KEGG   ORTHOLOGY: K11646
Entry
K11646                      KO                                     
Symbol
K11646
Name
3-dehydroquinate synthase II [EC:1.4.1.24]
Pathway
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K11646  K11646; 3-dehydroquinate synthase II
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.24  3-dehydroquinate synthase II
     K11646  K11646; 3-dehydroquinate synthase II
Other DBs
RN: R08569
COG: COG1465
Genes
GHL: GM160_10825
BUG: BC1001_PA6183
DEL: DelCs14_2367
DVU: DVU_0461
DVM: DvMF_1750
DVG: Deval_0422
DDS: Ddes_0337
DFI: AXF13_12005
DPG: DESPIGER_2217
DEF: CNY67_12560
DTR: RSDT_0005(aroB)
DFL: DFE_3006
DMA: DMR_05360
DGG: DGI_0593
DDE: Dde_3488
DAS: Daes_0955
DPI: BN4_11437
PPRF: DPRO_2849
DBA: Dbac_2808
DRT: Dret_0115
DMM: dnm_037720(aroB1)
SFU: Sfum_2724
AXL: AXY_21120
AAE: aq_1922
HTH: HTH_1199
TAL: Thal_0223
TTK: TST_1081
MJA: MJ_1249
MESG: MLAUSG7_1286(aroB)
MESA: MLASG1_0490(aroB)
MMP: MMP0006
MMD: GYY_00030
MMAK: MMKA1_00060(aroB)
MMAO: MMOS7_00060(aroB)
MMAD: MMJJ_10950(griH)
MAE: Maeo_1164
MVO: Mvol_1425
MTH: MTH_580
MMG: MTBMA_c09610(aroB)
METC: MTCT_0504
MWO: MWSIV6_0940(aroB')
METE: tca_00549(griH)
MTEE: MTTB_10060
MST: Msp_0090
MRU: mru_0998(aroB)
MSI: Msm_0055
MEB: Abm4_0655(aroB)
MMIL: sm9_1017(aroB2)
MEYE: TL18_05335
MOL: YLM1_0541
METH: MBMB1_1071
MFC: BRM9_1273(aroB)
MCUB: MCBB_0940(aroB')
MFV: Mfer_0601
MKA: MK1408
AFU: AF_0229
FPL: Ferp_2249
GAC: GACE_1229
GAH: GAH_01752
MBAR: MSBR2_2306
MBAK: MSBR3_2365
MAC: MA_4592
MMA: MM_1272
MMAC: MSMAC_0044
METM: MSMTP_0059
MTHR: MSTHT_1781
MTHE: MSTHC_1505
MHOR: MSHOH_0049
MBU: Mbur_2000
MMET: MCMEM_0228
MMH: Mmah_0240
MPY: Mpsy_1419
MTP: Mthe_0539
MCJ: MCON_1239(aroB)
MHI: Mhar_0787
MHU: Mhun_1034
MLA: Mlab_1653
MEMA: MMAB1_2642
MPI: Mpet_2704
MBN: Mboo_1559
MPL: Mpal_2609
MPD: MCP_1668
MEZ: Mtc_1382(aroB)
RCI: RRC152(aroB)
HAL: VNG_0310C
HSL: OE_1475F(aroB)
HHB: Hhub_1456(aroB)
HALH: HTSR_1438(aroB)
HHSR: HSR6_1510(aroB)
HSU: HLASF_0625(aroB)
HSF: HLASA_0621(aroB)
HARA: AArcS_2624
HMA: rrnAC1879(aroB)
HHI: HAH_2395(aroB)
NPH: NP_2238A(aroB)
NMO: Nmlp_1201(aroB)
HUT: Huta_1180
HTI: HTIA_1102
HMU: Hmuk_3035
HALL: LC1Hm_2380
HWA: HQ_1155A(aroB)
HWC: Hqrw_1192(aroB)
HVO: HVO_0792(aroB)
HME: HFX_0757
HLA: Hlac_1277
HTU: Htur_0813
NMG: Nmag_2808(aroB)
NAT: NJ7G_4142
SALI: L593_01230
MELU: MTLP_01130
MEAR: Mpt1_c10440(aroB')
MARC: AR505_0509
NMR: Nmar_0552
NID: NPIRD3C_1722(aroB)
NIN: NADRNF5_1626(aroB)
NCT: NMSP_1119(aroB')
NGA: Ngar_c16220(aroB)
NVN: NVIE_005840(aroB)
NEV: NTE_01959
TAA: NMY3_02543(griH)
NFN: NFRAN_0127(aroB)
NCV: NCAV_0389(aroB)
NBV: T478_0479
NDV: NDEV_0553(aroB)
CCAI: NAS2_0560
KCR: Kcr_1100
BARB: AOA66_0831(aroB')
LOKI: Lokiarch_16770(aroB')
 » show all
Reference
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_1249]
LinkDB

KEGG   ENZYME: 1.4.1.24
Entry
EC 1.4.1.24                 Enzyme                                 
Name
3-dehydroquinate synthase II;
DHQ synthase II;
MJ1249 (gene name);
aroB' (gene name)
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+ [RN:R08569]
Reaction(KEGG)
R08569
Substrate
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate;
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
3-dehydroquinate [CPD:C00944];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.
