KEGG   ORTHOLOGY: K10226
Entry
K10226                      KO                                     
Symbol
FADS2
Name
acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]
Pathway
map00592  alpha-Linolenic acid metabolism
map01040  Biosynthesis of unsaturated fatty acids
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01212  Fatty acid metabolism
map03320  PPAR signaling pathway
Reaction
R03814  linoleoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
R07861  
R07933  alpha-linolenoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
R11110  (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
R11111  (9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
R12167  oleoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
R12168  icosenoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (8,9 cis-dehydrogenating)
R12170  (11Z,14Z,17Z)-icosatrienoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (8,9 cis-dehydrogenating)
R12171  (11Z,14Z)-icosadienoyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (8,9 cis-dehydrogenating)
R12172  palmitoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00592 alpha-Linolenic acid metabolism
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
   01040 Biosynthesis of unsaturated fatty acids
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.3  acyl-CoA 6-desaturase
     K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Lipid biosynthesis proteins [BR:ko01004]
 Desaturase
  Front-end
   K10226  FADS2; acyl-CoA 6-desaturase (Delta-6 desaturase)
Other DBs
GO: 0016213
Genes
HSA: 9415(FADS2)
PTR: 451244(FADS2)
PPS: 100980611(FADS2)
GGO: 109024898(FADS2)
PON: 100190814(FADS2)
PPYG: 129007403(FADS2)
NLE: 100596455(FADS2)
HMH: 116468868(FADS2)
SSYN: 129485110(FADS2)
MCC: 719037(FADS2)
MCF: 101926688(FADS2)
MTHB: 126935474
MNI: 105469424(FADS2)
CSAB: 103234245(FADS2)
CATY: 105577581(FADS2)
PANU: 100126749(FADS2)
TGE: 112606127(FADS2)
MLEU: 105549019(FADS2)
RRO: 104679373(FADS2)
RBB: 108533600(FADS2)
TFN: 117080261(FADS2)
PTEH: 111524318(FADS2)
CANG: 105512289(FADS2)
CJC: 100387410(FADS2)
SBQ: 101051429(FADS2)
CIMI: 108286221(FADS2)
ANAN: 105718627(FADS2)
CSYR: 103269267(FADS2)
MMUR: 105878617(FADS2)
LCAT: 123641268(FADS2)
PCOQ: 105825053(FADS2)
OGA: 100953713(FADS2)
MMU: 56473(Fads2)
MCAL: 110285898(Fads2)
MPAH: 110322460(Fads2)
RNO: 83512(Fads2)
MCOC: 116103546(Fads2)
ANU: 117707574(Fads2)
MUN: 110548092(Fads2)
CGE: 100757464(Fads2)
MAUA: 101844598(Fads2)
PROB: 127228840(Fads2)
PLEU: 114703436(Fads2)
MORG: 121453878(Fads2)
MFOT: 126498526
AAMP: 119814598(Fads2)
NGI: 103729125(Fads2)
HGL: 101726663(Fads2)
CPOC: 100724176(Fads2)
CCAN: 109695673(Fads2)
DORD: 105993195 105995277(Fads2)
DSP: 122104886(Fads2)
PLOP: 125362342(Fads2)
NCAR: 124958641
MMMA: 107160135(Fads2)
OCU: 100352712(FADS2)
OPI: 101520480(FADS2)
TUP: 102475407(FADS2)
GVR: 103604810(FADS2)
CFA: 483792(FADS2)
CLUD: 112659414(FADS2)
VVP: 112911087(FADS2)
VLG: 121472257(FADS2)
NPO: 129500992(FADS2)
AML: 100470289(FADS2)
UMR: 103678231
UAH: 113246983(FADS2)
UAR: 123785126(FADS2)
ELK: 111149586
LLV: 125078518
MPUF: 101675571(FADS2)
MNP: 132020124(FADS2)
MLK: 131813734(FADS2)
NVS: 122912990(FADS2)
ORO: 101364529(FADS2)
EJU: 114220204(FADS2)
ZCA: 113914859(FADS2)
MLX: 118015922(FADS2)
NSU: 110576322(FADS2)
LWW: 102726376
FCA: 101085071(FADS2)
PYU: 121043312(FADS2)
PCOO: 112851879(FADS2)
PBG: 122483864(FADS2)
PVIV: 125176351(FADS2)
LRUF: 124505588
PTG: 102968308(FADS2) 102969100
PPAD: 109246554(FADS2) 109261216
PUC: 125911228
BTA: 521822(FADS2)
BOM: 102275533(FADS2)
BIU: 109554370(FADS2)
BBUB: 102405983(FADS2)
BBIS: 104998707(FADS2)
CHX: 100861212 102171133(FADS2)
OAS: 101108615(FADS2)
BTAX: 128069159(FADS2)
ODA: 120874547(FADS2)
CCAD: 122431166(FADS2) 122451127
