KEGG ORTHOLOGY: K12705

ORTHOLOGY: K12705

Entry

K12705            Tight     KO

Symbol

novO, couO

Name

8-demethylnovobiocic acid C8-methyltransferase [EC:2.1.1.284]

Pathway

map00401

Novobiocin biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Reaction

R06778

R10454

S-adenosyl-L-methionine:8-demethylnovobiocic acid C8-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00401 Novobiocin biosynthesis
    K12705  novO, couO; 8-demethylnovobiocic acid C8-methyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.284  8-demethylnovobiocic acid C8-methyltransferase
     K12705  novO, couO; 8-demethylnovobiocic acid C8-methyltransferase

Genes

AG:	AAF67508(novO) AAG29793(couO)

Reference

PMID:10770754

Authors

Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L

Title

Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.

Journal

Antimicrob Agents Chemother 44:1214-22 (2000)
DOI:10.1128/AAC.44.5.1214-1222.2000

Sequence

[ag:AAF67508]

Reference

PMID:18663394

Authors

Sattely ES, Fischbach MA, Walsh CT

Title

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.

Journal

Nat Prod Rep 25:757-93 (2008)
DOI:10.1039/b801747f

LinkDB

REACTION: R06778

Entry

R06778                      Reaction

Definition

5-[[(4,7-Dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]carbonyl]-4-methyl-1H-pyrrole-3-carboxylate + 3-Amino-4,7-dihydroxycoumarin + ATP + 2 S-Adenosyl-L-methionine <=> Coumermic acid + AMP + Diphosphate + 2 S-Adenosyl-L-homocysteine

Equation

C20637 + C12468 + C00002 + 2 C00019 <=> C12479 + C00020 + C00013 + 2 C00021