KEGG ORTHOLOGY: K11610

ORTHOLOGY: K11610

Entry

K11610                      KO

Symbol

mabA

Name

meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]

Pathway

map00074

Mycolic acid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Reaction

R13259

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase

R13263

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase

R13267

ultra-long-chain-mono-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase

R13271

ultra-long-chain-di-unsaturated-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00074 Mycolic acid biosynthesis
    K11610  mabA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K11610  mabA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase
Lipid biosynthesis proteins [BR:ko01004]
Fatty acid synthase
  Component type
   K11610  mabA; meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase

Other DBs

COG:

COG1028

GO:

0004316

Genes

PSNC:

C0058_20955

RPOP:

K1718_11430

FWA:	DCMF_21330

EUZ:	DVS28_a2038

MTU:	Rv1483(fabG1)

MTV:

RVBD_1483

MTC:	MT1530(fabG-2)

MRA:	MRA_1493(fabG1)

MTF:	TBFG_11512

MTB:	TBMG_02498

MTK:	TBSG_02509

MTZ:	TBXG_002477

MTG:	MRGA327_09300

MTI:	MRGA423_09310

MTE:	CCDC5079_1379

MTUR:

CFBS_1580(fabG3)

MTL:	CCDC5180_1371

MTO:	MTCTRI2_1521(fabG1)

MTD:	UDA_1483(fabG1)

MTN:	ERDMAN_1651(fabG1)

MTJ:	J112_07965

MTUB:

MT7199_1515

MTUC:

J113_10350

MTUE:

J114_07975

MTX:	M943_07775

MTUH:

I917_10535

MTUL:

TBHG_01462

MTUT:

HKBT1_1580(fabG1)

MTUU:

HKBT2_1587(fabG1)

MTQ:	HKBS1_1584(fabG1)

MBO:	BQ2027_MB1519(fabG1)

MBB:	BCG_1545(fabG1)

MBT:	JTY_1520(fabG1)

MBM:	BCGMEX_1517(fabG1)

MBK:	K60_015900

MBX:

BCGT_1321

MAF:	MAF_15060(fabG1)

MMIC:

RN08_1662

MCE:	MCAN_15001(fabG1)

MCQ:	BN44_20038(fabG)

MCV:	BN43_30596(fabG)

MCX:	BN42_21408(fabG)

MCZ:	BN45_30582(fabG)

MORY:

MO_001592(fabG1)

MLE:	ML1807(fabG1)

MLB:	MLBr01807(fabG1)

MPA:	MAP_1209(fabG1)

MAO:

MAP4_2644

MAVI:

RC58_13115

MAVU:

RE97_13140

MAV:	MAV_3295(fabG)

MIT:

MIA:

MID:

MYO:

MCHI:

MIR:

MMAL:

MLP:

MMAN:

MMAN_07190(fabG_1)

MSER:

MTY59_48560(fabG)

MSA:	Mycsm_02906

MUL:	MUL_1491(fabG1)

MMI:	MMAR_2289(fabG1)

MMAE:

MMARE11_22110(fabG1)

MLI:	MULP_03319(fabG)

MPSE:

MPSD_23200(fabG_1)

MSHO:

MSHO_35330(fabG1)

MMC:

MKM:

MJL:

MMM:

MKN:	MKAN_27235

MYV:	G155_14290

MYE:	AB431_13615

MHAD:

B586_13175

MDX:	BTO20_18320

MSHG:

MSG_02156(fabG_1)

MFJ:	MFLOJ_11060(fabG_2)

MSTO:

MSTO_12240(fabG1)

MSIM:

MSIM_01970(fabG_1)

MSAK:

MSAS_02510(fabG_1)

MKU:	I2456_11300(fabG)

MLW:	MJO58_11465(fabG1)

MXE:	MYXE_28440(fabG1)

MNV:	MNVI_37770(fabG1)

MPAG:

C0J29_12990

MNM:	MNVM_38200(fabG_5)

MGOR:

H0P51_12405

MCOO:

MCOO_05330(fabG_1)

MBAI:

MB901379_02117(fabG1_1)

MSEO:

MSEO_09340(fabG_1)

MHEK:

JMUB5695_02783(fabG1)

MGAU:

MGALJ_12560(fabG_4)

MLJ:	MLAC_13500(fabG1)

MBRD:

MBRA_42310(fabG_4)

MSHJ:

MSHI_17270(fabG1)

MMAM:

K3U93_10430

MSPG:

F6B93_09510

MOT:	LTS72_12905

MLM:	MLPF_2286(fabG1)

MPAA:

MKK62_13695(fabG1)

MMEH:

M5I08_12740(fabG1)

MADI:

A7U43_17330

MWU:	PT015_04140(fabG1)

MYW:	BVC93_28275

MSM:	MSMEG_3150(fabG)

MSG:	MSMEI_3069(fabG)

MSB:	LJ00_15665

MSN:	LI99_15670

MSH:	LI98_15675

MVA:

Mvan_2752

MGI:

Mflv_3658

MSP:	Mspyr1_30040

MCB:	Mycch_2471

MNE:	D174_13480

MYN:	MyAD_13235

MFT:	XA26_29590

MPHL:

MPHLCCUG_02863(fabG1)

MVQ:	MYVA_2651(fabG)

MLL:	B1R94_15735

MRH:	MycrhN_5281

MTHN:

4412656_01967(fabG1)

MHAS:

MHAS_02111(fabG1)

MDU:	MDUV_16020(fabG_2)

MCHT:

MCHIJ_41030(fabG_5)

MDR:	MDOR_17260(fabG_3)

MAUU:

NCTC10437_02604(fabG_11)

MMAG:

MMAD_26340(fabG_4)

MMOR:

MMOR_37230(fabG_7)

MFX:	MFAL_06560(fabG1)

MAIC:

MAIC_24390(fabG_4)

MIJ:	MINS_24610(fabG_4)

MALV:

MALV_10040(fabG_1)

MTY:	MTOK_44690(fabG_4)

MPSC:

MPSYJ_39380(fabG_3)

MARZ:

MARA_13240(fabG_4)

MGAD:

MGAD_11690(fabG_1)

MHEV:

MHEL_48940(fabG_8)

MSAR:

MSAR_43950(fabG_4)

MANY:

MANY_10890(fabG_3)

MAUB:

MAUB_03710(fabG_1)

MPOF:

MPOR_30670(fabG_2)

MPHU:

MPHO_09130(fabG_2)

MMUC:

C1S78_013645

MMAT:

MMAGJ_61600(fabG_8)

MBOK:

MBOE_44980(fabG_4)

MFG:	K6L26_17725

MSEI:

MSEDJ_38370(fabG_5)

MFLV:

NCTC10271_02818(fabG1)

MCEE:

MCEL_10900(fabG_1)

MBRM:

L2Z93_002122

MMON:

EWR22_12480

MGO:	AFA91_24110

MHOL:

K3U96_14080

MSEN:

K3U95_12000

MPAE:

K0O64_13415

MRF:	MJO55_12475(fabG1)

MDF:	K0O62_13780

MCRO:

MI149_14240(fabG1)

MGRO:

FZ046_18510

MAUS:

JN090_12880

MKR:	MKOR_10090(fabG1)

MPAK:

MIU77_09445(fabG1)

MAB:

MAB_2723c

MMV:	MYCMA_08295

MABB:

MASS_2669

MABL:

MMASJCM_2687

MCHE:

BB28_13595

MIZ:	BAB75_14745

MSTE:

MSTE_02664(fabG1)

MSAO:

MYCSP_12115

MSAL:

DSM43276_02424(fabG1)

MJD:	JDM601_2232(fabG1)

MTER:

4434518_02154(fabG_14)