MREE: 136169613(FADS2)
MBEZ: 129548882(FADS2) 129560310
SSC: 444997(FADS2)
CFR: 102506325(FADS2)
CBAI: 105070113(FADS2)
CDK: 105091525(FADS2) 105104977
VPC: 102535510 102543923(FADS2)
BACU: 103000252(FADS2)
BMUS: 118899178(FADS2)
LVE: 103083143(FADS2)
OOR: 101275563(FADS2)
DLE: 111183883(FADS2)
PCAD: 114487991
PSIU: 116757879(FADS2)
NASI: 112402052(FADS2)
ECB: 100062709(FADS2)
EPZ: 103543786 103567043(FADS2)
EAI: 106847560(FADS2)
MYB: 102261893(FADS2)
MYD: 102773468(FADS2)
MMYO: 118649000(FADS2)
MLF: 102433969
MDT: 132233086 132241565(FADS2)
PKL: 118707198(FADS2)
EFUS: 103303327(FADS2)
MNA: 107527684(FADS2)
DRO: 112317237(FADS2)
SHON: 118996917(FADS2)
AJM: 119043681(FADS2)
PDIC: 114499454(FADS2)
PHAS: 123829520(FADS2)
MMF: 118627539(FADS2)
PPAM: 129062749(FADS2)
HAI: 109390019(FADS2)
RFQ: 117030358(FADS2)
PALE: 102894063(FADS2)
PGIG: 120600650(FADS2)
PVP: 105297786(FADS2)
RAY: 107501589(FADS2)
MJV: 108407763(FADS2)
TOD: 119250071(FADS2)
SARA: 101540602(FADS2)
SETR: 126017652(FADS2)
LAV: 100677680
TMU: 101347025
ETF: 101661366(FADS2)
DNM: 101419118(FADS2)
MDO: 100009895(FADS2)
GAS: 123252763(FADS2)
SHR: 100930034(FADS2)
AFZ: 127541862
PCW: 110195307(FADS2)
TVP: 118853378(FADS2)
OAA: 100086288
GGA: 423122(FADS2)
PCOC: 116239008(FADS2)
MGP: 100549977
CJO: 107314439(FADS2)
TPAI: 128085490
LMUT: 125695386
NMEL: 110400735(FADS2)
APLA: 101798758(FADS2)
ACYG: 106033870(FADS2)
CATA: 118249734(FADS2)
AFUL: 116489695(FADS2)
TGU: 100222881(FADS2)
LSR: 110484926(FADS2)
SCAN: 103822123(FADS2)
PMOA: 120499564(FADS2)
OTC: 121339150(FADS2)
PRUF: 121354750(FADS2)
GFR: 102040567(FADS2)
FAB: 101810111(FADS2)
OMA: 130253519
PHI: 102112585(FADS2)
PMAJ: 107205402
CCAE: 111930632
CCW: 104697641(FADS2)
CBRC: 103614698(FADS2)
ETL: 114067866
ZAB: 102066733
ZLE: 135449015
ACHL: 103799150
SVG: 106854756(FADS2)
MMEA: 130580081
HRT: 120753732
SATI: 136362058
FPG: 101910606(FADS2)
FCH: 102058085(FADS2)
CCRI: 104168591
NNT: 104413574
SHAB: 115606141
ACUN: 113481354
TALA: 104369427(FADS2)
ACHC: 115352166(FADS2)
HALD: 104323730
HLE: 104829423(FADS2)
AGEN: 126046833
GCL: 127016608
CSTI: 104556935
LDI: 104349227
MNB: 103779901
DPUB: 104304413(FADS2)
AVIT: 104271174
BRHI: 104495821
EGZ: 104122147
NNI: 104009393(FADS2)
PCRI: 104029808
PCAO: 104047971
PADL: 103925785(FADS2)
AFOR: 103905746(FADS2)
FGA: 104078771
GSTE: 104261724
CLV: 102098615(FADS2)
MUI: 104535393
PGUU: 104458947
PLET: 104623342
EHS: 104504871
CMAC: 104479690
CUCA: 104062412
TEO: 104376392
BREG: 104632474
OHA: 104339401(FADS2)
ACAR: 104523447
CPEA: 104397494(FADS2)
CVF: 104287520(FADS2)
RTD: 128908397(FADS2)
AAM: 106490046
AROW: 112978021
NPD: 112948004(FADS2)
TGT: 104566742
DNE: 112991695(FADS2)
SCAM: 104139314(FADS2)
ASN: 102382989
AMJ: 102563693(FADS2)
CPOO: 109318131
GGN: 109295789(FADS2)
PSS: 102460236(FADS2)
CMY: 102933275
CCAY: 125639128
DCC: 119857372
CPIC: 101936434(FADS2)
TST: 117877425(FADS2)
CABI: 116830902(FADS2)
MRV: 120403580
ACS: 100551818(fads2)
ASAO: 132771965
PVT: 110086191(FADS2)
SUND: 121930482
PBI: 103050551(FADS2)
PMUR: 107300095
CTIG: 120312451
TSR: 106538426(FADS2)
PGUT: 117667019
APRI: 131184396
PTEX: 113440355
NSS: 113424551
VKO: 123021211
PMUA: 114600538
PRAF: 128417635
ZVI: 118089026
HCG: 128339343
GJA: 107108854(FADS2)
STOW: 125427058
EMC: 129324106
XLA: 399058(fads2.S) 446688(fads2.L)
XTR: 100145314(fads2)
NPR: 108794176(FADS2)
RTEM: 120917257(FADS2)
BBUF: 120981189(FADS2)
BGAR: 122920199(FADS2)
MUO: 115468974(FADS2)
GSH: 117352277(FADS2)
DRE: 140615(fads2)
SRX: 107754339
PTET: 122330662(fads2)
LROH: 127157126(fads2)
OMC: 131534870(fads2)
PPRM: 120474050(fads2)
RKG: 130106492(fads2)
MAMB: 125246733(fads2)
CIDE: 127506530
CERY: 137015406(fads2)
TROS: 130551795(fads2)
TDW: 130413973(fads2)
