KEGG   ORTHOLOGY: K09827
Entry
K09827                      KO                                     

Symbol
ERG27
Name
3-keto steroid reductase [EC:1.1.1.270]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K09827  ERG27; 3-keto steroid reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.270  3beta-hydroxysteroid 3-dehydrogenase
     K09827  ERG27; 3-keto steroid reductase
Other DBs
RN: R07495 R12405
COG: COG1028
GO: 0050576
Genes
QSU: 111993502 112014247
SCE: YLR100W(ERG27)
AGO: AGOS_AGR068W
ERC: Ecym_4279
KLA: KLLA0_F19756g
KMX: KLMA_40163(ERG27)
LTH: KLTH0G13046g
VPO: Kpol_1033p20
ZRO: ZYRO0D06534g
CGR: CAGL0M11506g
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PIC: PICST_61325(ERG27)
CAL: CAALFM_CR01140CA(ERG27)
CDU: CD36_26140(ERG27)
SLB: AWJ20_1569(ERG27)
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SSCK: SPSK_07425
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
MBE: MBM_01041
ANI: AN5585.2
ANG: ANI_1_1880184(An04g05000)
ABE: ARB_02354
TVE: TRV_04668
PTE: PTT_11743
SPO: SPBC1709.07(erg27)
CNE: CND03020
CNB: CNBD3330
TASA: A1Q1_03186
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
MGL: MGL_2564
MRT: MRET_0524
 » show all
Reference
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
LinkDB

KEGG   ORTHOLOGY: K13373
Entry
K13373                      KO                                     

Symbol
HSD17B7
Name
17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]
Pathway
map00100  Steroid biosynthesis
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04913  Ovarian steroidogenesis
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
   00140 Steroid hormone biosynthesis
    K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
    1.1.1.270  3beta-hydroxysteroid 3-dehydrogenase
     K13373  HSD17B7; 17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Other DBs
RN: R02352 R02353 R04681 R04682 R07495 R08945 R08980 R12405
GO: 0004303 0050576
Genes
HSA: 51478(HSD17B7)
PTR: 466046 747814(HSD17B7)
PPS: 100985156(HSD17B7)
GGO: 101137638(HSD17B7)
PON: 100446761(HSD17B7)
NLE: 100587120(HSD17B7)
MCC: 720399
MCF: 102127673(HSD17B7)
CSAB: 103223654(HSD17B7)
CATY: 105589219(HSD17B7)
PANU: 101019563(HSD17B7)
RRO: 104656967(HSD17B7)
RBB: 108535633
TFN: 117074787(HSD17B7)
PTEH: 111525046(HSD17B7)
CJC: 100410416(HSD17B7)
SBQ: 101047238(HSD17B7)
MMUR: 105873582(HSD17B7)
MMU: 15490(Hsd17b7)
MCAL: 110292934(Hsd17b7)
MPAH: 110322287(Hsd17b7)
RNO: 29540(Hsd17b7)
MCOC: 116103156(Hsd17b7)
MUN: 110550630(Hsd17b7)
CGE: 100767580(Hsd17b7)
PLEU: 114689903(Hsd17b7)
