.
  Journal
Biochemistry 9:2310-5 (1970)
DOI:10.1021/bi00813a014
Reference
4  [PMID:14071532]
  Authors
WILSON EM, KORNBERG HL.
  Title
PROPERTIES OF CRYSTALLINE L-ASPARTATE 4-CARBOXY-LYASE FROM ACHROMOBACTER SP.
  Journal
Biochem J 88:578-87 (1963)
DOI:10.1042/bj0880578
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.12
IUBMB Enzyme Nomenclature: 4.1.1.12
ExPASy - ENZYME nomenclature database: 4.1.1.12
BRENDA, the Enzyme Database: 4.1.1.12
CAS: 9024-57-1
LinkDB

KEGG   REACTION: R00397
Entry
R00397                      Reaction                               
Name
L-aspartate 4-carboxy-lyase (L-alanine-forming)
Definition
L-Aspartate <=> L-Alanine + CO2
Equation
Reaction class
RC00282  C00041_C00049
Enzyme
Pathway
rn00250  Alanine, aspartate and glutamate metabolism
rn01100  Metabolic pathways
rn01230  Biosynthesis of amino acids
Orthology
K09758  aspartate 4-decarboxylase [EC:4.1.1.12]
Other DBs
RHEA: 12624
LinkDB

DBGET integrated database retrieval system