KEGG ORTHOLOGY: K13240

ORTHOLOGY: K13240

Entry

K13240                      KO

Symbol

NOS1

Name

nitric-oxide synthase, brain [EC:1.14.13.39]

Pathway

map00220

Arginine biosynthesis

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04020

Calcium signaling pathway

map04145

Phagosome

map04371

Apelin signaling pathway

map04713

Circadian entrainment

map04730

Long-term depression

map04926

Relaxin signaling pathway

map04970

Salivary secretion

map05010

Alzheimer disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

map05416

Viral myocarditis

Reaction

R00111

N-(omega)-hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00557

L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00558

L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13240  NOS1; nitric-oxide synthase, brain
   00330 Arginine and proline metabolism
    K13240  NOS1; nitric-oxide synthase, brain
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
   04020 Calcium signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K13240  NOS1; nitric-oxide synthase, brain
09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
  09154 Digestive system
   04970 Salivary secretion
    K13240  NOS1; nitric-oxide synthase, brain
  09156 Nervous system
   04730 Long-term depression
    K13240  NOS1; nitric-oxide synthase, brain
  09159 Environmental adaptation
   04713 Circadian entrainment
    K13240  NOS1; nitric-oxide synthase, brain
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K13240  NOS1; nitric-oxide synthase, brain
   05014 Amyotrophic lateral sclerosis
    K13240  NOS1; nitric-oxide synthase, brain
   05022 Pathways of neurodegeneration - multiple diseases
    K13240  NOS1; nitric-oxide synthase, brain
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K13240  NOS1; nitric-oxide synthase, brain
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K13240  NOS1; nitric-oxide synthase, brain
   05414 Dilated cardiomyopathy
    K13240  NOS1; nitric-oxide synthase, brain
   05416 Viral myocarditis
    K13240  NOS1; nitric-oxide synthase, brain
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13240  NOS1; nitric-oxide synthase, brain

Other DBs

GO:

0004517

Genes

HSA:	4842(NOS1)

PTR:	467139(NOS1)

PPS:	100996089(NOS1)

GGO:	101147071(NOS1)

PON:	100433069(NOS1)

NLE:	100597250(NOS1)

HMH:	116477857(NOS1)

MCC:	693781(NOS1)

MCF:	102123521(NOS1)

MTHB:

126930595

MNI:	105495113(NOS1)

CATY:

105592744(NOS1)

PANU:

101025542(NOS1)

TGE:	112634545(NOS1)

MLEU:

105527995(NOS1)

RRO:	104675533(NOS1)

RBB:	108539288(NOS1)

TFN:	117089332(NOS1)

PTEH:

111537519(NOS1)

CANG:

105502297(NOS1)

CJC:	100895717(NOS1)

SBQ:	101034544(NOS1)

CIMI:

108305039(NOS1)

CSYR:

103250172

MMUR:

105866961(NOS1)

LCAT:

123626251(NOS1)

PCOQ:

105825189(NOS1)

OGA:	100946509(NOS1)

MMU:	18125(Nos1)

MCAL:

110294416(Nos1)

MPAH:

110312876(Nos1)

RNO:	24598(Nos1)

MCOC:

116068288(Nos1)

ANU:	117697935(Nos1)

MUN:	110551884(Nos1)

CGE:	100758127(Nos1)

MAUA:

101830457(Nos1)

PROB:

127216013(Nos1)

PLEU:

114699651(Nos1)

MORG:

121445990(Nos1)

MFOT:

126511745

AAMP:

119824418(Nos1)

NGI:	103745523(Nos1)

HGL:	101711993(Nos1)

CPOC:

100729682(Nos1)

CCAN:

109686387(Nos1)

DORD:

105984213(Nos1)

DSP:	122099033(Nos1)

PLOP:

125349073(Nos1)

NCAR:

124991150

OCU:	100009243(NOS1)

OPI:	101522087(NOS1)

TUP:	102480558(NOS1)

GVR:	103593457(NOS1)

CFA:	477498(NOS1)

CLUD:

112676630(NOS1)

VVP:	112932933(NOS1)

VLG:	121475796(NOS1)

NPO:	129508386(NOS1)

AML:	100468087(NOS1)

UMR:	103661304(NOS1)

UAH:	113266817(NOS1)