NGI: 103746788(Hsd17b7)
HGL: 101712707(Hsd17b7)
CCAN: 109690973(Hsd17b7)
OCU: 100008778(HSD17B7) 100349261
OPI: 101524723(HSD17B7)
TUP: 102473205(HSD17B7)
CFA: 609364(HSD17B7)
VVP: 112914306(HSD17B7)
VLG: 121501279(HSD17B7)
AML: 100477716(HSD17B7)
UMR: 103658287(HSD17B7)
UAH: 113268675(HSD17B7)
ORO: 101368538(HSD17B7)
ELK: 111151061
MPUF: 101689203(HSD17B7)
EJU: 114210516(HSD17B7)
MLX: 118014038(HSD17B7)
FCA: 101083482(HSD17B7)
PYU: 121020915(HSD17B7)
PBG: 122475607(HSD17B7)
PTG: 102968316(HSD17B7)
PPAD: 109276652(HSD17B7)
AJU: 106986761(HSD17B7)
HHV: 120241069(HSD17B7)
BTA: 505212(HSD17B7)
BOM: 102266348(HSD17B7)
BIU: 109577890(HSD17B7)
BBUB: 102389083(HSD17B7)
CHX: 102179058(HSD17B7)
OAS: 101110013(HSD17B7)
ODA: 120855521(HSD17B7)
CCAD: 122429981(HSD17B7) 122432561
SSC: 100155418(HSD17B7)
CFR: 102512546(HSD17B7)
CBAI: 105068038(HSD17B7)
CDK: 105092702(HSD17B7)
BACU: 103014331(HSD17B7)
LVE: 103084050(HSD17B7)
OOR: 101286750(HSD17B7)
DLE: 111169243(HSD17B7)
PCAD: 102984493(HSD17B7)
ECB: 100059061(HSD17B7)
EPZ: 103559639(HSD17B7)
EAI: 106823694(HSD17B7)
MYB: 102251181(HSD17B7)
MYD: 102767046(HSD17B7)
MMYO: 118673077(HSD17B7)
MNA: 107535110(HSD17B7)
PKL: 118712029(HSD17B7)
HAI: 109392309(HSD17B7)
DRO: 112298817(HSD17B7)
SHON: 118979201(HSD17B7)
AJM: 119052313(HSD17B7)
MMF: 118637572(HSD17B7)
PALE: 102892079(HSD17B7)
PGIG: 120584178(HSD17B7)
MJV: 108396655(HSD17B7)
TOD: 119241348(HSD17B7)
LAV: 100676060 100676343(HSD17B7)
TMU: 101361551
MDO: 100016071(HSD17B7)
SHR: 100926227(HSD17B7)
PCW: 110209887(HSD17B7)
OAA: 114817513(HSD17B7)
GGA: 424367(HSD17B7)
PCOC: 116230531(HSD17B7)
MGP: 100542640(HSD17B7)
CJO: 107317140(HSD17B7)
NMEL: 110402344(HSD17B7)
APLA: 101799136(HSD17B7)
ACYG: 106041628(HSD17B7)
TGU: 100222823(HSD17B7)
LSR: 110478897(HSD17B7)
SCAN: 103824326(HSD17B7)
PMOA: 120497588(HSD17B7)
OTC: 121344332(HSD17B7)
PRUF: 121359833(HSD17B7)
GFR: 102042580(HSD17B7)
FAB: 101818521(HSD17B7)
PHI: 102107312(HSD17B7)
PMAJ: 107198613(HSD17B7)
CCAE: 111932684(HSD17B7)
CCW: 104695594(HSD17B7)
ETL: 114067481(HSD17B7)
FPG: 101919410(HSD17B7)
FCH: 102059217(HSD17B7)
CLV: 102097738(HSD17B7)
EGZ: 104132130(HSD17B7)
NNI: 104010459(HSD17B7)
ACUN: 113483111(HSD17B7)
PADL: 103914076(HSD17B7)
AAM: 106499711(HSD17B7)
AROW: 112977170(HSD17B7)
NPD: 112951140(HSD17B7)
DNE: 112997417(HSD17B7)
ASN: 102374189(HSD17B7)
AMJ: 102565865(HSD17B7)
CPOO: 109307069(HSD17B7)
GGN: 109287068(HSD17B7)
PSS: 102461698(HSD17B7)
CMY: 102944731(HSD17B7)
CPIC: 101953232(HSD17B7)
TST: 117881449(HSD17B7)
CABI: 116831149(HSD17B7)
