KEGG   ORTHOLOGY: K11337
Entry
K11337                      KO                                     
Symbol
bchC
Name
bacteriochlorophyllide a dehydrogenase [EC:1.1.1.396]
Pathway
map00860  Porphyrin metabolism
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    K11337  bchC; bacteriochlorophyllide a dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.396  bacteriochlorophyllide a dehydrogenase
     K11337  bchC; bacteriochlorophyllide a dehydrogenase
Other DBs
RN: R09055
Genes
ALV: Alvin_2563
ATEP: Atep_25160
TVI: Thivi_2012
TMB: Thimo_3006
MPUR: MARPU_13280
TSY: THSYN_31090
TTP: E6P07_01735
THIP: N838_12390(bchC)
CJAP: GWK36_12645
THIM: KFB96_13105(bchC)
TBOG: LT988_08910(bchC)
HHA: Hhal_1611
LIM: L103DPR2_00971(yjjN)
LIH: L63ED372_00627(yjjN)
HYR: BSY239_1382(bchC)
METP: C1M51_03580(bchC)
RGE: RGE_33710(bchC)
METR: BSY238_2447(bchC)
RPOD: E0E05_11785(bchC)
AGC: BSY240_3669(bchC)
ABAW: D5400_04835(bchC)
PDES: FE840_002320(bchC)
BRA: BRADO1617(bchC)
BBT: BBta_6438(bchC)
BRS: S23_19170(bchC)
AOL: S58_59190
BRO: BRAD285_5782(bchC)
BRQ: CIT40_23945(bchC)
BGZ: XH91_02640(bchC)
BBET: F8237_24670(bchC)
RPA: RPA1521(bchC)
RPB: RPB_4002
RPC: RPC_1292
RPD: RPD_3757
RPE: RPE_1326
RPT: Rpal_1709
BOS: BSY19_4056(bchC)
MEA: Mex_1p2926(bchC)
MDI: METDI3495(bchC)
MEX: Mext_2729
MCH: Mchl_2956
MPO: Mpop_2851
MET: M446_3696
MOR: MOC_3184(bchC)
META: Y590_13135
MEE: DA075_03955(bchC)
METD: C0214_15300(bchC)
METS: DK389_31440(bchC)
METI: DK427_17900(bchC)
MMES: MMSR116_13610(bchC)
MTEA: DK419_04915(bchC)
MIND: mvi_08970
MOG: MMB17_23890(bchC)
MSL: Msil_2051
BBAR: RHAL1_03015(bchC)
RVA: Rvan_0209
BVR: BVIR_598
BLAG: BLTE_02340
MROS: EHO51_17030(bchC)
CMET: K6K41_01670(bchC)
AUB: LXB15_06385(bchC)
RUT: FIU92_10160(yjjN)
JAN: Jann_0180(bchC)
RDE: RD1_0112(bchC)
RLI: RLO149_p940150(bchC)
RPON: G3256_18655(bchC)
DSH: Dshi_3516(bchC)
RID: RIdsm_01754(yjjN)
ROM: EI983_05435(bchC)
ROH: FIU89_14240(yjjN2)
THAA: CFI11_23545(bchC)
MARU: FIU81_13865(yjjN2)
ROT: FIV09_18065(yjjN)
MALU: KU6B_16420(bchC)
RSP: RSP_0263(bchC)
CAZT: LV780_09080(bchC)
RCP: RCAP_rcc00686(bchC)
PTP: RCA23_c29610(bchC)
RSU: NHU_04286(bchC)
RHC: RGUI_1962
LVS: LOKVESSMR4R_03678(lgoD)
RBG: BG454_03030(bchC)
GEH: HYN69_05520(bchC)
TAW: EI545_18940(bchC)
POZ: I0K15_00015(bchC)
FAQ: G5B39_11885(bchC)
NOT: C7W88_00475(bchC)
NGF: FRF71_09140(bchC)
NOG: GKE62_08430(bchC)
SPHI: TS85_22900
SSAN: NX02_18455
SCHY: GVO57_11635(bchC)
BLAS: BSY18_3554(bchC)
PALG: HFP57_06955(bchC)
PARJ: J4G78_07540(bchC)
SAND: H3309_05745(bchC)
POQ: KZX46_18710(bchC)
ALH: G6N82_11425(bchC)
ERK: CD351_13865(bchC)
ERF: FIU90_13825(yjjN)
PHZ: CHX26_14495(bchC)
POT: E2E27_07340(bchC)
AMV: ACMV_18800(bchC)
NCB: C0V82_18170(bchC)
SKT: IGS68_17120(bchC)
SMUC: JL100_008915(bchC)
SROE: JL101_015300(bchC)
RRU: Rru_A2981
RRF: F11_15270
RCE: RC1_2093(bchC)
RPM: RSPPHO_01501(bchC)
ELIO: KO353_03080(bchC)
CAU: Caur_0416
CAG: Cagg_3128
GGR: HKW67_08760(bchC)
CTE: CT1422(bchC)
CPC: Cpar_0742
CCH: Cag_0401
CLI: Clim_0898
PVI: Cvib_1240
PLT: Plut_1422
PPH: Ppha_0980
PAA: Paes_1534
PROC: Ptc2401_00668(yjjN)
PROS: CHL67_03605(bchC)
CTS: Ctha_2719
 » show all
Reference
  Authors
Kim EJ, Kim JS, Lee IH, Rhee HJ, Lee JK
  Title
Superoxide generation by chlorophyllide a reductase of Rhodobacter sphaeroides.
