KEGG ORTHOLOGY: K12447

ORTHOLOGY: K12447

Entry

K12447                      KO

Symbol

USP

Name

UDP-sugar pyrophosphorylase [EC:2.7.7.64]

Pathway

map00040

Pentose and glucuronate interconversions

map00052

Galactose metabolism

map00053

Ascorbate and aldarate metabolism

map00520

Amino sugar and nucleotide sugar metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01250

Biosynthesis of nucleotide sugars

Module

M00014

Glucuronate pathway (uronate pathway)

M00549

Nucleotide sugar biosynthesis, glucose => UDP-glucose

Reaction

R00289

UTP:alpha-D-glucose-1-phosphate uridylyltransferase

R00502

UTP:alpha-D-galactose-1-phosphate uridylyltransferase

R01381

UTP:1-phospho-alpha-D-glucuronate uridylyltransferase

R03077

UTP:beta-L-arabinose-1-phosphate uridylyltransferase

R08845

UTP:monosaccharide-1-phosphate uridylyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    K12447  USP; UDP-sugar pyrophosphorylase
   00052 Galactose metabolism
    K12447  USP; UDP-sugar pyrophosphorylase
   00053 Ascorbate and aldarate metabolism
    K12447  USP; UDP-sugar pyrophosphorylase
   00520 Amino sugar and nucleotide sugar metabolism
    K12447  USP; UDP-sugar pyrophosphorylase
Enzymes [BR:ko01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.64  UTP-monosaccharide-1-phosphate uridylyltransferase
     K12447  USP; UDP-sugar pyrophosphorylase

Other DBs

GO:

0051748

Genes

ATH:	AT5G52560(USP)

ALY:

9301995

CRB:

17875462

CSAT:

104725768 104727645 104761268 109127935

EUS:	EUTSA_v10000457mg

BRP:

103842186

BNA:	106368564 106415929

BOE:	106307311 106336398

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10000592mg

PVY:	116116047 116140087

MINC:

123203258 123206225

TCC:

18592423

GRA:	105783427 105792654

GHI:	107897588 107938693 107939552 107949516

GAB:	108462975 108467534

HSYR:

120207178

DZI:	111298632 111312249

EGR:

104450548

GMX:	100793599 778158(USP1)

GSJ:	114410378 114415459

PVU:	PHAVU_009G130500g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131626432 131661385

LJA:

130739242

ADU:

107460668

AIP:

107606001

AHF:	112706017 112764737 114927234

LANG:

109344323

PCIN:

129294265 129304189

QSA:	O6P43_015120 O6P43_019795

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:	103945204 103946766

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110632622 110647558

MESC:

POP:

PEU:

PALZ:

JRE:	109004826 109012130

CILL:

CAVE:

QSU:

QLO:

TWL:	119996987 120017142

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107804078 107808766

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:	111397495 111408714

EGT:

105963411

SSPL:

121783004 121785967 121810605

SMIL:

131011810

SHIS:

125208178 125218199

APAN:

127246463

HAN:	110904244 110927044

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:	130758359 130776324

BVG:

104894442

SOE:

110782013

CQI:	110685928 110725744

ATRI:

MOF:

NNU:

MING:

TSS:	122655413 122657876 122670080

PSOM:

113291734 113326815 113332494 113358220

OSA:	4341967(P0596H10.4)

OBR:

OGL:

BDI:

ATS:

TDC:	119329157 119337370

TAES:

123148643 123157133 123163925

TUA:

125519710

LPER:

127312522 127324064

LRD:	124684174 124692501 124692520 124697546

SBI:

8065566

ZMA:	100285949 100382378 103625925 109939773

MFLO:

136520317 136527325 136527568

SITA:

101760295 101768879

SVS:	117854042 117863004

PVIR:

PHAI:

PDA:

EGU:

MUS:	103985547 103997892

ZOF:	121970675 121975759 121988662 121997589

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_100378 SELMODRAFT_118485

PPP:	112284456 112291294

CRE:	CHLRE_14g621751v5

VCN:	VOLCADRAFT_120799

CSL:	COCSUDRAFT_53808

CVR:	CHLNCDRAFT_35169

APRO:

F751_3978

OLU:	OSTLU_51241 OSTLU_52106

OTA:	OT_ostta13g02030

BPG:	Bathy17g01210

MIS:	MICPUN_106965

MPP:	MICPUCDRAFT_60817

PFA:	PF3D7_0517500

PFD:	PFDG_01194

PFH:	PFHG_00237

PREI:

