KEGG ORTHOLOGY: K12467

ORTHOLOGY: K12467

Entry

K12467                      KO

Symbol

E4.2.3.15

Name

myrcene/ocimene synthase [EC:4.2.3.15]

Pathway

map00902

Monoterpenoid biosynthesis

map01110

Biosynthesis of secondary metabolites

Reaction

R02009

geranyldiphosphate diphosphate-lyase (myrcene-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K12467  E4.2.3.15; myrcene/ocimene synthase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.15  myrcene synthase
     K12467  E4.2.3.15; myrcene/ocimene synthase

Other DBs

GO:

0050551

Genes

ATH:	AT2G24210(TPS10) AT3G25810

CRB:	17889158 17889311

CSAT:

104702938

BRP:	103858386 103858582

BNA:	106385578 106402047 106443840

BOE:	106328108 106334082

RSZ:	108837661 108846403 108846672

TWL:

119980547

AG:	AAB71084(ag2)

Reference

PMID:9268308

Authors

Bohlmann J, Steele CL, Croteau R

Title

Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.

Journal

J Biol Chem 272:21784-92 (1997)
DOI:10.1074/jbc.272.35.21784

Sequence

[ag:AAB71084]

Reference

PMID:12566586

Authors

Chen F, Tholl D, D'Auria JC, Farooq A, Pichersky E, Gershenzon J

Title

Biosynthesis and emission of terpenoid volatiles from Arabidopsis flowers.

Journal

Plant Cell 15:481-94 (2003)
DOI:10.1105/tpc.007989

LinkDB

ORTHOLOGY: K21925

Entry

K21925                      KO

Symbol

TPS3

Name

(-)-camphene/tricyclene/(4S)-limonene/myrcene synthase [EC:4.2.3.117 4.2.3.105 4.2.3.16 4.2.3.15]

Pathway

map00902

Monoterpenoid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R02009

geranyldiphosphate diphosphate-lyase (myrcene-forming)

R02013

geranyl-diphosphate diphosphate-lyase [cyclizing; (4S)-limonene-forming]

R09972

geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-camphene-forming]

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00902 Monoterpenoid biosynthesis
    K21925  TPS3; (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
Enzymes [BR:ko01000]
4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.15  myrcene synthase
     K21925  TPS3; (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
    4.2.3.16  (4S)-limonene synthase
     K21925  TPS3; (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
    4.2.3.105  tricyclene synthase
     K21925  TPS3; (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
    4.2.3.117  (-)-camphene synthase
     K21925  TPS3; (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase

Other DBs

GO:	0102703 0102701 0050552 0050551

Genes

SLY:	101245212(TPS3) 101249864

SPEN:

107012939 107012948

SOT:	102591915 102602070

SSTN:

125861389 125861571

CANN:

107840093

LBB:

132598839

NTA:	107785945 107787835

NSY:

NTO:

NAU:

SMIL:

SHIS:

125185612 125200997 125204274 125208619 125218604 125219856

» show all

Reference

PMID:21813655

Authors

Falara V, Akhtar TA, Nguyen TT, Spyropoulou EA, Bleeker PM, Schauvinhold I, Matsuba Y, Bonini ME, Schilmiller AL, Last RL, Schuurink RC, Pichersky E

Title

The tomato terpene synthase gene family.

Journal

Plant Physiol 157:770-89 (2011)
DOI:10.1104/pp.111.179648

Sequence

[sly:101245212]

LinkDB

ENZYME: 4.2.3.15

Entry

EC 4.2.3.15                 Enzyme

Name

myrcene synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

geranyl-diphosphate diphosphate-lyase (myrcene-forming)

Reaction(IUBMB)

geranyl diphosphate = myrcene + diphosphate [RN:R02009]

Reaction(KEGG)

R02009

Substrate

geranyl diphosphate [CPD:C00341]

Product

myrcene [CPD:C06074];
diphosphate [CPD:C00013]

Comment

A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.

History

EC 4.2.3.15 created 2000 as EC 4.1.99.9, transferred 2000 to EC 4.2.3.15

Pathway

ec00902

Monoterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K12467

myrcene/ocimene synthase

K21925

(-)-camphene/tricyclene/(4S)-limonene/myrcene synthase

Genes

ATH:	AT2G24210(TPS10) AT3G25810

CRB:	17889158 17889311

CSAT:

104702938

BRP:	103858386 103858582

BNA:	106385578 106402047 106443840

BOE:	106328108 106334082

RSZ:	108837661 108846403 108846672

TWL:

119980547

SLY:	101245212(TPS3) 101249864

SPEN:

107012939 107012948

SOT:	102591915 102602070

SSTN:

125861389 125861571

CANN:

107840093

LBB:

132598839

NTA:	107785945 107787835

NSY:

104238653

NTO:

104090536

NAU:

109214608

SMIL:

131005775

SHIS:

125185612 125200997 125204274 125208619 125218604 125219856

CJF:

131027736 131030273 131030284 131036390 131040614 131042617 131042631 131042632 131042634 131042635 131042678 131042692 131042757 131046574 131049606 131050055 131051798 131051812 131051813 131053066 131053802 131054885 131056546 131056704 131058258 131058925 131058926 131058927 131058928 131060558 131061200 131064577 131065313 131065363 131066127 131066129 131066130 131066145 131066146 131067592 131067684 131067686 131067688 131067689 131067913 131067914 131068917 131068918 131068927 131068928 131068932 131068933 131068962 131068963 131068964 131068965 131070110 131073180 131073183 131073184 131073222 131073234 131073236 131073238 131076545 131079059 131079061 131856196 131862178 131863424 131873601 131873643

» show all

Reference

1 [PMID:9268308]

Authors

Bohlmann J, Steele CL, Croteau R

Title

Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.

Journal

J Biol Chem 272:21784-92 (1997)
DOI:10.1074/jbc.272.35.21784

Sequence

[ag:AAB71084]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.15

IUBMB Enzyme Nomenclature:

4.2.3.15

ExPASy - ENZYME nomenclature database:

4.2.3.15

BRENDA, the Enzyme Database:

4.2.3.15

CAS:	197462-59-2

LinkDB

REACTION: R02009

Entry

R02009                      Reaction

Name

geranyldiphosphate diphosphate-lyase (myrcene-forming)

Definition

Geranyl diphosphate <=> Myrcene + Diphosphate

Equation

C00341 <=> C06074 + C00013

Comment

myrcene synthase

Reaction class

RC00637

C00341_C06074

Enzyme

4.2.3.15

Pathway

rn00902

Monoterpenoid biosynthesis

rn01110

Biosynthesis of secondary metabolites

Brite

Enzymatic reactions [BR:br08201]
4. Lyase reactions
  4.2  Carbon-oxygen lyases
   4.2.3  Acting on phosphates
    4.2.3.15
     R02009  Geranyl diphosphate <=> Myrcene + Diphosphate

Orthology

K12467

myrcene/ocimene synthase [EC:4.2.3.15]

K21925

(-)-camphene/tricyclene/(4S)-limonene/myrcene synthase [EC:4.2.3.117 4.2.3.105 4.2.3.16 4.2.3.15]

Reference

1 [PMID:10700382]

Authors

Bohlmann J, Martin D, Oldham NJ, Gershenzon J.

Title

Terpenoid secondary metabolism in Arabidopsis thaliana: cDNA cloning, characterization, and functional expression of a myrcene/(E)-beta-ocimene synthase.

Journal

Arch Biochem Biophys 375:261-9 (2000)
DOI:10.1006/abbi.1999.1669

Other DBs

RHEA:

16968

LinkDB

DBGET integrated database retrieval system