UAR:	123778556(NOS1)

ELK:

111156411

LLV:

125082424

MPUF:

101692439(NOS1)

MNP:	132023203(NOS1)

NVS:	122903384(NOS1)

ORO:	101375441(NOS1)

EJU:	114219124(NOS1)

ZCA:	113913115(NOS1)

MLX:	118018518(NOS1)

NSU:	110588225(NOS1)

LWW:	102726309(NOS1)

FCA:	101100342(NOS1)

PYU:	121010269(NOS1)

PCOO:

112870473(NOS1)

PBG:	122470274(NOS1)

LRUF:

124518489

PTG:	102962715(NOS1)

PPAD:

109277571(NOS1)

PUC:

125914124

AJU:

106971710

HHV:	120232363(NOS1)

BTA:	536132(NOS1)

BOM:	102280537(NOS1)

BIU:	109571319(NOS1)

BBUB:

102400136(NOS1)

BBIS:

104980001(NOS1)

CHX:	102185490(NOS1)

OAS:	443533(NOS1)

BTAX:

128062518(NOS1)

ODA:	120871573(NOS1)

CCAD:

122423224(NOS1)

MBEZ:

129542907(NOS1)

SSC:	100520934(NOS1)

CFR:	102508946(NOS1)

CBAI:

105075702(NOS1)

CDK:	105104911(NOS1)

VPC:	102542069(NOS1)

BACU:

103008209(NOS1)

LVE:	103090138(NOS1)

OOR:	101273057(NOS1)

DLE:	111186931(NOS1)

PCAD:

102991967(NOS1)

PSIU:

116738822(NOS1)

NASI:

112408771(NOS1)

ECB:	100051079(NOS1)

EPZ:	103547950(NOS1)

EAI:	106839766(NOS1)

MYB:	102260489(NOS1)

MYD:	102763635(NOS1)

MMYO:

118678505(NOS1)

MLF:	102433074(NOS1)

MNA:	107528483(NOS1)

PKL:	118725282(NOS1)

EFUS:

103287084(NOS1)

HAI:	109382238(NOS1)

DRO:	112310614(NOS1)

SHON:

118991149(NOS1)

AJM:	119057483(NOS1)

PDIC:

114509381(NOS1)

PHAS:

123820989(NOS1)

MMF:	118639832(NOS1)

RFQ:	117017522(NOS1)

PALE:

102884569(NOS1)

PGIG:

120606760(NOS1)

PVP:	105289401(NOS1)

RAY:	107513162(NOS1)

MJV:	108397443(NOS1)

TOD:	119244938(NOS1)

SARA:

101559239(NOS1)

LAV:	100673992(NOS1)

TMU:

101342004

ETF:	101649945(NOS1)

DNM:	101411311(NOS1)

MDO:	100013712(NOS1)

GAS:	123256892(NOS1)

SHR:	100921140(NOS1)

AFZ:

127545521

PCW:	110222812(NOS1)

OAA:	100093259(NOS1)

GGA:	427721(NOS1)

PCOC:

116228339(NOS1)

MGP:	100538441(NOS1)

CJO:	107321466(NOS1)

TPAI:

128084048(NOS1)

LMUT:

125701757(NOS1)

NMEL:

110406170(NOS1)

APLA:

101798766(NOS1)

ACYG:

106045554(NOS1)

CATA:

118252937(NOS1)

AFUL:

116496320(NOS1)

TGU:	100231414(NOS1) 116807264

LSR:	110474155(NOS1)

SCAN:

103818226(NOS1)

PMOA:

120510300(NOS1)

OTC:	121344475(NOS1)

PRUF:

121364923(NOS1)

GFR:	102042821(NOS1)

FAB:	101820761(NOS1)

OMA:	130259689(NOS1)

PHI:	102106809(NOS1)

PMAJ:

107211573(NOS1)

CCAE:

111936662(NOS1)

CCW:	104695038(NOS1)

CBRC:

103623761(NOS1)

ETL:	114071586(NOS1)

ZAB:	102072905(NOS1)

ACHL:

103801580(NOS1)

SVG:	106864783(NOS1)

MMEA:

130580139(NOS1)

HRT:	120760593(NOS1)

FPG:	101916747(NOS1)

FCH:	102047821(NOS1)