SMEO: 124392159 124392817(fads2)
TRN: 134311758(fads2)
AMEX: 103027972(fads2)
CMAO: 118811918(fads2)
EEE: 113588191(fads2)
CHAR: 105904229(fads2)
LCO: 104937137(fads2)
NCC: 104956187(fads2)
TBEN: 117491472(fads2)
CGOB: 115010175(fads2)
PGEO: 117447932(fads2)
GACU: 117538871(fads2)
EMAC: 134878275(fads2)
ELY: 117262279(fads2)
EFO: 125887440(fads2)
PLEP: 121949837(fads2)
ECRA: 117949003
PFLV: 114560045 114560046(fads2)
PPUG: 119195671(fads2)
AFB: 129108760(fads2)
CLUM: 117732372(fads2)
PSWI: 130195900(fads2)
CANA: 137804416(fads2)
CVE: 137881646(fads2)
SCHU: 122875428(fads2)
CUD: 121515126(fads2)
ALAT: 119023767(fads2)
ASTR: 137593460(fads2)
KMR: 108230083(fads2) 108230084
AOCE: 111582148(fads2)
MCEP: 125014531(fads2)
CSEM: 103380276(fads2)
POV: 109623584(fads2)
SSEN: 122760510 122775367(fads2)
HHIP: 117763209(fads2) 117777344
HSP: 118109441(fads2)
SMAU: 118314794 118314795(fads2)
LCF: 108886851
SDU: 111229900(fads2)
SLAL: 111666947(fads2)
XGL: 120793558(fads2)
HCQ: 109507604(fads2)
SSCV: 125970130(fads2)
SBIA: 133502004(fads2)
PEE: 133402376(fads2)
PTAO: 133478499(fads2)
BPEC: 110167702(fads2)
BSPL: 114856803(fads2)
SJO: 128359300(fads2)
SASA: 100136383(fadsd5) 100136441(fadsd6) 100329172(d6fadc) 100337624(d6fad_b) 106584797(D6fad_b)
SALP: 112071110
ELS: 105018065(fads2)
AANG: 118215202(fads2)
PSPA: 121330343
ARUT: 117434917(fads2)
PSEX: 120535951(fads2)
LCM: 102349949(FADS2)
CMK: 103174861
RTP: 109937250
CPLA: 122557873(fads2)
HOC: 132824407
LERI: 129705771(fads2)
PMRN: 116958616
LRJ: 133360007
BFO: 118428221
BBEL: 109463898
AJC: 117113999
DPA: 109544444
OBI: 106867675
OSN: 115223335
SHX: MS3_00001558(FADS1_1)
AQU: 100632154
 » show all
Reference
PMID:9867867
  Authors
Cho HP, Nakamura MT, Clarke SD
  Title
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
  Journal
J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471
  Sequence
[hsa:9415] [mmu:56473]
LinkDB

KEGG   ENZYME: 1.14.19.3
Entry
EC 1.14.19.3                Enzyme                                 
Name
acyl-CoA 6-desaturase;
Delta6-desaturase;
Delta6-fatty acyl-CoA desaturase;
Delta6-acyl CoA desaturase;
fatty acid Delta6-desaturase;
fatty acid 6-desaturase;
linoleate desaturase;
linoleic desaturase;
linoleic acid desaturase;
linoleoyl CoA desaturase;
linoleoyl-coenzyme A desaturase;
long-chain fatty acid Delta6-desaturase;
linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase;
linoleoyl-CoA desaturase;
FADS2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
Sysname
acyl-CoA,ferrocytochrome b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
Reaction(IUBMB)
(1) linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R03814];
(2) alpha-linolenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = stearidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O [RN:R07933]
Reaction(KEGG)
Substrate
linoleoyl-CoA [CPD:C02050];
ferrocytochrome b5 [CPD:C00999];
O2 [CPD:C00007];
H+ [CPD:C00080];
alpha-linolenoyl-CoA [CPD:C16162]
Product
gamma-linolenoyl-CoA [CPD:C03035];
ferricytochrome b5 [CPD:C00996];
H2O [CPD:C00001];
stearidonoyl-CoA [CPD:C16163]
Comment
An iron protein. The enzyme introduces a cis double bond at carbon 6 of acyl-CoAs. It is a front-end desaturase, introducing the new double bond between a pre-existing double bond and the carboxyl-end of the fatty acid. The human enzyme has a broad substrate range. It also acts on palmitoyl-CoA, generating sapienoyl-CoA [4], and on (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoyl-CoA, converting it to (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoyl-CoA as part of a pathway that produces docosahexaenoate [3]. The enzyme contains a cytochrome b5 domain that is assumed to act in vivo as the electron donor to the active site of the desaturase.