PRSY57_0008200

PGAB:

PGSY75_0517500

PLAG:

39740480(PADL01_0516500)

PYO:	PY17X_1235700

PCB:	PCHAS_1232900

PBE:	PBANKA_1232300

PVV:	PVVCY_1203320

PKN:	PKNH_1015800

PVX:	PVX_080375

PCY:	PCYB_102430

PMAL:

PMUG01_10027200

PBRS:

92371307(MKS88_003220)

PREL:

PRELSG_1014400

PCOT:

PCOAH_00029880

CPV:

cgd7_1830

CHO:	Chro.70213

TGO:	TGME49_218200

BBES:

BESB_039100

TET:	TTHERM_00929520 TTHERM_00951720

PTM:	GSPATT00032995001

PTI:	PHATRDRAFT_23639 PHATRDRAFT_54493

FCY:	FRACYDRAFT_211962(USP2) FRACYDRAFT_237242(USP1)

TPS:	THAPSDRAFT_13482 THAPSDRAFT_42326

AAF:	AURANDRAFT_22705 AURANDRAFT_23667 AURANDRAFT_28944 AURANDRAFT_70780

PIF:	PITG_10315

PSOJ:

PHYSODRAFT_312734

EHX:	EMIHUDRAFT_426133 EMIHUDRAFT_427850 EMIHUDRAFT_454930 EMIHUDRAFT_51739 EMIHUDRAFT_68020 EMIHUDRAFT_74985

GTT:	GUITHDRAFT_115181 GUITHDRAFT_157482 GUITHDRAFT_159419

TCR:	503493.10 511761.10

LMA:	LMJF_17_1160(USP)

LIF:	LINJ_17_1260(USP)

LDO:	LDBPK_171260

LMI:	LMXM_17_1160

LMAT:

92515557(LSCM1_05597)

LBZ:	LBRM_17_1270(USP)

LPAN:

LPMP_171130(USP)

LOI:	92362805(LSCM4_06964)

CAA:

Caka_1908

VBS:	EGM51_17175

AG:	BAD66876(USP)

» show all

Reference

PMID:15326166

Authors

Kotake T, Yamaguchi D, Ohzono H, Hojo S, Kaneko S, Ishida HK, Tsumuraya Y

Title

UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.

Journal

J Biol Chem 279:45728-36 (2004)
DOI:10.1074/jbc.M408716200

Sequence

[ag:BAD66876]

LinkDB

ENZYME: 2.7.7.64

Entry

EC 2.7.7.64                 Enzyme

Name

UTP-monosaccharide-1-phosphate uridylyltransferase;
UDP-sugar pyrophosphorylase;
PsUSP

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Reaction(IUBMB)

UTP + a monosaccharide 1-phosphate = diphosphate + UDP-monosaccharide [RN:R08845]

Reaction(KEGG)

R08845 > R00289 R00502 R01381 R01471 R03077

Substrate

UTP [CPD:C00075];
monosaccharide 1-phosphate [CPD:C00991]

Product

diphosphate [CPD:C00013];
UDP-monosaccharide [CPD:C05227]

Comment

Requires Mg2+ or Mn2+ for maximal activity. The reaction can occur in either direction and it has been postulated that MgUTP and Mg-diphosphate are the actual substrates [1,2]. The enzyme catalyses the formation of UDP-Glc, UDP-Gal, UDP-GlcA, UDP-L-Ara and UDP-Xyl, showing broad substrate specificity towards monosaccharide 1-phosphates. Mannose 1-phosphate, L-Fucose 1-phosphate and glucose 6-phosphate are not substrates and UTP cannot be replaced by other nucleotide triphosphates [1].

History

EC 2.7.7.64 created 2006

Pathway

ec00040

Pentose and glucuronate interconversions

ec00052

Galactose metabolism

ec00053

Ascorbate and aldarate metabolism

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K12447

UDP-sugar pyrophosphorylase

Genes

ATH:	AT5G52560(USP)

ALY:

9301995

CRB:

17875462

CSAT:

104725768 104727645 104761268 109127935

EUS:	EUTSA_v10000457mg

BRP:

103842186

BNA:	106368564 106415929

BOE:	106307311 106336398

RSZ:

108805857

THJ:

104808371

CPAP:

110813513

CIT:

102628031

CIC:	CICLE_v10000592mg

PVY:	116116047 116140087

MINC:

123203258 123206225

TCC:

18592423

GRA:	105783427 105792654

GHI:	107897588 107938693 107939552 107949516

GAB:	108462975 108467534

HSYR:

120207178

DZI:	111298632 111312249

EGR:

104450548

GMX:	100793599 778158(USP1)

GSJ:	114410378 114415459

PVU:	PHAVU_009G130500g

VRA:

106762599

VAR:

108332148

VUN:

114164681

VUM:

124826520

CCAJ:

109796895

APRC:

113869536

MTR:

25489712

TPRA:

123909387

CAM:

101505137

PSAT:

127082747

VVO:	131626432 131661385

LJA:

130739242

ADU:

107460668

AIP:

107606001

AHF:	112706017 112764737 114927234

LANG:

109344323

PCIN:

129294265 129304189

QSA:	O6P43_015120 O6P43_019795

FVE:

101297604

RCN:

112172726

PPER:

18790905

PMUM:

103319759

PAVI:

110766413

PDUL:

117614229

MDM:

103456258

MSYL:

126604195

PXB:	103945204 103946766

ZJU:

107421126

MNT:

21387354

CSAV:

115698731 115709730

CSV:

101202798

CMO:

103485690

BHJ:

120075699

MCHA:

111011819

CMAX:

111487149

CMOS:

111462581

CPEP:

111802306

RCU:

8270969

MEAN:

126673921 126676147

JCU:

105639006

HBR:	110632622 110647558

MESC:

110606169

POP:

7467856

PEU:

105127743

PALZ:

118061551

JRE:	109004826 109012130

CILL:

122296207 122299491

CAVE:

132185829

QSU:

111984090

QLO:

115960014

TWL:	119996987 120017142

VVI:

100259254

VRI:

117906610

SLY:

101247010

SPEN:

107018439

SOT:

102596087

SSTN:

125849909

SDUL:

129902203

CANN:

107852493

LBB:

132627176

NTA:	107804078 107808766

NSY:

104232978

NTO:

104119089

NAU:

109234273

INI:

109170461

ITR:

116014919

SIND:

105180105

OEU:	111397495 111408714

EGT:

105963411

SSPL:

121783004 121785967 121810605

SMIL:

131011810

SHIS:

125208178 125218199

APAN:

127246463

HAN:	110904244 110927044

ECAD:

122603150 122609402

LSV:

111901456

CCAV:

112522223 112523107

DCR:

108204601

CSIN:

114267052

RVL:

131307323

AEW:	130758359 130776324

BVG:

104894442

SOE:

110782013

CQI:	110685928 110725744

ATRI:

130818202

MOF:

131162338

NNU:

104606683

MING:

122072129 122094797

TSS:	122655413 122657876 122670080

PSOM:

113291734 113326815 113332494 113358220

OSA:	4341967(P0596H10.4)

OBR:

102704348

OGL:

127777429

BDI:

100845164

ATS:

109751835

TDC:	119329157 119337370

TAES:

123148643 123157133 123163925

TUA:

125519710

LPER:

127312522 127324064

LRD:	124684174 124692501 124692520 124697546

SBI:

8065566

ZMA:	100285949 100382378 103625925 109939773

MFLO:

136520317 136527325 136527568

SITA:

101760295 101768879

SVS:	117854042 117863004

PVIR:

120668692 120704388

PHAI:

112888690

PDA:

103713110

EGU:

105049301

MUS:	103985547 103997892

ZOF:	121970675 121975759 121988662 121997589

DCT:

110114106

PEQ:

110033390

AOF:

109850719

MSIN:

131221063 131226735

NCOL:

116261024

ATR:

18424675

SMO:	SELMODRAFT_100378 SELMODRAFT_118485

PPP:	112284456 112291294

CRE:	CHLRE_14g621751v5

VCN:	VOLCADRAFT_120799

CSL:	COCSUDRAFT_53808

CVR:	CHLNCDRAFT_35169

APRO:

F751_3978

OLU:	OSTLU_51241 OSTLU_52106

OTA:	OT_ostta13g02030

BPG:	Bathy17g01210

MIS:	MICPUN_106965

MPP:	MICPUCDRAFT_60817

PFA:	PF3D7_0517500

PFD:	PFDG_01194

PFH:	PFHG_00237

PREI:

PRSY57_0008200

PGAB:

PGSY75_0517500

PLAG:

39740480(PADL01_0516500)

PYO:	PY17X_1235700

PCB:	PCHAS_1232900

PBE:	PBANKA_1232300

PVV:	PVVCY_1203320

PKN:	PKNH_1015800

PVX:	PVX_080375

PCY:	PCYB_102430

PMAL:

PMUG01_10027200

PBRS:

92371307(MKS88_003220)

PREL:

PRELSG_1014400

PCOT:

PCOAH_00029880

CPV:

cgd7_1830

CHO:	Chro.70213

TGO:	TGME49_218200

BBES:

BESB_039100

TET:	TTHERM_00929520 TTHERM_00951720

PTM:	GSPATT00032995001

PTI:	PHATRDRAFT_23639 PHATRDRAFT_54493

FCY:	FRACYDRAFT_211962(USP2) FRACYDRAFT_237242(USP1)

TPS:	THAPSDRAFT_13482 THAPSDRAFT_42326

AAF:	AURANDRAFT_22705 AURANDRAFT_23667 AURANDRAFT_28944 AURANDRAFT_70780

PIF:	PITG_10315

PSOJ:

PHYSODRAFT_312734

EHX:	EMIHUDRAFT_426133 EMIHUDRAFT_427850 EMIHUDRAFT_454930 EMIHUDRAFT_51739 EMIHUDRAFT_68020 EMIHUDRAFT_74985

GTT:	GUITHDRAFT_115181 GUITHDRAFT_157482 GUITHDRAFT_159419

TCR:	503493.10 511761.10

LMA:	LMJF_17_1160(USP)

LIF:	LINJ_17_1260(USP)

LDO:	LDBPK_171260

LMI:	LMXM_17_1160

LMAT:

92515557(LSCM1_05597)

LBZ:	LBRM_17_1270(USP)

LPAN:

LPMP_171130(USP)

LOI:	92362805(LSCM4_06964)

CAA:

Caka_1908

VBS:	EGM51_17175

» show all

Reference

1 [PMID:15326166]

Authors

Kotake T, Yamaguchi D, Ohzono H, Hojo S, Kaneko S, Ishida HK, Tsumuraya Y

Title

UDP-sugar pyrophosphorylase with broad substrate specificity toward various monosaccharide 1-phosphates from pea sprouts.

Journal

J Biol Chem 279:45728-36 (2004)
DOI:10.1074/jbc.M408716200

Sequence

[ag:BAD66876]

Reference

2 [PMID:4430676]

Authors

Rudick VL, Weisman RA.

Title

Uridine diphosphate glucose pyrophosphorylase of Acanthamoeba castellanii. Purification, kinetic, and developmental studies.

Journal

J Biol Chem 249:7832-40 (1974)

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.64

IUBMB Enzyme Nomenclature:

2.7.7.64

ExPASy - ENZYME nomenclature database:

2.7.7.64

BRENDA, the Enzyme Database:

2.7.7.64

LinkDB

REACTION: R01381

Entry

R01381                      Reaction

Name

UTP:1-phospho-alpha-D-glucuronate uridylyltransferase

Definition

UTP + D-Glucuronate 1-phosphate <=> Diphosphate + UDP-glucuronate

Equation

C00075 + C05385 <=> C00013 + C00167

Reaction class

RC00002

C00167_C05385

Enzyme

2.7.7.44 2.7.7.64

Pathway

rn00040

Pentose and glucuronate interconversions

rn00053

Ascorbate and aldarate metabolism

rn00520

Amino sugar and nucleotide sugar metabolism

rn01100

Metabolic pathways

rn01250

Biosynthesis of nucleotide sugars

Module

M00014

Glucuronate pathway (uronate pathway)

Brite

Enzymatic reactions [BR:br08201]
2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.44
     R01381  UTP + D-Glucuronate 1-phosphate <=> Diphosphate + UDP-glucuronate
    2.7.7.64
     R01381  UTP + D-Glucuronate 1-phosphate <=> Diphosphate + UDP-glucuronate
IUBMB reaction hierarchy [BR:br08202]
2. Transferase reactions
  2.7.7.64
   R08845  alpha-D-Aldose 1-phosphate <=> UDP-sugar
    R01381  D-Glucuronate 1-phosphate <=> UDP-glucuronate

Orthology

K12447

UDP-sugar pyrophosphorylase [EC:2.7.7.64]

Other DBs

RHEA:

16328

LinkDB

DBGET integrated database retrieval system