ACS: 100556465(hsd17b7)
PVT: 110081655(HSD17B7)
PBI: 103063132(HSD17B7)
PMUR: 107302880(HSD17B7)
PGUT: 117661207(HSD17B7)
PMUA: 114598525(HSD17B7)
ZVI: 118089365(HSD17B7)
GJA: 107121042(HSD17B7)
XLA: 734717(hsd17b7.S)
XTR: 548963(hsd17b7)
NPR: 108801354(HSD17B7)
DRE: 768185(hsd17b7)
SANH: 107684349(hsd17b7) 107692446
CCAR: 109091408
IPU: 108271889(hsd17b7)
PHYP: 113538418(hsd17b7)
AMEX: 103035681(hsd17b7)
EEE: 113570462(hsd17b7)
TRU: 101072277 101079626(hsd17b7)
NCC: 104948248(hsd17b7) 104967182
CGOB: 115007156(hsd17b7)
ELY: 117253561(hsd17b7) 117271615
PLEP: 121940863(hsd17b7) 121951731
SLUC: 116045810 116063209(hsd17b7)
ECRA: 117950534(hsd17b7) 117954002
GAT: 120816127(hsd17b7)
PPUG: 119202648(hsd17b7)
MSAM: 119900960(hsd17b7) 119902362
CUD: 121511992(hsd17b7) 121520534
OAU: 116327922(hsd17b7) 116331994
OML: 112147206 112150931(hsd17b7)
XMA: 102223080(hsd17b7) 102225591
CTUL: 119789912 119790042(hsd17b7)
KMR: 108230837(hsd17b7) 108238258
ALIM: 106528419(hsd17b7)
POV: 109625649(hsd17b7) 109644359
XGL: 120790306(hsd17b7) 120798840
BPEC: 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109966957
SASA: 106568727
OTW: 112260221(hsd17b7)
OMY: 110530031(hsd17b7)
SALP: 111957119(hsd17b7)
SNH: 120055749(hsd17b7)
ELS: 105024805
SFM: 108935177(hsd17b7)
PKI: 111841069(hsd17b7)
AANG: 118230844(hsd17b7)
LOC: 102696390(hsd17b7)
PSPA: 121327382
LCM: 102348492(HSD17B7)
CMK: 103180036(hsd17b7)
RTP: 109925128(hsd17b7)
BFO: 118426285
CIN: 100180521
SCLV: 120336480
SPU: 588363
APLC: 110976300
SKO: 102804082
PCAN: 112564142
BGT: 106062648
GAE: 121381187
CRG: 105338891
MYI: 110457107
PMAX: 117343915
OSN: 115231651
LAK: 106150742
AQU: 100638506
 » show all
Reference
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
LinkDB

KEGG   ENZYME: 1.1.1.270
Entry
EC 1.1.1.270                Enzyme                                 

Name
3beta-hydroxysteroid 3-dehydrogenase;
3-keto-steroid reductase;
3-KSR;
HSD17B7 (gene name);
ERG27 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3beta-hydroxysteroid:NADP+ 3-oxidoreductase
Reaction(IUBMB)
a 3beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH + H+ [RN:R12402]
Reaction(KEGG)
Substrate
3beta-hydroxysteroid [CPD:C02945];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on multiple 3beta-hydroxysteroids. Participates in the biosynthesis of zemosterol and cholesterol, where it catalyses the reaction in the opposite direction to that shown. The mammalian enzyme is bifunctional and also catalyses EC 1.1.1.62, 17beta-estradiol 17-dehydrogenase [4].
