Entry
Name
acyl-CoA 6-desaturase;
Delta6-desaturase;
Delta6-fatty acyl-CoA desaturase;
Delta6-acyl CoA desaturase;
fatty acid Delta6-desaturase;
fatty acid 6-desaturase;
linoleate desaturase;
linoleic desaturase;
linoleic acid desaturase;
linoleoyl CoA desaturase;
linoleoyl-coenzyme A desaturase;
long-chain fatty acid Delta6-desaturase;
linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase;
linoleoyl-CoA desaturase;
FADS2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
Reaction(IUBMB)
(1) linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:
R03814 ];
(2) alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:
R07933 ]
Reaction(KEGG)
Substrate
Product
Comment
An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.
History
EC 1.14.19.3 created 1986 as EC 1.14.99.25, transferred 2000 to EC 1.14.19.3, modified 2015
Pathway
ec01040 Biosynthesis of unsaturated fatty acids
Orthology
K00508 linoleoyl-CoA desaturase
K10226 acyl-CoA 6-desaturase (Delta-6 desaturase)
Genes
DORD : 105993195 105995277(Fads2)
PTG : 102968308(FADS2) 102969100
PPAD : 109246554(FADS2) 109261216
HHV : 120227477 120227525 120246152(FADS2)
CHX : 100861212 102171133(FADS2)
CCAD : 122431166(FADS2) 122451127
MBEZ : 129548882(FADS2) 129560310
CDK : 105091525(FADS2) 105104977
VPC : 102535510 102543923(FADS2)
EPZ : 103543786 103567043(FADS2)
MDT : 132233086 132241565(FADS2)
XLA : 399058(fads2.S) 446688(fads2.L)
SANH : 107655157 107674834
CCAR : 109079315 109089845 109112895
CAUA : 113042868 113043033 113060802 113066630
CGIB : 127946970 128014141
MASI : 127435798 127437192
PHYP : 113529790 113529791
SMEO : 124392159 124392817(fads2)
SLUC : 116038811 116038812
PFLV : 114560045 114560046(fads2)
GAT : 120809502(fads2) 120813621 120829775
MSAM : 119884848 119893991(fads2) 119914409
MZE : 101473241 101473919 101474216
ONL : 100534418(fadsd6) 100700077 100700348
OAU : 116326238 116326239 116326240
OLA : 101156321 101156571 101156814
OML : 112139866 112151777 112151778
CSAI : 133444169 133444170
XMA : 102222635 102222890 102223144
XCO : 114151212 114151221 114151228
XHE : 116729101 116729638 116732254
PRET : 103466509 103466510 103466511
PFOR : 103141299 103141300 103141301
PLAI : 106955830 106955832 106955833
PMEI : 106921859 106921860 106921863
GAF : 122835839 122835840(fads2) 122835841
PPRL : 129358437(fads2) 129358445 129361675
CVG : 107096151 107096160 107096161
CTUL : 119787411 119787428 119787429
GMU : 124878229 124878243(fads2) 124878251
NFU : 107388683 107388684 107388685 107388686
KMR : 108230083(fads2) 108230084
ALIM : 106521189 106521190 106521191
NWH : 119416317 119416318(fads2) 119416319 119416460
SSEN : 122760510 122775367(fads2)
HHIP : 117763209(fads2) 117777344
