KEGG   ORTHOLOGY: K10047
Entry
K10047                      KO                                     
Symbol
VTC4
Name
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.25 3.1.3.93]
Pathway
map00053  Ascorbate and aldarate metabolism
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01240  Biosynthesis of cofactors
map04070  Phosphatidylinositol signaling system
Module
M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate
Reaction
R01185  1D-myo-inositol 1-phosphate phosphohydrolase
R01186  1D-myo-inositol 4-phosphate phosphohydrolase
R01187  1D-myo-inositol 3-phosphate phosphohydrolase
R07674  beta-L-galactose-1-phosphate phosphohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
   00562 Inositol phosphate metabolism
    K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.25  inositol-phosphate phosphatase
     K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
    3.1.3.93  L-galactose 1-phosphate phosphatase
     K10047  VTC4; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
Other DBs
GO: 0008934 0010347
Genes
NMEA: 116425303
SGRE: 126324494
OSN: 115231278 118761388
ATH: AT3G02870(VTC4)
ALY: 9320409
CRB: 17892437
CSAT: 104744369 104756767 104763907 104779537
EUS: EUTSA_v10021317mg
BRP: 103870884
BNA: 106443867 106447599 106453198 106453206
CPAP: 110812677
CIT: 102624075
PVY: 116115806
MINC: 123219581
TCC: 18597288
EGR: 104445626
MTR: 11405917
TPRA: 123898559
CAM: 101496687
PSAT: 127076822
VVO: 131595392
FVE: 101293560
PPER: 18779066
PMUM: 103326976
PAVI: 110771639
PDUL: 117624102
ZJU: 107435207
MNT: 21387774
CSAV: 115707333
RCU: 8285763
MEAN: 126664668
QSU: 111986426
QLO: 115992494
VVI: 100241840
VRI: 117923349
SLY: 544013(IMP3) 544014(IMP2) 544280(IMP1)
NSY: 104225424
INI: 109165281
ITR: 116032181
LSV: 111875888
CCAV: 112522603
DCR: 108210045
BVG: 104900878
SOE: 110776252
ATRI: 130815298
MOF: 131152859
MING: 122093141
OSA: 4333347
OBR: 102705514
OGL: 127765913
BDI: 100844148
ATS: 109738639
TUA: 125551778
LPER: 127323229
LRD: 124698732
SBI: 8063002
ZMA: 100283131
SITA: 101785092
SVS: 117836191
PHAI: 112874556
PDA: 103697686
EGU: 105036034
MUS: 103986548
DCT: 110108213
MSIN: 131219545
NCOL: 116259296
ATR: 18446646
DDI: DDB_G0281239(impa1)
DFA: DFA_07272(impa1)
NGD: NGA_0525100(IMPA)
 » show all
Reference
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
  Sequence
[ath:AT3G02870]
Reference
  Authors
Torabinejad J, Donahue JL, Gunesekera BN, Allen-Daniels MJ, Gillaspy GE
  Title
VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
  Journal
Plant Physiol 150:951-61 (2009)
DOI:10.1104/pp.108.135129
  Sequence
[ath:AT3G02870]
LinkDB

KEGG   ORTHOLOGY: K18649
Entry
K18649                      KO                                     
Symbol
IMPL2
Name
inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]
Pathway
map00053  Ascorbate and aldarate metabolism
map00340  Histidine metabolism
map00562  Inositol phosphate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01230  Biosynthesis of amino acids
map04070  Phosphatidylinositol signaling system
Module
M00026  Histidine biosynthesis, PRPP => histidine
Reaction
R01185  1D-myo-inositol 1-phosphate phosphohydrolase
R01186  1D-myo-inositol 4-phosphate phosphohydrolase
R01187  1D-myo-inositol 3-phosphate phosphohydrolase
R03013  L-histidinol-phosphate phosphohydrolase
R07674  beta-L-galactose-1-phosphate phosphohydrolase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
   00562 Inositol phosphate metabolism