History
EC 1.1.1.270 created 2002, modified 2012
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K09827  3-keto steroid reductase
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
K22970  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase
Genes
HSA: 51478(HSD17B7) 79154(DHRS11)
PTR: 454598(DHRS11) 466046 747814(HSD17B7)
PPS: 100985156(HSD17B7) 100989828(DHRS11)
GGO: 101133645(DHRS11) 101137638(HSD17B7)
PON: 100446761(HSD17B7) 100450428(DHRS11)
NLE: 100580130(DHRS11) 100587120(HSD17B7)
MCC: 713823(DHRS11) 720399
MCF: 102127673(HSD17B7) 102133734(DHRS11)
CSAB: 103223654(HSD17B7) 103242795(DHRS11)
CATY: 105583369(DHRS11) 105589219(HSD17B7)
PANU: 101007886(DHRS11) 101019563(HSD17B7)
RRO: 104656967(HSD17B7) 104672997(DHRS11)
RBB: 108526295(DHRS11) 108535633
TFN: 117067355(DHRS11) 117074787(HSD17B7)
PTEH: 111525046(HSD17B7) 111537680(DHRS11)
CJC: 100410416(HSD17B7) 100415468(DHRS11)
SBQ: 101047238(HSD17B7) 101049784(DHRS11)
MMUR: 105873582(HSD17B7) 105879451(DHRS11)
MMU: 15490(Hsd17b7) 192970(Dhrs11)
MCAL: 110292934(Hsd17b7) 110304998(Dhrs11)
MPAH: 110322287(Hsd17b7) 110332326(Dhrs11)
RNO: 29540(Hsd17b7) 360583(Dhrs11)
MCOC: 116078372(Dhrs11) 116103156(Hsd17b7)
MUN: 110550630(Hsd17b7) 110555253(Dhrs11)
CGE: 100763193(Dhrs11) 100767580(Hsd17b7)
PLEU: 114689903(Hsd17b7) 114707715(Dhrs11)
NGI: 103732605(Dhrs11) 103746788(Hsd17b7)
HGL: 101704213(Dhrs11) 101712707(Hsd17b7)
CCAN: 109690973(Hsd17b7) 109691233(Dhrs11)
OCU: 100008778(HSD17B7) 100349261 100350282(DHRS11)
OPI: 101524723(HSD17B7) 101526339(DHRS11)
TUP: 102473205(HSD17B7) 102481007(DHRS11)
CFA: 491129(DHRS11) 609364(HSD17B7)
VVP: 112914306(HSD17B7) 112917964(DHRS11)
VLG: 121473558(DHRS11) 121501279(HSD17B7)
AML: 100477716(HSD17B7) 100483445(DHRS11)
UMR: 103658287(HSD17B7) 103667445(DHRS11)
UAH: 113268675(HSD17B7) 113268922(DHRS11)
ORO: 101368538(HSD17B7) 101372465(DHRS11)
MPUF: 101688526(DHRS11) 101689203(HSD17B7)
EJU: 114210516(HSD17B7) 114213877(DHRS11)
MLX: 118014038(HSD17B7) 118025129(DHRS11)
FCA: 101083482(HSD17B7) 101083724(DHRS11)
PYU: 121017066(DHRS11) 121020915(HSD17B7)
PBG: 122475607(HSD17B7) 122485272(DHRS11)
PTG: 102953856(DHRS11) 102968316(HSD17B7)
PPAD: 109251987(DHRS11) 109276652(HSD17B7)
AJU: 106980443(DHRS11) 106986761(HSD17B7)
HHV: 120241069(HSD17B7) 120248116(DHRS11)
BTA: 505212(HSD17B7) 510264(DHRS11)
BOM: 102266348(HSD17B7) 102267490(DHRS11)
BIU: 109574096(DHRS11) 109577890(HSD17B7)
BBUB: 102389083(HSD17B7) 102414485(DHRS11)
CHX: 102176160(DHRS11) 102179058(HSD17B7)
OAS: 101109465(DHRS11) 101110013(HSD17B7)
ODA: 120855521(HSD17B7) 120866412(DHRS11)