History
EC 1.4.1.24 created 2012
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K11646  3-dehydroquinate synthase II
Genes
GHLGM160_10825
BUGBC1001_PA6183
DELDelCs14_2367
DVUDVU_0461
DVMDvMF_1750
DVGDeval_0422
DDSDdes_0337
DFIAXF13_12005
DPGDESPIGER_2217
DEFCNY67_12560
DTRRSDT_0005(aroB)
DFLDFE_3006
DSDGD606_15910
DMADMR_05360
DCBC3Y92_17725
DGGDGI_0593
DDEDde_3488
DMSE8L03_13390
DSADesal_3064
DHYDESAM_21549
DAFDesaf_1880
DASDaes_0955
DPIBN4_11437
DEJAWY79_15690
PPRFDPRO_2849
PSELGM415_01300
DDNDND132_3202
DSXGD604_03175
PBIZLWC08_10795
DBADbac_2808
DOAAXF15_05890
DRTDret_0115
DMMdnm_037720(aroB1)
DEKDSLASN_18970
DAODesac_0651
SFUSfum_2724
AXLAXY_21120
HHDHBHAL_4201
SJEAAV35_010780
GRCGI584_21530
SEDDERJ70_18380
QDOH9Q78_12445
AAEaq_1922
HYAHY04AAS1_0883
HHOHydHO_0879
HYSHydSN_0902
HTHHTH_1199
HTEHydth_1191
TALThal_0223
TRDTHERU_02290
SULSYO3AOP1_0392
SAFSULAZ_0497
PMXPERMA_1476
TTKTST_1081
TAMTheam_1067
DTEDester_0533
MJAMJ_1249
MFEMefer_0373
MVUMetvu_0910
MFSMFS40622_0687
MIFMetin_0931
MJHJH146_0476
MESGMLAUSG7_1286(aroB)
MESAMLASG1_0490(aroB)
MIGMetig_1087
MMPMMP0006
MMQMmarC5_1678
MMXMmarC6_0943
MMZMmarC7_1003
MMDGYY_00030
MMAKMMKA1_00060(aroB)
MMAOMMOS7_00060(aroB)
MMADMMJJ_10950(griH)
MAEMaeo_1164
MVNMevan_1215
MVOMvol_1425
MOKMetok_0735
METFCFE53_04710
MTHMTH_580
MMGMTBMA_c09610(aroB)
METCMTCT_0504
MWOMWSIV6_0940(aroB')
METEtca_00549(griH)
METZMETMT2_0850
METKFVF72_08660
MTHMFZP57_04500
METJFZP68_04965
MTEEMTTB_10060
MSTMsp_0090
METBAW729_06720
MRUmru_0998(aroB)
MSIMsm_0055
MEBAbm4_0655(aroB)
MMILsm9_1017(aroB2)
MEYETL18_05335
MOLYLM1_0541
MAROMarbSA_04650
MELMetbo_1360
MEWMSWAN_0908
METHMBMB1_1071
MFCBRM9_1273(aroB)
MFIDSM1535_1957
MCUBMCBB_0940(aroB')
MSUBBK009_02845
METNBK008_10570
METTCIT01_09450
METOCIT02_02140
MEMEHYG87_09825
MFVMfer_0601
MKAMK1408
AFUAF_0229
AFGAFULGI_00002150
APOArcpr_0974
AVEArcve_0431
ASTAsulf_00977
FPLFerp_2249
GACGACE_1229
GAHGAH_01752
MBAMbar_A0921
MBYMSBRM_0074
MBWMSBRW_0077
MBARMSBR2_2306
MBAKMSBR3_2365
MACMA_4592
MMAMM_1272
MMAZMmTuc01_1318
MMJMSMAS_0044
MMACMSMAC_0044
MVCMSVAZ_3440
MEKMSKOL_3400
MLSMSLAZ_0043
METMMSMTP_0059
MEFMSWH1_0052
MEQMSWHS_0055
MSJMSSAC_0061
MSZMSSIH_0054
MSWMSSIT_0054
MTHRMSTHT_1781
MTHEMSTHC_1505
MHORMSHOH_0049
MFZAOB57_008130
MBUMbur_2000
MMETMCMEM_0228
MELOJ7W08_11210
MMHMmah_0240
MHAZBHR79_02310
MEVMetev_1693
MZHMzhil_0267
MPYMpsy_1419
MZIHWN40_01700
MHZMetho_0267
MTPMthe_0539
MCJMCON_1239(aroB)
MHIMhar_0787
MHUMhun_1034
MRTJKHC33_11775
MLAMlab_1653
MEMMemar_1301
MBGBN140_2037
MEMAMMAB1_2642
MCHKMchiMG62_14870
MPIMpet_2704
MBNMboo_1559
MFOMetfor_1591
MPLMpal_2609
MPDMCP_1668
MEZMtc_1382(aroB)
RCIRRC152(aroB)
HALVNG_0310C
HSLOE_1475F(aroB)
HDLHALDL1_05735
HHBHhub_1456(aroB)
HAGSJT689_02645
HABOJRZ79_01150
HNOLT974_02315
HLULT972_11235
HANRLJ422_01360
HJEHacjB3_14330
HALHHTSR_1438(aroB)
HHSRHSR6_1510(aroB)
HSUHLASF_0625(aroB)
HSFHLASA_0621(aroB)
SALRFQU85_02210
HALREFA46_006150
HARAAArcS_2624
HAADMW046_10350
HALXM0R89_10650
HMArrnAC1879(aroB)
HHIHAH_2395(aroB)
HHNHISP_12195
