KEGG   ORTHOLOGY: K13064
Entry
K13064                      KO                                     
Symbol
PTAL
Name
phenylalanine/tyrosine ammonia-lyase [EC:4.3.1.25]
Pathway
map00360  Phenylalanine metabolism
map00940  Phenylpropanoid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00039  Monolignol biosynthesis, phenylalanine/tyrosine => monolignol
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K13064  PTAL; phenylalanine/tyrosine ammonia-lyase
  09110 Biosynthesis of other secondary metabolites
   00940 Phenylpropanoid biosynthesis
    K13064  PTAL; phenylalanine/tyrosine ammonia-lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.1  Ammonia-lyases
    4.3.1.25  phenylalanine/tyrosine ammonia-lyase
     K13064  PTAL; phenylalanine/tyrosine ammonia-lyase
Other DBs
RN: R00697 R00737
Genes
OSA: 4330034
DOSA: Os02t0626100-01(Os02g0626100) Os04t0518100-01(Os04g0518100)
OBR: 102717680
BDI: 100839236
ATS: 109753501 109753502 109764465 109782978 109783107 109786255
TDC: 119270978 119279096 119280476 119317181 119320474
TAES: 123057580 123064291 123064383 123073645 123073646 123099255 123100813 123137534 123144878 542819
TUA: 125547568 125547608
SBI: 8054282 8074774
ZMA: 542258
PHAI: 112882472
 » show all
Reference
PMID:9008393
  Authors
Rosler J, Krekel F, Amrhein N, Schmid J
  Title
Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity.
  Journal
Plant Physiol 113:175-9 (1997)
DOI:10.1104/pp.113.1.175
  Sequence
[zma:542258]
LinkDB

KEGG   ENZYME: 4.3.1.25
Entry
EC 4.3.1.25                 Enzyme                                 
Name
phenylalanine/tyrosine ammonia-lyase;
PTAL;
bifunctional PAL
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
L-phenylalanine(or L-tyrosine):trans-cinnamate(or trans-p-hydroxycinnamate) ammonia-lyase
Reaction(IUBMB)
(1) L-phenylalanine = trans-cinnamate + NH3 [RN:R00697];
(2) L-tyrosine = trans-p-hydroxycinnamate + NH3 [RN:R00737]
Reaction(KEGG)
R00697 R00737;
(other) R06132
Substrate
L-phenylalanine [CPD:C00079];
L-tyrosine [CPD:C00082]
Product
trans-cinnamate [CPD:C00423];
NH3 [CPD:C00014];
trans-p-hydroxycinnamate [CPD:C00811]
Comment
This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.3 (histidine ammonia-lyase), EC 4.3.1.23 (tyrosine ammonia-lyase) and EC 4.3.1.24 (phenylalanine ammonia-lyase). The enzyme from some monocots, including maize, and from the yeast Rhodosporidium toruloides, deaminate L-phenylalanine and L-tyrosine with similar catalytic efficiency [3]. The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [4].
History
EC 4.3.1.25 created 2008 (EC 4.3.1.5 created 1965, part-incorporated 2008)
Pathway
ec00360  Phenylalanine metabolism
ec00940  Phenylpropanoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13064  phenylalanine/tyrosine ammonia-lyase
Genes
OSA4330034
DOSAOs02t0626100-01(Os02g0626100) Os04t0518100-01(Os04g0518100)
OBR102717680
BDI100839236
ATS109753501 109753502 109764465 109782978 109783107 109786255
TDC119270978 119279096 119280476 119317181 119320474
TAES123057580 123064291 123064383 123073645 123073646 123099255 123100813 123137534 123144878 542819
TUA125547568 125547608
SBI8054282 8074774
ZMA542258
SITA101756300 101766005 101780319
SVS117861038 117862866 117864498
PVIR120656506 120709319
PHAI112882472
 » show all
Reference
1  [PMID:9008393]
  Authors
Rosler J, Krekel F, Amrhein N, Schmid J
  Title
Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity.
  Journal
Plant Physiol 113:175-9 (1997)
DOI:10.1104/pp.113.1.175
  Sequence
[zma:542258]
Reference
2  [PMID:17185227]
  Authors
Watts KT, Mijts BN, Lee PC, Manning AJ, Schmidt-Dannert C
  Title
Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family.
  Journal
Chem Biol 13:1317-26 (2006)
DOI:10.1016/j.chembiol.2006.10.008
Reference
3  [PMID:17185228]
  Authors
Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP.
  Title
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
  Journal
Chem Biol 13:1327-38 (2006)
DOI:10.1016/j.chembiol.2006.11.011
Reference
4  [PMID:10220322]
  Authors
Schwede TF, Retey J, Schulz GE
  Title
Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile.
  Journal
Biochemistry 38:5355-61 (1999)
DOI:10.1021/bi982929q
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.25
IUBMB Enzyme Nomenclature: 4.3.1.25
ExPASy - ENZYME nomenclature database: 4.3.1.25
BRENDA, the Enzyme Database: 4.3.1.25
LinkDB

KEGG   REACTION: R00697
Entry
R00697                      Reaction                               
Name
L-phenylalanine ammonia-lyase (trans-cinnamate-forming)
Definition
L-Phenylalanine <=> trans-Cinnamate + Ammonia
Equation
Reaction class
RC00361  C00079_C00423
Enzyme
4.3.1.24        4.3.1.25
Pathway
rn00360  Phenylalanine metabolism
rn00940  Phenylpropanoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00039  Monolignol biosynthesis, phenylalanine/tyrosine => monolignol
M00137  Flavanone biosynthesis, phenylalanine => naringenin
Orthology
K10775  phenylalanine ammonia-lyase [EC:4.3.1.24]
K13064  phenylalanine/tyrosine ammonia-lyase [EC:4.3.1.25]
Other DBs
RHEA: 21387
LinkDB

DBGET integrated database retrieval system