KEGG   ORTHOLOGY: K10702
Entry
K10702            Tight     KO                                     
Symbol
todF
Name
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase [EC:3.7.1.25]
Pathway
map00622  Xylene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01220  Degradation of aromatic compounds
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00622 Xylene degradation
    K10702  todF; 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.25  2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
     K10702  todF; 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
Other DBs
RN: R05138
COG: COG0596
GO: 0018765
Genes
PPF: Pput_2882
PPX: T1E_4265(todF)
PMON: X969_10925
PMOT: X970_10580
BPT: Bpet3737
Reference
  Authors
Goncalves ER, Hara H, Miyazawa D, Davies JE, Eltis LD, Mohn WW
  Title
Transcriptomic assessment of isozymes in the biphenyl pathway of Rhodococcus sp. strain RHA1.
  Journal
Appl Environ Microbiol 72:6183-93 (2006)
DOI:10.1128/AEM.00947-06
Reference
PMID:1916282
  Authors
Menn FM, Zylstra GJ, Gibson DT
  Title
Location and sequence of the todF gene encoding 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase in Pseudomonas putida F1.
  Journal
Gene 104:91-4 (1991)
DOI:10.1016/0378-1119(91)90470-V
  Sequence
[ppf:Pput_2882]
LinkDB

KEGG   ENZYME: 3.7.1.25
Entry
EC 3.7.1.25                 Enzyme                                 
Name
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
todF (gene name)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase
Reaction(IUBMB)
(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + acetate
Reaction(KEGG)
(other) R05138
Substrate
(2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate;
H2O [CPD:C00001]
Product
(2Z)-2-hydroxypenta-2,4-dienoate;
acetate [CPD:C00033]
Comment
A bacterial enzyme that participates in the degradation of toluene and 2-nitrotoluene.
History
EC 3.7.1.25 created 2019
Pathway
ec00622  Xylene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10702  2-hydroxy-6-oxohepta-2,4-dienoate hydrolase
Genes
PPFPput_2882
PPXT1E_4265(todF)
PMONX969_10925
PMOTX970_10580
BPTBpet3737
Reference
1  [PMID:1856161]
  Authors
Kukor JJ, Olsen RH
  Title
Genetic organization and regulation of a meta cleavage pathway for catechols produced from catabolism of toluene, benzene, phenol, and cresols by Pseudomonas  pickettii PKO1.
  Journal
J Bacteriol 173:4587-94 (1991)
DOI:10.1128/jb.173.15.4587-4594.1991
Reference
2  [PMID:1916282]
  Authors
Menn FM, Zylstra GJ, Gibson DT
  Title
Location and sequence of the todF gene encoding 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase in Pseudomonas putida F1.
  Journal
Gene 104:91-4 (1991)
DOI:10.1016/0378-1119(91)90470-V
  Sequence
[ppf:Pput_2882]
Reference
3  [PMID:7944378]
  Authors
Haigler BE, Wallace WH, Spain JC
  Title
Biodegradation of 2-nitrotoluene by Pseudomonas sp. strain JS42.
  Journal
Appl Environ Microbiol 60:3466-9 (1994)
DOI:10.1128/AEM.60.9.3466-3469.1994
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.25
IUBMB Enzyme Nomenclature: 3.7.1.25
ExPASy - ENZYME nomenclature database: 3.7.1.25
BRENDA, the Enzyme Database: 3.7.1.25
LinkDB

KEGG   REACTION: R05138
Entry
R05138                      Reaction                               
Name
2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase
Definition
2-Hydroxy-2,4-pentadienoate + Acetate <=> 2-Hydroxy-6-keto-2,4-heptadienoate + H2O
Equation
Reaction class
RC00753  C00596_C06210
RC01277  C00033_C06210
Enzyme
Pathway
rn00622  Xylene degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Orthology
K10702  2-hydroxy-6-oxohepta-2,4-dienoate hydrolase [EC:3.7.1.25]
LinkDB

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