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
  09105 Amino acid metabolism
   00340 Histidine metabolism
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.15  histidinol-phosphatase
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
    3.1.3.25  inositol-phosphate phosphatase
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
    3.1.3.93  L-galactose 1-phosphate phosphatase
     K18649  IMPL2; inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
Other DBs
GO: 0008934 0010347 0004401
Genes
ATH: AT4G39120(IMPL2)
ALY: 9304959
CRB: 17879544
CSAT: 104716190 104720823 104729217
EUS: EUTSA_v10025644mg
BRP: 103835143
BNA: 106353357 106361489 106406767
BOE: 106336071
RSZ: 108834826 130498826
THJ: 104807751
CPAP: 110810458
CIT: 102617016
PVY: 116110131
MINC: 123213625
TCC: 18607733
GRA: 105795327
GAB: 108474730
DZI: 111297018
EGR: 104453354
GMX: 100527811
VRA: 106762079
VAR: 108330818
VUN: 114163228
VUM: 124824591
CCAJ: 109788874
APRC: 113864744
MTR: 11419457
TPRA: 123899510
CAM: 101502853
PSAT: 127083375
LJA: 130729128
LANG: 109327793
FVE: 101290997
RCN: 112173712
PPER: 18768639
PMUM: 103335696
PAVI: 110768479
PDUL: 117637438
MSYL: 126623914
ZJU: 107426610
MNT: 21384156
CSAV: 115695844
CSV: 101205614
CMO: 103499699
BHJ: 120087575
MCHA: 111015418
CMAX: 111484263
CMOS: 111448992
CPEP: 111777092
RCU: 8284328
MEAN: 126683119
JCU: 105630124
HBR: 110657808
MESC: 110613017
POP: 7464008
PALZ: 118058937
PNZ: 133680276
CILL: 122314369
CAVE: 132184145
QSU: 112020757
QLO: 115969608
VVI: 100260677
VRI: 117909421
SLY: 101254644
CANN: 107840437
INI: 109162162
ITR: 116015736
SIND: 105169672
EGT: 105957671
SMIL: 131005402
SHIS: 125187025
APAN: 127258756
HAN: 110929164
ECAD: 122599474
LSV: 111918256
CCAV: 112501301
CSIN: 114267151
AEW: 130779094
SOE: 110792578
ATRI: 130823150
MOF: 131156480
NNU: 104595613
PSOM: 113308035
OSA: 4342620
OBR: 102719163
OGL: 127778364
BDI: 100838580
ATS: 109768500
TUA: 125543533
LPER: 127342405
LRD: 124665501
SBI: 8085818
ZMA: 100280816
MFLO: 136458031
SITA: 101782298
SVS: 117854542
PVIR: 120706421
PHAI: 112894336
PDA: 103711558
EGU: 105058778
MUS: 103994951
DCT: 110107577
PEQ: 110031830
MSIN: 131237920
NCOL: 116246642
ATR: 18426768
APRO: F751_5675
 » show all
Reference
  Authors
Torabinejad J, Donahue JL, Gunesekera BN, Allen-Daniels MJ, Gillaspy GE
  Title
VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
  Journal
Plant Physiol 150:951-61 (2009)
DOI:10.1104/pp.108.135129
  Sequence
[ath:AT4G39120]
Reference
  Authors
Petersen LN, Marineo S, Mandala S, Davids F, Sewell BT, Ingle RA
  Title
The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.
  Journal
Plant Physiol 152:1186-96 (2010)
DOI:10.1104/pp.109.150805
  Sequence
[ath:AT4G39120]
LinkDB

KEGG   ENZYME: 3.1.3.93
Entry
EC 3.1.3.93                 Enzyme                                 
Name
L-galactose 1-phosphate phosphatase;
VTC4 (gene name) (ambiguous);
IMPL2 (gene name) (ambiguous)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
beta-L-galactose-1-phosphate phosphohydrolase
Reaction(IUBMB)
beta-L-galactose 1-phosphate + H2O = L-galactose + phosphate [RN:R07674]
Reaction(KEGG)
R07674
Substrate
beta-L-galactose 1-phosphate [CPD:C15926];
H2O [CPD:C00001]
Product
L-galactose [CPD:C01825];
phosphate [CPD:C00009]
Comment
The enzyme from plants also has the activity of EC 3.1.3.25, inositol-phosphate phosphatase. The enzymes have very low activity with D-galactose 1-phosphate (cf. EC 3.1.3.94, D-galactose 1-phosphate phosphatase).
