KEGG   ORTHOLOGY: K11337
Entry
K11337                      KO                                     
Symbol
bchC
Name
bacteriochlorophyllide a dehydrogenase [EC:1.1.1.396]
Pathway
map00860  Porphyrin metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K11337  bchC; bacteriochlorophyllide a dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.396  bacteriochlorophyllide a dehydrogenase
     K11337  bchC; bacteriochlorophyllide a dehydrogenase
Other DBs
RN: R09055
Genes
ALV: Alvin_2563
ATEP: Atep_25160
TVI: Thivi_2012
TMB: Thimo_3006
MPUR: MARPU_13280
TSY: THSYN_31090
TTP: E6P07_01735
THIP: N838_12390(bchC)
CJAP: GWK36_12645
THIM: KFB96_13105(bchC)
TBOG: LT988_08910(bchC)
HHA: Hhal_1611
HHK: HH1059_06260
HHC: M911_10355
EBS: ECTOBSL9_3047
PDQ: CL55_00013600
RAC: RA876_05995
LIM: L103DPR2_00971(yjjN)
LIH: L63ED372_00627(yjjN)
HYR: BSY239_1382(bchC)
METP: C1M51_03580(bchC)
RGE: RGE_33710(bchC)
RBN: RBXJA2T_09437
RDP: RD2015_1036
METR: BSY238_2447(bchC)
BEB: AEM42_07470
RPOD: E0E05_11785(bchC)
AGC: BSY240_3669(bchC)
ABAW: D5400_04835(bchC)
PDES: FE840_002320(bchC)
BRA: BRADO1617(bchC)
BBT: BBta_6438(bchC)
BRS: S23_19170(bchC)
AOL: S58_59190
BRO: BRAD285_5782(bchC)
BRQ: CIT40_23945(bchC)
BGZ: XH91_02640(bchC)
BBET: F8237_24670(bchC)
RPA: RPA1521(bchC)
RPB: RPB_4002
RPC: RPC_1292
RPD: RPD_3757
RPE: RPE_1326
RPT: Rpal_1709
RPX: Rpdx1_3999
BOS: BSY19_4056(bchC)
MEA: Mex_1p2926(bchC)
MDI: METDI3495(bchC)
MEX: Mext_2729
MCH: Mchl_2956
MPO: Mpop_2851
MZA: B2G69_21185
MRD: Mrad2831_2819
MET: M446_3696
MOR: MOC_3184(bchC)
META: Y590_13135
MAQU: Maq22A_1p32540
MPHY: MCBMB27_02260
MEE: DA075_03955(bchC)
METD: C0214_15300(bchC)
METX: A3862_17695
METS: DK389_31440(bchC)
METI: DK427_17900(bchC)
MMES: MMSR116_13610(bchC)
MTEA: DK419_04915(bchC)
MIND: mvi_08970
MOG: MMB17_23890(bchC)
MSL: Msil_2051
BBAR: RHAL1_03015(bchC)
RVA: Rvan_0209
BVR: BVIR_598
BLAG: BLTE_02340
MROS: EHO51_17030(bchC)
CMET: K6K41_01670(bchC)
AUB: LXB15_06385(bchC)
BSB: Bresu_3046
BRL: BZG35_15460
RUT: FIU92_10160(yjjN)
JAN: Jann_0180(bchC)
RDE: RD1_0112(bchC)
RLI: RLO149_p940150(bchC)
RPON: G3256_18655(bchC)
DSH: Dshi_3516(bchC)
RED: roselon_01077
SUAM: BOO69_19415
TOM: BWR18_20235
RMM: ROSMUCSMR3_00906
ROK: RAK1035_3775
RID: RIdsm_01754(yjjN)
ROM: EI983_05435(bchC)
ROH: FIU89_14240(yjjN2)
THAA: CFI11_23545(bchC)
MARU: FIU81_13865(yjjN2)
ROT: FIV09_18065(yjjN)
MALU: KU6B_16420(bchC)
RSP: RSP_0263(bchC)
RSH: Rsph17029_1907
RSQ: Rsph17025_2037
RSK: RSKD131_1590
CAZT: LV780_09080(bchC)
RCP: RCAP_rcc00686(bchC)
RBL: B6K69_00185
PTP: RCA23_c29610(bchC)
RSU: NHU_04286(bchC)
RHM: B5V46_17490
RHC: RGUI_1962