CCAD: 122429981(HSD17B7) 122432561 122449929(DHRS11)
SSC: 100155418(HSD17B7) 100513307(DHRS11)
CFR: 102507556(DHRS11) 102512546(HSD17B7)
CBAI: 105064308(DHRS11) 105068038(HSD17B7)
CDK: 105092702(HSD17B7) 105097850(DHRS11)
BACU: 103011691(DHRS11) 103014331(HSD17B7)
LVE: 103069867(DHRS11) 103084050(HSD17B7)
OOR: 101278328(DHRS11) 101286750(HSD17B7)
DLE: 111163734(DHRS11) 111169243(HSD17B7)
PCAD: 102984493(HSD17B7) 102995379(DHRS11)
ECB: 100059061(HSD17B7) 100071416(DHRS11)
EPZ: 103554456(DHRS11) 103559639(HSD17B7)
EAI: 106823694(HSD17B7) 106844689(DHRS11)
MYB: 102251181(HSD17B7) 102262752(DHRS11)
MYD: 102765268(DHRS11) 102767046(HSD17B7)
MMYO: 118671682(DHRS11) 118673077(HSD17B7)
MNA: 107530816(DHRS11) 107535110(HSD17B7)
PKL: 118712029(HSD17B7) 118726466(DHRS11)
HAI: 109379798(DHRS11) 109392309(HSD17B7)
DRO: 112298817(HSD17B7) 112316505(DHRS11)
SHON: 118979201(HSD17B7) 119003587(DHRS11)
AJM: 119052313(HSD17B7) 119062640(DHRS11)
MMF: 118633927(DHRS11) 118637572(HSD17B7)
PALE: 102892079(HSD17B7) 102894290(DHRS11)
PGIG: 120584178(HSD17B7) 120620857(DHRS11)
RAY: 107510114(DHRS11)
MJV: 108383263(DHRS11) 108396655(HSD17B7)
TOD: 119231930(DHRS11) 119241348(HSD17B7)
LAV: 100676060 100676239(DHRS11) 100676343(HSD17B7)
MDO: 100016071(HSD17B7) 100618596(DHRS11)
SHR: 100926227(HSD17B7) 100933320(DHRS11)
PCW: 110209887(HSD17B7) 110212020(DHRS11)
OAA: 100077820(DHRS11) 114817513(HSD17B7)
GGA: 395172(DHRS11) 424367(HSD17B7)
PCOC: 116227942(DHRS11) 116230531(HSD17B7)
MGP: 100542399(DHRS11) 100542640(HSD17B7)
CJO: 107317140(HSD17B7) 107322636(DHRS11)
NMEL: 110402344(HSD17B7)
APLA: 101796287(DHRS11) 101799136(HSD17B7)
ACYG: 106041628(HSD17B7) 106046860(DHRS11)
TGU: 100222823(HSD17B7) 100230987(DHRS11)
LSR: 110467717(DHRS11) 110478897(HSD17B7)
SCAN: 103820184(DHRS11) 103824326(HSD17B7)
PMOA: 120497588(HSD17B7) 120507831(DHRS11)
OTC: 121344332(HSD17B7) 121347083(DHRS11)
PRUF: 121359833(HSD17B7) 121361824(DHRS11)
GFR: 102031952(DHRS11) 102042580(HSD17B7)
FAB: 101806967(DHRS11) 101818521(HSD17B7)
PHI: 102107312(HSD17B7) 102113937(DHRS11)
PMAJ: 107198613(HSD17B7) 107213026(DHRS11)
CCAE: 111932684(HSD17B7) 111937859(DHRS11)
CCW: 104690988(DHRS11) 104695594(HSD17B7)
ETL: 114057489(DHRS11) 114067481(HSD17B7)
FPG: 101912846(DHRS11) 101919410(HSD17B7)
FCH: 102050282(DHRS11) 102059217(HSD17B7)
CLV: 102090168(DHRS11) 102097738(HSD17B7)
EGZ: 104121871(DHRS11) 104132130(HSD17B7)
NNI: 104010459(HSD17B7) 104016400(DHRS11)
ACUN: 113483111(HSD17B7) 113487258(DHRS11)
PADL: 103914076(HSD17B7) 103917037(DHRS11)
AAM: 106494687(DHRS11) 106499711(HSD17B7)
AROW: 112968787(DHRS11) 112977170(HSD17B7)
