KEGG   ORTHOLOGY: K13227
Entry
K13227                      KO                                     
Symbol
BX8_9
Name
UDP-glucosyltransferase BX8/BX9 [EC:2.4.1.202]
Pathway
map00402  Benzoxazinoid biosynthesis
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00402 Benzoxazinoid biosynthesis
    K13227  BX8_9; UDP-glucosyltransferase BX8/BX9
   00999 Biosynthesis of various plant secondary metabolites
    K13227  BX8_9; UDP-glucosyltransferase BX8/BX9
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.202  2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase
     K13227  BX8_9; UDP-glucosyltransferase BX8/BX9
Other DBs
RN: R04579 R07426
GO: 0047254
CAZy: GT1
Genes
OSA: 4342809 4350429
DOSA: Os11t0444000-01(Os11g0444000)
OBR: 102699351 102716206
BDI: 100830893
ATS: 109735346 109736907 109754422
TDC: 119314690 119315414 119328279 119330805 119334371 119336035 119336866 119340106 119341052 119349903 119349904
TAES: 100682422 123147887 123150283 123150314 123159126 123160005 123167683 123172831
TUA: 125523142 125523860
SBI: 110430107 8069138
ZMA: 100274317 100277344 103632152
SVS: 117859511
PHAI: 112897861
 » show all
Reference
  Authors
Bailey BA, Larson RL
  Title
Hydroxamic Acid glucosyltransferases from maize seedlings.
  Journal
Plant Physiol 90:1071-6 (1989)
DOI:10.1104/pp.90.3.1071
  Sequence
[zma:100274317]
Reference
  Authors
von Rad U, Huttl R, Lottspeich F, Gierl A, Frey M.
  Title
Two glucosyltransferases are involved in detoxification of benzoxazinoids in maize.
  Journal
Plant J 28:633-42 (2001)
DOI:10.1046/j.1365-313x.2001.01161.x
  Sequence
LinkDB

KEGG   ENZYME: 2.4.1.202
Entry
EC 2.4.1.202                Enzyme                                 
Name
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase;
uridine diphosphoglucose-2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-glucosyltransferase;
BX8;
BX9;
benzoxazinoid glucosyltransferase;
DIMBOA glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-glucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-beta-D-glucosyltransferase
Reaction(IUBMB)
(1) UDP-alpha-D-glucose + 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [RN:R04579];
(2) UDP-alpha-D-glucose + 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one = UDP + (2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [RN:R07426]
Reaction(KEGG)
R04579 R07426
Substrate
UDP-alpha-D-glucose [CPD:C00029];
2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one [CPD:C04720];
2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one [CPD:C15770]
Product
UDP [CPD:C00015];
(2R)-4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:C04831];
(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside [CPD:C15772]
Comment
The enzyme is involved in the detoxification of the benzoxazinoids DIBOA (2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one) and DIMBOA (2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one) which are stored as the respective non-toxic glucosides in the vacuoles in some plants, most commonly from the family of Poaceae (grasses). Benzoxazinoids are known to exhibit antimicrobial, antifeedant, and antiinsecticidal effects and are involved in the interaction of plants with other plants, insects, or microorganisms.
History
EC 2.4.1.202 created 1992, modified 2012
Pathway
ec00402  Benzoxazinoid biosynthesis
ec00999  Biosynthesis of various plant secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13227  UDP-glucosyltransferase BX8/BX9
Genes
OSA4342809 4350429
DOSAOs11t0444000-01(Os11g0444000)
OBR102699351 102716206
BDI100830893
ATS109735346 109736907 109754422
TDC119314690 119315414 119328279 119330805 119334371 119336035 119336866 119340106 119341052 119349903 119349904
TAES100682422 123147887 123150283 123150314 123159126 123160005 123167683 123172831
TUA125523142 125523860
SBI110430107 8069138
ZMA100274317 100277344 103632152
SITA101752637 101753321 101778310 101780325
SVS117859511
PVIR120644461 120644612 120684540 120684928 120696099
PHAI112897861
 » show all
Reference
1  [PMID:16666853]
  Authors
Bailey BA, Larson RL
  Title
Hydroxamic Acid glucosyltransferases from maize seedlings.
  Journal
Plant Physiol 90:1071-6 (1989)
DOI:10.1104/pp.90.3.1071
  Sequence
[zma:100274317]
Reference
2  [PMID:11851909]
  Authors
von Rad U, Huttl R, Lottspeich F, Gierl A, Frey M.
  Title
Two glucosyltransferases are involved in detoxification of benzoxazinoids in maize.
  Journal
Plant J 28:633-42 (2001)
DOI:10.1046/j.1365-313x.2001.01161.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.202
IUBMB Enzyme Nomenclature: 2.4.1.202
ExPASy - ENZYME nomenclature database: 2.4.1.202
BRENDA, the Enzyme Database: 2.4.1.202
CAS: 122544-56-3
LinkDB

KEGG   REACTION: R07426
Entry
R07426                      Reaction                               
Name
UDP-glucose:DIBOA 2-D-glucosyltransferase
Definition
UDP-glucose + DIBOA <=> UDP + DIBOA-glucoside
Equation
Comment
UDP-glucosyltransferase, bx8, bx9
Reaction class
RC00005  C00015_C00029
RC00049  C15770_C15772
Enzyme
Pathway
rn00402  Benzoxazinoid biosynthesis
rn00999  Biosynthesis of various plant secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K13227  UDP-glucosyltransferase BX8/BX9 [EC:2.4.1.202]
Other DBs
RHEA: 33958
LinkDB

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