KEGG   ORTHOLOGY: K10222
Entry
K10222                      KO                                     
Symbol
bphD
Name
2,6-dioxo-6-phenylhexa-3-enoate hydrolase [EC:3.7.1.8]
Pathway
map00621  Dioxin degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00621 Dioxin degradation
    K10222  bphD; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.8  2,6-dioxo-6-phenylhexa-3-enoate hydrolase
     K10222  bphD; 2,6-dioxo-6-phenylhexa-3-enoate hydrolase
Dioxygenases [br01602.html]
 Dioxygenases in aromatic ring cleavage
  K10222
Other DBs
RN: R02606 R05359
GO: 0018774
Genes
PSD: DSC_09385
PPHA: BVH74_16335
BXE: Bxe_C1186(bphD)
BXB: DR64_8619(bphD)
PNA: Pnap_4141
ACK: C380_15950(bphD)
CTES: O987_08230
AZI: AzCIB_4408
Reference
PMID:8344527
  Authors
Hofer B, Eltis LD, Dowling DN, Timmis KN
  Title
Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation.
  Journal
Gene 130:47-55 (1993)
DOI:10.1016/0378-1119(93)90345-4
  Sequence
[bxe:Bxe_C1186]
LinkDB

KEGG   ENZYME: 3.7.1.8
Entry
EC 3.7.1.8                  Enzyme                                 
Name
2,6-dioxo-6-phenylhexa-3-enoate hydrolase;
HOHPDA hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase
Reaction(IUBMB)
2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate [RN:R02606]
Reaction(KEGG)
R02606;
(other) R05359
Substrate
2,6-dioxo-6-phenylhexa-3-enoate [CPD:C01273];
H2O [CPD:C00001]
Product
benzoate [CPD:C00180];
2-oxopent-4-enoate [CPD:C00596]
Comment
Cleaves the products from biphenol, 3-isopropylcatechol and 3-methylcatechol produced by EC 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase, by ring-fission at a -CO-C bond. Involved in the breakdown of biphenyl-related compounds by Pseudomonas sp.
History
EC 3.7.1.8 created 1989
Pathway
ec00621  Dioxin degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10222  2,6-dioxo-6-phenylhexa-3-enoate hydrolase
Genes
PSDDSC_09385
PPHABVH74_16335
BXEBxe_C1186(bphD)
BXBDR64_8619(bphD)
PNAPnap_4141
ACKC380_15950(bphD)
CTESO987_08230
AZIAzCIB_4408
Reference
1
  Authors
Omori, T., Sugimura, K., Ishigooka, H. and Minoda, Y.
  Title
Purification and some properties of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolyzing enzyme from Pseudomonas cruciviae S93 B1 involved in the degradation of biphenyl.
  Journal
Agric Biol Chem 50:931-937 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.8
IUBMB Enzyme Nomenclature: 3.7.1.8
ExPASy - ENZYME nomenclature database: 3.7.1.8
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.8
BRENDA, the Enzyme Database: 3.7.1.8
CAS: 102925-38-2
LinkDB

KEGG   REACTION: R05359
Entry
R05359                      Reaction                               
Name
2-Hydroxy-6-oxo-6-(4'-chlorophenyl)-hexa-2,4-dienoate benzoylhydrolase
Definition
2-Hydroxy-6-oxo-6-(4'-chlorophenyl)-hexa-2,4-dienoate + H2O <=> 4-Chlorobenzoate + 2-Hydroxy-2,4-pentadienoate
Equation
Comment
BphD
Reaction class
RC00753  C00596_C06587
RC00757  C02370_C06587
Enzyme
Pathway
rn00621  Dioxin degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00543  Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate
Orthology
K10222  2,6-dioxo-6-phenylhexa-3-enoate hydrolase [EC:3.7.1.8]
LinkDB

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