NPD: 112951140(HSD17B7) 112954713(DHRS11)
DNE: 112987422(DHRS11) 112997417(HSD17B7)
ASN: 102374189(HSD17B7) 112551119(DHRS11)
AMJ: 102561890(DHRS11) 102565865(HSD17B7)
CPOO: 109307069(HSD17B7) 109317147(DHRS11)
GGN: 109287068(HSD17B7) 109293262(DHRS11)
PSS: 102452802(DHRS11) 102461698(HSD17B7)
CMY: 102944731(HSD17B7) 102944881(DHRS11)
CPIC: 101936463(DHRS11) 101953232(HSD17B7)
TST: 117867488(DHRS11) 117881449(HSD17B7)
CABI: 116824223(DHRS11) 116831149(HSD17B7)
ACS: 100556465(hsd17b7)
PVT: 110075560(DHRS11) 110081655(HSD17B7)
PBI: 103063132(HSD17B7) 103065679(DHRS11)
PMUR: 107294873(DHRS11) 107302880(HSD17B7)
TSR: 106539066(DHRS11)
PGUT: 117661207(HSD17B7) 117675673(DHRS11)
PMUA: 114585448(DHRS11) 114598525(HSD17B7)
ZVI: 118078620 118089365(HSD17B7) 118097242(DHRS11)
GJA: 107108933(DHRS11) 107121042(HSD17B7)
XLA: 108704561(dhrs11.L) 495296(dhrs11.S) 734717(hsd17b7.S)
XTR: 496708(dhrs11) 548963(hsd17b7)
NPR: 108801354(HSD17B7)
DRE: 436969(dhrs11b.2) 768185(hsd17b7) 791578(dhrs11a) 791770(dhrs11b.1)
IPU: 108260417(dhrs11) 108271889(hsd17b7)
PHYP: 113531061(dhrs11) 113538418(hsd17b7)
EEE: 113570462(hsd17b7) 113577576(dhrs11)
NCC: 104948248(hsd17b7) 104963923(dhrs11) 104967182 104967580
CGOB: 115007156(hsd17b7) 115017925 115018914(dhrs11)
ELY: 117253561(hsd17b7) 117260047 117268096(dhrs11a) 117271615
SLUC: 116045810 116048477 116058070(dhrs11a) 116063209(hsd17b7)
ECRA: 117942184 117950534(hsd17b7) 117954002 117955964(dhrs11a)
GAT: 120816127(hsd17b7) 120822622(dhrs11a)
PPUG: 119202648(hsd17b7) 119215510(dhrs11a) 119216850
MSAM: 119882883 119895317(dhrs11a) 119900960(hsd17b7) 119902362
OML: 112138999(dhrs11a) 112147206 112149002 112150931(hsd17b7)
POV: 109625649(hsd17b7) 109628284(dhrs11) 109644359
XGL: 120790306(hsd17b7) 120792442 120798840 120803065(dhrs11a)
BPEC: 110163629 110165106(dhrs11) 110173518(hsd17b7) 110174039
MALB: 109951354(hsd17b7) 109960466(dhrs11) 109966957
SFM: 108921710(dhrs11) 108935177(hsd17b7) 108938265
PKI: 111841069(hsd17b7) 111854721(dhrs11) 111859701
AANG: 118209261 118230844(hsd17b7) 118236726(dhrs11a)
LOC: 102694052(dhrs11) 102696390(hsd17b7)
PSPA: 121308431(dhrs11a) 121327382
LCM: 102348492(HSD17B7) 102362545(DHRS11)
CMK: 103180036(hsd17b7) 103180635(dhrs11a)
RTP: 109920236(dhrs11) 109925128(hsd17b7)
ACER: 107993351
BBIF: 117205728
BVK: 117230776
BVAN: 117157352
NMEA: 116424013
CGIG: 122405241
FEX: 115240720
CCIN: 107266625
PPYR: 116171680
DMK: 116930984
PTEP: 107437425
SCE: YLR100W(ERG27)
ERC: Ecym_4279
KMX: KLMA_40163(ERG27)
NCS: NCAS_0B03680(NCAS0B03680) NCAS_0B05180(NCAS0B05180)
