KEGG   ORTHOLOGY: K12702
Entry
K12702                      KO                                     
Symbol
novI, CYP163A
Name
novobiocin biosynthesis protein NovI
Pathway
map00401  Novobiocin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06752  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12702  novI, CYP163A; novobiocin biosynthesis protein NovI
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K12702  novI, CYP163A; novobiocin biosynthesis protein NovI
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, bacteria type
  CYP163 family
   K12702  novI, CYP163A; novobiocin biosynthesis protein NovI
Other DBs
COG: COG2124
Genes
STAA: LDH80_10555
STPB: QR97_26085 QR97_26120
SCAJ: O1G22_18790
NGV: CDO52_02185
AG: AAF67502(novI) AAG29781(couI) AAN65225(cloI)
Reference
PMID:10770754
  Authors
Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L
  Title
Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.
  Journal
Antimicrob Agents Chemother 44:1214-22 (2000)
DOI:10.1128/AAC.44.5.1214-1222.2000
  Sequence
[ag:AAF67502]
Reference
PMID:16171397
  Authors
Pacholec M, Hillson NJ, Walsh CT
  Title
NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis.
  Journal
Biochemistry 44:12819-26 (2005)
DOI:10.1021/bi051297m
LinkDB

KEGG   REACTION: R06752
Entry
R06752                      Reaction                               
Definition
L-Tyrosyl-[pcp] + Oxygen <=> beta-Hydroxy-L-tyrosyl-[pcp] + H2O
Equation
C12461 + C00007 <=> C12462 + C00001
Comment
monooxygenase, NovI CloI CouI
Reaction class
RC01680  C12461_C12462
Pathway
rn00401  Novobiocin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K12702  novobiocin biosynthesis protein NovI
LinkDB

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