  Journal
J Biol Chem 283:3718-30 (2008)
DOI:10.1074/jbc.M707774200
Reference
PMID:8437569
  Authors
McGlynn P, Hunter CN
  Title
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
  Journal
Mol Gen Genet 236:227-34 (1993)
DOI:10.1007/BF00277117
  Sequence
LinkDB

KEGG   ENZYME: 1.1.1.396
Entry
EC 1.1.1.396                Enzyme                                 
Name
bacteriochlorophyllide a dehydrogenase;
bchC (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
Reaction(IUBMB)
(1) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+ [RN:R09055];
(2) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+
Reaction(KEGG)
R09055
Substrate
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a [CPD:C18153];
NAD+ [CPD:C00003];
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a [CPD:C18154]
Product
bacteriochlorophyllide a [CPD:C18155];
NADH [CPD:C00004];
H+ [CPD:C00080];
3-acetyl-3-devinylchlorophyllide a
Comment
The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.
History
EC 1.1.1.396 created 2016
Pathway
ec00860  Porphyrin metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K11337  bacteriochlorophyllide a dehydrogenase
Genes
ALVAlvin_2563
ATEPAtep_25160
TVIThivi_2012
TMBThimo_3006
MPURMARPU_13280
TSYTHSYN_31090
TTPE6P07_01735
THIPN838_12390(bchC)
CJAPGWK36_12645
THIMKFB96_13105(bchC)
TBOGLT988_08910(bchC)
HHAHhal_1611
HHKHH1059_06260
HHCM911_10355
EBSECTOBSL9_3047
PDQCL55_00013600
RACRA876_05995
LIML103DPR2_00971(yjjN)
LIHL63ED372_00627(yjjN)
HYRBSY239_1382(bchC)
METPC1M51_03580(bchC)
RGERGE_33710(bchC)
RBNRBXJA2T_09437
RDPRD2015_1036
METRBSY238_2447(bchC)
BEBAEM42_07470
RPODE0E05_11785(bchC)
AGCBSY240_3669(bchC)
ABAWD5400_04835(bchC)
PDESFE840_002320(bchC)
BRABRADO1617(bchC)
BBTBBta_6438(bchC)
BRSS23_19170(bchC)
AOLS58_59190
BROBRAD285_5782(bchC)
BRQCIT40_23945(bchC)
BGZXH91_02640(bchC)
BBETF8237_24670(bchC)
RPARPA1521(bchC)
RPBRPB_4002
RPCRPC_1292
RPDRPD_3757
RPERPE_1326
RPTRpal_1709
RPXRpdx1_3999
BOSBSY19_4056(bchC)
MEAMex_1p2926(bchC)
MDIMETDI3495(bchC)
MEXMext_2729
MCHMchl_2956
MPOMpop_2851
MZAB2G69_21185
MRDMrad2831_2819
METM446_3696
MORMOC_3184(bchC)
METAY590_13135
MAQUMaq22A_1p32540
MPHYMCBMB27_02260
MEEDA075_03955(bchC)
METDC0214_15300(bchC)
METXA3862_17695
METSDK389_31440(bchC)
METIDK427_17900(bchC)
MMESMMSR116_13610(bchC)
MTEADK419_04915(bchC)
MINDmvi_08970
MOGMMB17_23890(bchC)
MSLMsil_2051
BBARRHAL1_03015(bchC)
RVARvan_0209
BVRBVIR_598
BLAGBLTE_02340
MROSEHO51_17030(bchC)
CMETK6K41_01670(bchC)
AUBLXB15_06385(bchC)
BSBBresu_3046
BRLBZG35_15460
RUTFIU92_10160(yjjN)
JANJann_0180(bchC)
RDERD1_0112(bchC)
RLIRLO149_p940150(bchC)
RPONG3256_18655(bchC)
DSHDshi_3516(bchC)
REDroselon_01077
SUAMBOO69_19415
TOMBWR18_20235
RMMROSMUCSMR3_00906
ROKRAK1035_3775
RIDRIdsm_01754(yjjN)
ROMEI983_05435(bchC)
ROHFIU89_14240(yjjN2)
THAACFI11_23545(bchC)
MARUFIU81_13865(yjjN2)
ROTFIV09_18065(yjjN)
MALUKU6B_16420(bchC)
RSPRSP_0263(bchC)
RSHRsph17029_1907
RSQRsph17025_2037
