KEGG   ORTHOLOGY: K11394
Entry
K11394                      KO                                     
Symbol
PRODH2
Name
hydroxyproline dehydrogenase [EC:1.5.5.3]
Pathway
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
Reaction
R03295  trans-4-hydroxy-L-proline:quinone oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    K11394  PRODH2; hydroxyproline dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.5  With a quinone or similar compound as acceptor
    1.5.5.3  hydroxyproline dehydrogenase
     K11394  PRODH2; hydroxyproline dehydrogenase
Genes
HSA: 58510(PRODH2)
PTR: 469076(PRODH2)
PPS: 100988900(PRODH2)
GGO: 101154315(PRODH2)
PON: 100441645(PRODH2)
PPYG: 129019526(PRODH2)
NLE: 100582687(PRODH2)
HMH: 116479635(PRODH2)
SSYN: 129460140(PRODH2)
MCC: 718914(PRODH2)
MCF: 102119447(PRODH2)
MTHB: 126941910
MNI: 105495496(PRODH2)
CSAB: 103235488(PRODH2)
CATY: 105578193(PRODH2)
PANU: 101016659(PRODH2)
TGE: 112611985(PRODH2)
MLEU: 105543103(PRODH2)
RRO: 104667131(PRODH2)
TFN: 117092378
PTEH: 111529920(PRODH2)
CANG: 105516704(PRODH2)
CJC: 100409353(PRODH2)
SBQ: 101051757(PRODH2)
CIMI: 108298522(PRODH2)
ANAN: 105707000(PRODH2)
CSYR: 103249678(PRODH2)
MMUR: 105876908(PRODH2)
LCAT: 123624454(PRODH2)
PCOQ: 105816146(PRODH2)
OGA: 105887642(PRODH2)
MMU: 56189(Prodh2)
MCAL: 110297695(Prodh2)
MPAH: 110335390(Prodh2)
RNO: 361538(Prodh2)
MCOC: 116100441(Prodh2)
ANU: 117721570(Prodh2)
MUN: 110550901(Prodh2)
CGE: 100773901(Prodh2)
MAUA: 106022088(Prodh2)
PROB: 127238421(Prodh2)
PLEU: 114681696(Prodh2)
MORG: 121449990(Prodh2)
MFOT: 126486731
AAMP: 119820680(Prodh2)
NGI: 103729941(Prodh2)
HGL: 101703531(Prodh2)
CPOC: 100736006(Prodh2)
CCAN: 109689445(Prodh2)
DORD: 105993097(Prodh2)
DSP: 122097495(Prodh2)
PLOP: 125368012(Prodh2)
NCAR: 124966378
MMMA: 107151783(Prodh2)
OCU: 100354740
OPI: 101536287(PRODH2)
TUP: 102492745(PRODH2)
GVR: 103592829(PRODH2)
CFA: 484572(PRODH2)
CLUD: 112643571(PRODH2)
VVP: 112928512(PRODH2)
VLG: 121484394(PRODH2)
NPO: 129500989(PRODH2)
AML: 100474293(PRODH2)
UMR: 103682563(PRODH2)
UAH: 113244764(PRODH2)
UAR: 123793900(PRODH2)
ELK: 111161589
LLV: 125088416
MPUF: 101671462(PRODH2)
MNP: 132006160(PRODH2)
MLK: 131818468(PRODH2)
NVS: 122911569(PRODH2)
ORO: 101380565(PRODH2)
EJU: 114224383(PRODH2)
ZCA: 113935606(PRODH2)
MLX: 118022832(PRODH2)
NSU: 110590134(PRODH2)
LWW: 102738808(PRODH2)
FCA: 101087368(PRODH2)
PYU: 121011544(PRODH2)
PCOO: 112851027(PRODH2)
PBG: 122495009(PRODH2)
PVIV: 125153574(PRODH2)
LRUF: 124511931
PTG: 102963452(PRODH2)
PPAD: 109251455(PRODH2)
PUC: 125915107
AJU: 106974672
HHV: 120243503(PRODH2)
BTA: 508542(PRODH2)
BOM: 102278759(PRODH2)
BIU: 109572365(PRODH2)
BBUB: 102409119(PRODH2)
BBIS: 104995257(PRODH2)
CHX: 102176816(PRODH2)
