KEGG ORTHOLOGY: K12313

ORTHOLOGY: K12313

Entry

K12313                      KO

Symbol

ACTA2

Name

actin, aortic smooth muscle

Pathway

map04270

Vascular smooth muscle contraction

map04371

Apelin signaling pathway

map04814

Motor proteins

map04926

Relaxin signaling pathway

Disease

H00801

Familial thoracic aortic aneurysm and dissection

H01396

Moyamoya disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K12313  ACTA2; actin, aortic smooth muscle
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    K12313  ACTA2; actin, aortic smooth muscle
09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K12313  ACTA2; actin, aortic smooth muscle
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12313  ACTA2; actin, aortic smooth muscle
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K12313  ACTA2; actin, aortic smooth muscle
   04147 Exosome
    K12313  ACTA2; actin, aortic smooth muscle
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     K12313  ACTA2; actin, aortic smooth muscle
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K12313  ACTA2; actin, aortic smooth muscle

Genes

HSA:

59(ACTA2)

PTR:	466148(ACTA2)

PPS:	100987623(ACTA2)

GGO:	101151850(ACTA2)

PON:	100173819(ACTA2)

PPYG:

129006219(ACTA2)

NLE:	100579983(ACTA2)

HMH:	116457858(ACTA2)

SSYN:

129480474(ACTA2)

MCC:	100427024(ACTA2)

MCF:	102139312(ACTA2)

MTHB:

126963191

MNI:	105480757(ACTA2)

CSAB:

103216222(ACTA2)

CATY:

105587159(ACTA2)

PANU:

101021287(ACTA2)

TGE:	112631568(ACTA2)

MLEU:

105552440(ACTA2)

RRO:	104675148(ACTA2)

RBB:	108526651(ACTA2)

TFN:	117086211(ACTA2)

PTEH:

111551314(ACTA2)

CANG:

105515920(ACTA2)

CJC:	100396597(ACTA2)

SBQ:	101035102(ACTA2)

CIMI:

108290336(ACTA2)

ANAN:

105718908(ACTA2)

CSYR:

103260552(ACTA2)

MMUR:

105871641(ACTA2)

LCAT:

123650203(ACTA2)

PCOQ:

105822690(ACTA2)

OGA:	100962009(ACTA2)

MMU:	11475(Acta2)

MCAL:

110286110(Acta2)

MPAH:

110337380(Acta2)

RNO:	81633(Acta2)

MCOC:

116103759(Acta2)

ANU:	117696974(Acta2)

MUN:	110561524(Acta2)

CGE:	100758575(Acta2)

MAUA:

101844160(Acta2)

PROB:

127233248(Acta2)

MORG:

121453934(Acta2)

MFOT:

126511222

AAMP:

119812239(Acta2)

NGI:	103738035(Acta2)

HGL:	101718388(Acta2)

CPOC:

100722917(Acta2)

CCAN:

109691143(Acta2)

DORD:

105986335(Acta2)

DSP:	122115806(Acta2)

PLOP:

125346315(Acta2)

NCAR:

124984582

MMMA:

107153331(Acta2)

OCU:	100009271(ACTA2)

OPI:	101522787(ACTA2)

TUP:	102476173(ACTA2)

GVR:

103607183

CFA:	477587(ACTA2)

CLUD:

112656198(ACTA2)

VVP:	112931966(ACTA2)

VLG:	121475591(ACTA2)

NPO:	129508126(ACTA2)

AML:	100470496(ACTA2)

UMR:	103661931(ACTA2)

UAH:	113258969(ACTA2)

UAR:	123795547(ACTA2)

ELK:

111144833

LLV:

125084638

MPUF:

101678263(ACTA2)

MNP:	132016208(ACTA2)

MLK:	131830064(ACTA2)

NVS:	122900655(ACTA2)

ORO:	101363837(ACTA2)

EJU:	114210273(ACTA2)

ZCA:	113923496(ACTA2)

MLX:	118012959(ACTA2)

NSU:	110585977(ACTA2)

LWW:

102750715

FCA:	101093547(ACTA2)

