KEGG ORTHOLOGY: K11539

ORTHOLOGY: K11539

Entry

K11539                      KO

Symbol

CBR4

Name

carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1.-]

Pathway

map00061

Fatty acid biosynthesis

map01100

Metabolic pathways

map01212

Fatty acid metabolism

Module

M00873

Fatty acid biosynthesis in mitochondria, animals

Reaction

R02767

(3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP+ oxidoreductase

R04533

(3R)-3-hydroxybutanoyl-[acyl-carrier protein]:NADP+ oxidoreductase

R04534

(3R)-3-hydroxydecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase

R04536

(3R)-3-hydroxyoctanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase

R04543

(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein]:NADP+ oxidoreductase

R04566

(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase

R04953

(3R)-3-hydroxyhexanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase

R04964

(3R)-3-hydroxydodecanoyl-[acyl-carrier-protein]:NADP+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K11539  CBR4; carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit

Genes

HSA:	84869(CBR4)

PTR:	471344(CBR4)

PPS:	100988490(CBR4)

GGO:	101141113(CBR4)

PON:	100462086(CBR4)

PPYG:

129035076(CBR4)

NLE:	100579544(CBR4)

HMH:	116466007(CBR4)

SSYN:

129481225(CBR4)

MCC:	693949(CBR4)

MCF:	102142233(CBR4)

MTHB:

126955304

MNI:	105466708(CBR4)

CSAB:

103236512(CBR4)

CATY:

105597830(CBR4)

PANU:

101020557(CBR4)

TGE:	112624230(CBR4)

MLEU:

105530308(CBR4)

RRO:	104662878(CBR4)

RBB:	108522861(CBR4)

TFN:	117086108(CBR4)

PTEH:

111537906 111553776(CBR4)

CANG:

105524399(CBR4)

CJC:	100406542(CBR4)

SBQ:	101044331(CBR4)

CIMI:

108288581(CBR4)

ANAN:

105720599(CBR4)

CSYR:

103268287(CBR4)

MMUR:

105874616(CBR4)

LCAT:

123638707(CBR4)

ERUF:

138386263 138399137(CBR4)

PCOQ:

105820594(CBR4)

OGA:	100949547(CBR4)

MMU:	234309(Cbr4)

MCAL:

110300675(Cbr4)

MPAH:

110336964(Cbr4)

RNO:	359725(Cbr4)

MCOC:

116069352(Cbr4)

ANU:	117721251(Cbr4)

ASYL:

127669027(Cbr4)

MUN:	110563483(Cbr4)

CGE:	100758439(Cbr4)

MAUA:

101834556(Cbr4)

PROB:

127220591(Cbr4)

PLEU:

114701098(Cbr4)

PMAV:

102910227(Cbr4)

MORG:

121462510(Cbr4)

MFOT:

126513450

AAMP:

119812401(Cbr4)

CNL:	130863257(Cbr4)

NGI:	103727143(Cbr4)

HGL:	101701861(Cbr4)

CPOC:

100729071(Cbr4)

CCAN:

109681810(Cbr4)

DORD:

105991856(Cbr4)

DSP:	122125596(Cbr4)

DMER:

138823300(Cbr4)

PLOP:

125339451(Cbr4)

NCAR:

124972022 124983502

MMMA:

107142720(Cbr4)

ITI:	101968912(Cbr4)

OCU:

100346176

OPI:	101520637(CBR4)

OCZ:	121146428(CBR4)

TUP:	102488343(CBR4)

GVR:	103588792(CBR4)

CFA:	477352(CBR4)

CLUD:

112669588(CBR4)

VVP:	112918575(CBR4)

VLG:	121497078(CBR4)

NPO:	129504557(CBR4)

AML:	100482588(CBR4)

UMR:	103658144(CBR4)

UAH:	113245456(CBR4)

UAR:	123793166(CBR4)

ELK:

111156121

LLV:

125093057

MPUF:

101684055(CBR4)

MNP:	132000375(CBR4)