History
EC 1.14.19.3 created 1986 as EC 1.14.99.25, transferred 2000 to EC 1.14.19.3, modified 2015
Pathway
ec00591  Linoleic acid metabolism
ec01040  Biosynthesis of unsaturated fatty acids
ec01100  Metabolic pathways
Orthology
K00508  linoleoyl-CoA desaturase
K10226  acyl-CoA 6-desaturase (Delta-6 desaturase)
Genes
HSA9415(FADS2)
PTR451244(FADS2)
PPS100980611(FADS2)
GGO109024898(FADS2)
PON100190814(FADS2)
PPYG129007403(FADS2)
NLE100596455(FADS2)
HMH116468868(FADS2)
SSYN129485110(FADS2)
MCC719037(FADS2)
MCF101926688(FADS2)
MTHB126935474
MNI105469424(FADS2)
CSAB103234245(FADS2)
CATY105577581(FADS2)
PANU100126749(FADS2)
TGE112606127(FADS2)
MLEU105549019(FADS2)
RRO104679373(FADS2)
RBB108533600(FADS2)
TFN117080261(FADS2)
PTEH111524318(FADS2)
CANG105512289(FADS2)
CJC100387410(FADS2)
SBQ101051429(FADS2)
CIMI108286221(FADS2)
ANAN105718627(FADS2)
CSYR103269267(FADS2)
MMUR105878617(FADS2)
LCAT123641268(FADS2)
PCOQ105825053(FADS2)
OGA100953713(FADS2)
MMU56473(Fads2)
MCAL110285898(Fads2)
MPAH110322460(Fads2)
RNO83512(Fads2)
MCOC116103546(Fads2)
ANU117707574(Fads2)
MUN110548092(Fads2)
CGE100757464(Fads2)
MAUA101844598(Fads2)
PROB127228840(Fads2)
PLEU114703436(Fads2)
MORG121453878(Fads2)
MFOT126498526
AAMP119814598(Fads2)
NGI103729125(Fads2)
HGL101726663(Fads2)
CPOC100724176(Fads2)
CCAN109695673(Fads2)
DORD105993195 105995277(Fads2)
DSP122104886(Fads2)
PLOP125362342(Fads2)
NCAR124958641
MMMA107160135(Fads2)
OCU100352712(FADS2)
OPI101520480(FADS2)
TUP102475407(FADS2)
GVR103604810(FADS2)
CFA483792(FADS2)
CLUD112659414(FADS2)
VVP112911087(FADS2)
VLG121472257(FADS2)
NPO129500992(FADS2)
AML100470289(FADS2)
UMR103678231
UAH113246983(FADS2)
UAR123785126(FADS2)
ELK111149586
LLV125078518
MPUF101675571(FADS2)
MNP132020124(FADS2)
MLK131813734(FADS2)
NVS122912990(FADS2)
ORO101364529(FADS2)
EJU114220204(FADS2)
ZCA113914859(FADS2)
MLX118015922(FADS2)
NSU110576322(FADS2)
LWW102726376
FCA101085071(FADS2)
PYU121043312(FADS2)
PCOO112851879(FADS2)
PBG122483864(FADS2)
PVIV125176351(FADS2)
LRUF124505588
PTG102968308(FADS2) 102969100
PPAD109246554(FADS2) 109261216
PUC125911228
AJU106986967 106988351
HHV120227477 120227525 120246152(FADS2)
BTA521822(FADS2)
BOM102275533(FADS2)
BIU109554370(FADS2)
BBUB102405983(FADS2)
BBIS104998707(FADS2)
CHX100861212 102171133(FADS2)
OAS101108615(FADS2)
BTAX128069159(FADS2)
ODA120874547(FADS2)
CCAD122431166(FADS2) 122451127
MREE136169613(FADS2)
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LVE103083143(FADS2)
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SMWSMWW4_v1c28750 SMWW4_v1c28760
SPESpro_2862 Spro_2863
SRRSerAS9_2954 SerAS9_2955
SRLSOD_c26990(des1) SOD_c27000(des)
SRYM621_14700 M621_14705
SRSSerAS12_2955 SerAS12_2956
SRASerAS13_2956 SerAS13_2957
SLQM495_14805 M495_14810
SERFL085_14410 L085_14415
SERSSERRSCBI_13560 SERRSCBI_13565
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SFGAV650_19345 AV650_19350
SQUE4343_01725 E4343_01730
SSURATE40_010980 ATE40_010985
SURIJ0X03_09570 J0X03_09575
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SNEMNLX84_14490 NLX84_14495
SNEVOI978_18120 OI978_18125
SGRISGBXF1_02913 SGBXF1_02914
SSARSSARUM_002784 SSARUM_002785
SFOZ042_22645 Z042_22650