LVS: LOKVESSMR4R_03678(lgoD)
RBG: BG454_03030(bchC)
GEH: HYN69_05520(bchC)
TAW: EI545_18940(bchC)
POZ: I0K15_00015(bchC)
FAQ: G5B39_11885(bchC)
HBC: AEM38_14590
NOT: C7W88_00475(bchC)
NGF: FRF71_09140(bchC)
NOG: GKE62_08430(bchC)
SPHI: TS85_22900
SSAN: NX02_18455
SCHY: GVO57_11635(bchC)
CIJ: WG74_05040
BLAS: BSY18_3554(bchC)
BFW: B5J99_08565
PALG: HFP57_06955(bchC)
PARJ: J4G78_07540(bchC)
SAND: H3309_05745(bchC)
POQ: KZX46_18710(bchC)
ALH: G6N82_11425(bchC)
ELQ: Ga0102493_111839
ERK: CD351_13865(bchC)
ERF: FIU90_13825(yjjN)
PNS: A9D12_01285
PORL: BG023_112669
PHZ: CHX26_14495(bchC)
POT: E2E27_07340(bchC)
AMV: ACMV_18800(bchC)
NCB: C0V82_18170(bchC)
SKT: IGS68_17120(bchC)
SMUC: JL100_008915(bchC)
SROE: JL101_015300(bchC)
RRU: Rru_A2981
RRF: F11_15270
RCE: RC1_2093(bchC)
RPM: RSPPHO_01501(bchC)
ELIO: KO353_03080(bchC)
PPSC: EHS13_04565
PALB: EJC50_10200
PRZ: GZH47_08510
PLYC: GXP70_07785
COHN: KCTCHS21_04640
LXL: KDY119_00661
MICG: GJV80_17645
RRS: RoseRS_3261
RCA: Rcas_3133 Rcas_3747
CAU: Caur_0416
CHL: Chy400_0443
CAG: Cagg_3128
OLE: K0B96_14295
CTM: Cabther_A1526
CVL: J8C06_09550
CHLO: J8C02_07530
GPH: GEMMAAP_06525
GGR: HKW67_08760(bchC)
CTE: CT1422(bchC)
CPC: Cpar_0742
CLZ: BIU88_03605
CCH: Cag_0401
CPH: Cpha266_1791
CPB: Cphamn1_0938
CLI: Clim_0898
PVI: Cvib_1240
PLT: Plut_1422
PPH: Ppha_0980
PAA: Paes_1534
PROC: Ptc2401_00668(yjjN)
PRS: B9H02_04015
PROS: CHL67_03605(bchC)
CTS: Ctha_2719
DTH: DICTH_0472
 » show all
Reference
PMID:18079120
  Authors
Kim EJ, Kim JS, Lee IH, Rhee HJ, Lee JK
  Title
Superoxide generation by chlorophyllide a reductase of Rhodobacter sphaeroides.
  Journal
J Biol Chem 283:3718-30 (2008)
DOI:10.1074/jbc.M707774200
Reference
PMID:8437569
  Authors
McGlynn P, Hunter CN
  Title
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
  Journal
Mol Gen Genet 236:227-34 (1993)
DOI:10.1007/BF00277117
  Sequence
[rcp:RCAP_rcc00686]
LinkDB

KEGG   ENZYME: 1.1.1.396
Entry
EC 1.1.1.396                Enzyme                                 
Name
bacteriochlorophyllide a dehydrogenase;
bchC (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
Reaction(IUBMB)
(1) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+ [RN:R09055];
(2) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+
Reaction(KEGG)
R09055
Substrate
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a [CPD:C18153];
NAD+ [CPD:C00003];
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a [CPD:C18154]
Product
bacteriochlorophyllide a [CPD:C18155];
NADH [CPD:C00004];
H+ [CPD:C00080];
3-acetyl-3-devinylchlorophyllide a
Comment
The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.
