KEGG   ORTHOLOGY: K12703
Entry
K12703                      KO                                     
Symbol
novJ
Name
novobiocin biosynthesis protein NovJ
Pathway
map00401  Novobiocin biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06753  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12703  novJ; novobiocin biosynthesis protein NovJ
Genes
NGV: CDO52_02190
AG: AAF67503(novJ) AAG29782(couJ) AAN65226(cloJ)
Reference
PMID:16171397
  Authors
Pacholec M, Hillson NJ, Walsh CT
  Title
NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis.
  Journal
Biochemistry 44:12819-26 (2005)
DOI:10.1021/bi051297m
LinkDB

KEGG   REACTION: R06753
Entry
R06753                      Reaction                               
Definition
beta-Hydroxy-L-tyrosyl-[pcp] <=> beta-Keto-L-tyrosyl-[pcp]
Equation
C12462 <=> C12463
Comment
3-ketoacyl reductase, NovJ CloJ CouJ
reductase, NovK CloK CouK
Reaction class
RC01681  C12462_C12463
Pathway
rn00401  Novobiocin biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K12703  novobiocin biosynthesis protein NovJ
K12704  novobiocin biosynthesis protein NovK
LinkDB

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