KEGG   ORTHOLOGY: K12901
Entry
K12901            Tight     KO                                     
Symbol
fomC
Name
phosphonoacetaldehyde reductase
Pathway
map00440  Phosphonate and phosphinate metabolism
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K12901  fomC; phosphonoacetaldehyde reductase
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K12901  fomC; phosphonoacetaldehyde reductase
Other DBs
RN: R08861
Genes
AG: BAA32497(fomC)
Reference
  Authors
Metcalf WW, van der Donk WA
  Title
Biosynthesis of phosphonic and phosphinic acid natural products.
  Journal
Annu Rev Biochem 78:65-94 (2009)
DOI:10.1146/annurev.biochem.78.091707.100215
Reference
  Authors
Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H
  Title
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster.
  Journal
Chem Biol 13:1171-82 (2006)
DOI:10.1016/j.chembiol.2006.09.007
LinkDB

KEGG   REACTION: R08861
Entry
R08861                      Reaction                               
Definition
Phosphonoacetaldehyde + NADPH + H+ <=> 2-Hydroxyethylphosphonate + NADP+
Equation
Comment
PnAA reductase
Reaction class
RC00001  C00005_C00006
RC00087  C03167_C06451
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn00998  Biosynthesis of various antibiotics
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Orthology
K12901  phosphonoacetaldehyde reductase
LinkDB

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