SMAU : 118314794 118314795(fads2)
MALB : 109971223 109971244
SASA : 100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)
STRU : 115192896 115192933 115192934 115192935
OTW : 112237565 112237566 112237567(fads2) 112264870
OMY : 100135943(fd6d) 110521168 110521170(fads2) 110522693
OGO : 124037455 124037456 124037457 124037484
ONE : 115124847 115124994 115128068 115144681
OKI : 109884127 109884128 109886014 109898183
OKE : 118359378 118376163 118376164 118382825
SNH : 120042185 120042187 120042189 120052325
CCLU : 121540732 121540762 121540763 121540765
SPU : 105441844 581114 586594 756151
LPIC : 129256333 129261239 129281274
APLC : 110985398 110985778 110985855 110985906
ARUN : 117291165 117291166 117291499
LGI : LOTGIDRAFT_113523 LOTGIDRAFT_143229 LOTGIDRAFT_198790
PVUL : 126807806 126831574 126832441 126832661 130014276
PCAN : 112556233 112566738
BGT : 106060307 106066585 106080202
GAE : 121387335 121387621 121387746
HRF : 124123564 124149223 124149233
HASI : 137298036 137298351 137299138
CANU : 128156737 128193262
CVN : 111122923 111124908 111126646
PMAX : 117317607 117317694
MCAF : 127717696 127717925 127718229 127718232
MMER : 123538004 123538337 123563593
RPHI : 132725645 132731975 132755222
DPOL : 127845194 127846985 127849143 127865988
MAEA : 128240074 128241739
LJP : 135464558 135464607 135464662
LAK : 106159034 106169957 112042655
SHX : MS3_00001558(FADS1_1)
OVI : T265_11098 T265_12033
LLON : 135483848 135499632 135499848
CSZ : CSSP291_07070 CSSP291_07075
CSJ : CSK29544_02752 CSK29544_02753
CCON : AFK62_11310 AFK62_11315
CDM : AFK67_11655 AFK67_11660
CMW : AFK63_06925 AFK63_06930
YSI : BF17_18735 BF17_18740
SMAR : SM39_2335 SM39_2336
SMAC : SMDB11_2131 SMDB11_2132
SMW : SMWW4_v1c28750 SMWW4_v1c28760
SRR : SerAS9_2954 SerAS9_2955
SRL : SOD_c26990(des1) SOD_c27000(des)
SRY : M621_14700 M621_14705
SRS : SerAS12_2955 SerAS12_2956
SRA : SerAS13_2956 SerAS13_2957
SLQ : M495_14805 M495_14810
SERF : L085_14410 L085_14415
SERS : SERRSCBI_13560 SERRSCBI_13565
SFW : WN53_23625 WN53_23630
SFG : AV650_19345 AV650_19350
SQU : E4343_01725 E4343_01730
SSUR : ATE40_010980 ATE40_010985
SURI : J0X03_09570 J0X03_09575
SENP : KHA73_14160 KHA73_14165
SNEM : NLX84_14490 NLX84_14495
SNEV : OI978_18120 OI978_18125
SGRI : SGBXF1_02913 SGBXF1_02914
SSAR : SSARUM_002784 SSARUM_002785
SFO : Z042_22645 Z042_22650
PATR : EV46_00590 EV46_00595
PATO : GZ59_01200 GZ59_01210
PCC : PCC21_001080 PCC21_001090
PCV : BCS7_00370 BCS7_00375
PWA : Pecwa_4416 Pecwa_4417
PPAR : A8F97_19355 A8F97_19360
PWS : A7983_08465 A7983_08470
PPOA : BJK05_17125 BJK05_17130
PBRA : B5S52_21360 B5S52_21365
PPUJ : E2566_20975 E2566_20980
PARI : I2D83_21425 I2D83_21430
PVZ : OA04_01280 OA04_01290
PPAV : LOZ86_01345 LOZ86_01350
