KEGG   ORTHOLOGY: K12677
Entry
K12677                      KO                                     
Symbol
car
Name
clavulanate-9-aldehyde reducatase
Pathway
map00331  Clavulanic acid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R05471  clavulanate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00331 Clavulanic acid biosynthesis
    K12677  car; clavulanate-9-aldehyde reducatase
Genes
SFA: Sfla_0547
STRP: F750_6333
SCLF: BB341_07840
SVI: Svir_33490
AG: CAA04227(car)
Reference
PMID:9602162
  Authors
Perez-Redondo R, Rodriguez-Garcia A, Martin JF, Liras P
  Title
The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.
  Journal
Gene 211:311-21 (1998)
DOI:10.1016/S0378-1119(98)00106-1
  Sequence
[ag:CAA04227]
LinkDB

KEGG   REACTION: R05471
Entry
R05471                      Reaction                               
Name
clavulanate:NADP+ oxidoreductase
Definition
Clavulanate-9-aldehyde + NADPH + H+ <=> Clavulanic acid + NADP+
Equation
C06661 + C00005 + C00080 <=> C06662 + C00006
Comment
car, clavulanate-9-aldehyde reductase
cad, clavulanic acid dehydrogenase
Reaction class
RC00001  C00005_C00006
RC00649  C06661_C06662
Pathway
rn00331  Clavulanic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K12677  clavulanate-9-aldehyde reducatase
Reference
1  [PMID:9614345]
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7
Other DBs
RHEA: 42071
LinkDB

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