OAS: 101105181(PRODH2)
BTAX: 128063762(PRODH2)
CSUM: 138095806(PRODH2)
ODA: 120872535(PRODH2)
CCAD: 122421420(PRODH2)
MREE: 136161228(PRODH2)
MBEZ: 129546106(PRODH2)
CFR: 102508280(PRODH2)
CBAI: 105065057(PRODH2)
CDK: 105088061(PRODH2)
VPC: 102527118(PRODH2)
BACU: 103020530(PRODH2)
BMUS: 118884847(PRODH2)
LVE: 103075818(PRODH2)
OOR: 101279871(PRODH2)
DLE: 111181175(PRODH2)
PCAD: 102988845(PRODH2)
PSIU: 116744597(PRODH2)
NASI: 112392264(PRODH2)
ECB: 100630262(PRODH2)
EPZ: 103566804(PRODH2)
EAI: 106829258(PRODH2)
MYB: 102243035(PRODH2)
MYD: 102760255(PRODH2)
MMYO: 118674658(PRODH2)
MLF: 102420802(PRODH2)
MDT: 132216976(PRODH2)
PKL: 118720660(PRODH2)
EFUS: 103284519(PRODH2)
MNA: 107543420(PRODH2)
DRO: 112320057(PRODH2)
SHON: 118982564(PRODH2)
AJM: 119044201(PRODH2)
PDIC: 114511204(PRODH2)
PHAS: 123823819(PRODH2)
MMF: 118638631(PRODH2)
PPAM: 129083102(PRODH2)
HAI: 109372033(PRODH2)
RFQ: 117034953(PRODH2)
PALE: 102881173(PRODH2)
PGIG: 120592449(PRODH2)
PVP: 105306655(PRODH2)
RAY: 107497651(PRODH2)
MJV: 108401524(PRODH2)
TOD: 119250206(PRODH2)
SARA: 101538488(PRODH2)
SETR: 126027622(PRODH2)
LAV: 100665466(PRODH2)
TMU: 101347296
ETF: 101657990(PRODH2)
DNM: 101424361(PRODH2)
MDO: 100016428(PRODH2)
GAS: 123243033(PRODH2)
SHR: 111719924(PRODH2)
AFZ: 127556084
PCW: 110201606(PRODH2)
TVP: 118839038(PRODH2)
PBRV: 138154098(PRODH2)
OAA: 114812117(PRODH2)
GGA: 107050361(PRODH2)
CATA: 118261618
LSR: 116184746
PRUF: 121364410
PHI: 102108371(PRODH2)
SHAB: 115602951
AGEN: 126036653
ASN: 102378835(PRODH2)
AMJ: 102567357(PRODH2)
CMY: 119566296(PRODH2)
CCAY: 125637978(PRODH2)
DCC: 119856739(PRODH2)
CPIC: 103306964(PRODH2)
CABI: 116826185(PRODH2)
MRV: 120404560(PRODH2)
ACS: 100555092(prodh2)
ASAO: 132779394(PRODH2)
PVT: 110078478(PRODH2)
SUND: 121932668(PRODH2)
PBI: 103056447(PRODH2)
PMUR: 107282463
CTIG: 120304571(PRODH2)
TSR: 106555418
PGUT: 117669155(PRODH2)
APRI: 131198602(PRODH2)
PTEX: 113443488(PRODH2)
NSS: 113418577(PRODH2)
VKO: 123032097(PRODH2)
PMUA: 114582127(PRODH2)
PRAF: 128401066(PRODH2)
ZVI: 118095866(PRODH2)
HCG: 128330949(PRODH2)
GJA: 107116343(PRODH2)
EMC: 129338259(PRODH2)
XLA: 398760(prodh2.L)
XTR: 101734436(prodh2)
NPR: 108789185(PRODH2)
RTEM: 120943083(PRODH2)
BBUF: 121007568(PRODH2)
BGAR: 122945283(PRODH2)
MUO: 115474312(PRODH2)
GSH: 117361299(PRODH2)
DRE: 436664(zgc:92040)
SRX: 107708971(prodh2)
SANH: 107693688(prodh2)
SGH: 107562014
CCAR: 109052804
CAUA: 113112084(prodh2)
CGIB: 127968710
PTET: 122333364(prodh2)
LROH: 127174616(prodh2)
OMC: 131551143(prodh2)
PPRM: 120469022(prodh2)
RKG: 130080601(prodh2)
MAMB: 125255611(prodh2)
CIDE: 127523442
CERY: 137007768(prodh2)
TROS: 130568787(prodh2)
TDW: 130438579(prodh2)
MANU: 129420497(prodh2)
IPU: 108273642
IFU: 128617398(prodh2)
