KEGG ORTHOLOGY: K12552

ORTHOLOGY: K12552

Entry

K12552                      KO

Symbol

pbpA

Name

penicillin-binding protein 1 [EC:3.4.-.-]

Pathway

map00550

Peptidoglycan biosynthesis

map01100

Metabolic pathways

map01501

beta-Lactam resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    K12552  pbpA; penicillin-binding protein 1
09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K12552  pbpA; penicillin-binding protein 1
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins
    K12552  pbpA; penicillin-binding protein 1
Peptidoglycan biosynthesis and degradation proteins [BR:ko01011]
Peptidoglycan biosynthesis and degradation
  DD-Transpeptidase (Class B PBP)
   K12552  pbpA; penicillin-binding protein 1

Other DBs

COG:

COG0768

GO:

0008658

Genes

SDO:	SD1155_08065

SAU:	SA1024(pbpA)

SAV:	SAV1181(pbpA)

SAW:	SAHV_1171(pbpA)

SAH:	SaurJH1_1265

SAJ:	SaurJH9_1240

SAM:	MW1064(pbpA)

SAS:

SAS1115

SAR:	SAR1157(pbpA)

SAC:	SACOL1194(pbp1)

SAX:	USA300HOU_1121(pbpA)

SAA:	SAUSA300_1075(pbpA)

SAO:	SAOUHSC_01145

SAE:	NWMN_1091(pbpA)

SAD:	SAAV_1152(pbp1)

SUU:	M013TW_1115

SUV:	SAVC_05070

SUE:

SAOV_1182

SUJ:	SAA6159_01032

SUK:	SAA6008_01135(pbpA)

SUC:	ECTR2_1037

SUT:	SAT0131_01226

SUQ:	HMPREF0772_12051

SUZ:

MS7_1138

SUD:	ST398NM01_1178

SUX:	SAEMRSA15_10140(pbpA)

SUW:	SATW20_11750(pbpA)

SUG:

SAPIG1178

SUF:	SARLGA251_10920(pbpA)

SAUA:

SAAG_01779

SAUE:

RSAU_001062(pbp1)

SAUN:

SAKOR_01107

SAUS:

SA40_1052(pbpA)

SAUU:

SA957_1067(pbpA)

SAUG:

SA268_1071(pbpA)

SAUZ:

SAZ172_1183(pbpA)

SAUT:

SAI1T1_2008370(pbpA)

SAUJ:

SAI2T2_1008390(pbpA)

SAUK:

SAI3T3_1008380(pbpA)

SAUQ:

SAI4T8_1008370(pbpA)

SAUV:

SAI7S6_1008380(pbpA)

SAUW:

SAI5S5_1008340(pbpA)

SAUX:

SAI6T6_1008350(pbpA)

SAUY:

SAI8T7_1008380(pbpA)

SAUF:

X998_1180

SAB:	SAB1045(pbpA)

SUY:	SA2981_1139(ftsI)

SAUB:

C248_1210(pbpA)

SAUM:

SAUC:

SAUR:

SAUI:

SAUD:

SAMS:

SUH:	SAMSHR1132_10230

SER:	SERP0746(pbp1)

SEP:

SE_0856

SEPP:

SEB_00835

SEPS:

DP17_2188

SHA:	SH1734(pbpA)

SHH:	ShL2_01667(pbpA)

SSP:

SSP1590

SCA:	SCA_0794(pbpA)

SLG:	SLGD_01722

SLN:	SLUG_17190(pbpA)

SSD:	SPSINT_0879

SDT:	SPSE_1628(pbp1)

SDP:	NCTC12225_01867(pbp1)

SWA:	A284_07710

SPAS:

STP1_2212

SXL:	SXYLSMQ121_1631

SXO:	SXYL_01707(pbp1)

SHU:	SHYC_08520

SCAP:

AYP1020_0489(pbpB)

SSCH:

SSCZ:

SAGQ:

SEQO:

SSIF:

SCV:	A4G25_03425

SPET:

CEP67_00605

SLZ:	B5P37_09940

SCOH:

BZ166_00095

SURY:

MUA21_04290

SNL:	BJD96_09135

SKL:	C7J89_09930

SFQ:	C7J90_07675

SHOM:

SMUS:

SCAR:

SARL:

SPIC:

SAMEA4384060_1774(pbpA)

SSH:	NCTC13712_01126(pbpX)

SSIM:

SAMEA4384339_1069(ftsI_1)

SDB:	CNQ82_05800

SLLO:

SAUL:

SSAC:

SRAI:

SPSD:

STAS:

SEDA:

SCAQ:

SDEV:

SROT:

STAP:

SHSI:

SSCU:

SFF:	FOB90_11565

SSTE:

SAMEA4384403_1650(pbpA)

MLEN:

H3V22_00280

MVT:	I6J10_03030

MACR:

MARY:

MBRU:

MEPI:

MEQU:

MBOC:

MCL:	MCCL_0753(pbpA)

MCAK:

MCCS_09820

MBOE:

HT586_05150

SHV:	AAT16_05405

JEA:	JEM45_03980

NAMP:

KPF49_02445

NMY:	CJ229_000220

SBAC:

BVH56_05325

GOT:	AXE85_03550

GMO:	NCTC11323_01095(pbpX)

GEQ:	CG018_05690

GSA:	FOC50_07410

GHA:	NCTC10459_00672(pbpX)

» show all

Reference

PMID:16304175

Authors

Fuller E, Elmer C, Nattress F, Ellis R, Horne G, Cook P, Fawcett T

Title

Beta-lactam resistance in Staphylococcus aureus cells that do not require a cell wall for integrity.

Journal

Antimicrob Agents Chemother 49:5075-80 (2005)
DOI:10.1128/AAC.49.12.5075-5080.2005

Sequence

[sao:SAOUHSC_01145]

LinkDB

ORTHOLOGY: K12553

Entry

K12553                      KO

Symbol

pbp3

Name

penicillin-binding protein 3 [EC:3.4.-.-]

Pathway

map00550

Peptidoglycan biosynthesis

map01100

Metabolic pathways

map01501

beta-Lactam resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    K12553  pbp3; penicillin-binding protein 3
09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K12553  pbp3; penicillin-binding protein 3
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins
    K12553  pbp3; penicillin-binding protein 3
Peptidoglycan biosynthesis and degradation proteins [BR:ko01011]
Peptidoglycan biosynthesis and degradation
  DD-Transpeptidase (Class B PBP)
   K12553  pbp3; penicillin-binding protein 3

Other DBs

COG:

COG0768

GO:

0008658

Genes

SDO:	SD1155_09845

SAU:	SA1381(pbp3)

SAV:	SAV1552(pbp3)

SAW:	SAHV_1539(pbp3)

SAH:	SaurJH1_1644

SAJ:	SaurJH9_1610

SAM:	MW1504(pbp3)

SAS:

SAS1490

SAR:	SAR1629(pbpF)

SAC:	SACOL1609(pbp3)

SAX:	USA300HOU_1554(pbp3)

SAA:	SAUSA300_1512(pbp3)

SAO:	SAOUHSC_01652

SAE:	NWMN_1455(pbpC)

SAD:	SAAV_1544(pbp3)

SUU:	M013TW_1567

SUV:	SAVC_07010

SUE:

SAOV_1552

SUJ:	SAA6159_01487

SUK:	SAA6008_01521(pbp3)

SUC:	ECTR2_1402

SUT:	SAT0131_01646

SUQ:	HMPREF0772_11588

SUZ:

MS7_1569

SUD:	ST398NM01_1617

SUX:	SAEMRSA15_14720(pbpF)

SUW:	SATW20_15480(pbpF)

SUG:

SAPIG1617

SUF:	SARLGA251_14580(pbpF)

SAUA:

SAAG_01466

SAUE:

RSAU_001417(pbp3)

SAUN:

SAKOR_01499

SAUS:

SA40_1423(pbpF)

SAUU:

SA957_1506(pbpF)

SAUG:

SA268_1510(pbpF)

SAUZ:

SAZ172_1565(pbp3)

SAUT:

SAI1T1_2011250(pbp3)

SAUJ:

SAI2T2_1011270(pbp3)

SAUK:

SAI3T3_1011250(pbp3)

SAUQ:

SAI4T8_1011260(pbp3)

SAUV:

SAI7S6_1011270(pbp3)

SAUW:

SAI5S5_1011220(pbp3)

SAUX:

SAI6T6_1011230(pbp3)

SAUY:

SAI8T7_1011260(pbp3)

SAUF:

X998_1577

SAB:	SAB1424c(pbpF)

SUY:	SA2981_1510(ftsI)

SAUB:

C248_1595(pbpF)

SAUM:

SAUC:

SAUR:

SAUI:

SAUD:

SAMS:

SUH:	SAMSHR1132_13920

SER:	SERP1117(pbp3)

SEP:

SE_1238

SEPP:

SEB_01258

SEPS:

DP17_196

SHA:	SH1364(pbp3)

SHH:	ShL2_01247(pbp3)

SSP:

SSP1204

SCA:	SCA_1173(pbpF)

SLG:	SLGD_01363

SLN:	SLUG_13590(pbpF)

SSD:	SPSINT_1316

SDT:	SPSE_1240(pbp3)

SDP:	NCTC12225_01456(pbp3)

SWA:	A284_05955

SPAS:

STP1_0129

SXY:	BE24_05100

SXL:	SXYLSMQ121_1240

SXO:	SXYL_01304(pbp3)

SHU:	SHYC_06795(pbp3)

SCAP:

AYP1020_0850(pbpH)

SSCH:

SAGQ:

SEQO:

SSIF:

SPET:

SLZ:	B5P37_00110

SCOH:

BZ166_10615

SURY:

MUA21_06490

SNL:	BJD96_06585

SKL:	C7J89_08115

SFQ:	C7J90_09335

SHOM:

SMUS:

SCAR:

SCHR:

SARL:

SPIC:

SAMEA4384060_1396(pbpF)

SSH:	NCTC13712_01549(pbpH)

SSIM:

SAMEA4384339_1443(ftsI_2)

SDB:	CNQ82_07705

SLLO:

SAUL:

SSAC:

SRAI:

SPSD:

STAS:

SEDA:

SCAQ:

SDEV:

SROT:

STAP:

SHSI:

SSCU:

SFF:	FOB90_01730

SSTE:

SAMEA4384403_1214(pbp3)

MLEN:

H3V22_02795

MVT:	I6J10_05240

MARY:

MBRU:

MEPI:

MEQU:

MBOC:

MCL:	MCCL_1199(pbpC)

MCAK:

MCCS_14850

MBOE:

HT586_07745

SHV:	AAT16_06990

JEA:	JEM45_02350

NAMP:

KPF49_03840

NMY:	CJ229_001595

SBAC:

BVH56_03670

» show all

Reference

PMID:10648534

Authors

Pinho MG, de Lencastre H, Tomasz A

Title

Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus.