History
EC 3.1.3.93 created 2014
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K10047  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase
K18649  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase
Genes
NMEA116425303
SGRE126324494
OSN115231278 118761388
ATHAT3G02870(VTC4) AT4G39120(IMPL2)
ALY9304959 9320409
CRB17879544 17892437
CSAT104716190 104720823 104729217 104744369 104756767 104763907 104779537
EUSEUTSA_v10021317mg EUTSA_v10025644mg
BRP103835143 103870884
BNA106353357 106361489 106406767 106443867 106447599 106453198 106453206
BOE106293897 106332503 106336071
RSZ108834826 108835903 108860365 108863576 130498826
THJ104807751 104812780 104815485
CPAP110810458 110812677
CIT102617016 102624075
CICCICLE_v10017102mg CICLE_v10028779mg
PVY116110131 116115806
MINC123213625 123219581
TCC18597288 18607733
GRA105769546 105776961 105795327
GHI107905686 107908803 107925171 107927829 107930396
GAB108453651 108460500 108474730
HSYR120175431 120190308 120191338 120194598 120214810
DZI111274054 111278317 111297018
EGR104445626 104453354
GMX100527811 100790820 100799849 100817591
GSJ114367021 114388732 114408443 114414466 114420225
PVUPHAVU_003G084500g PHAVU_006G1424001 PHAVU_009G005100g
VRA106762079 106766982 106774484
VAR108330818 108332122 108341122
VUN114163228 114176501 114186922
VUM124824591 124836571 124839448
CCAJ109788874 109804004 109808510
APRC113846571 113864744 113872664
MTR11405917 11419457
TPRA123898559 123899510
CAM101496687 101502853
PSAT127076822 127083375
VVO131595392 131657633 131660419 131660427
LJA130714290 130726320 130729128
ADU107459071 107459873 107466189 107482925
AIP107609158 107613726 107636682 107638701
AHF112703118 112703639 112706277 112722831 112741308 112765607 112771437 112796012
LANG109327793 109334908 109362898
PCIN129285765 129287211 129293427 129295225 129304535
QSAO6P43_001872 O6P43_011566 O6P43_012012 O6P43_031329
FVE101290997 101293560
RCN112167446 112172659 112173712
PPER18768639 18779066
PMUM103326976 103335696
PAVI110768479 110771639
PDUL117624102 117637438
MDM103410485 103412081 103422491 103434428
MSYL126586088 126621466 126623914
PXB103936818 103939855 103943393 103962046 103963758
ZJU107426610 107435207
MNT21384156 21387774
CSAV115695844 115707333
CSV101205614 101206261 101217972
CMO103484661 103499699 103501724
BHJ120073866 120084238 120087575
MCHA111005250 111012748 111015418
CMAX111466554 111478849 111484263 111495495
CMOS111432599 111434392 111448992 111453628
CPEP111777092 111782853 111785922 111785977 111801415 111803740
RCU8284328 8285763
MEAN126664668 126683119
JCU105630124
HBR110657808 110664496 110667092
MESC110607532 110613017 110621875
POP112323239 18106030 7455821 7458515 7464008
PEU105114198 105120157 105136524 105142070
PALZ118030947 118044535 118049589 118049590 118052868 118058937
PNZ133677440 133680276 133689730
JRE108986922 109004560 109004567 109013338
CILL122275989 122279679 122314369
CAVE132170607 132170673 132170728 132184145
QSU111986426 112020757
QLO115969608 115992494
TWL119988414 119990867 119997809 119998841 119998857 119999079 119999080 120005194 120005195 120006753
VVI100241840 100260677
VRI117909421 117923349
SLY101254644 544013(IMP3) 544014(IMP2) 544280(IMP1)
SPEN107002996 107004365 107014064 107016217 107025374
SOT102589172 102594242 102601018 102601710 107060700
SSTN125844882 125856179 125856926 125860054 125873217
SDUL129869928 129870450 129885429 129895996
CANN107840437 107851391 107870111
LBB132599198 132614884 132614953 132615550 132644329
NTA107765195 107767520 107779235 107791846 107795668 107797228 107801850 107815806 107831188
NSY104216633 104225424 104241226 104244592
NTO104085856 104085994 104099465 104101224 104110594 104119600
NAU109207069 109209275 109213673 109214303 109242737
INI109162162 109165281
ITR116015736 116032181
SIND105168029 105169672 105175262
OEU111370675 111379676 111394577 111408057 111412108
EGT105957671 105962202 105973481
SSPL121749700 121753114 121773348 121777073 121788306 121789369 121804509
SMIL130985890 131005402 131011257
