KEGG   ORTHOLOGY: K12926
Entry
K12926            Tight     KO                                     
Symbol
DBAT
Name
10-deacetylbaccatin III 10-O-acetyltransferase [EC:2.3.1.167]
Pathway
map00904  Diterpenoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06311  acetyl-CoA:taxan-10beta-ol O-transferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00904 Diterpenoid biosynthesis
    K12926  DBAT; 10-deacetylbaccatin III 10-O-acetyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.167  10-deacetylbaccatin III 10-O-acetyltransferase
     K12926  DBAT; 10-deacetylbaccatin III 10-O-acetyltransferase
Other DBs
GO: 0050643
Genes
AG: AAF27621(DBAT)
Reference
PMID:10639122
  Authors
Walker K, Croteau R
  Title
Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 97:583-7 (2000)
DOI:10.1073/pnas.97.2.583
  Sequence
[ag:AAF27621]
LinkDB

KEGG   ENZYME: 2.3.1.167
Entry
EC 2.3.1.167                Enzyme                                 
Name
10-deacetylbaccatin III 10-O-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:taxan-10beta-ol O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III [RN:R06311]
Reaction(KEGG)
R06311
Substrate
acetyl-CoA [CPD:C00024];
10-deacetylbaccatin III [CPD:C11700]
Product
CoA [CPD:C00010];
baccatin III [CPD:C11900]
Comment
The enzyme will not acylate the hydroxy group at 1beta, 7beta or 13alpha of 10-deacetyl baccatin III, or at 5alpha of taxa-4(20),11-dien-5alpha-ol. May be identical to EC 2.3.1.163, 10-hydroxytaxane O-acetyltransferase.
History
EC 2.3.1.167 created 2002
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12926  10-deacetylbaccatin III 10-O-acetyltransferase
Reference
1  [PMID:10639122]
  Authors
Walker K, Croteau R
  Title
Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 97:583-7 (2000)
DOI:10.1073/pnas.97.2.583
  Sequence
[ag:AAF27621]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.167
IUBMB Enzyme Nomenclature: 2.3.1.167
ExPASy - ENZYME nomenclature database: 2.3.1.167
BRENDA, the Enzyme Database: 2.3.1.167
CAS: 220946-63-4
LinkDB

KEGG   REACTION: R06311
Entry
R06311                      Reaction                               
Name
acetyl-CoA:taxan-10beta-ol O-transferase
Definition
10-Deacetylbaccatin III + Acetyl-CoA <=> Baccatin III + CoA
Equation
C11700 + C00024 <=> C11900 + C00010
Reaction class
RC00004  C00010_C00024
RC00055  C11700_C11900
Enzyme
2.3.1.167
Pathway
rn00904  Diterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.167
     R06311  10-Deacetylbaccatin III + Acetyl-CoA <=> Baccatin III + CoA
Orthology
K12926  10-deacetylbaccatin III 10-O-acetyltransferase [EC:2.3.1.167]
Other DBs
RHEA: 20140
LinkDB

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