RIUI2123_14800
ECAECA0115 ECA0116
PATREV46_00590 EV46_00595
PATOGZ59_01200 GZ59_01210
PCTPC1_4135 PC1_4136
PCCPCC21_001080 PCC21_001090
PCVBCS7_00370 BCS7_00375
PWAPecwa_4416 Pecwa_4417
PPARA8F97_19355 A8F97_19360
PECW5S_4596 W5S_4597
PWSA7983_08465 A7983_08470
PPOABJK05_17125 BJK05_17130
PBRAB5S52_21360 B5S52_21365
PPUJE2566_20975 E2566_20980
PARII2D83_21425 I2D83_21430
PVZOA04_01280 OA04_01290
PPAVLOZ86_01345 LOZ86_01350
PPOOLW347_21025 LW347_21030
PACBM9782_02805
PCOAPJ912_13565
PARLPEC302110_39520 PEC302110_39530
PPEUDUT67_21415 DUT67_21420
EPECI789_00700 CI789_00705
ERWIGN242_04345 GN242_04350
ERPLJN55_18055 LJN55_18060
PRGRB151_029770(desA3) RB151_039160
PALACO695_07030
PHEINCTC12003_01329 NCTC12003_03452
PRQCYG50_01490 CYG50_19130
PRJNCTC6933_03440
PVCG3341_06785 G3341_17290
PMAGJI723_06695 JI723_17570
PHAGPZ638_06530 PZ638_17835
PZJQS795_015075
MWIMNY66_10115
LRINCTC12151_00626
RGLCS053_14415
DTXATSB10_36650
DYGDYGSA30_39090
DKOI596_2530
PAVLBKM03_28990
PSYIMME58_25550
PSKUKUIN1_50640
PPSEBN5_0558
TOLTOL_2040
TORR615_07535
OAIOLEAN_C27500
BSANCHH28_12110
VCWGJQ55_07790
OMEOLMES_1114
FPPFPB0191_02197 FPB0191_02198
SALVSALWKB2_0699
SCOMPYG29_08790
CVICV_1644(desD) CV_2452
CVCBKX93_02755 BKX93_21455
CHRIDK842_15490
CHRBDK843_21020
RMNTK49_20560
RINACS15_5784
RWEKOL96_02900
BUBBW23_4705
BSTGWT74_24150
JAZYQ44_03125
JALBZG29_24440
JSVCNX70_24830
JASFJQ89_14060
JLVG3257_25145
JAHJAB4_050380
JRIP9875_25520
ETBN7L95_24100
DMPFAK_12480 FAK_41190
ADEAdeh_1021
ACPA2cp1_3380
AFWAnae109_3187
ANKAnaeK_0374 AnaeK_1080
AORYAMOR_37230
MYXQEG98_06420
CCXCOCOR_07436(des6)
SURSTAUR_0738
AGEAA314_05794
MBDMEBOL_001021 MEBOL_004617
HOHHoch_5632
BSEDDN745_02880 DN745_05975
PCAYFRD00_03300 FRD00_23105
SYNsll0262(desD(des6))
SYZMYO_119490(desD(des6))
SYYSYNGTS_1931(desD)
SYTSYNGTI_1930(desD)
SYSSYNPCCN_1929(desD)
SYQSYNPCCP_1929(desD)
SYJD082_30330(desD)
SYOC7I86_10070
SYNHHTZ78_09105
SYNPSyn7502_02943
CGCCyagr_2722
AMRAM1_1073
KOVK9N68_09575
PSERABRG53_2437
PGXOA858_22390
GEEGM3708_945
MARMAE_48160(desD)
MPKVL20_3454
MIQB5D77_04380
MVZmyaer102_21530(desD)
ARPNIES39_J03090(desD)
LFSHFV01_08435
LIXH2674_17420
OACOscil6304_3294
MICMic7113_1421
NCWNIES2107_57400(desD)
AWAAA650_11345 AA650_11350
HBQQI031_00935
CALTCal6303_1445
CALNNIES2098_27880(desD)
CALSNIES3974_16680(desD)
RIVRiv7116_4400
MDPNIES3275_51850(desD)
NSPHBDGGKGIB_02538(desA3)
TOQHCG51_19350
TTQNIES37_04690(desD)
ALAXNIES50_15150(desD)
BSENDP114_30275
BOXDP113_30415
PUVPUV_10250(des6)
WCHwcw_0161
AMOBHG15A2_45670(desA3)
FMRFuma_00671(desA)
GESVT84_04450 VT84_12735
GOGC1280_12875
GMSSOIL9_48780 SOIL9_57870
FTJFTUN_3002
TSPHKIH39_09120
SACISinac_0398
HBSIPV69_24075
TPXTurpa_1866
ADINH7849_03985
TGIRBB81_02710
TEMPRBB75_09600
TPSCRBB77_14155
MCOSGM418_05800 GM418_21175 GM418_23330
CPICpin_5676 Cpin_5677
CBAECOR50_08285
CHITFW415_01170 FW415_18530
CHIHGWR21_29075
CFILMYF79_18645
CHFKTO58_22430
CHORMKQ68_03065 MKQ68_16115
CSACSIO70_03010 SIO70_19005 SIO70_30580
CHIMCK934_06350
NKONiako_0028 Niako_2214 Niako_5619 Niako_6564
NSONIASO_08625
NIAA8C56_04725
NYNU0035_04485 U0035_07075
NDFKRR40_44435
FLASY85_04130 SY85_23690 SY85_23835
FGGFSB75_19400