History
EC 1.1.1.396 created 2016
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K11337  bacteriochlorophyllide a dehydrogenase
Genes
ALV: Alvin_2563
ATEP: Atep_25160
TVI: Thivi_2012
TMB: Thimo_3006
MPUR: MARPU_13280
TSY: THSYN_31090
TTP: E6P07_01735
THIP: N838_12390(bchC)
CJAP: GWK36_12645
THIM: KFB96_13105(bchC)
TBOG: LT988_08910(bchC)
HHA: Hhal_1611
HHK: HH1059_06260
HHC: M911_10355
EBS: ECTOBSL9_3047
PDQ: CL55_00013600
RAC: RA876_05995
LIM: L103DPR2_00971(yjjN)
LIH: L63ED372_00627(yjjN)
HYR: BSY239_1382(bchC)
METP: C1M51_03580(bchC)
RGE: RGE_33710(bchC)
RBN: RBXJA2T_09437
RDP: RD2015_1036
METR: BSY238_2447(bchC)
BEB: AEM42_07470
RPOD: E0E05_11785(bchC)
AGC: BSY240_3669(bchC)
ABAW: D5400_04835(bchC)
PDES: FE840_002320(bchC)
BRA: BRADO1617(bchC)
BBT: BBta_6438(bchC)
BRS: S23_19170(bchC)
AOL: S58_59190
BRO: BRAD285_5782(bchC)
BRQ: CIT40_23945(bchC)
BGZ: XH91_02640(bchC)
BBET: F8237_24670(bchC)
RPA: RPA1521(bchC)
RPB: RPB_4002
RPC: RPC_1292
RPD: RPD_3757
RPE: RPE_1326
RPT: Rpal_1709
RPX: Rpdx1_3999
BOS: BSY19_4056(bchC)
MEA: Mex_1p2926(bchC)
MDI: METDI3495(bchC)
MEX: Mext_2729
MCH: Mchl_2956
MPO: Mpop_2851
MZA: B2G69_21185
MRD: Mrad2831_2819
MET: M446_3696
MOR: MOC_3184(bchC)
META: Y590_13135
MAQU: Maq22A_1p32540
MPHY: MCBMB27_02260
MEE: DA075_03955(bchC)
METD: C0214_15300(bchC)
METX: A3862_17695
METS: DK389_31440(bchC)
METI: DK427_17900(bchC)
MMES: MMSR116_13610(bchC)
MTEA: DK419_04915(bchC)
MIND: mvi_08970
MOG: MMB17_23890(bchC)
MSL: Msil_2051
BBAR: RHAL1_03015(bchC)
RVA: Rvan_0209
BVR: BVIR_598
BLAG: BLTE_02340
MROS: EHO51_17030(bchC)
CMET: K6K41_01670(bchC)
AUB: LXB15_06385(bchC)
BSB: Bresu_3046
BRL: BZG35_15460
RUT: FIU92_10160(yjjN)
JAN: Jann_0180(bchC)
RDE: RD1_0112(bchC)
RLI: RLO149_p940150(bchC)
RPON: G3256_18655(bchC)
DSH: Dshi_3516(bchC)
RED: roselon_01077
SUAM: BOO69_19415
TOM: BWR18_20235
RMM: ROSMUCSMR3_00906
ROK: RAK1035_3775
RID: RIdsm_01754(yjjN)
ROM: EI983_05435(bchC)
ROH: FIU89_14240(yjjN2)
THAA: CFI11_23545(bchC)
MARU: FIU81_13865(yjjN2)
ROT: FIV09_18065(yjjN)
MALU: KU6B_16420(bchC)
RSP: RSP_0263(bchC)
RSH: Rsph17029_1907
RSQ: Rsph17025_2037
RSK: RSKD131_1590
CAZT: LV780_09080(bchC)
RCP: RCAP_rcc00686(bchC)
RBL: B6K69_00185
PTP: RCA23_c29610(bchC)
RSU: NHU_04286(bchC)
RHM: B5V46_17490
RHC: RGUI_1962
LVS: LOKVESSMR4R_03678(lgoD)
RBG: BG454_03030(bchC)
GEH: HYN69_05520(bchC)
TAW: EI545_18940(bchC)
POZ: I0K15_00015(bchC)
FAQ: G5B39_11885(bchC)
HBC: AEM38_14590
NOT: C7W88_00475(bchC)
NGF: FRF71_09140(bchC)
NOG: GKE62_08430(bchC)
SPHI: TS85_22900
SSAN: NX02_18455
SCHY: GVO57_11635(bchC)
CIJ: WG74_05040
BLAS: BSY18_3554(bchC)
BFW: B5J99_08565