NDI: NDAI_0B02550(NDAI0B02550) NDAI_0J01100(NDAI0J01100)
TPF: TPHA_0C01040(TPHA0C01040)
TBL: TBLA_0D04010(TBLA0D04010)
TDL: TDEL_0F04160(TDEL0F04160)
KAF: KAFR_0B02860(KAFR0B02860) KAFR_0B05590(KAFR0B05590)
PIC: PICST_61325(ERG27)
CAL: CAALFM_CR01140CA(ERG27)
CDU: CD36_26140(ERG27)
SLB: AWJ20_1569(ERG27)
NCR: NCU05991
NTE: NEUTE1DRAFT69544(NEUTE1DRAFT_69544)
SSCK: SPSK_07425
MAW: MAC_02683
MAJ: MAA_02120
CMT: CCM_05105
MBE: MBM_01041
ANI: AN5585.2
ANG: ANI_1_1880184(An04g05000)
ABE: ARB_02354
TVE: TRV_04668
PTE: PTT_11743
SPO: SPBC1709.07(erg27)
CNE: CND03020
CNB: CNBD3330
TASA: A1Q1_03186
ABP: AGABI1DRAFT79443(AGABI1DRAFT_79443)
ABV: AGABI2DRAFT202140(AGABI2DRAFT_202140)
MGL: MGL_2564
MRT: MRET_0524
 » show all
Reference
1  [PMID:4387005]
  Authors
Swindell AC, Gaylor JL.
  Title
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
  Journal
J Biol Chem 243:5546-55 (1968)
Reference
2  [PMID:6946726]
  Authors
Billheimer JT, Alcorn M, Gaylor JL.
  Title
Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis.
  Journal
Arch Biochem Biophys 211:430-8 (1981)
DOI:10.1016/0003-9861(81)90474-4
Reference
3  [PMID:10535978]
  Authors
Gachotte D, Sen SE, Eckstein J, Barbuch R, Krieger M, Ray BD, Bard M
  Title
Characterization of the Saccharomyces cerevisiae ERG27 gene encoding the 3-keto reductase involved in C-4 sterol demethylation.
  Journal
Proc Natl Acad Sci U S A 96:12655-60 (1999)
DOI:10.1073/pnas.96.22.12655
  Sequence
[sce:YLR100W]
Reference
4  [PMID:12829805]
  Authors
Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R
  Title
Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.
  Journal
Mol Endocrinol 17:1715-25 (2003)
DOI:10.1210/me.2002-0436
  Sequence
[hsa:51478]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.270
IUBMB Enzyme Nomenclature: 1.1.1.270
ExPASy - ENZYME nomenclature database: 1.1.1.270
BRENDA, the Enzyme Database: 1.1.1.270
CAS: 42616-29-5
LinkDB

KEGG   REACTION: R07495
Entry
R07495                      Reaction                               

Name
4alpha-methylzymosterol:NADP+ 3-oxidoreductase
Definition
3-Keto-4-methylzymosterol + NADPH + H+ <=> 4alpha-Methylzymosterol + NADP+
Equation
Reaction class
RC00001  C00005_C00006
RC00154  C05103_C15816
Enzyme
Pathway
rn00100  Steroid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
M00102  Ergocalciferol biosynthesis, squalene 2,3-epoxide => ergosterol/ergocalciferol
Orthology
K09827  3-keto steroid reductase [EC:1.1.1.270]
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]
Other DBs
RHEA: 36382
LinkDB

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