ARBA9P82_07590 A9P82_12885
ARKD6B99_14620
AGIFSB73_05040 FSB73_09885 FSB73_11865
ATEEK9M52_05815 K9M52_10175
ARACE0W69_012610
FLNFLA_2034 FLA_3880
PSEGD3H65_02955 D3H65_14270 D3H65_21685
PGINFRZ67_13380 FRZ67_21700
PGOFSB84_05680 FSB84_28195
FLSGLV81_10500
LACSH4075_12235 H4075_17930
FEIK9M53_08205
FLPLK994_06745 LK994_09070 LK994_14080
FLCKJS93_09095 KJS93_09225 KJS93_12245 KJS93_12775 KJS93_13655
FLVKJS94_07185 KJS94_10255 KJS94_17800
SEDTTEGAF0_01790
THEOIMW88_05580 IMW88_06715
CBAMPIECOFPK_01427
HHYHalhy_3263 Halhy_3651
SGNSGRA_0953 SGRA_3738
PHEPhep_0579
PEPAQ505_23795
PCMAY601_0291
PSTYBFS30_12445
PEKFFJ24_000610 FFJ24_000615 FFJ24_009255
PROEH9L23_04740 H9L23_11790
PEXIZT61_16130
PMUOLOK61_08145
PRKH9N25_10080
PGJQG516_17325
PSNPedsa_0092
SHGSph21_1254
SHTKO02_08730
SPHNBV902_16925
SMIZ4412673_01383(desA3_1) 4412673_04012(desA3_2)
SPSCE2P86_12690 E2P86_12970
SPHEGFH32_00630 GFH32_03190 GFH32_06585 GFH32_11525
SPDRG6053_13355
SDJNCTC13534_02135(desA3)
SSPII6J01_08990
SSIYJVX97_14820
SFAEMUK51_09655
SBAMSCB77_22100
SOPPQ465_09075
SCNSolca_2015
SLASL2B55_10575
MGINFRZ54_12455
MDJLLH06_12505
AGDFRZ59_03065 FRZ59_14730
OLIFKG96_03215
SBXCA265_00630 CA265_00635 CA265_10185
CMRCycma_1461
CAMUCA2015_1137 CA2015_1138 CA2015_1357 CA2015_4277
BBDBelba_0611 Belba_0817
EVIEchvi_1008 Echvi_2487
ESTDN752_11560 DN752_18445
ECHIFKX85_04965 FKX85_20520
EMAIKZP23_05365
ALMAO498_08640
ALGOGYM62_06400 GYM62_12700
MDAIPZ59_05475 IPZ59_05660 IPZ59_16190
CHUCHU_3762 CHU_3764
SLISlin_4655
SRDSD10_21800
SMONAWR27_12490
SPIRCWM47_23570
SPIKEXU85_12795
SPIBG8759_25875
STAEHNV11_11570 HNV11_21120
SOQLQ777_30240
SFOLH3H32_15745 H3H32_16765
SENFGJR95_40500
RHOZGXP67_00645 GXP67_00790 GXP67_19925 GXP67_34085 GXP67_34095
EMZMB380_12550
ALSDJ013_11725
MAQALAG90_05115 LAG90_08950 LAG90_18070
DFEDfer_0898 Dfer_3204
DSNHWI92_21275
DYCNFI80_21445
DFQNFI81_00830 NFI81_22590
DCNMUK70_26880
DPFON006_21660
RSIRunsl_2603 Runsl_4114
RUNDR864_01875 DR864_13000
RUPDTQ70_15945
FAEFAES_3358 FAES_4414(desD)
FIBA6C57_20910
FLIFleli_2211 Fleli_3763
HSWHsw_0774 Hsw_3072
HYMN008_13645
HYDPK28_13650
HYEAM218_02795
HYGAUC43_10760 AUC43_17580
HYPA0257_10485
HYZAXW84_22490
HNVDDQ68_16005
HYHD3Y59_00565
HYJFHG12_14055 FHG12_18880
HRSHER32_05380 HER32_10030
HBNGUY19_19465 GUY19_19470
HTSHMJ29_01695 HMJ29_10905
HMTMTP16_22770
HTBMTX78_16955
HYKO9Z63_11765
HSKH4317_05740 H4317_05745 H4317_07045
HCWO3303_09875
HSBMWH26_12760 MWH26_17065
HAEIMUN82_13020
HVLMUN86_16805
HCFMUN80_23735 MUN80_23740
PKOPKOR_12515 PKOR_12520 PKOR_15525
PACTCA264_02175 CA264_03165 CA264_03620
PONTC1N53_08975 C1N53_09015
RUFTH63_04060 TH63_14235
RTIDC20_14245 DC20_14660
RUDTH61_12240
NIBGU926_18085
ADDHUW48_10675
ASWUHUW51_01025 HUW51_20485
MTTFtrac_1277 Ftrac_1374
MHAAQ3Y49_01250 Q3Y49_18410
MARPQYS47_30740 QYS47_33900
MSAAQYS49_13145 QYS49_29410
FPFDCC35_20270
CLITOQ292_20050
IRORT717_15385 RT717_20555 RT717_21990
FBTD770_01380 D770_10140 D770_22385
CHRWKA713_17535
CHKD4L85_06785 D4L85_13615 D4L85_30080
FUVJR347_07595 JR347_12655 JR347_15925
FMMLVD15_04060 LVD15_13350 LVD15_26280 LVD15_26705
FUALVD17_02965 LVD17_14155 LVD17_17735 LVD17_26230
FLWLVD16_07845 LVD16_11895 LVD16_25410