PALG: HFP57_06955(bchC)
PARJ: J4G78_07540(bchC)
SAND: H3309_05745(bchC)
POQ: KZX46_18710(bchC)
ALH: G6N82_11425(bchC)
ELQ: Ga0102493_111839
ERK: CD351_13865(bchC)
ERF: FIU90_13825(yjjN)
PNS: A9D12_01285
PORL: BG023_112669
PHZ: CHX26_14495(bchC)
POT: E2E27_07340(bchC)
AMV: ACMV_18800(bchC)
NCB: C0V82_18170(bchC)
SKT: IGS68_17120(bchC)
SMUC: JL100_008915(bchC)
SROE: JL101_015300(bchC)
RRU: Rru_A2981
RRF: F11_15270
RCE: RC1_2093(bchC)
RPM: RSPPHO_01501(bchC)
ELIO: KO353_03080(bchC)
PPSC: EHS13_04565
PALB: EJC50_10200
PRZ: GZH47_08510
PLYC: GXP70_07785
COHN: KCTCHS21_04640
LXL: KDY119_00661
MICG: GJV80_17645
RRS: RoseRS_3261
RCA: Rcas_3133 Rcas_3747
CAU: Caur_0416
CHL: Chy400_0443
CAG: Cagg_3128
OLE: K0B96_14295
CTM: Cabther_A1526
CVL: J8C06_09550
CHLO: J8C02_07530
GPH: GEMMAAP_06525
GGR: HKW67_08760(bchC)
CTE: CT1422(bchC)
CPC: Cpar_0742
CLZ: BIU88_03605
CCH: Cag_0401
CPH: Cpha266_1791
CPB: Cphamn1_0938
CLI: Clim_0898
PVI: Cvib_1240
PLT: Plut_1422
PPH: Ppha_0980
PAA: Paes_1534
PROC: Ptc2401_00668(yjjN)
PRS: B9H02_04015
PROS: CHL67_03605(bchC)
CTS: Ctha_2719
DTH: DICTH_0472
 » show all
Reference
1  [PMID:2555268]
  Authors
Wellington CL, Beatty JT
  Title
Promoter mapping and nucleotide sequence of the bchC bacteriochlorophyll biosynthesis gene from Rhodobacter capsulatus.
  Journal
Gene 83:251-61 (1989)
DOI:10.1016/0378-1119(89)90111-X
  Sequence
[rcp:RCAP_rcc00686]
Reference
2  [PMID:8437569]
  Authors
McGlynn P, Hunter CN
  Title
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
  Journal
Mol Gen Genet 236:227-34 (1993)
DOI:10.1007/BF00277117
  Sequence
[rsp:RSP_0263]
Reference
3  [PMID:26088139]
  Authors
Lange C, Kiesel S, Peters S, Virus S, Scheer H, Jahn D, Moser J
  Title
Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a.
  Journal
J Biol Chem 290:19697-709 (2015)
DOI:10.1074/jbc.M115.660555
  Sequence
[cte:CT1422]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.396
IUBMB Enzyme Nomenclature: 1.1.1.396
ExPASy - ENZYME nomenclature database: 1.1.1.396
BRENDA, the Enzyme Database: 1.1.1.396
LinkDB

KEGG   REACTION: R09055
Entry
R09055                      Reaction                               
Name
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
Definition
3-Hydroxyethylbacteriochlorophyllide a + NAD+ <=> Bacteriochlorophyllide a + NADH + H+
Equation
C18153 + C00003 <=> C18155 + C00004 + C00080
Reaction class
RC01377  C18153_C18155
Enzyme
1.1.1.396
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K11337  bacteriochlorophyllide a dehydrogenase [EC:1.1.1.396]
Other DBs
RHEA: 19736
LinkDB

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