PHYP: 113527045(prodh2)
SMEO: 124388555(prodh2)
TFD: 113653517(prodh2)
TVC: 132841530(prodh2)
TRN: 134321739(prodh2)
AMEX: 103022862(prodh2)
CMAO: 118809756(prodh2)
EEE: 113587524(prodh2)
CHAR: 105909097(prodh2)
TRU: 101078218(prodh2)
TFS: 130522305(prodh2)
LCO: 104926870(prodh2)
NCC: 104953237(prodh2)
TBEN: 117473940(prodh2)
CGOB: 115024870(prodh2)
PGEO: 117464422(prodh2)
GACU: 117545004(prodh2)
EMAC: 134870598(prodh2)
ELY: 117246798(prodh2)
EFO: 125880413(prodh2)
PLEP: 121958569(prodh2)
SLUC: 116061559(prodh2)
ECRA: 117937303(prodh2)
ESP: 116671297(prodh2)
PFLV: 114548408(prodh2)
GAT: 120819101(prodh2)
PPUG: 119212632(prodh2)
AFB: 129091288(prodh2)
PSWI: 130203323(prodh2)
CANA: 137789529(prodh2)
MSAM: 119916307(prodh2)
SCHU: 122868155(prodh2)
CUD: 121528303(prodh2)
ALAT: 119009899(prodh2)
ASTR: 137588586(prodh2)
MZE: 101487644(prodh2)
ONL: 100703669(prodh2)
OAU: 116327639(prodh2)
OLA: 101155724(prodh2)
OML: 112154696(prodh2)
CSAI: 133419346(prodh2)
XMA: 102226277(prodh2)
XCO: 114151741(prodh2)
XHE: 116726804(prodh2)
PRET: 103481397(prodh2)
PFOR: 103152334(prodh2)
PLAI: 106956243(prodh2)
PMEI: 106904144
GAF: 122823377(prodh2)
PPRL: 129377768(prodh2)
CVG: 107097212(prodh2)
CTUL: 119796745(prodh2)
GMU: 124874790(prodh2)
NFU: 107387966(prodh2)
KMR: 108247131(prodh2)
ALIM: 106521389(prodh2)
NWH: 119423598(prodh2)
AOCE: 111581595(prodh2)
EJA: 138202014(prodh2)
MCEP: 125022425(prodh2)
CSEM: 103381976(prodh2)
POV: 109642723(prodh2)
SSEN: 122759684(prodh2)
HHIP: 117752768(prodh2)
HSP: 118100647(prodh2)
PPLT: 128426661(prodh2)
SMAU: 118287419(prodh2)
LCF: 108884464
SDU: 111219983(prodh2)
SLAL: 111658668(prodh2)
XGL: 120794641(prodh2)
HCQ: 109523978(prodh2)
SSCV: 125990918(prodh2)
SBIA: 133496028(prodh2)
PEE: 133395254(prodh2)
PTAO: 133469695(prodh2)
BPEC: 110159594(prodh2)
MALB: 109973598(prodh2)
BSPL: 114845927(prodh2)
SJO: 128381410(prodh2)
SASA: 106578328(prodh2)
STRU: 115200976(prodh2)
OTW: 112232855(prodh2)
OMY: 110498805(prodh2)
OGO: 124039926(prodh2)
ONE: 115143935(prodh2)
OKI: 109881735(prodh2)
OKE: 118357763(prodh2)
SALP: 111976348(prodh2)
SNH: 120060911(prodh2)
CCLU: 121547167(prodh2)
ELS: 105024364(prodh2)
SFM: 108933021(prodh2)
PKI: 111835827(prodh2)
AANG: 118220234(prodh2)
PSPA: 121306794(prodh2)
ARUT: 117398777(prodh2)
PSEX: 120536561(prodh2)
LCM: 102354203(PRODH2)
CIN: 100180610
SCLV: 120330165
SPU: 576696
APLC: 110986277
ARUN: 117290549
CSEC: 111870040
BROR: 134529400
IEL: 124155633
DMK: 116931073
DPZ: 124349686
PVM: 113809427
PJA: 122250188
PCHN: 125030369
HAME: 121871864
PCLA: 123756392
CQD: 128694649
PTRU: 123520676
ESN: 126998472
MNZ: 135202330
MRJ: 136847129
HAZT: 108677818
DSV: 119440384
RSAN: 119386917
RMP: 119178297
CSCU: 111619182