HABSG26_04505
HTABVU17_11655
HALJG9465_07490
HSINKDQ40_01450
NPHNP_2238A(aroB)
NMONmlp_1201(aroB)
NHOHWV23_11645
NSALHWV07_13605
HUTHuta_1180
HTIHTIA_1102
HALAHrd1104_09450
HMUHmuk_3035
HALZE5139_02440
HALLLC1Hm_2380
HAZPGBQ70_02440
HALIBV210_04325
HSNDV733_05020
HDSHSR122_2612
HRRHZS55_09330
HPELHZS54_13415
HLTI7X12_04885
HARCHARCEL1_12960
HDOMUK72_03650
HWAHQ_1155A(aroB)
HWCHqrw_1192(aroB)
HVOHVO_0792(aroB)
HMEHFX_0757
HGIABY42_03780
HALEG3A49_03985
HBOHbor_24250
HAQDU484_08630
HAJDU500_08670
HAERDU502_05970
HRAEI982_07825
HLMDV707_11410
HALMFCF25_10555
HLAHlac_1277
HALPDOS48_06140
HALBEKH57_03850
HEZZEO776_07620
HALQHrr1229_015375
HSSJ7656_08785
HSAIHPS36_14195
HAZZKI388_05330
SRUBC2R22_04760
HAEhalTADL_0574
HALNB4589_008490
HALGHUG10_01105
HALUHUG12_16490
HMPK6T50_14130
HREK6T36_14075
HRMK6T25_02710
HACBHbl1158_05905
HDFAArcSl_0523
HAHHalar_0977
HTUHtur_0813
HDABB347_01125
HJTDVR14_06630
HALYHYG82_19465
HSALJMJ58_04845
HLOJ0X27_10805
HAKZJ0X25_11125
NMGNmag_2808(aroB)
HXAHalxa_4001
NATNJ7G_4142
NPENatpe_3306
NVRFEJ81_15815
NPLFGF80_14920
NAYHYG81_12450
NGENatgr_1033
HRUHalru_2308
NOUNatoc_0631
SALIL593_01230
SAIMK0C01_01380
HLRHALLA_07820
HLCCHINAEXTREME00870
NAJB1756_11610
NAGAArcMg_0899
NANAArc1_2810
NBGDV706_03270
NASGCU68_10245
MELUMTLP_01130
MEAMMU439_07200
TARTALC_00561
MAXMMALV_05110
MERMMINT_14410
MEARMpt1_c10440(aroB')
MARCAR505_0509
NMRNmar_0552
NIRNSED_02800
NKRNKOR_02860
NIDNPIRD3C_1722(aroB)
NINNADRNF5_1626(aroB)
NIWNisw_02105
NCLC5F47_02840
NOXC5F49_03020
NUEC5F50_04215
NIPNsoK4_05580
NCTNMSP_1119(aroB')
NICDSQ20_03070
CSYCENSYa_0201
NGANgar_c16220(aroB)
NVNNVIE_005840(aroB)
NEVNTE_01959
TAANMY3_02543(griH)
NFNNFRAN_0127(aroB)
NCVNCAV_0389(aroB)
CSUCSUB_C0896
NBVT478_0479
TAHSU86_003325
NIUDSQ19_02825
NDVNDEV_0553(aroB)
CCAINAS2_0560
KCRKcr_1100
BARBAOA66_0831(aroB')
LOKILokiarch_16770(aroB')
 » show all
Reference
1  [PMID:15182204]
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
  Sequence
[mja:MJ_1249]
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.24
IUBMB Enzyme Nomenclature: 1.4.1.24
ExPASy - ENZYME nomenclature database: 1.4.1.24
BRENDA, the Enzyme Database: 1.4.1.24
LinkDB

KEGG   REACTION: R08569
Entry
R08569                      Reaction                               
Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
Definition
2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid + H2O + NAD+ <=> 3-Dehydroquinate + Ammonia + NADH + H+
Equation
Comment
two-step reaction (oxidative deamination, cyclization)
possibly intermediate (3,7-dideoxy-D-threo-hept-2,6-diulosonic acid)
Reaction class
RC00001  C00003_C00004
RC02302  C00944_C16850
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K11646  3-dehydroquinate synthase II [EC:1.4.1.24]
Reference
1  [PMID:15182204]
  Authors
White RH
  Title
L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.
  Journal
Biochemistry 43:7618-27 (2004)
DOI:10.1021/bi0495127
Other DBs
RHEA: 25959
LinkDB

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