KEGG ORTHOLOGY: K11170

ORTHOLOGY: K11170

Entry

K11170                      KO

Symbol

DHRSX

Name

polyprenol dehydrogenase [NAD(P)H] [EC:1.1.1.441]

Pathway

map00510

N-Glycan biosynthesis

map01100

Metabolic pathways

Reaction

R13402

ditrans,polycis-polyprenol:NAD+ oxidoreductase

R13403

dolichol:NADP+ oxidoreductase

Disease

H00118

Congenital disorders of glycosylation type I

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00510 N-Glycan biosynthesis
    K11170  DHRSX; polyprenol dehydrogenase [NAD(P)H]
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.441  polyprenol dehydrogenase [NAD(P)H]
     K11170  DHRSX; polyprenol dehydrogenase [NAD(P)H]

Genes

HSA:	207063(DHRSX)

PTR:	112207529(DHRSX)

PPS:	100993911(DHRSX)

GGO:	109024747(DHRSX)

PON:	129047218(DHRSX)

PPYG:

129025809(DHRSX)

NLE:	101177204(DHRSX)

HMH:	116812241(DHRSX)

SSYN:

129475920

MCC:	106996625(DHRSX)

MCF:	102121273 141406861

MTHB:

126946842 126947116

MNI:	105478059(DHRSX)

CSAB:

103231531(DHRSX)

CATY:

105574775(DHRSX)

TGE:	112615536(DHRSX)

MLEU:

105533644(DHRSX)

RRO:	104663358(DHRSX)

TFN:	117076141(DHRSX)

PTEH:

111530994(DHRSX)

CANG:

105516174(DHRSX)

CJC:	100402351(DHRSX)

SBQ:	101040065(DHRSX)

CIMI:

108296378(DHRSX)

ANAN:

105730451(DHRSX)

MMUR:

105870815(DHRSX)

ERUF:

138378001(DHRSX)

PCOQ:

105820336(DHRSX)

OGA:	100946740(DHRSX)

MMU:	236082(Dhrsx)

MCAL:

110287625 110288866

MPAH:

110321494(Dhrsx)

RNO:	288525(Dhrsx)

MCOC:

116102287(Dhrsx)

ANU:	117695844(Dhrsx)

ASYL:

127676127(Dhrsx)

MUN:	110542398(Dhrsx)

CGE:

113838539

MAUA:

121136418(Dhrsx)

PROB:

127214527 127236272

PLEU:

114689413

MORG:

121452842(Dhrsx)

MFOT:

126499225

AAMP:

119826486(Dhrsx)

NGI:	103750118(Dhrsx)

HGL:	101705890(Dhrsx)

CPOC:

100731599

CCAN:

109691929(Dhrsx)

DORD:

106000185(Dhrsx)

DSP:	122102638 122102763

DMER:

138818302(Dhrsx)

PLOP:

125345396(Dhrsx)

NCAR:

124972171

MMMA:

107160191(Dhrsx)

ITI:	101962986(Dhrsx)

OCZ:	121168443 121168466

TUP:	102473527(DHRSX)

GVR:	103586851(DHRSX)

CFA:	609792(DHRSX)

CLUD:

112652015(DHRSX)

VVP:	112908947(DHRSX)

VLG:	121482310(DHRSX)

NPO:	129517730(DHRSX)

AML:	100469003(DHRSX)

UMR:	103666334(DHRSX)

UAH:	113240784 130544375

UAR:	123802743(DHRSX)

ELK:

111157095

LLV:

125092428

MPUF:

101693353(DHRSX)

MNP:	132007411(DHRSX)

MLK:	131821667(DHRSX)

NVS:	122897198(DHRSX)

ORO:	101380388(DHRSX)

EJU:	114218024(DHRSX)

ZCA:	113930841(DHRSX)

MLX:	118026673(DHRSX)

NSU:	110569930(DHRSX)

LWW:	102736294(DHRSX)

FCA:	109496409(DHRSX)

PYU:	121020203(DHRSX)

PCOO:

112871677(DHRSX)

PBG:	122477473(DHRSX)

PVIV:

125159260(DHRSX)

LRUF:

124509320

LGF:	123594916(DHRSX)

AJU:

106982047

PTG:	102965048(DHRSX)

PPAD:

109256158(DHRSX)