CVS: 136980139
PTEP: 107456183
ABRU: 129980899
UDV: 129227683
SDM: 118192813
PVUL: 126824415
PCAN: 112562444
BGT: 106070289
HRF: 124141689
HRJ: 124278048
CANU: 128190697
OED: 125664753
MMER: 123530308
DPOL: 127877427
MAEA: 128216660
OBI: 106869190
LJP: 135476916
LAK: 106181047
LLON: 135482803
NVE: 5511574
EPA: 110253348
ATEN: 116290773
AMIL: 114959075
PDAM: 113673699
SPIS: 111329332
DGT: 114523876
XEN: 124434978
HMG: 100204778
HSY: 130656712
RES: 135683123
 » show all
Reference
  Authors
Cooper SK, Pandhare J, Donald SP, Phang JM
  Title
A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.
  Journal
J Biol Chem 283:10485-92 (2008)
DOI:10.1074/jbc.M702181200
  Sequence
[hsa:58510]
Reference
  Authors
Summitt CB, Johnson LC, Jonsson TJ, Parsonage D, Holmes RP, Lowther WT
  Title
Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.
  Journal
Biochem J 466:273-81 (2015)
DOI:10.1042/BJ20141159
  Sequence
[hsa:58510]
LinkDB

KEGG   ENZYME: 1.5.5.3
Entry
EC 1.5.5.3                  Enzyme                                 
Name
hydroxyproline dehydrogenase;
HYPDH;
OH-POX;
hydroxyproline oxidase;
PRODH2 (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a quinone or similar compound as acceptor
Sysname
trans-4-hydroxy-L-proline:quinone oxidoreductase
Reaction(IUBMB)
trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol [RN:R03295]
Reaction(KEGG)
R03295
Substrate
trans-4-hydroxy-L-proline [CPD:C01157];
quinone [CPD:C00472]
Product
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate [CPD:C04281];
quinol [CPD:C00530]
Comment
A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase).
History
EC 1.5.5.3 created 2017
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K11394  hydroxyproline dehydrogenase
Genes
HSA58510(PRODH2)
PTR469076(PRODH2)
PPS100988900(PRODH2)
GGO101154315(PRODH2)
PON100441645(PRODH2)
PPYG129019526(PRODH2)
NLE100582687(PRODH2)
HMH116479635(PRODH2)
SSYN129460140(PRODH2)
MCC718914(PRODH2)
MCF102119447(PRODH2)
MTHB126941910
MNI105495496(PRODH2)
CSAB103235488(PRODH2)
CATY105578193(PRODH2)
PANU101016659(PRODH2)
TGE112611985(PRODH2)
MLEU105543103(PRODH2)
RRO104667131(PRODH2)
TFN117092378
PTEH111529920(PRODH2)
CANG105516704(PRODH2)
CJC100409353(PRODH2)
SBQ101051757(PRODH2)
CIMI108298522(PRODH2)
ANAN105707000(PRODH2)
CSYR103249678(PRODH2)
MMUR105876908(PRODH2)
LCAT123624454(PRODH2)
PCOQ105816146(PRODH2)
OGA105887642(PRODH2)
MMU56189(Prodh2)
MCAL110297695(Prodh2)
MPAH110335390(Prodh2)
RNO361538(Prodh2)
MCOC116100441(Prodh2)
ANU117721570(Prodh2)
MUN110550901(Prodh2)
CGE100773901(Prodh2)
MAUA106022088(Prodh2)
PROB127238421(Prodh2)
PLEU114681696(Prodh2)
MORG121449990(Prodh2)
MFOT126486731
AAMP119820680(Prodh2)
NGI103729941(Prodh2)
HGL101703531(Prodh2)