MLK:	131832193(CBR4)

NVS:	122889568(CBR4)

ORO:	101383337(CBR4)

EJU:	114210197(CBR4)

ZCA:	113925733(CBR4)

MLX:	118022170(CBR4)

NSU:	110588545(CBR4)

LWW:	102743559(CBR4)

FCA:	101094263(CBR4)

PYU:	121027452(CBR4)

PCOO:

112858641(CBR4)

PBG:	122474786(CBR4)

PVIV:

125163401(CBR4)

LRUF:

124520576

LGF:	123590395(CBR4)

AJU:

106988794

PTG:	102953494(CBR4)

PPAD:

109262437(CBR4)

PUC:

125923192

PLEZ:

122217720(CBR4)

HHV:	120244766(CBR4)

BTA:	533020(CBR4)

BOM:	102267961(CBR4)

BIU:	109562751(CBR4)

BBUB:

102392346(CBR4)

BKE:	129649791(CBR4)

BBIS:

104997851(CBR4)

CHX:	102168724(CBR4)

OAS:	101111166 101122167(CBR4)

BTAX:

128052185(CBR4)

CSUM:

138081505(CBR4)

ODA:	120854407(CBR4)

CCAD:

122453123(CBR4)

MREE:

136148533(CBR4)

OVR:	110144398(CBR4)

MBEZ:

129557463(CBR4)

SSC:	100153608(CBR4)

CFR:	102518024(CBR4)

CBAI:

105073355(CBR4)

CDK:	105101613(CBR4)

VPC:	102537023(CBR4)

BACU:

103016221(CBR4)

BMUS:

118897126(CBR4)

LVE:	103073947(CBR4)

OOR:	101276282(CBR4)

LALB:

132523937(CBR4)

GMF:	115846492(CBR4) 132597952

DDP:	132427621(CBR4) 132434350

DLE:	111185339(CBR4)

PCAD:

102980886(CBR4)

PSIU:

116755441(CBR4)

PPHC:

136124815(CBR4)

NASI:

112403188(CBR4)

ECB:	100061412(CBR4)

EPZ:	103550083(CBR4)

EAI:	106837729(CBR4)

MYB:	102252651(CBR4)

MYD:	102763051(CBR4)

MMYO:

118659072(CBR4)

MLF:	102418604 102419857(CBR4)

MDT:	132235394(CBR4)

MYUM:

139010679(CBR4)

PKL:	118711733(CBR4)

EFUS:

103288934 129150477

MNA:	107527526(CBR4)

DRO:	112312696(CBR4)

SHON:

118995336(CBR4)

AJM:	119045612(CBR4)

PDIC:

114503124(CBR4)

PHAS:

123813949

MMF:	118615444(CBR4)

PPAM:

129072568(CBR4)

HAI:	109394918(CBR4)

RFQ:	117037424(CBR4)

PALE:

102888794(CBR4)

PGIG:

120613488(CBR4)

PVP:	105292166(CBR4)

RAY:	107512540(CBR4)

MJV:	108410130(CBR4)

TOD:	119257962(CBR4)

SARA:

101542050(CBR4)

SFUM:

130023629(CBR4)

SETR:

126005979(CBR4)

LAV:	100676246(CBR4)

TMU:

101357516

ETF:	101655663(CBR4)

DNM:

101428805

MDO:	100015144(CBR4)

GAS:	123251035(CBR4)

SHR:	100917532(CBR4)

AFZ:

127539803

PCW:	110215991(CBR4)

TVP:	118854489(CBR4)

PBRV:

138168199(CBR4)

MLAO:

141517701(CBR4)

OAA:	114815528(CBR4)

TACU:

119935871(CBR4)

GGA:	422435(CBR4)

PCOC:

116226084(CBR4)

MGP:	100539549(CBR4)

CJO:	107313084(CBR4)

TPAI:

128084264(CBR4)

LMUT:

125691687(CBR4)

NMEL:

110397753(CBR4)