CLV:	102093432(NOS1)

EGZ:	104129871(NOS1)

NNI:	104010553(NOS1)

PCRI:

104029088(NOS1)

EHS:	104503743(NOS1)

PCAO:

104047115(NOS1)

ACUN:

113486129(NOS1)

TALA:

104361402(NOS1)

PADL:

103913684(NOS1)

AFOR:

103894609(NOS1)

ACHC:

115346336(NOS1)

HALD:

104317081

HLE:	104829234(NOS1)

AGEN:

126041320

GCL:

127022735

CCRI:

104160807(NOS1)

CSTI:

104560255(NOS1)

CMAC:

104476523(NOS1)

MUI:	104545975(NOS1)

BREG:

104640291(NOS1)

FGA:	104079195(NOS1)

GSTE:

104256505

LDI:	104350797(NOS1)

MNB:	103780992(NOS1)

OHA:	104334673(NOS1)

NNT:	104404829(NOS1)

SHAB:

115614078(NOS1)

DPUB:

104308456(NOS1)

PGUU:

104463690(NOS1)

ACAR:

104533031(NOS1)

CPEA:

104386992(NOS1)

AVIT:

104270931(NOS1)

CVF:	104288003(NOS1)

RTD:	128917230(NOS1)

CUCA:

104056123(NOS1)

TEO:

104378429

BRHI:

104498566(NOS1)

AAM:	106493898(NOS1)

AROW:

112976786(NOS1)

NPD:	112950374(NOS1)

TGT:	104566767(NOS1)

DNE:	112994650(NOS1)

SCAM:

104144123(NOS1)

ASN:	102380334(NOS1)

AMJ:	102561243(NOS1)

CPOO:

109312966(NOS1)

GGN:	109290264(NOS1)

PSS:	102444149(NOS1)

CMY:	102941829(NOS1)

CCAY:

125622860(NOS1)

DCC:	119843783(NOS1)

CPIC:

101937660(NOS1)

TST:	117888179(NOS1)

CABI:

116836436(NOS1)

MRV:	120386165(NOS1)

ACS:	100562233(nos1)

PVT:	110090104(NOS1)

SUND:

121916538(NOS1)

PBI:	103052972(NOS1)

PMUR:

107295430(NOS1)

CTIG:

120303216(NOS1)

PGUT:

117657845(NOS1)

APRI:

131185597(NOS1)

PTEX:

113448063(NOS1)

NSS:	113423103(NOS1)

VKO:	123032750(NOS1)

PMUA:

114587067(NOS1)

PRAF:

128404348(NOS1)

ZVI:	118075983(NOS1)

HCG:	128337869(NOS1)

GJA:	107112296(NOS1)

STOW:

125442897(NOS1)

EMC:	129341149(NOS1)

XLA:	108707179(nos1.S) 373705(nos1.L)

XTR:	100497595(nos1)

NPR:	108785232(NOS1)

RTEM:

120932977(NOS1)

BBUF:

120991402(NOS1)

BGAR:

122935037(NOS1)

MUO:	115480833(NOS1)

GSH:	117365575(NOS1)

DRE:	60658(nos1)

SRX:	107726721 107755829(nos1)

SANH:

107668720 107704495(nos1)

SGH:	107599142(nos1) 107599638

CCAR:

109079125 109079156

CAUA:

113068104 113072250

CGIB:

127958782 128014048

PTET:

122345918(nos1)

LROH:

127165699(nos1)

OMC:	131540926(nos1)

PPRM:

120470411(nos1)

MAMB:

125267321(nos1)

CIDE:

127513479

MASI:

127430098 127437581

TROS:

130568910(nos1)

MANU:

129439681(nos1)

IPU:

108255344

IFU:	128625645(nos1)

PHYP:

113537215(nos1)

SMEO:

124380832(nos1)

TFD:	113653396(nos1)

AMEX:

103046065(nos1)

CMAO:

118827487(nos1)

EEE:	113577767(nos1)

CHAR:

105901066(nos1)

TRU:	101066909(nos1)

TFS:	130525474(nos1)

TNG:	GSTEN00029052G001

LCO:	104923687(nos1)

NCC:	104967506(nos1)

CGOB:

115014031(nos1)

ELY:	117252891(nos1)

EFO:	125890062(nos1)