CPOC100736006(Prodh2)
CCAN109689445(Prodh2)
DORD105993097(Prodh2)
DSP122097495(Prodh2)
PLOP125368012(Prodh2)
NCAR124966378
MMMA107151783(Prodh2)
OCU100354740
OPI101536287(PRODH2)
TUP102492745(PRODH2)
GVR103592829(PRODH2)
CFA484572(PRODH2)
CLUD112643571(PRODH2)
VVP112928512(PRODH2)
VLG121484394(PRODH2)
NPO129500989(PRODH2)
AML100474293(PRODH2)
UMR103682563(PRODH2)
UAH113244764(PRODH2)
UAR123793900(PRODH2)
ELK111161589
LLV125088416
MPUF101671462(PRODH2)
MNP132006160(PRODH2)
MLK131818468(PRODH2)
NVS122911569(PRODH2)
ORO101380565(PRODH2)
EJU114224383(PRODH2)
ZCA113935606(PRODH2)
MLX118022832(PRODH2)
NSU110590134(PRODH2)
LWW102738808(PRODH2)
FCA101087368(PRODH2)
PYU121011544(PRODH2)
PCOO112851027(PRODH2)
PBG122495009(PRODH2)
PVIV125153574(PRODH2)
LRUF124511931
PTG102963452(PRODH2)
PPAD109251455(PRODH2)
PUC125915107
AJU106974672
HHV120243503(PRODH2)
BTA508542(PRODH2)
BOM102278759(PRODH2)
BIU109572365(PRODH2)
BBUB102409119(PRODH2)
BBIS104995257(PRODH2)
CHX102176816(PRODH2)
OAS101105181(PRODH2)
BTAX128063762(PRODH2)
CSUM138095806(PRODH2)
ODA120872535(PRODH2)
CCAD122421420(PRODH2)
MREE136161228(PRODH2)
MBEZ129546106(PRODH2)
CFR102508280(PRODH2)
CBAI105065057(PRODH2)
CDK105088061(PRODH2)
VPC102527118(PRODH2)
BACU103020530(PRODH2)
BMUS118884847(PRODH2)
LVE103075818(PRODH2)
OOR101279871(PRODH2)
DLE111181175(PRODH2)
PCAD102988845(PRODH2)
PSIU116744597(PRODH2)
NASI112392264(PRODH2)
ECB100630262(PRODH2)
EPZ103566804(PRODH2)
EAI106829258(PRODH2)
MYB102243035(PRODH2)
MYD102760255(PRODH2)
MMYO118674658(PRODH2)
MLF102420802(PRODH2)
MDT132216976(PRODH2)
PKL118720660(PRODH2)
EFUS103284519(PRODH2)
MNA107543420(PRODH2)
DRO112320057(PRODH2)
SHON118982564(PRODH2)
AJM119044201(PRODH2)
PDIC114511204(PRODH2)
PHAS123823819(PRODH2)
MMF118638631(PRODH2)
PPAM129083102(PRODH2)
HAI109372033(PRODH2)
RFQ117034953(PRODH2)
PALE102881173(PRODH2)
PGIG120592449(PRODH2)
PVP105306655(PRODH2)
RAY107497651(PRODH2)
MJV108401524(PRODH2)
TOD119250206(PRODH2)
SARA101538488(PRODH2)
SETR126027622(PRODH2)
LAV100665466(PRODH2)
TMU101347296
ETF101657990(PRODH2)
DNM101424361(PRODH2)
MDO100016428(PRODH2)
GAS123243033(PRODH2)
SHR111719924(PRODH2)
AFZ127556084
PCW110201606(PRODH2)
TVP118839038(PRODH2)
PBRV138154098(PRODH2)
OAA114812117(PRODH2)
GGA107050361(PRODH2)
CATA118261618
LSR116184746
PRUF121364410
PHI102108371(PRODH2)
SHAB115602951
AGEN126036653
ASN102378835(PRODH2)
AMJ102567357(PRODH2)
CMY119566296(PRODH2)
CCAY125637978(PRODH2)
DCC119856739(PRODH2)
CPIC103306964(PRODH2)
CABI116826185(PRODH2)
MRV120404560(PRODH2)
ACS100555092(prodh2)
ASAO132779394(PRODH2)
PVT110078478(PRODH2)
SUND121932668(PRODH2)
PBI103056447(PRODH2)
PMUR107282463
CTIG120304571(PRODH2)
TSR106555418
PGUT117669155(PRODH2)
APRI131198602(PRODH2)