PPOO : LW347_21025 LW347_21030
PARL : PEC302110_39520 PEC302110_39530
PPEU : DUT67_21415 DUT67_21420
EPE : CI789_00700 CI789_00705
ERWI : GN242_04345 GN242_04350
ERP : LJN55_18055 LJN55_18060
PRG : RB151_029770(desA3) RB151_039160
PHEI : NCTC12003_01329 NCTC12003_03452
PRQ : CYG50_01490 CYG50_19130
PVC : G3341_06785 G3341_17290
PMAG : JI723_06695 JI723_17570
PHAG : PZ638_06530 PZ638_17835
FPP : FPB0191_02197 FPB0191_02198
CVI : CV_1644(desD) CV_2452
CVC : BKX93_02755 BKX93_21455
ANK : AnaeK_0374 AnaeK_1080
MBD : MEBOL_001021 MEBOL_004617
BSED : DN745_02880 DN745_05975
PCAY : FRD00_03300 FRD00_23105
SYZ : MYO_119490(desD(des6))
MVZ : myaer102_21530(desD)
NCW : NIES2107_57400(desD)
AWA : AA650_11345 AA650_11350
CALN : NIES2098_27880(desD)
CALS : NIES3974_16680(desD)
MDP : NIES3275_51850(desD)
NSPH : BDGGKGIB_02538(desA3)
AMOB : HG15A2_45670(desA3)
GES : VT84_04450 VT84_12735
GMS : SOIL9_48780 SOIL9_57870
MCOS : GM418_05800 GM418_21175 GM418_23330
CHIT : FW415_01170 FW415_18530
CHOR : MKQ68_03065 MKQ68_16115
CSAC : SIO70_03010 SIO70_19005 SIO70_30580
NKO : Niako_0028 Niako_2214 Niako_5619 Niako_6564
NYN : U0035_04485 U0035_07075
FLA : SY85_04130 SY85_23690 SY85_23835
ARB : A9P82_07590 A9P82_12885
AGI : FSB73_05040 FSB73_09885 FSB73_11865
ATEE : K9M52_05815 K9M52_10175
PSEG : D3H65_02955 D3H65_14270 D3H65_21685
PGIN : FRZ67_13380 FRZ67_21700
PGO : FSB84_05680 FSB84_28195
LACS : H4075_12235 H4075_17930
FLP : LK994_06745 LK994_09070 LK994_14080
FLC : KJS93_09095 KJS93_09225 KJS93_12245 KJS93_12775 KJS93_13655
FLV : KJS94_07185 KJS94_10255 KJS94_17800
THEO : IMW88_05580 IMW88_06715
HHY : Halhy_3263 Halhy_3651
PEK : FFJ24_000610 FFJ24_000615 FFJ24_009255
PROE : H9L23_04740 H9L23_11790
SMIZ : 4412673_01383(desA3_1) 4412673_04012(desA3_2)
SPSC : E2P86_12690 E2P86_12970
SPHE : GFH32_00630 GFH32_03190 GFH32_06585 GFH32_11525
SDJ : NCTC13534_02135(desA3)
AGD : FRZ59_03065 FRZ59_14730
SBX : CA265_00630 CA265_00635 CA265_10185
CAMU : CA2015_1137 CA2015_1138 CA2015_1357 CA2015_4277
BBD : Belba_0611 Belba_0817
EVI : Echvi_1008 Echvi_2487
EST : DN752_11560 DN752_18445
ECHI : FKX85_04965 FKX85_20520
ALGO : GYM62_06400 GYM62_12700
MDA : IPZ59_05475 IPZ59_05660 IPZ59_16190
STAE : HNV11_11570 HNV11_21120
SFOL : H3H32_15745 H3H32_16765
RHOZ : GXP67_00645 GXP67_00790 GXP67_19925 GXP67_34085 GXP67_34095
MAQA : LAG90_05115 LAG90_08950 LAG90_18070
DFQ : NFI81_00830 NFI81_22590
RSI : Runsl_2603 Runsl_4114
RUN : DR864_01875 DR864_13000
FAE : FAES_3358 FAES_4414(desD)
FLI : Fleli_2211 Fleli_3763
HYG : AUC43_10760 AUC43_17580
HYJ : FHG12_14055 FHG12_18880
HRS : HER32_05380 HER32_10030
HBN : GUY19_19465 GUY19_19470
HTS : HMJ29_01695 HMJ29_10905
HSK : H4317_05740 H4317_05745 H4317_07045