SHIS125187025 125193985 125201273
APAN127249765 127253438 127258756 127263911
HAN110918067 110923354 110923355 110929164
ECAD122582030 122587288 122599474
LSV111875888 111918256
CCAV112501301 112522603
DCR108200932 108210045 108227607
CSIN114267151 114295583 114309059
RVL131307958 131310556 131312893 131325178
AEW130752343 130759734 130779094
BVG104900878 104904312 104907756
SOE110776252 110792578
CQI110687456 110698430 110705128 110731241
ATRI130815298 130823150
MOF131152859 131156480
NNU104594191 104595613 104602512 104606566
MING122072599 122091979 122093141
TSS122639821 122643662 122657434 122661423
PSOM113288098 113302809 113308035
OSA4333347 4342620
OBR102705514 102719163
OGL127765913 127778364
BDI100838580 100844148
ATS109738639 109768500
TDC119267870 119275762 119285949 119295985
TAES100415843 123060988 123069600 123078087 123086122 123097129
TUA125543533 125551778
LPER127323229 127342405
LRD124665501 124698732
SBI8063002 8085818
ZMA100280816 100283131
MFLO136458031 136472011 136538268 136538678
SITA101782298 101785092
SVS117836191 117854542
PVIR120650449 120691757 120706421
PHAI112874556 112894336
PDA103697686 103711558
EGU105036034 105058778
MUS103986548 103994951
ZOF121971558 121972880 121976096 121978554 121978561 121978567 121979752 121981732 121984073 121985600
DCT110107577 110108213
PEQ110031830 110032631 110032633
AOF109820443 109820444 109828921 109834403 109844836
MSIN131219545 131237920
NCOL116246642 116259296
ATR18426768 18446646
SMOSELMODRAFT_232297 SELMODRAFT_234860 SELMODRAFT_270021 SELMODRAFT_81253
PPP112274227 112275224 112285229 112288452 112291813 112295845
CRECHLRE_06g278202v5
VCNVOLCADRAFT_78931
MNGMNEG_14064 MNEG_15624
CSLCOCSUDRAFT_17466 COCSUDRAFT_47143
CVRCHLNCDRAFT_34254 CHLNCDRAFT_58575
APROF751_5675
OLUOSTLU_31726 OSTLU_38679
OTAOT_ostta05g02610 OT_ostta05g04730
BPGBathy03g03320 Bathy03g05420
MISMICPUN_108257 MICPUN_79551
MPPMICPUCDRAFT_14899 MICPUCDRAFT_15690
CMECYME_CMH095C
GSLGasu_46960
CCPCHC_T00007726001
SREPTSG_02105
DDIDDB_G0281239(impa1)
DFADFA_07272(impa1)
ACANACA1_065900 ACA1_149190
TPSTHAPSDRAFT_31846 THAPS_17443
NGDNGA_0525100(IMPA)
AAFAURANDRAFT_4399
EHXEMIHUDRAFT_66633 EMIHUDRAFT_73492
GTTGUITHDRAFT_118366
 » show all
Reference
1  [PMID:15550539]
  Authors
Laing WA, Bulley S, Wright M, Cooney J, Jensen D, Barraclough D, MacRae E
  Title
A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis.
  Journal
Proc Natl Acad Sci U S A 101:16976-81 (2004)
DOI:10.1073/pnas.0407453101
  Sequence
Reference
2  [PMID:19339506]
  Authors
Torabinejad J, Donahue JL, Gunesekera BN, Allen-Daniels MJ, Gillaspy GE
  Title
VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
  Journal
Plant Physiol 150:951-61 (2009)
DOI:10.1104/pp.108.135129
  Sequence
Reference
3  [PMID:20023146]
  Authors
Petersen LN, Marineo S, Mandala S, Davids F, Sewell BT, Ingle RA
  Title
The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.
  Journal
Plant Physiol 152:1186-96 (2010)
DOI:10.1104/pp.109.150805
  Sequence
[ath:AT4G39120]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.93
IUBMB Enzyme Nomenclature: 3.1.3.93
ExPASy - ENZYME nomenclature database: 3.1.3.93
BRENDA, the Enzyme Database: 3.1.3.93
LinkDB

KEGG   REACTION: R07674
Entry
R07674                      Reaction                               
Name
beta-L-galactose-1-phosphate phosphohydrolase
Definition
beta-L-Galactose 1-phosphate + H2O <=> L-Galactose + Orthophosphate
Equation
Reaction class
RC00078  C01825_C15926
Enzyme
Pathway
rn00053  Ascorbate and aldarate metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01240  Biosynthesis of cofactors
Module
M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.93
     R07674  beta-L-Galactose 1-phosphate + H2O <=> L-Galactose + Orthophosphate
Orthology
K10047  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase [EC:3.1.3.25 3.1.3.93]
K18649  inositol-phosphate phosphatase / L-galactose 1-phosphate phosphatase / histidinol-phosphatase [EC:3.1.3.25 3.1.3.93 3.1.3.15]
Other DBs
RHEA: 26352
LinkDB

DBGET integrated database retrieval system