PTEX113443488(PRODH2)
NSS113418577(PRODH2)
VKO123032097(PRODH2)
PMUA114582127(PRODH2)
PRAF128401066(PRODH2)
ZVI118095866(PRODH2)
HCG128330949(PRODH2)
GJA107116343(PRODH2)
EMC129338259(PRODH2)
XLA398760(prodh2.L)
XTR101734436(prodh2)
NPR108789185(PRODH2)
RTEM120943083(PRODH2)
BBUF121007568(PRODH2)
BGAR122945283(PRODH2)
MUO115474312(PRODH2)
GSH117361299(PRODH2)
DRE436664(zgc:92040)
SRX107708971(prodh2)
SANH107693688(prodh2)
SGH107562014
CCAR109052804
CAUA113112084(prodh2)
CGIB127968710
PTET122333364(prodh2)
LROH127174616(prodh2)
OMC131551143(prodh2)
PPRM120469022(prodh2)
RKG130080601(prodh2)
MAMB125255611(prodh2)
CIDE127523442
CERY137007768(prodh2)
MASI127422819 127427392
TROS130568787(prodh2)
TDW130438579(prodh2)
MANU129420497(prodh2)
IPU108273642
IFU128617398(prodh2)
PHYP113527045(prodh2)
SMEO124388555(prodh2)
TFD113653517(prodh2)
TVC132841530(prodh2)
TRN134321739(prodh2)
AMEX103022862(prodh2)
CMAO118809756(prodh2)
EEE113587524(prodh2)
CHAR105909097(prodh2)
TRU101078218(prodh2)
TFS130522305(prodh2)
TNGGSTEN00028317G001
LCO104926870(prodh2)
NCC104953237(prodh2)
TBEN117473940(prodh2)
CGOB115024870(prodh2)
PGEO117464422(prodh2)
GACU117545004(prodh2)
EMAC134870598(prodh2)
ELY117246798(prodh2)
EFO125880413(prodh2)
PLEP121958569(prodh2)
SLUC116061559(prodh2)
ECRA117937303(prodh2)
ESP116671297(prodh2)
PFLV114548408(prodh2)
GAT120819101(prodh2)
PPUG119212632(prodh2)
AFB129091288(prodh2)
PSWI130203323(prodh2)
CANA137789529(prodh2)
MSAM119916307(prodh2)
SCHU122868155(prodh2)
CUD121528303(prodh2)
ALAT119009899(prodh2)
ASTR137588586(prodh2)
MZE101487644(prodh2)
ONL100703669(prodh2)
OAU116327639(prodh2)
OLA101155724(prodh2)
OML112154696(prodh2)
CSAI133419346(prodh2)
XMA102226277(prodh2)
XCO114151741(prodh2)
XHE116726804(prodh2)
PRET103481397(prodh2)
PFOR103152334(prodh2)
PLAI106956243(prodh2)
PMEI106904144
GAF122823377(prodh2)
PPRL129377768(prodh2)
CVG107097212(prodh2)
CTUL119796745(prodh2)
GMU124874790(prodh2)
NFU107387966(prodh2)
KMR108247131(prodh2)
ALIM106521389(prodh2)
NWH119423598(prodh2)
AOCE111581595(prodh2)
EJA138202014(prodh2)
MCEP125022425(prodh2)
CSEM103381976(prodh2)
POV109642723(prodh2)
SSEN122759684(prodh2)
HHIP117752768(prodh2)
HSP118100647(prodh2)
PPLT128426661(prodh2)
SMAU118287419(prodh2)
LCF108884464
SDU111219983(prodh2)
SLAL111658668(prodh2)
XGL120794641(prodh2)
HCQ109523978(prodh2)
SSCV125990918(prodh2)
SBIA133496028(prodh2)
PEE133395254(prodh2)
PTAO133469695(prodh2)
BPEC110159594(prodh2)
MALB109973598(prodh2)
BSPL114845927(prodh2)
SJO128381410(prodh2)
SASA106578328(prodh2)
STRU115200976(prodh2)
OTW112232855(prodh2)
OMY110498805(prodh2)
OGO124039926(prodh2)
ONE115143935(prodh2)
OKI109881735(prodh2)
OKE118357763(prodh2)
SALP111976348(prodh2)
SNH120060911(prodh2)