MMIN:

MMIN_38320(fabG_3)

MHIB:

MHIB_16790(fabG_3)

MHER:

K3U94_12555

MVM:	MJO54_12500(fabG1)

ASD:	AS9A_1921(fabG1)

NFA:	NFA_34770(fabG)

NFR:	ERS450000_00571(fabG1)

NCY:	NOCYR_2629(fabG)

NBR:	O3I_027550

NNO:	NONO_c41280(fabG1)

NSL:	BOX37_18750

NSR:	NS506_04891(mabA)

NTP:	CRH09_09460 CRH09_21615

NOZ:	DMB37_00525 DMB37_06530

NOD:	FOH10_14745

NAH:	F5544_27305

NAD:	NCTC11293_04847(fabG1)

NWL:	NWFMUON74_35760

NIE:	KV110_26820(fabG)

NTC:	KHQ06_26680

NHU:	H0264_25415(fabG)

NYA:	LTV02_08875(fabG)

NGP:	LTT66_26265

NSPU:

IFM12276_21280

NYU:	D7D52_17980 D7D52_34900

RHA:	RHA1_ro07213(fabG1)

RER:	RER_30740(fabG) RER_pREC1-00530(fabG)

REY:

O5Y_14090

REB:	XU06_14305

RQI:	C1M55_15330

ROP:	ROP_70010(fabG)

ROA:	Pd630_LPD03963 Pd630_LPD11070

RPY:	Y013_02750

RBY:	CEJ39_13430

RHB:

NY08_1067

RAV:	AAT18_13395

RHW:	BFN03_07660

RRZ:	CS378_03165

RHU:	A3Q40_01679(fabG1_1)

RHQ:	IM25_16715

RHOD:

AOT96_25535

RRT:	4535765_02251(fabG1_3)

RCR:	NCTC10994_00570(fabG1)

RTM:	G4H71_21225

RKO:	JWS14_37780 JWS14_39950(fabG)

RGO:	KYT97_03605

ROZ:	CBI38_15660

RPSK:

JWS13_05275(fabG) JWS13_06445

RGOR:

NMQ04_10015(fabG1)

RANT:

RHODO2019_07280(fabG)

RHOP:

D8W71_16775

RHOO:

RA302_14560(fabG1)

RHOU:

KZJ41_14475

RHOW:

A4U64_11400

RHOJ:

JVH1_00420(fabG1)

RFA:	A3L23_04316(fabG1)

RHS:	A3Q41_03951(fabG1)

REQ:

REQ_22490

WHR:	OG579_02145(fabG1)

GBR:

Gbro_2407

GPO:	GPOL_c23400(fabG1)

GOR:

KTR9_2325

GOQ:	ACH46_10280

GTA:	BCM27_12390

GOC:	CXX93_12705

GIT:	C6V83_10715

GRU:	GCWB2_13275(fabG20)

GOM:	D7316_00937(fabG1_1)

GAV:	C5O27_14815

GOD:	GKZ92_12035

GOS:	QAD21_11625(fabG1)

GOJ:	GR168_11435

GAM:	GII34_12135

GPD:	GII33_11430

GJI:	H1R19_11595

GOI:	LK459_21790

GHN:	MVF96_11800(fabG1)

GAMI:

IHQ52_15780(fabG1)

GMG:	NWF22_22130(fabG1)

GSI:	P5P27_09225(fabG1)

SPIN:

KV203_10200(fabG)

TPR:

Tpau_2081

TSM:	ASU32_11305

TPUL:

TPB0596_25110

TSD:	MTP03_23380

SRT:

Srot_2520

DTM:	BJL86_1671

DIT:	C3V38_13875

DIZ:	CT688_08070

DPC:	A6048_08335

DLU:	A6035_07920

DKN:	NHB83_07640(fabG1) NHB83_17775(fabG)

TOY:	FO059_08850

CCIT:

QPK07_08780(fabG)