REKN6H18_09105
RCGN7E81_09120 N7E81_17880 N7E81_18455
PRHOPZB74_19095
TPELP0M28_09140 P0M28_30060
RSRT7867_08970
ATKAUTU_29800 AUTU_45020
GFOGFO_1576
GRLLPB144_03720
GRSC7S20_13800 C7S20_17135 C7S20_18515
FPSFP0413
FPCFPSM_00450
FPYFPG101_02255
FPOFPG3_02170
FPQIB65_01940
FPVIA03_02025
FPWIA04_01965
FPKIA06_02005
FPSZAMR72_11020 AMR72_12580
FJOFjoh_1748 Fjoh_4604
FJGBB050_00859(desA3_1) BB050_02987(desA3_2)
FBRFBFL15_0640
FCOFCOL_03090
FINKQS_11875
FGLEM308_06050 EM308_06795
FCMBIW12_09460
FFAFFWV33_01325
FATDVK85_08110
FKIFK004_01385
FPALHYN49_01635
FMGHYN48_01600
FALBHYN59_06915
FCRHYN56_07485 HYN56_09200 HYN56_22190
FSEDI487_00875 DI487_09345
FSNGS03_00241
FNKE1750_13170
FAKFUA48_01500
FFLHYN86_08210 HYN86_18615
FENJ0383_06845 J0383_08685 J0383_18340
FCVAWN65_01780
FOEJJC03_07225
FSDLXD69_02525
FLOK1I41_01625
FCCLOS86_02380
FCBLOS89_10880
FPBNLJ00_09245 NLJ00_22200
FEHLZF87_01210
FAZM0M57_04100
FBIL0669_09080 L0669_20585
FCSTRV642_1801
FAOSHINM13_01670
FANGENT5_01820
FPLUNLG42_08485 NLG42_21180
FHUM0M44_09045 M0M44_21335
FCUNOX80_01095
FPECQ1W71_02660 Q1W71_21030
FOKKK2020170_03000
FAVLNP19_06655
FGCLNP27_06315
FCGLNP23_08585
FFVLNP22_08470
RBIRB2501_02670
ZPRZPR_0940 ZPR_1492
CATCA2559_07355
FBCFB2170_16751
MARMYQ22_03825
MARTBTR34_03930
MARBCJ263_13770
MAREEJ994_00970
MLIONYZ99_14280
CAOCelal_2252
CLYCelly_0637
CLHIX49_02930
CBALM667_08640
CBATM666_08605
COMNPBN93_03195
KDIKrodi_1870
DOKMED134_12621
DDOI597_1302(desA3)
DODDCS32_02495
LANLacal_0517
LVNBWR22_13235
LACICW733_04270 CW733_09735
LACWFG167_02610
ZGAZOBELLIA_1067(des6-2) ZOBELLIA_755(des6-1)
ZLAQ5W13_03625
ASLAeqsu_0518
AEVEI546_14540
AICJK629_01570 JK629_12490
AEQUQCQ61_07640
PTQP700755_002699
PSYDIMZ30_02630
POMMED152_06405
POBLPB03_14685
PRNBW723_00980
POLABXQ17_06895
POACW731_14315
PHALH9I45_13935
PLITK8354_11165
PPECH9W90_09185
PBATJL193_04995
PCEAJ3359_15260
PUNNQP51_15885
PHGKCTC32516_00465(desA3)
POLQJOP69_16210
WINWPG_2001
WIJBWZ20_06125
SZEAW14_08200
AHZAPS56_08280
SYISB49_00400
TDIAUW17_12185
TENLPB136_09710
TJETJEJU_3739
TMARMARIT_2781
TMPF9Y86_06280
TOVPG911_17440
TRTPG912_01315
TPACPG913_11730
TFIPJJ26_12910
TTGP8625_12730
TSIGD6T69_04030
LUTLupro_06980
LULLPB138_09110
WFUAXE80_00775
FORFORMB_06270
FOHFORMA_06960
FOPFNB79_06940
SALTAO058_00115
SMISLDL76_09110
SEONBWZ22_11950 BWZ22_15155
AALGAREALGSMS7_02543(desA3)
OLLCW732_06150
OAQDZC78_12695
FEKC1H87_06880
FAYQ4Q34_02805
TAJC1A40_11340
AUEC5O00_08760
MARFCJ739_552
MLILQLS71_003980
AQBD1818_09380 D1818_09485 D1818_09490
AQAD1815_21665 D1815_21670 D1815_21765
AQDD1816_10945
AQENBT05_08765
AQRHN014_11630
EMARD1013_05915 D1013_15030
MUREQY75_02165
PSYNE9099_04030
PPONMUN68_013590
AFLAFHG64_13475
ANPFK178_00105
OCIFEZ18_11675
MESQC7H62_0634
GAAHX109_09955
CAGGHYG79_02970
MARXINR76_01415
LPALLDL79_12280
SINHLS482_08330 LS482_12605
ASAGFGM00_02900
FLGLV716_02865
FLBLV704_03710
MRSMurru_0575 Murru_2048
MLTVC82_2131
MUTGVT53_01095
MAQILDL77_10735 LDL77_12845
SPONHME9304_02346
SABUMBM09_05465
ZSPMQE36_09485
BIAGMA17_04560 GMA17_09985
FBEFF125_11040 FF125_18070
FBMMQE35_03580
SAHNJRG66_03265
ALUTO5O44_13390
LUYQZH61_13390
AESTRBH94_09470
MANGRBH95_14805