Journal

J Bacteriol 182:1074-9 (2000)
DOI:10.1128/JB.182.4.1074-1079.2000

Sequence

[sao:SAOUHSC_01652]

LinkDB

ORTHOLOGY: K02545

Entry

K02545                      KO

Symbol

mecA

Name

penicillin-binding protein 2 prime [EC:3.4.16.4]

Pathway

map00550

Peptidoglycan biosynthesis

map01100

Metabolic pathways

map01501

beta-Lactam resistance

Module

M00625

Methicillin resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    K02545  mecA; penicillin-binding protein 2 prime
09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K02545  mecA; penicillin-binding protein 2 prime
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins
    K02545  mecA; penicillin-binding protein 2 prime
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K02545  mecA; penicillin-binding protein 2 prime
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.16  Serine-type carboxypeptidases
    3.4.16.4  serine-type D-Ala-D-Ala carboxypeptidase
     K02545  mecA; penicillin-binding protein 2 prime
Peptidoglycan biosynthesis and degradation proteins [BR:ko01011]
Peptidoglycan biosynthesis and degradation
  DD-Transpeptidase (Class B PBP)
   K02545  mecA; penicillin-binding protein 2 prime
Antimicrobial resistance genes [BR:ko01504]
Gene sets
  beta-Lactam resistance modules
   Methicillin resistance
    K02545  mecA; penicillin-binding protein 2 prime

Other DBs

COG:

COG0768

GO:	0008658 0009002

Genes

SAU:	SA0038(mecA)

SAV:	SAV0041(mecA)

SAW:	SAHV_0040(mecA)

SAH:	SaurJH1_0029

SAJ:	SaurJH9_0029

SAM:	MW0031(mecA)

SAR:	SAR0039(mecA)

SAC:	SACOL0033(mecA)

SAX:	USA300HOU_0031(mecA)

SAA:	SAUSA300_0032(mecA)

SUU:	M013TW_0045(mecA)

SUJ:	SAA6159_00031(mecA)

SUK:	SAA6008_00039(mecA)

SUT:	SAT0131_00034

SUQ:	HMPREF0772_10435

SUZ:	MS7_0033(mecA)

SUX:	SAEMRSA15_00310(mecA)

SUW:	SATW20_00740(mecA)

SUG:

SAPIG0042

SUF:	SARLGA251_00260(mecA)

SAUN:

SAKOR_00039

SAUS:

SA40_0033(mecA)

SAUU:

SA957_0040(mecA)

SAUG:

SA268_0042(mecA)

SAUZ:

SAZ172_0072(mecA)

SAUT:

SAI1T1_2000270(mecA)

SAUJ:

SAI2T2_1000270(mecA)

SAUK:

SAI3T3_1000270(mecA)

SAUQ:

SAI4T8_1000270(mecA)

SAUV:

SAI7S6_1000270(mecA)

SAUW:

SAI5S5_1000270(mecA)

SAUX:

SAI6T6_1000270(mecA)

SAUY:

SAI8T7_1000270(mecA)

SAUF:

X998_0034

SUY:	SA2981_0039(mecA)

SAUB:

C248_0036(mecA)

SAUM:

BN843_630

SAUC:

CA347_39(mecA)

SAUR:

SABB_01772(pbp)

SAMS:

NI36_00210

SUH:	SAMSHR1132_00320

SER:	SERP2521(mecA)

SHA:	SH0091(mecA)

SHH:	ShL2_00029(mecA)

SSCZ:

RN70_00210

STAS:

HYI43_00225(mecA)

SEDA:

MNY58_00150(mecC)

SSCU:

CEP64_13620

MLEN:

H3V22_09070(mecA)

MARY:

LAU42_01295(mecD)

MEPI:

KFV12_00185(mecB)

MEQU:

KFV11_00280(mecB)

MCL:	MCCL_plsB0023(mecAm)

MCAK:

MCCS_00770

MBOE:

HT586_00310(mecD)

SHV:	AAT16_11340

» show all

Reference

PMID:19685276

Authors

Turutoglu H, Hasoksuz M, Ozturk D, Yildirim M, Sagnak S

Title

Methicillin and aminoglycoside resistance in Staphylococcus aureus isolates from bovine mastitis and sequence analysis of their mecA genes.

Journal

Vet Res Commun 33:945-56 (2009)
DOI:10.1007/s11259-009-9313-5

Sequence

[sau:SA0038]

LinkDB

DBGET integrated database retrieval system