PYU:	121016585(ACTA2)

PCOO:

112851467(ACTA2)

PBG:	122493448(ACTA2)

PVIV:

125147669(ACTA2)

LRUF:

124518701

PTG:	102950751(ACTA2)

PPAD:

109255403(ACTA2)

PUC:

125933217

AJU:

106980969

HHV:	120223794(ACTA2)

BTA:	515610(ACTA2)

BOM:	102274194(ACTA2)

BIU:	109579170(ACTA2)

BBUB:

102408421(ACTA2)

BBIS:

104987520(ACTA2)

CHX:	102191486(ACTA2)

OAS:	101121051(ACTA2)

BTAX:

128067862(ACTA2)

ODA:	120873791(ACTA2)

CCAD:

122446183(ACTA2)

MBEZ:

129555566(ACTA2)

SSC:	733615(ACTA2)

CFR:	102516380(ACTA2)

CBAI:

105081853(ACTA2)

CDK:	105102830(ACTA2)

VPC:	102529430(ACTA2)

BACU:

103020047(ACTA2)

BMUS:

118882329(ACTA2)

LVE:	103076696(ACTA2)

OOR:	101270403(ACTA2)

DLE:	111172520(ACTA2)

PCAD:

102985765(ACTA2)

PSIU:

116741751(ACTA2)

NASI:

112399578(ACTA2)

ECB:	100062175(ACTA2)

EPZ:	103558122(ACTA2)

EAI:	106822179(ACTA2)

MYB:	102259532(ACTA2)

MYD:	102755942(ACTA2)

MMYO:

118669992(ACTA2)

MLF:	102425464(ACTA2)

MDT:	132214977(ACTA2)

PKL:	118719269(ACTA2)

EFUS:

103296384(ACTA2)

MNA:	107543359(ACTA2)

DRO:	112307333(ACTA2)

SHON:

118987955(ACTA2)

AJM:	119057748(ACTA2)

PDIC:

114496729(ACTA2)

PHAS:

123828844(ACTA2)

MMF:	118632300(ACTA2)

PPAM:

129069994(ACTA2)

HAI:	109377704(ACTA2)

RFQ:	117035806(ACTA2)

PALE:

102880134(ACTA2)

PGIG:

120609348(ACTA2)

PVP:	105293137(ACTA2)

RAY:	107502214(ACTA2)

MJV:	108400343(ACTA2)

TOD:	119234398(ACTA2)

SARA:

101556706(ACTA2)

SETR:

125995121(ACTA2)

LAV:	100658952(ACTA2)

TMU:

101357176

ETF:	101638987(ACTA2)

DNM:	101411191(ACTA2)

MDO:	100012397(ACTA2)

SHR:	100916692(ACTA2)

AFZ:

127552170

PCW:	110198957(ACTA2)

TVP:	118829229(ACTA2)

OAA:	100074413(ACTA2)

GGA:	423787(ACTA2)

PCOC:

116238137(ACTA2)

MGP:	100549984(ACTA2)

CJO:	107315889(ACTA2)

TPAI:

128077626(ACTA2)

LMUT:

125693447(ACTA2)

NMEL:

110400541(ACTA2)

APLA:

101793497(ACTA2)

ACYG:

106044345(ACTA2)

CATA:

118243435(ACTA2)

AFUL:

116491456(ACTA2)

TGU:	115495783(ACTA2)

LSR:	110475302(ACTA2)

SCAN:

103813933(ACTA2)

PMOA:

120501987(ACTA2)

OTC:	121341679(ACTA2)

PRUF:

121350049(ACTA2)

GFR:	102033705(ACTA2)

FAB:	101805665(ACTA2)

OMA:	130254602(ACTA2)

PHI:	102102121(ACTA2)

PMAJ:

107206852(ACTA2)

CCAE:

111931165(ACTA2)

CCW:	104696526(ACTA2)

CBRC:

103624501(ACTA2)

ETL:	114055890(ACTA2)

ZAB:	102072992(ACTA2)

ZLE:	135449924(ACTA2)

ACHL:

103803125(ACTA2)