CCLU121547167(prodh2)
ELS105024364(prodh2)
SFM108933021(prodh2)
PKI111835827(prodh2)
AANG118220234(prodh2)
PSPA121306794(prodh2)
ARUT117398777(prodh2)
PSEX120536561(prodh2)
LCM102354203(PRODH2)
BFO118417335 118426280
BBEL109467218 109482107
CIN100180610
SCLV120330165
SPU576696
APLC110986277
ARUN117290549
SKO100377930 102805849 102805974
CSEC111870040
BROR134529400
IEL124155633
DPXDAPPUDRAFT_204241
DMK116931073
DPZ124349686
PVM113809427
PJA122250188
PCHN125030369
HAME121871864
PCLA123756392
CQD128694649
PTRU123520676
ESN126998472
MNZ135202330
MRJ136847129
HAZT108677818
EAF111711121 111717152
TCF131883838 131886973
PPOI119094904 119094914 119095844 119110169
DSV119440384
RSAN119386917
RMP119178297
CSCU111619182
CVS136980139
PTEP107456183
ABRU129980899
UDV129227683
SDM118192813
LPOL106459347 106464159
PVUL126824415
PCAN112562444
BGT106070289
HRF124141689
HRJ124278048
CRG105335584 117680326
CANU128190697
CVN111132312 111136064
OED125664753
MYI110443255 110443384
PMAX117332253 117333133 117333135
MMER123530308
DPOL127877427
MAEA128216660
OBI106869190
OSN115221635 115221636 115229811 115231961
LJP135476916
LAK106181047
LLON135482803
NVE5511574
EPA110253348
ATEN116290773
ADF107336175 107352366
AMIL114959075
PDAM113673699
SPIS111329332
DGT114523876
XEN124434978
HMG100204778
HSY130656712
RES135683123
 » show all
Reference
1  [PMID:18287100]
  Authors
Cooper SK, Pandhare J, Donald SP, Phang JM
  Title
A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.
  Journal
J Biol Chem 283:10485-92 (2008)
DOI:10.1074/jbc.M702181200
  Sequence
[hsa:58510]
Reference
2  [PMID:25697095]
  Authors
Summitt CB, Johnson LC, Jonsson TJ, Parsonage D, Holmes RP, Lowther WT
  Title
Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.
  Journal
Biochem J 466:273-81 (2015)
DOI:10.1042/BJ20141159
  Sequence
[hsa:58510]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.5.3
IUBMB Enzyme Nomenclature: 1.5.5.3
ExPASy - ENZYME nomenclature database: 1.5.5.3
BRENDA, the Enzyme Database: 1.5.5.3
LinkDB

KEGG   REACTION: R03295
Entry
R03295                      Reaction                               
Name
trans-4-hydroxy-L-proline:quinone oxidoreductase
Definition
Hydroxyproline + Quinone <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + Hydroquinone
Equation
Reaction class
RC00054  C01157_C04281
Enzyme
Pathway
rn00330  Arginine and proline metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.5  With a quinone or similar compound as acceptor
    1.5.5.3
     R03295  Hydroxyproline + Quinone <=> L-1-Pyrroline-3-hydroxy-5-carboxylate + Hydroquinone
Orthology
K11394  hydroxyproline dehydrogenase [EC:1.5.5.3]
Other DBs
RHEA: 52515
LinkDB

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