HSB : MWH26_12760 MWH26_17065
HCF : MUN80_23735 MUN80_23740
PKO : PKOR_12515 PKOR_12520 PKOR_15525
PACT : CA264_02175 CA264_03165 CA264_03620
PONT : C1N53_08975 C1N53_09015
RUF : TH63_04060 TH63_14235
RTI : DC20_14245 DC20_14660
ASWU : HUW51_01025 HUW51_20485
MTT : Ftrac_1277 Ftrac_1374
MHAA : Q3Y49_01250 Q3Y49_18410
MARP : QYS47_30740 QYS47_33900
MSAA : QYS49_13145 QYS49_29410
IRO : RT717_15385 RT717_20555 RT717_21990
FBT : D770_01380 D770_10140 D770_22385
CHK : D4L85_06785 D4L85_13615 D4L85_30080
FUV : JR347_07595 JR347_12655 JR347_15925
FMM : LVD15_04060 LVD15_13350 LVD15_26280 LVD15_26705
FUA : LVD17_02965 LVD17_14155 LVD17_17735 LVD17_26230
FLW : LVD16_07845 LVD16_11895 LVD16_25410
RCG : N7E81_09120 N7E81_17880 N7E81_18455
TPEL : P0M28_09140 P0M28_30060
ATK : AUTU_29800 AUTU_45020
GRS : C7S20_13800 C7S20_17135 C7S20_18515
FPSZ : AMR72_11020 AMR72_12580
FJG : BB050_00859(desA3_1) BB050_02987(desA3_2)
FGL : EM308_06050 EM308_06795
FCR : HYN56_07485 HYN56_09200 HYN56_22190
FSE : DI487_00875 DI487_09345
FFL : HYN86_08210 HYN86_18615
FEN : J0383_06845 J0383_08685 J0383_18340
FPB : NLJ00_09245 NLJ00_22200
FBI : L0669_09080 L0669_20585
FPLU : NLG42_08485 NLG42_21180
FHU : M0M44_09045 M0M44_21335
FPEC : Q1W71_02660 Q1W71_21030
LACI : CW733_04270 CW733_09735
ZGA : ZOBELLIA_1067(des6-2) ZOBELLIA_755(des6-1)
AIC : JK629_01570 JK629_12490
PHG : KCTC32516_00465(desA3)
SEON : BWZ22_11950 BWZ22_15155
AALG : AREALGSMS7_02543(desA3)
AQB : D1818_09380 D1818_09485 D1818_09490
AQA : D1815_21665 D1815_21670 D1815_21765
EMAR : D1013_05915 D1013_15030
SINH : LS482_08330 LS482_12605
MRS : Murru_0575 Murru_2048
MAQI : LDL77_10735 LDL77_12845
BIA : GMA17_04560 GMA17_09985
FBE : FF125_11040 FF125_18070
CPIP : CJF12_09160 CJF12_11850
CARH : EGY05_00090 EGY05_16690
FTE : Fluta_0285 Fluta_0832 Fluta_1718 Fluta_4072
FLU : CHH17_00735 CHH17_06930 CHH17_10485 CHH17_16625
CRM : K6119_02165 K6119_02195 K6119_18185
OHO : Oweho_1245 Oweho_2759
BBAU : AEM51_07385 AEM51_12040
» show all
Taxonomy
Reference
Authors
Okayasu T, Nagao M, Ishibashi T, Imai Y.
Title
Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes.
Journal
Reference
Authors
Cho HP, Nakamura MT, Clarke SD
Title
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
Journal
Sequence
Reference
Authors
Sprecher H
Title
Metabolism of highly unsaturated n-3 and n-6 fatty acids.
Journal
Reference
Authors
Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM
Title
Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.
Journal
Reference
Authors
Domergue F, Abbadi A, Zahringer U, Moreau H, Heinz E
Title
In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.14.19.3
LinkDB
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