SVG:	106852627(ACTA2)

MMEA:

130576366(ACTA2)

HRT:	120755583(ACTA2)

SATI:

136364191(ACTA2)

FPG:	101915277(ACTA2)

FCH:	102045674(ACTA2)

CCRI:

104156152

NNT:	104405815(ACTA2)

SHAB:

115608046(ACTA2)

ACUN:

113481537(ACTA2)

TALA:

104360751(ACTA2)

ACHC:

115348643(ACTA2)

HALD:

104311583

HLE:	104830186(ACTA2)

AGEN:

126042999

GCL:

127017875

CSTI:

104552930

LDI:	104340903 104345607

MNB:	103777501(ACTA2)

DPUB:

104297729(ACTA2)

AVIT:

104268890(ACTA2)

BRHI:

104493459

EGZ:	104129155(ACTA2)

NNI:	104013129(ACTA2)

PCRI:

104025769

PCAO:

104048048(ACTA2)

PADL:

103913661(ACTA2)

AFOR:

103897650(ACTA2)

FGA:	104075734(ACTA2)

GSTE:

104256877

CLV:	102084341(ACTA2)

MUI:	104536426(ACTA2)

PGUU:

104468561(ACTA2)

PLET:

104614686

EHS:

104515686

CMAC:

104484133

CUCA:

104067878(ACTA2)

TEO:

104381401

BREG:

104638112(ACTA2)

OHA:	104330442(ACTA2)

ACAR:

104528889

CPEA:

104390824(ACTA2)

CVF:	104289714(ACTA2)

RTD:	128910962(ACTA2)

AAM:	106487836(ACTA2)

AROW:

112975239(ACTA2)

NPD:	112957539(ACTA2)

TGT:	104579298(ACTA2)

DNE:	112979759(ACTA2)

SCAM:

104145999(ACTA2)

ASN:	102372571(ACTA2)

AMJ:	102577392(ACTA2)

CPOO:

109324169(ACTA2)

GGN:	109287467(ACTA2)

PSS:	102456465(ACTA2)

CMY:	102939405(ACTA2)

CCAY:

125639643(ACTA2)

DCC:	119858225(ACTA2)

CPIC:

101937631(ACTA2)

TST:	117880158(ACTA2)

CABI:

116818984(ACTA2)

MRV:	120368626(ACTA2)

ACS:	100551887(acta2)

ASAO:

132771116(ACTA2)

PVT:	110083111(ACTA2)

SUND:

121926092(ACTA2)

PBI:

103064165

PMUR:

107302731

CTIG:

120304889(ACTA2)

PGUT:

117673166(ACTA2)

APRI:

131200639(ACTA2)

PTEX:

113442733(ACTA2)

NSS:

113425163

VKO:	123018471(ACTA2)

PMUA:

114597295(ACTA2)

PRAF:

128414018(ACTA2)

ZVI:	118096149(ACTA2)

HCG:	128350204(ACTA2)

GJA:	107121656(ACTA2)

STOW:

125438276(ACTA2)

EMC:	129332369(ACTA2)

XLA:	100653490(acta2.S) 431847(acta2.L)

XTR:	496696(acta2)

NPR:	108788870(ACTA2)

RTEM:

120947101(ACTA2)

BBUF:

121005247(ACTA2)

BGAR:

122940012(ACTA2)

MUO:	115470129(ACTA2)

GSH:	117360057(ACTA2)

DRE:	322509(acta2)

SRX:

SANH:

SGH:

CCAR:

CAUA:

113056212 113111795(acta2)

CGIB:

127969098 128025121

PTET:

122355494(acta2)

LROH:

127174376(acta2)

OMC:	131550665(acta2)

PPRM:

120488774(acta2)

RKG:	130086856(acta2)

MAMB:

125255373(acta2)

CIDE:

127523382

CERY:

137007775(acta2)

MASI:

127422947 127427187

TROS:

130568868(acta2)

TDW:	130439359(acta2)

MANU:

129420958(acta2)

IPU:

100304861

IFU:	128616510(acta2)

PHYP:

113527698(acta2)