PLEZ:

122212686(DHRSX)

HHV:	120240546(DHRSX)

BTA:	513482(DHRSX)

BOM:	102285450(DHRSX)

BBUB:

102396634(DHRSX)

BKE:	129638581(DHRSX)

BBIS:

104983528(DHRSX)

CHX:	102180212(DHRSX)

OAS:

101115005

BTAX:

128069802(DHRSX)

CSUM:

138070824(DHRSX)

ODA:	120882416(DHRSX)

CCAD:

122434468(DHRSX)

MREE:

136153250(DHRSX)

OVR:	110148419(DHRSX)

MBEZ:

129534920(DHRSX)

SSC:	102159510 110255319(DHRSX)

CFR:	102503928(DHRSX)

CBAI:

105079531(DHRSX)

CDK:	105097381(DHRSX)

VPC:	102542481(DHRSX)

BACU:

103007133(DHRSX)

BMUS:

118888809(DHRSX)

LVE:	103085812(DHRSX)

OOR:	101290436(DHRSX)

LALB:

132513816(DHRSX)

GMF:	115842369(DHRSX)

DDP:	132418606(DHRSX)

PCAD:

102994622(DHRSX)

PSIU:

116746973(DHRSX)

PPHC:

136142743(DHRSX)

NASI:

112407105(DHRSX)

ECB:	102148434(DHRSX)

EPZ:	103544904(DHRSX)

EAI:	106821897(DHRSX)

MYB:	102263210(DHRSX)

MMYO:

118657308(DHRSX)

MDT:	132224880(DHRSX)

MYUM:

139000554(DHRSX)

EFUS:

129150047(DHRSX)

MNA:	107542467(DHRSX)

DRO:	112313324(DHRSX)

SHON:

118974314(DHRSX)

AJM:	119045665(DHRSX)

PDIC:

114489864(DHRSX)

PHAS:

123829881(DHRSX)

MMF:	118635670(DHRSX)

PPAM:

129079750(DHRSX)

HAI:	109373343(DHRSX)

RFQ:	117022994(DHRSX)

PGIG:

120594202(DHRSX)

PVP:	105309072(DHRSX) 105309716

TOD:	119246371(DHRSX)

SARA:

101542644(DHRSX)

SFUM:

130017202(DHRSX)

SETR:

126000586(DHRSX)

LAV:	100655889(DHRSX)

TMU:

101358257

DNM:

101423330

MDO:	100010479(DHRSX)

GAS:	123241724(DHRSX)

SHR:	100928376(DHRSX)

AFZ:

127553680

TVP:	118835842(DHRSX)

PBRV:

138149687(DHRSX)

MLAO:

141506672(DHRSX)

OAA:	100075072(DHRSX)

TACU:

119937541(DHRSX)

GGA:	428007(DHRSX)

PCOC:

116230781(DHRSX)

MGP:

100547097

CJO:	107305930(DHRSX)

TPAI:

128071720(DHRSX)

LMUT:

125688415(DHRSX)

NMEL:

110405826(DHRSX)

APLA:

101799228(DHRSX)

AACU:

137856587(DHRSX)

ACYG:

106035711(DHRSX)

CATA:

118245685(DHRSX)

AFUL:

116489367(DHRSX)

TGU:	100218020(DHRSX)

LSR:	110479367(DHRSX)

SCAN:

103812314(DHRSX)

PMOA:

120510164(DHRSX)

OTC:	121345327(DHRSX)

PRUF:

121354106(DHRSX)

ATRC:

139604169(DHRSX)

GFR:	102033889(DHRSX)

FAB:	101816922(DHRSX)

OMA:	130252895(DHRSX)

PHI:	102111977(DHRSX)

PMAJ:

107203421(DHRSX)

CCAE:

111944512(DHRSX)

CCW:	104686011(DHRSX)

CBRC:

103611765(DHRSX)

ACOE:

138106491(DHRSX)

ETL:	114061203(DHRSX)

ZAB:	102069124(DHRSX)

ZLE:	135447035(DHRSX)

ACHL:

103804263(DHRSX)

SVG:	106862870(DHRSX)

MMEA:

130577907(DHRSX)

HRT:	120765590(DHRSX)

SATI:

136357902(DHRSX)

CFAI:

136285376(DHRSX)