MCAAR3L15_01700
HWSRNZ46_09970
MGELG5B37_12950
FBQD1817_13600
EAOBD94_3599
EMNM876_15070
EENBBD30_08675
ELBVO54_03046
EMGBBD33_05475
EGMAYC65_19675
ELZFCS00_12860
ELIZJCR23_12755
CHZCHSO_0007
CGNOK18_10425
CIHATE47_14660
CIOCEQ15_20755
CPIPCJF12_09160 CJF12_11850
CARHEGY05_00090 EGY05_16690
CSHAEG350_17865
CNKEG343_16780
CJTEG359_17215
CILEG358_03810
CBENEG339_08225
CGLENCTC11432_03868
CTAINCTC12078_01616
CLACEG342_08295
CTAK4412677_01961
CNPM0D58_13535
CCAOH5J24_19795
CRHIKB553_18450
CCABPFY12_11545
CHRJCHRYMOREF3P_3431
CORAN0B40_13105
CFLUODZ84_16640
CMAQH0S70_09120
CCUCJNG87_20650
CIVIMZ16_00065
FTEFluta_0285 Fluta_0832 Fluta_1718 Fluta_4072
FLUCHH17_00735 CHH17_06930 CHH17_10485 CHH17_16625
CRMK6119_02165 K6119_02195 K6119_18185
OHOOweho_1245 Oweho_2759
CHYDH4K34_06255
PTANCRYO30217_01395
BBAUAEM51_07385 AEM51_12040
SRGXF24_00844(desA3)
 » show all
Reference
1  [PMID:7212717]
  Authors
Okayasu T, Nagao M, Ishibashi T, Imai Y.
  Title
Purification and partial characterization of linoleoyl-CoA desaturase from rat liver microsomes.
  Journal
Arch Biochem Biophys 206:21-8 (1981)
DOI:10.1016/0003-9861(81)90061-8
Reference
2  [PMID:9867867]
  Authors
Cho HP, Nakamura MT, Clarke SD
  Title
Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase.
  Journal
J Biol Chem 274:471-7 (1999)
DOI:10.1074/jbc.274.1.471
  Sequence
[hsa:9415] [mmu:56473]
Reference
3  [PMID:10903473]
  Authors
Sprecher H
  Title
Metabolism of highly unsaturated n-3 and n-6 fatty acids.
  Journal
Biochim Biophys Acta 1486:219-31 (2000)
DOI:10.1016/S1388-1981(00)00077-9
Reference
4  [PMID:12713571]
  Authors
Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM
  Title
Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity.
  Journal
J Invest Dermatol 120:707-14 (2003)
DOI:10.1046/j.1523-1747.2003.12123.x
Reference
5  [PMID:15769252]
  Authors
Domergue F, Abbadi A, Zahringer U, Moreau H, Heinz E
  Title
In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri.
  Journal
Biochem J 389:483-90 (2005)
DOI:10.1042/BJ20050111
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.3
IUBMB Enzyme Nomenclature: 1.14.19.3
ExPASy - ENZYME nomenclature database: 1.14.19.3
BRENDA, the Enzyme Database: 1.14.19.3
CAS: 9082-66-0
LinkDB

KEGG   REACTION: R11111
Entry
R11111                      Reaction                               
Name
(9Z,12Z,15Z,18Z)-tetracosatetraenoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (6,7 cis-dehydrogenating)
Definition
(9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + 2 Ferricytochrome b5 + 2 H2O
Equation
C16171 + 2 C00999 + C00007 + 2 C00080 <=> C16172 + 2 C00996 + 2 C00001
Reaction class
RC00917  C16171_C16172
Enzyme
Pathway
rn01040  Biosynthesis of unsaturated fatty acids
rn01212  Fatty acid metabolism
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.3
     R11111  (9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA + 2 Ferrocytochrome b5 + Oxygen + 2 H+ <=> (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + 2 Ferricytochrome b5 + 2 H2O
Orthology
K10226  acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]
LinkDB

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