RSKRSKD131_1590
CAZTLV780_09080(bchC)
RCPRCAP_rcc00686(bchC)
RBLB6K69_00185
PTPRCA23_c29610(bchC)
RSUNHU_04286(bchC)
RHMB5V46_17490
RHCRGUI_1962
LVSLOKVESSMR4R_03678(lgoD)
RBGBG454_03030(bchC)
GEHHYN69_05520(bchC)
TAWEI545_18940(bchC)
POZI0K15_00015(bchC)
FAQG5B39_11885(bchC)
HBCAEM38_14590
NOTC7W88_00475(bchC)
NGFFRF71_09140(bchC)
NOGGKE62_08430(bchC)
SPHITS85_22900
SSANNX02_18455
SCHYGVO57_11635(bchC)
CIJWG74_05040
BLASBSY18_3554(bchC)
BFWB5J99_08565
PALGHFP57_06955(bchC)
PARJJ4G78_07540(bchC)
SANDH3309_05745(bchC)
POQKZX46_18710(bchC)
ALHG6N82_11425(bchC)
ELQGa0102493_111839
ERKCD351_13865(bchC)
ERFFIU90_13825(yjjN)
PNSA9D12_01285
PORLBG023_112669
PHZCHX26_14495(bchC)
POTE2E27_07340(bchC)
AMVACMV_18800(bchC)
NCBC0V82_18170(bchC)
SKTIGS68_17120(bchC)
SMUCJL100_008915(bchC)
SROEJL101_015300(bchC)
RRURru_A2981
RRFF11_15270
RCERC1_2093(bchC)
RPMRSPPHO_01501(bchC)
ELIOKO353_03080(bchC)
PPSCEHS13_04565
PALBEJC50_10200
PRZGZH47_08510
PLYCGXP70_07785
COHNKCTCHS21_04640
LXLKDY119_00661
MICGGJV80_17645
RRSRoseRS_3261
RCARcas_3133 Rcas_3747
CAUCaur_0416
CHLChy400_0443
CAGCagg_3128
OLEK0B96_14295
CTMCabther_A1526
CVLJ8C06_09550
CHLOJ8C02_07530
GPHGEMMAAP_06525
GGRHKW67_08760(bchC)
CTECT1422(bchC)
CPCCpar_0742
CLZBIU88_03605
CCHCag_0401
CPHCpha266_1791
CPBCphamn1_0938
CLIClim_0898
PVICvib_1240
PLTPlut_1422
PPHPpha_0980
PAAPaes_1534
PROCPtc2401_00668(yjjN)
PRSB9H02_04015
PROSCHL67_03605(bchC)
CTSCtha_2719
DTHDICTH_0472
 » show all
Reference
1  [PMID:2555268]
  Authors
Wellington CL, Beatty JT
  Title
Promoter mapping and nucleotide sequence of the bchC bacteriochlorophyll biosynthesis gene from Rhodobacter capsulatus.
  Journal
Gene 83:251-61 (1989)
DOI:10.1016/0378-1119(89)90111-X
  Sequence
Reference
2  [PMID:8437569]
  Authors
McGlynn P, Hunter CN
  Title
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
  Journal
Mol Gen Genet 236:227-34 (1993)
DOI:10.1007/BF00277117
  Sequence
[rsp:RSP_0263]
Reference
3  [PMID:26088139]
  Authors
Lange C, Kiesel S, Peters S, Virus S, Scheer H, Jahn D, Moser J
  Title
Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a.
  Journal
J Biol Chem 290:19697-709 (2015)
DOI:10.1074/jbc.M115.660555
  Sequence
[cte:CT1422]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.396
IUBMB Enzyme Nomenclature: 1.1.1.396
ExPASy - ENZYME nomenclature database: 1.1.1.396
BRENDA, the Enzyme Database: 1.1.1.396
LinkDB

KEGG   REACTION: R09055
Entry
R09055                      Reaction                               
Name
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
Definition
3-Hydroxyethylbacteriochlorophyllide a + NAD+ <=> Bacteriochlorophyllide a + NADH + H+
Equation
Reaction class
RC01377  C18153_C18155
Enzyme
Pathway
rn00860  Porphyrin metabolism
rn01110  Biosynthesis of secondary metabolites
Orthology
K11337  bacteriochlorophyllide a dehydrogenase [EC:1.1.1.396]
Other DBs
RHEA: 19736
LinkDB

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