Entry
Symbol
metL
Name
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4 1.1.1.3 ]
Pathway
map00260 Glycine, serine and threonine metabolism
map00270 Cysteine and methionine metabolism
map01110 Biosynthesis of secondary metabolites
map01120 Microbial metabolism in diverse environments
Module
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
M00017 Methionine biosynthesis, aspartate => homoserine => methionine
M00018 Threonine biosynthesis, aspartate => homoserine => threonine
M00526 Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine
M00527 Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine
Reaction
R00480 ATP:L-aspartate 4-phosphotransferase
R01773 L-homoserine:NAD+ oxidoreductase
R01775 L-homoserine:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
K12525 metL; bifunctional aspartokinase / homoserine dehydrogenase 2
00270 Cysteine and methionine metabolism
K12525 metL; bifunctional aspartokinase / homoserine dehydrogenase 2
00300 Lysine biosynthesis
K12525 metL; bifunctional aspartokinase / homoserine dehydrogenase 2
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
K12525 metL; bifunctional aspartokinase / homoserine dehydrogenase 2
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
K12525 metL; bifunctional aspartokinase / homoserine dehydrogenase 2
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
K12525 metL; bifunctional aspartokinase / homoserine dehydrogenase 2
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Genes
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Taxonomy UniProt
Reference
Authors
Zakin MM, Duchange N, Ferrara P, Cohen GN
Title
Nucleotide sequence of the metL gene of Escherichia coli. Its product, the bifunctional aspartokinase ii-homoserine dehydrogenase II, and the bifunctional product of the thrA gene, aspartokinase I-homoserine dehydrogenase I, derive from a common ancestor.
Journal
J Biol Chem 258:3028-31 (1983)
Sequence
LinkDB
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