KEGG   ORTHOLOGY: K10724
Entry
K10724                      KO                                     
Symbol
EO
Name
ecdysone oxidase [EC:1.1.3.16]
Pathway
map00981  Insect hormone biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00981 Insect hormone biosynthesis
    K10724  EO; ecdysone oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.16  ecdysone oxidase
     K10724  EO; ecdysone oxidase
Other DBs
RN: R02373
GO: 0047875
Genes
DME: Dmel_CG9504(Eo)
DER: 6550614
DSE: 6619576
DSI: Dsimw501_GD29422(Dsim_GD29422)
DYA: Dyak_GE16082
DSR: 110187124
DPO: 4816073
DPE: 6602889
DMN: 108155790
DWI: 6641390
DGR: 6565256
DAZ: 108619298
DNV: 108656494
DHE: 111591882
AARA: 120904385
 » show all
Reference
  Authors
Takeuchi H, Chen JH, O'Reilly DR, Turner PC, Rees HH
  Title
Regulation of ecdysteroid signaling: cloning and characterization of ecdysone oxidase: a novel steroid oxidase from the cotton leafworm, Spodoptera littoralis.
  Journal
J Biol Chem 276:26819-28 (2001)
DOI:10.1074/jbc.M104291200
Reference
  Authors
Takeuchi H, Rigden DJ, Ebrahimi B, Turner PC, Rees HH
  Title
Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration.
  Journal
Biochem J 389:637-45 (2005)
DOI:10.1042/BJ20050498
LinkDB

KEGG   ENZYME: 1.1.3.16
Entry
EC 1.1.3.16                 Enzyme                                 
Name
ecdysone oxidase;
beta-ecdysone oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
ecdysone:oxygen 3-oxidoreductase
Reaction(IUBMB)
ecdysone + O2 = 3-dehydroecdysone + H2O2 [RN:R02373]
Reaction(KEGG)
R02373
Substrate
ecdysone [CPD:C00477];
O2 [CPD:C00007]
Product
3-dehydroecdysone [CPD:C02513];
H2O2 [CPD:C00027]
Comment
2,6-Dichloroindophenol can act as an acceptor.
History
EC 1.1.3.16 created 1976
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K10724  ecdysone oxidase
Genes
DMEDmel_CG9504(Eo)
DER6550614
DSE6619576
DSIDsimw501_GD29422(Dsim_GD29422)
DYADyak_GE16082
DSR110187124
DPO4816073
DPE6602889
DMN108155790
DWI6641390
DGR6565256
DMODmoj_GI15204
DAZ108619298
DNV108656494
DHE111591882
AARA120904385
 » show all
Reference
1  [PMID:297]
  Authors
Koolman J, Karlson P.
  Title
Ecdysone Oxidase, an enzyme from the blowfly Calliphora erythrocephala (Meigen).
  Journal
Hoppe Seylers Z Physiol Chem 356:1131-8 (1975)
DOI:10.1515/bchm2.1975.356.2.1131
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.16
IUBMB Enzyme Nomenclature: 1.1.3.16
ExPASy - ENZYME nomenclature database: 1.1.3.16
BRENDA, the Enzyme Database: 1.1.3.16
CAS: 56803-12-4
LinkDB

KEGG   REACTION: R02373
Entry
R02373                      Reaction                               
Name
ecdysone:oxygen 3-oxidoreductase
Definition
Ecdysone + Oxygen <=> 3-Dehydroecdysone + Hydrogen peroxide
Equation
Reaction class
RC00154  C00477_C02513
RC02755  C00007_C00027
Enzyme
Pathway
rn00981  Insect hormone biosynthesis
Orthology
K10724  ecdysone oxidase [EC:1.1.3.16]
Reference
1  [PMID:15813704]
  Authors
Takeuchi H, Rigden DJ, Ebrahimi B, Turner PC, Rees HH
  Title
Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration.
  Journal
Biochem J 389:637-45 (2005)
DOI:10.1042/BJ20050498
Other DBs
RHEA: 11799
LinkDB

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