CPOI:

OE229_17680

LLUT:

K1X41_01815(fabG)

JAY:	H7A72_08290(fabG)

PSOI:

PCC79_11800(fabG)

SVI:	Svir_22340

AOI:	AORI_3780(fabG)

AJA:	AJAP_20260(fabG2)

AMYB:

BKN51_11370

AAB:	A4R43_11045

AMYY:

YIM_27550(fabG22)

PMAD:

BAY61_17100

DFU:	Dfulv_09940(fabG)

DAUR:

Daura_09895

DMAT:

Dmats_10115(fabG)

DACT:

KZZ52_09865(fabG)

CALG:

SH580_03905

CACI:

CLOAM1438

» show all

Reference

PMID:9802011

Authors

Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR Jr

Title

The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

Journal

Microbiology 144 ( Pt 10):2697-704 (1998)
DOI:10.1099/00221287-144-10-2697

Sequence

[mtu:Rv1483]

Reference

PMID:11932442

Authors

Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard AK.

Title

MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II.

Journal

Microbiology (Reading) 148:951-960 (2002)
DOI:10.1099/00221287-148-4-951

LinkDB

REACTION: R13259

Entry

R13259                      Reaction

Name

long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase

Definition

Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Long-chain 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

Equation

C22859 + C00006 <=> C22858 + C00005 + C00080

Comment

general reaction

Reaction class

RC00029

C22858_C22859

Enzyme

1.1.1.-

Pathway

rn00074

Mycolic acid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R13259  Long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Long-chain 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

Orthology

K11610

meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]

Reference

1 [PMID:12079383]

Authors

Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A.

Title

Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.

Journal

J Mol Biol 320:249-61 (2002)

Reference

2 [PMID:11932442]

Authors

Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard AK.

Title

MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II.

Journal

Microbiology (Reading) 148:951-960 (2002)
DOI:10.1099/00221287-148-4-951

Reference

3 [PMID:20178986]

Authors

Veyron-Churlet R, Zanella-Cleon I, Cohen-Gonsaud M, Molle V, Kremer L.

Title

Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis.

Journal

J Biol Chem 285:12714-25 (2010)
DOI:10.1074/jbc.M110.105189

Reference

4 [PMID:17059223]

Authors

Silva RG, de Carvalho LP, Blanchard JS, Santos DS, Basso LA.

Title

Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms.

Journal

Biochemistry 45:13064-73 (2006)

LinkDB

REACTION: R13263

Entry

R13263                      Reaction

Name

very-long-chain-(3R)-3-hydroxyacyl-[acyl-carrier protein]:NADP+ oxidoreductase

Definition

Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Very-long-chain 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

Equation

C22863 + C00006 <=> C22862 + C00005 + C00080

Comment

general reaction

Enzyme

1.1.1.-

Pathway

rn00074

Mycolic acid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00885

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA)

M00886

Meromycolic acid biosynthesis, initiation and elongation FAS II (KasA and KasB)

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R13263  Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ <=> Very-long-chain 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

Orthology

K11610

meromycolic acid 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.-]

Reference

1 [PMID:12079383]

Authors

Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A.

Title

Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.

Journal

J Mol Biol 320:249-61 (2002)

Reference

2 [PMID:11932442]

Authors

Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard AK.

Title

MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II.

Journal

Microbiology (Reading) 148:951-960 (2002)
DOI:10.1099/00221287-148-4-951

Reference

3 [PMID:20178986]

Authors

Veyron-Churlet R, Zanella-Cleon I, Cohen-Gonsaud M, Molle V, Kremer L.

Title

Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis.

Journal

J Biol Chem 285:12714-25 (2010)
DOI:10.1074/jbc.M110.105189

Reference

4 [PMID:17059223]

Authors

Silva RG, de Carvalho LP, Blanchard JS, Santos DS, Basso LA.

Title

Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms.

Journal

Biochemistry 45:13064-73 (2006)

LinkDB

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