SMEO:

124389446(acta2)

TFD:	113637171(acta2)

TVC:	132839702(acta2)

TRN:	134321434(acta2)

AMEX:

103040556(acta2)

CMAO:

118809572(acta2)

EEE:	113579474(acta2)

CHAR:

105893601(acta2)

TRU:	101064889(acta2)

TFS:	130540373(acta2)

TNG:	GSTEN00003894G001

LCO:

104936549

TBEN:

117498792

EMAC:

134870339(acta2)

ELY:	117246871(acta2)

EFO:	125880370(acta2)

PLEP:

121958561(acta2)

SLUC:

116059256(acta2)

PFLV:

114548618(acta2)

GAT:	120819659(acta2)

PPUG:

119212842(acta2)

CLUM:

117748376(acta2)

MSAM:

119916034(acta2)

SCHU:

122868196(acta2)

CUD:	121528111(acta2)

ALAT:

119009749(acta2)

MZE:	101471135(acta2)

ONL:	100708176(acta2)

OAU:	116324407(acta2)

OLA:	101163135(acta2)

OML:	112141837(acta2)

CSAI:

133418804(acta2)

XMA:	102235924(acta2)

XCO:	114150601(acta2)

XHE:	116726579(acta2)

PFOR:

103129793(acta2)

PLAI:

106941768

PMEI:

106910448

GAF:	122823402(acta2)

PPRL:

129352291(acta2)

CVG:	107099849(acta2)

CTUL:

119792872(acta2)

GMU:	124874988(acta2)

NFU:	107387497(acta2)

KMR:	108250739(acta2)

ALIM:

106528204(acta2)

AOCE:

111568524(acta2)

MCEP:

125022221(acta2)

CSEM:

103382302

POV:

109647312

SSEN:

122764408 122764899

HHIP:

117753467(acta2)

HSP:	118100539(acta2)

PPLT:

128426644(acta2)

SMAU:

118287243(acta2)

LCF:

108891483

SDU:

111219689

SLAL:

111655116(acta2)

XGL:	120794068(acta2)

HCQ:	109526523(acta2)

SSCV:

125991709

SBIA:

133496059(acta2)

PEE:	133418023(acta2)

PTAO:

133469079(acta2)

MALB:

109969639

BSPL:

114845638(acta2)

SJO:	128381595(acta2)

SASA:

106578961 106589387

STRU:

115157170 115201163

OTW:	112223448 112224762

OMY:	110491380 110498989

OGO:	124040031 124048165(acta2)

ONE:	115106359 115144049

OKI:	109865359 109870177

OKE:	118357476 118368371

SALP:

111967769 111978060

SNH:	120029457 120046144(acta2)

CCLU:

121533749 121547331

ELS:	105006355(acta2)

SFM:	108932828 108939636(acta2)

PKI:	111853701(acta2)

AANG:

118221042(acta2)

LOC:	102682501(acta2)

PSPA:

121321858 121325276

ARUT:

117415956 117418433

LCM:	102349699(ACTA2) 102352432

CMK:	103180779(acta2)

RTP:	109929458(acta2)

CPLA:

122561060(acta2)

HOC:	132826217(acta2)

LERI:

129704264(acta2)

PMRN:

116939766 116947790

LRJ:	133341370 133347057 133352775

BFO:

BBEL:

RMD:

Reference

PMID:22831780

Authors

Munot P, Saunders DE, Milewicz DM, Regalado ES, Ostergaard JR, Braun KP, Kerr T, Lichtenbelt KD, Philip S, Rittey C, Jacques TS, Cox TC, Ganesan V

Title

A novel distinctive cerebrovascular phenotype is associated with heterozygous Arg179 ACTA2 mutations.

Journal

Brain 135:2506-14 (2012)
DOI:10.1093/brain/aws172

Reference

PMID:2701935

Authors

Kamada S, Kakunaga T

Title

The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA.

Journal

Nucleic Acids Res 17:1767 (1989)
DOI:10.1093/nar/17.4.1767

Sequence

[hsa:59]

LinkDB

DBGET integrated database retrieval system