CCIC:

134057903(DHRSX)

FPG:	101917707(DHRSX)

FCH:	102059626(DHRSX)

NNT:	104401810(DHRSX)

SHAB:

115604535(DHRSX)

ACUN:

113485220(DHRSX)

SURA:

141939346(DHRSX)

TALA:

116963447(DHRSX)

ACHC:

115334668(DHRSX)

HALD:

104315429

HLE:	104839867(DHRSX)

AGEN:

126053019

HHAR:

128135093(DHRSX)

BBUT:

142044801(DHRSX)

GCL:

127021067

LDI:	104353713(DHRSX)

MNB:	103780901(DHRSX)

DPUB:

104302130(DHRSX)

PPUS:

135175204(DHRSX)

AVIT:

104277161(DHRSX)

BRHI:

104496520(DHRSX)

EGZ:	104127456(DHRSX)

NNI:	104009835(DHRSX)

PCAO:

104045857(DHRSX)

PADL:

103923050(DHRSX)

AFOR:

103900666(DHRSX)

FGA:	104073517(DHRSX)

CBOR:

142073787(DHRSX)

GSTE:

104264166(DHRSX)

CBOY:

140646121(DHRSX)

MAME:

142419691(DHRSX)

CLV:	102094034(DHRSX)

CNIC:

135984391(DHRSX)

MUI:	104546462(DHRSX)

PGUU:

104464872(DHRSX)

PLET:

104627603(DHRSX)

BREG:

104632330(DHRSX)

GAME:

129201680(DHRSX)

OHA:	104326405(DHRSX)

ACAR:

104529883(DHRSX)

CPEA:

104391827(DHRSX)

CVF:	104290352(DHRSX)

RTD:	128907568(DHRSX)

CRID:

134518286(DHRSX)

LMIC:

141751091(DHRSX)

NARQ:

141466847(DHRSX)

AAM:	106490952(DHRSX)

AROW:

112968856(DHRSX)

NPD:	112944033(DHRSX)

TGT:	104570993(DHRSX)

DNE:	112984470(DHRSX)

SCAM:

104138727(DHRSX)

ASN:	102368137(DHRSX)

AMJ:	102566055(DHRSX)

CPOO:

109306124(DHRSX)

GGN:	109302293(DHRSX)

PSS:	102461438(DHRSX)

CMY:	102937813(DHRSX)

CCAY:

125640817(DHRSX)

LKP:	140914958(DHRSX)

CPIC:

101938065(DHRSX)

TST:	117870403(DHRSX)

CABI:

116820190

MRV:	120403797(DHRSX)

ACS:	100557092(dhrsx)

ASAO:

132770227(DHRSX)

PMUR:

107296114(DHRSX)

TSR:	106552481(DHRSX)

PCAE:

139316735(DHRSX)

VKO:

123024679

PRAF:

128413240(DHRSX)

GJA:	107106792(DHRSX)

EMC:

129326080

XLA:	447183(dhrsx.L)

XTR:	100487450(dhrsx)

NPR:	108793185(DHRSX)

RTEM:

120927476(DHRSX)

ACAT:

141128840(DHRSX)

PADS:

140341728(DHRSX)

BBUF:

120994871(DHRSX)

BGAR:

122930552(DHRSX)

PWL:	138250325(DHRSX)

MUO:	115469441(DHRSX)

DRE:	100318301(dhrsx)

SRX:	107714300 107746640

SANH:

107654744 107691604

SGH:	107552235 107598749

CCAR:

109094305 109095143(dhrsx)

CAUA:

113044285(dhrsx)

CGIB:

127949285

PTET:

122341772(dhrsx)

LROH:

127168298(dhrsx) 127170476

GRF:	141337010(dhrsx)

OMC:	131544931(dhrsx)

PPRM:

120461402(dhrsx)

RKG:	130087887(dhrsx)

MAMB:

125272251(dhrsx)

CIDE:

127516452

CERY:

137032345(dhrsx)

MASI:

127444847

TROS:

130552388(dhrsx) 130555258

TDW:	130410687(dhrsx) 130427296

MANU:

129451555

PDAB:

135733655

IPU:	108259064 108266909

IFU:	128601914(dhrsx) 128609279

PHYP:

113524341 113537737(dhrsx)

SMEO:

124378130(dhrsx) 124379833

TFD:	113642089 113652583(dhrsx)

TVC:	132839227(dhrsx) 132850576

CGAR:

128507095(dhrsx) 128524435

NGRA:

132866296(dhrsx) 132895994

TRN:	134324273 134329316(dhrsx)

AMEX:

103024630(dhrsx) 111191271

CMAO:

118803054(dhrsx) 118811546

EEE:	113577526(dhrsx) 113586733

CHAR:

105898079 105910994

SPIL:

134071358(dhrsx) 134078602

ASAD:

121698040(dhrsx) 121702242

TRU:	101072900 101074707(dhrsx)

TFS:	130522601(dhrsx) 130529683

TNG:	GSTEN00027095G001

LCO:	104923847 104930736 109139865

NCC:	104948369 104961879

TBEN:

117485873 117498943(dhrsx)

CGOB:

115020936(dhrsx) 115026273

PGEO:

117458700(dhrsx) 117466292

GACU:

117541365 117546639(dhrsx)

EMAC:

134860769(dhrsx) 134867888

ELY:	117250172(dhrsx) 117251495

EFO:	125884768(dhrsx) 125899466

PLEP:

121949546(dhrsx)

SLUC:

116037699 116057805 116061884(dhrsx)

ECRA:

117939521(dhrsx) 117939523 117952401

ESP:	116673678 116674053 116698026

PFLV:

114550729 114551153 114564306

GAT:

120833967

PPUG:

119218731 119228689

AFB:	129104813 129111762(dhrsx)

CLUM:

117743167(dhrsx) 117750853

PSWI:

130201469 130204411(dhrsx)

CANA:

137782955 137794244(dhrsx)

CVE:	137879094 137892341

MSAM:

119900560(dhrsx) 119903953 119919277

SCHU:

122872090(dhrsx) 122885352

EARM:

139292850 139306833(dhrsx)

CUD:

121522803

SPUL:

138592925 138603695(dhrsx)

LMIX:

HTC:

ALAT:

ASTR:

PKLU:

MZE:	101479280 101481846

ONL:	100705640(dhrsx) 100711195

OAU:	116311977 116317524(dhrsx)

OLA:	101168099 105356811

OML:	112140219(dhrsx) 112155022

CSAI:

133425151(dhrsx) 133446048

XMA:	102233583 102237813

XCO:	114140424(dhrsx) 114148261

XHE:	116716031 116723141

PRET:

103461464 103477331

PFOR:

103141457 103156196 103156197

PLAI:

106949052 106961494(dhrsx)

PMEI:

106908010 106908011 106918871

GAF:	122826923(dhrsx) 122839352

PPRL:

129356464 129361342

CVG:	107102836 107104578

CTUL:

119775136 119779582

GMU:	124861331(dhrsx) 124871460

NFU:	107384511(dhrsx) 107390240

KMR:	108240431 108244136(dhrsx)

ALIM:

106519740(dhrsx) 106536778

NWH:	119419076 119428720(dhrsx)

AOCE:

111568484 111587285(dhrsx)

EJA:	138201239 138213912(dhrsx)

BFRE:

138620892 138635239(dhrsx)

MCEP:

125017832

CSEM:

103392243(dhrsx)

POV:	109631049(dhrsx) 109640048

SSEN:

122760538 122787018(dhrsx)

SSOE:

131449165 131455391(dhrsx)

HHIP:

117754663 117778298(dhrsx)

HSP:	118103583(dhrsx) 118119622

PPLT:

128431186(dhrsx) 128455852

SMAU:

118283082 118303471(dhrsx)

LCF:	108892750 108902587(dhrsx)

SDU:	111218122 111233243

SLAL:

111647544 111655620 111662713 111670320

XGL:	120787469(dhrsx) 120802038

HCQ:	109514745 109531303

SSCV:

125973679 125989385(dhrsx)

SBIA:

133509209(dhrsx)

PEE:	133409177(dhrsx) 133410930

PTAO:

133483290(dhrsx) 133486795

BPEC:

110156076 110161071

ENY:	140359864 140365083(dhrsx)

MALB:

109964377 109973584

BSPL:

114847071 114848692(dhrsx)

SJO:	128354479(dhrsx) 128367463

SSCO:

133976565(dhrsx) 133993115

TTY:	137176904(dhrsx) 137192528

GMH:	115547418(dhrsx)

SASA:

106574274 106586508

STRU:

115161041 115179353 115195996(dhrsx)

OTW:	112253792 112266544

OMY:	110495900(dhrsx) 110520355 118936317

OGO:	124008657 124010949 124042954

ONE:	115129679 115133823

OKI:	109890636 109906689

OKE:	118363725(dhrsx) 118366634 118370191 127931278

OMM:	135519526 135543558(dhrsx)

OCLA:

139413060

SALP:

111953414 111970950 111971454

SNH:	120033724 120051261 120058058

SFON:

129821580 129859574

CCLU:

121536940 121568081(dhrsx) 121572841

ELS:	105016359 105022515(dhrsx)

OEP:	134007407(dhrsx) 134017427

SFM:

108920426

PKI:	111849073(dhrsx)

AANG:

118214020(dhrsx)

AROT:

135241126(dhrsx)

CCOG:

133116533(dhrsx)

LOC:	102687911(dhrsx)

PSPA:

121320674(dhrsx) 121327958

ARUT:

117406464

LCM:	102346822(DHRSX)

CMK:	103177089(dhrsx)

RTP:	109916127(dhrsx)

CPLA:

122550921(dhrsx)

CPUN:

140481150(dhrsx)

HOC:	132816878(dhrsx)

SCAU:

119977185(dhrsx)

LERI:

129715275(dhrsx) 129716284

HAKA:

140727034(dhrsx)

PMRN:

LRJ:

BFO:

BBEL:

SPU:

LPIC:

LVG:	121409961 121410034 121417431 121417432 121417473

AFIL:

AJC:

RZE:

AMER:

AALI:

SLIU:

DPX:	DAPPUDRAFT_312401

DMK:	116919708 116920037

AFRA:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

MRJ:

PORN:

OOT:

EAF:

TCF:

PPOI:

DSV:	119449775 119449979 119449981

DALB:

135898138 135902892

RSAN:

119382855 119382990

RMP:	119170035 119170199

VDE:

VJA:

TUT:

DPTE:

DFR:	124493036 124499420

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:	118181076 118200620

LGI:	LOTGIDRAFT_65663

PVUL:

PCAN:

LSAX:

BARL:

GAE:

HRF:	124119973 124143697

HRJ:	124286416 124287980

HASI:

137273985

HCRA:

139449712 139474327

CRG:	105337539 105337700

CANU:

128171021 128175295 128184872

CVN:	111122067 111122283

OED:

MYI:

PMAX:

AIRR:

YBA:	132547874 132549640 132549648 132559267 132561799

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LJP:	135473484 135476959

LAK:

106176882

LLON:

135493741

NVE:

5519215

EPA:	110254817 110254825

ATEN:

116308778

ADF:	107329712 107345584

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

GMX:	100816309 100818046

GSJ:	114410315 114415528

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:	11422406 25497106

TPRA:

123909291

CAM:

101503084

PSAT:

127082173 127082176

VVO:	131622551 131655643

LJA:

130742736

ADU:

107475995

AIP:

107626198

AHF:	112728583 112756633

LANG:

109343511

PCIN:

129303973

NGR:	NAEGRDRAFT_67971

» show all

Reference

PMID:11731500

Authors

Gianfrancesco F, Sanges R, Esposito T, Tempesta S, Rao E, Rappold G, Archidiacono N, Graves JA, Forabosco A, D'Urso M

Title

Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution.

Journal

Genome Res 11:2095-100 (2001)
DOI:10.1101/gr.197001

Sequence

[hsa:207063]

Reference

PMID:38821050

Authors

Wilson MP, Kentache T, Althoff CR, Schulz C, de Bettignies G, Mateu Cabrera G, Cimbalistiene L, Burnyte B, Yoon G, Costain G, Vuillaumier-Barrot S, Cheillan D, Rymen D, Rychtarova L, Hansikova H, Bury M, Dewulf JP, Caligiore F, Jaeken J, Cantagrel V, Van Schaftingen E, Matthijs G, Foulquier F, Bommer GT

Title

A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis.

Journal

Cell 187:3585-3601.e22 (2024)
DOI:10.1016/j.cell.2024.04.041

LinkDB

DBGET integrated database retrieval system