APLA:

101804632(CBR4)

AACU:

137856154(CBR4)

ACYG:

106032341(CBR4)

CATA:

118250179(CBR4)

AFUL:

116488750(CBR4)

TGU:	100225160(CBR4)

LSR:	110467591(CBR4)

SCAN:

103825929(CBR4)

PMOA:

120497908(CBR4)

OTC:	121331406(CBR4)

PRUF:

121360181(CBR4)

ATRC:

139592337(CBR4)

GFR:	102039682(CBR4)

FAB:	101813892(CBR4)

OMA:	130252180(CBR4)

PHI:	102112601(CBR4)

PMAJ:

107203494(CBR4)

CCAE:

111927895(CBR4)

CCW:	104690536(CBR4)

CBRC:

103619998(CBR4)

ACOE:

138109736(CBR4)

ETL:	114064977(CBR4)

ZAB:	102062548(CBR4)

ZLE:	135446621(CBR4)

ACHL:

103807003(CBR4)

SVG:	106854535(CBR4)

MMEA:

130580655(CBR4)

HRT:	120753408(CBR4)

SATI:

136360403(CBR4)

CFAI:

136290626(CBR4)

CCIC:

134044460(CBR4)

FPG:	101913525 101915340(CBR4)

FCH:	102045843 102046622

CCRI:

104157773(CBR4)

NNT:	104403463(CBR4)

SHAB:

115610390(CBR4)

ACUN:

113479413(CBR4)

SURA:

141942700(CBR4)

TALA:

104356221(CBR4)

ACHC:

115345329(CBR4)

HALD:

104324253(CBR4)

HLE:	104833345(CBR4)

AGEN:

126035440

HHAR:

128137703(CBR4)

BBUT:

142031397(CBR4)

GCL:

127015819

CSTI:

104549883(CBR4)

LDI:	104340371(CBR4)

MNB:	103773938(CBR4)

DPUB:

104306718(CBR4)

PPUS:

135178184(CBR4)

AVIT:

104275699(CBR4)

BRHI:

104491659(CBR4)

EGZ:	104123107(CBR4)

NNI:	104021262(CBR4)

PCRI:

104031021(CBR4)

PCAO:

104043627(CBR4)

PADL:

103922556(CBR4)

AFOR:

103893277(CBR4)

FGA:	104069900(CBR4)

CBOR:

142081950(CBR4)

GSTE:

104250979(CBR4)

CBOY:

140652408(CBR4)

MAME:

142409154(CBR4)

CLV:	102089643(CBR4)

CNIC:

135988133(CBR4)

MUI:	104548319(CBR4)

PGUU:

104458393(CBR4)

PLET:

104614951(CBR4)

EHS:	104515497(CBR4)

CMAC:

104481512(CBR4)

CUCA:

104063016(CBR4)

TEO:	104380327(CBR4)

BREG:

104637123(CBR4)

GAME:

129206028(CBR4)

OHA:	104334800(CBR4)

ACAR:

104517944(CBR4)

CPEA:

104387223(CBR4)

CVF:	104294158(CBR4)

RTD:	128909745(CBR4)

CRID:

134515763(CBR4)

LMIC:

141743256(CBR4)

NARQ:

141464562(CBR4)

AAM:	106484084(CBR4)

AROW:

112971086(CBR4)

NPD:	112955409(CBR4)

TGT:	104580680(CBR4)

DNE:	112997057(CBR4)

SCAM:

104145587(CBR4)

ASN:	102387018(CBR4)

AMJ:	102559510(CBR4)

CPOO:

109309739(CBR4)

GGN:	109300887(CBR4)

PSS:	102446718(CBR4)

CIZ:	142012574(CBR4)

CMY:	102931938(CBR4)

CCAY:

125635682(CBR4)

LKP:	140910513(CBR4)

NDS:	141986544(CBR4)

DCC:	119854818(CBR4)

CPIC:

101938787(CBR4)

TST:	117877592(CBR4)

CABI:

