Entry Name abieta-7,13-diene synthase;
Class Lyases;BRITE hierarchy
Sysname (+)-copalyl-diphosphate diphosphate-lyase [cyclizing, abieta-7,13-diene-forming]
Reaction(IUBMB) (+)-copalyl diphosphate = abieta-7,13-diene + diphosphate [RN:
R06301 ]
Reaction(KEGG) Substrate (+)-copalyl diphosphate [CPD:
C11901 ]
Product Comment Part of a bifunctional enzyme involved in the biosynthesis of abietadiene. See also EC
5.5.1.12 , copalyl diphosphate synthase. Requires Mg2+.
History EC 4.2.3.18 created 2002, modified 2012
Pathway ec01110 Biosynthesis of secondary metabolites
Orthology K12927 abietadiene/neoabietadiene/copalyl diphosphate synthase
Reference Authors Peters RJ, Flory JE, Jetter R, Ravn MM, Lee HJ, Coates RM, Croteau RB.
Title Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme.
Journal Sequence Reference Authors Peters RJ1, Ravn MM, Coates RM, Croteau RB
Title Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites.
Journal Sequence Reference Authors Peters RJ, Croteau RB.
Title Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement.
Journal Sequence Reference Authors Peters RJ, Croteau RB.
Title Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate.
Journal Sequence Reference Authors Ravn MM, Peters RJ, Coates RM, Croteau R.
Title Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates.
Journal Other DBs ExplorEnz - The Enzyme Database: 4.2.3.18
ExPASy - ENZYME nomenclature database: 4.2.3.18
LinkDB All DBs
