| Entry |
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| Name |
5-guanidino-2-oxopentanoate decarboxylase;
alpha-ketoarginine decarboxylase;
2-oxo-5-guanidinopentanoate carboxy-lyase
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| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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| Sysname |
5-guanidino-2-oxopentanoate carboxy-lyase (4-guanidinobutanal-forming)
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| Reaction(IUBMB) |
5-guanidino-2-oxopentanoate = 4-guanidinobutanal + CO2 [RN: R03178]
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| Reaction(KEGG) |
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| Substrate |
5-guanidino-2-oxopentanoate [CPD: C03771]
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| Product |
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| Comment |
Enzyme activity is dependent on the presence of thiamine diphosphate and a divalent cation.
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| History |
EC 4.1.1.75 created 1999
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| Pathway |
| ec00330 | Arginine and proline metabolism |
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| Orthology |
| K12253 | 5-guanidino-2-oxopentanoate decarboxylase |
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| Genes |
| PCQ: | PcP3B5_02220(aruI_1) |
| PPRC: | PFLCHA0_c27750(ilvB1) |
| PTAE: | NCTC10697_02326(ilvB_2) |
| MICC: | AUP74_02851(aruI_1) |
| SPSE: | SULPSESMR1_00851(aruI) |
| RMM: | ROSMUCSMR3_00989(aruI) |
| AHT: | ANTHELSMS3_04191(aruI) |
| ASCA: | QEZ52_05455 QEZ52_07675 |
| SALL: | SAZ_03825 SAZ_31125 |
| LEU: | Leucomu_03870 Leucomu_11420 |
| LEB: | G7066_00485 G7066_04190 |
| LINS: | G7067_05385 G7067_05435 |
| LLUT: | K1X41_11780 K1X41_12460 |
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| Reference |
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| Authors |
Vanderbilt AS, Gaby NS, Rodwell VW. |
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| Title |
Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida. |
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| Journal |
J Biol Chem 250:5322-9 (1975) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.1.75 |
| ExPASy - ENZYME nomenclature database: | 4.1.1.75 |
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| LinkDB |
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