116838455(CBR4)

MRV:	120406831(CBR4)

ACS:	100552602(cbr4)

ASAO:

132776743(CBR4)

PVT:	110085385(CBR4)

PBI:	103053921(CBR4)

PMUR:

107287978(CBR4)

CTIG:

120300461(CBR4)

TSR:	106546804(CBR4)

PGUT:

117680131(CBR4)

PCAE:

139320383(CBR4)

APRI:

131203174(CBR4)

PTEX:

113435728(CBR4)

NSS:	113419474(CBR4)

VKO:	123023745(CBR4)

PMUA:

114604160(CBR4)

PRAF:

128420863(CBR4)

ZVI:	118084430(CBR4)

HCG:	128328116(CBR4)

GJA:	107114665(CBR4) 107119361

STOW:

125440262(CBR4)

EMC:	129336759(CBR4)

XLA:	108706632 414681(cbr4.L)

XTR:	493259(cbr4)

NPR:	108789901(CBR4)

RTEM:

120920748(CBR4)

ACAT:

141113217(CBR4)

PADS:

140326965(CBR4)

BBUF:

120991749(CBR4)

BGAR:

122931953(CBR4)

DTC:	141091520(CBR4)

PWL:	138304222(CBR4)

MUO:	115462671(CBR4)

GSH:	117359398(CBR4)

DRE:	402954(cbr4)

SRX:	107718413 107755259

SANH:

107665353 107683981

SGH:	107597475 107601946

CCAR:

122141042 122148968

CAUA:

113037773(cbr4)

CGIB:

127983810

PTET:

122324524(cbr4)

LROH:

127182743(cbr4)

OMC:	131527384(cbr4)

PPRM:

120493569(cbr4)

RKG:	130091768(cbr4)

MAMB:

125278025(cbr4)

CIDE:

127501799

CERY:

137018908(cbr4)

MASI:

127410004

TROS:

130565727(cbr4)

TDW:	130433864(cbr4)

MANU:

129429421(cbr4)

PDAB:

135738924(cbr4)

IPU:	100528833(cbr4)

IFU:	128601373(cbr4)

PHYP:

113546832(cbr4)

SMEO:

124377292(cbr4)

TFD:	113653663(cbr4)

TVC:	132843478(cbr4)

CGAR:

128515126(cbr4)

NGRA:

132882937(cbr4)

TRN:	134320593(cbr4)

AMEX:

103036748(cbr4)

CMAO:

118815366(cbr4)

EEE:	113581035(cbr4)

CHAR:

105895100(cbr4)

SPIL:

134102636(cbr4)

ASAD:

121678363(cbr4)

TRU:	101071530(cbr4)

TFS:	130528446(cbr4)

TNG:	GSTEN00032792G001

LCO:	104919073(cbr4)

TBEN:

117475799 117497680 117497683

CGOB:

115004591(cbr4)

PGEO:

117442703(cbr4)

GACU:

117559504(cbr4)

EMAC:

134869196(cbr4)

ELY:	117253673(cbr4)

EFO:	125895461(cbr4)

PLEP:

121941226(cbr4)

SLUC:

116058741(cbr4)

ECRA:

117950265(cbr4)

ESP:	116695325(cbr4)

PFLV:

114561022(cbr4)

GAT:	120823875(cbr4)

PPUG:

119216782(cbr4)

AFB:	129094997(cbr4)

CLUM:

117729752(cbr4)

PSWI:

130193857(cbr4)

CANA:

137795356(cbr4)

CVE:	137883768(cbr4)

MSAM:

119901086(cbr4)

SCHU:

122877768(cbr4)

CUD:	121512548(cbr4)

SPUL:

138607858(cbr4)

LMIX:

132956151(cbr4)

HTC:	141788660(cbr4)

ALAT:

119027999(cbr4)

ASTR:

137598577(cbr4)

MZE:	101485831(cbr4)

ONL:	100693322(cbr4)

OAU:	116331246(cbr4)

OLA:	101155177(cbr4)

OML:	112136902(cbr4)

CSAI:

133458256(cbr4)

XMA:	102227629(cbr4)

XCO:	114151543(cbr4)

XHE:	116725538(cbr4)

PRET:

103463859(cbr4)

PFOR:

103137137(cbr4)

PLAI:

106954442(cbr4)

PMEI:

106930387(cbr4)

GAF:	122838989(cbr4)

PPRL:

129372635(cbr4)

CVG:	107103725(cbr4)

CTUL:

119779374(cbr4)

GMU:	124874092(cbr4)

NFU:	107396096(cbr4)

KMR:	108240189(cbr4)

ALIM:

106526069(cbr4)

NWH:	119430868(cbr4)

AOCE:

111566275(cbr4)

EJA:	138198940(cbr4)

BFRE:

138621334(cbr4)

MCEP:

125009471(cbr4)

CSEM:

103398860(cbr4)

POV:	109625678(cbr4)

SSEN:

122780533(cbr4)

SSOE:

131465342(cbr4)

HHIP:

117759870(cbr4)

HSP:	118121050(cbr4)

PPLT:

128448087(cbr4)

SMAU:

118318135(cbr4)

LCF:

108878901

SDU:	111226332(cbr4)

SLAL:

111660160(cbr4)

XGL:	120790497(cbr4)

BPEC:

110154851(cbr4)

ENY:	140353782(cbr4)

MALB:

109962115(cbr4)

BSPL:

114853188(cbr4)

SJO:	128361580(cbr4)

SSCO:

133984516(cbr4)

TTY:	137188165(cbr4)

GMH:	115555349(cbr4)

SASA:

100196741(cbr4)

STRU:

115192400(cbr4)

OTW:	112248991 112251591(cbr4)

OMY:	110521654 110522998(cbr4)

OGO:	123997220(cbr4) 124037841

ONE:	115145106(cbr4)

OKI:	109898013(cbr4) 109903004

OKE:	118359051 118376052(cbr4)

OMM:

135556327

OCLA:

139406688 139409752

SALP:

111972299(cbr4) 111975311

SNH:	120052573 120054913(cbr4)

SFON:

129855373

CCLU:

121532670(cbr4) 121540172

ELS:	105011811(cbr4)

OEP:	134011100(cbr4)

SFM:

108922789

PKI:	111850053(cbr4)

AANG:

118226032(cbr4)

AROT:

135254015(cbr4)

CCOG:

133126533(cbr4)

LOC:	102692274(cbr4)

PSPA:

121300352(cbr4)

ARUT:

117421004(cbr4)

PSEX:

120527584(cbr4)

LCM:	102350295(CBR4)

BFO:

BBEL:

AFIL:

AJC:

SKO:

PFLL:

TDA:

DSV:

DALB:

RSAN:

RMP:

VDE:

VJA:

GOE:

DPTE:

DFR:

CSCU:

CVS:

LPOL:

LAK:

EPA:

ATEN:

ADF:	107332538 107337853

AMIL:

MCAZ:

MFOO:

FPOA:

FFC:	NCS54_00538400

FKR:	NCS57_00576600

FMU:	J7337_006698

PCHM:

VFPPC_12950

AMUS:

LMH87_000459

PTKZ:

JDV02_006064

RIE:	OCT59_002589

» show all

Reference

PMID:19000905

Authors

Endo S, Matsunaga T, Kitade Y, Ohno S, Tajima K, El-Kabbani O, Hara A

Title

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase.

Journal

Biochem Biophys Res Commun 377:1326-30 (2008)
DOI:10.1016/j.bbrc.2008.11.003

Reference

PMID:19571038

Authors

Chen Z, Kastaniotis AJ, Miinalainen IJ, Rajaram V, Wierenga RK, Hiltunen JK

Title

17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS.

Journal

FASEB J 23:3682-91 (2009)
DOI:10.1096/fj.09-133587

Sequence

[hsa:84869]

LinkDB

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