PLEP:

121943974(nos1)

SLUC:

116054158(nos1)

ECRA:

117944931(nos1)

ESP:	116688962(nos1)

PFLV:

114555256(nos1)

GAT:	120830799(nos1)

PPUG:

119225179(nos1)

AFB:	129100941(nos1)

CLUM:

117736441(nos1)

MSAM:

119892185(nos1)

SCHU:

122876330(nos1)

CUD:	121510247(nos1)

ALAT:

119019240(nos1)

MZE:	101485683(nos1)

ONL:	100534582(nos1)

OAU:	116325579(nos1)

OLA:	100049502(nos1)

OML:	112148312(nos1)

XMA:	102233853(nos1)

XCO:	114154866(nos1)

XHE:	116729879(nos1)

PRET:

103469871(nos1)

PFOR:

103134950(nos1)

PLAI:

106945253(nos1)

PMEI:

106919449(nos1)

GAF:	122827934(nos1)

CVG:	107087335(nos1)

CTUL:

119788886(nos1)

GMU:	124878013(nos1)

NFU:	107386248(nos1)

KMR:	108246938(nos1)

ALIM:

106519449(nos1)

NWH:	119413183(nos1)

AOCE:

111572539(nos1)

MCEP:

125012597(nos1)

CSEM:

103396877 103397851(nos1)

POV:	109637139(nos1)

SSEN:

122769681(nos1)

HHIP:

117768184(nos1)

HSP:	124852411(nos1)

LCF:

108903114

SDU:	111227324(nos1)

SLAL:

111663111(nos1)

XGL:	120805277(nos1)

HCQ:	109525272(nos1)

SSCV:

125994306

BPEC:

110155016(nos1)

MALB:

109959109(nos1)

BSPL:

114862412(nos1)

SASA:

100136388(nos1) 106585241

STRU:

115164132 115200502

OTW:	112248861(nos1) 112262564

OMY:	100136347(nos1) 110535113

OGO:	124034044(nos1) 124035286

ONE:	115111915(nos1)

OKI:	109883580 109896184

OKE:	118357968 118393530(nos1)

SALP:

111958203 111974596

SNH:	120043829(nos1) 120062808

CCLU:

121530778 121585214(nos1)

ELS:	105031277(nos1)

SFM:	108927312(nos1)

PKI:	111851114 111852748(nos1)

AANG:

118206631(nos1)

LOC:	102699252(nos1)

PSPA:

121296840 121299518

ARUT:

117394670 117394704 117426910 117428352

PSEX:

120540577(nos1)

LCM:	102348281(NOS1)

CMK:	103184386(nos1)

RTP:	109914181(nos1) 109922224

CPLA:

122557039 122562749(nos1)

LERI:

129709305(nos1)

BFO:	118404760 118413899 118426508

BBEL:

109469130 109475091 109479447

CIN:

100183039

SCLV:

120325991 120326000

SPU:	100888109 587111

LPIC:

129254933

APLC:

110976884 110976936

AJC:	117110033 117124583 117124609

DME:	Dmel_CG6713(Nos)

DER:

6542987

DSE:

6612066

DSI:	Dsimw501_GD22223(Dsim_GD22223)

DYA:	Dyak_GE13295

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17812

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:	106620796 106621192

RZE:	108355020 108373227 108374600

TDA:

SCAC:

LCQ:

LSQ:

ECOE:

HIS:

AGA:	AgaP_AGAP008255 AgaP_AGAP008257

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ000366 CpipJ_CPIJ019871

CPII:

120432426

CNS:

116341093

BCOO:

119078115 119085893

AME:	503861(NOS)

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

NVI:	100313941(Nos)

CSOL:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

100144542(NOS2) 692510(NOS1)

BMAN:

114243188 114243206

MSEX:

115445277 115445279

DPL:	KGM_202094

BANY:

112048436 112048444

MJU:	123878619 123879669

NIQ:	126769943 126769944

VCD:	124533560 124533780

MCIX:

123653672 123653673

PMAC:

106718432 106718546

PPOT:

106104091 106105182

PXU:	106128430 106128432

PRAP:

110995634 110995640

PBX:	123708272 123708858

PNAP:

125049457 125049759

ZCE:	119834982 119834983

CCRC:

123691099 123691247

LSIN:

126966145 126966156

HAW:	110378704 110378714

HZE:	124631003 124631184

TNL:	113504450 113504511 113504548

SLIU:

111351570 111351952

OFU:	114365595 114365602

PXY:	105388815 105388816

PGW:	126367455 126367457

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:	124367568 124367569

PHU:	Phum_PHUM176630

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

IEL:

FCD:

DPX:	DAPPUDRAFT_314346 DAPPUDRAFT_49977

DMK:

116928975

DPZ:

124310869

PVM:	113823177 113828626

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123754516 123754968 123755062 123759937

CQD:	128693791 128696545

PTRU:

123510911

ESN:	126998963 127006615

HAZT:

PPOI:

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

UDV:

SDM:

PMEO:

LGI:	LOTGIDRAFT_197993

PCAN:

112563084

GAE:	121368198 121368682 121390711 121391199

HRF:	124112147 124116041 124116043 124150822

HRJ:	124254027 124254028 124275692 124278491

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

127711441 127711952 127736405

MMER:

DPOL:

LAK:

NVE:

EPA:

ATEN:

ADF:	107337967 107341488 107355966

AMIL:

114957458 114967140

PDAM:

113685754

SPIS:

111339078 111345090

DGT:	114523867 114524113

XEN:

124433818

HSY:	130613373 130628780 130629288

TAD:	TRIADDRAFT_18893 TRIADDRAFT_19964 TRIADDRAFT_31504

NPA:	UCRNP2_4118

» show all

Reference

PMID:7528745

Authors

Hall AV, Antoniou H, Wang Y, Cheung AH, Arbus AM, Olson SL, Lu WC, Kau CL, Marsden PA

Title

Structural organization of the human neuronal nitric oxide synthase gene (NOS1).

Journal

J Biol Chem 269:33082-90 (1994)

Sequence

[hsa:4842]

LinkDB

ORTHOLOGY: K13241

Entry

K13241                      KO

Symbol

NOS2

Name

nitric-oxide synthase, inducible [EC:1.14.13.39]

Pathway

map00220

Arginine biosynthesis

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04020

Calcium signaling pathway

map04066

HIF-1 signaling pathway

map04146

Peroxisome

map04371

Apelin signaling pathway

map04926

Relaxin signaling pathway

map05010

Alzheimer disease

map05014

Amyotrophic lateral sclerosis

map05022

Pathways of neurodegeneration - multiple diseases

map05133

Pertussis

map05140

Leishmaniasis

map05142

Chagas disease

map05145

Toxoplasmosis

map05146

Amoebiasis

map05152

Tuberculosis

map05200

Pathways in cancer

map05222

Small cell lung cancer

Reaction

R00111

N-(omega)-hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00557

L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00558

L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Disease

H00017

Esophageal cancer

H00361

Malaria

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13241  NOS2; nitric-oxide synthase, inducible
   00330 Arginine and proline metabolism
    K13241  NOS2; nitric-oxide synthase, inducible
09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04066 HIF-1 signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04020 Calcium signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K13241  NOS2; nitric-oxide synthase, inducible
09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  09171 Infectious disease: bacterial
   05133 Pertussis
    K13241  NOS2; nitric-oxide synthase, inducible
   05152 Tuberculosis
    K13241  NOS2; nitric-oxide synthase, inducible
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05145 Toxoplasmosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05140 Leishmaniasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05142 Chagas disease
    K13241  NOS2; nitric-oxide synthase, inducible
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K13241  NOS2; nitric-oxide synthase, inducible
   05014 Amyotrophic lateral sclerosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05022 Pathways of neurodegeneration - multiple diseases
    K13241  NOS2; nitric-oxide synthase, inducible
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13241  NOS2; nitric-oxide synthase, inducible

Other DBs

GO:

0004517

Genes

HSA:	4843(NOS2)

PTR:	455026(NOS2)

PPS:	100976546(NOS2)

GGO:	101134923(NOS2)

PON:	100436584(NOS2)

NLE:	100589003(NOS2)

HMH:	116474634(NOS2)

MCC:	114673005 706921(NOS2)

MCF:	102121432(NOS2)

MTHB:

126938749

MNI:	105476942(NOS2)

CSAB:

103242598 103242600(NOS2)

CATY:

105591502(NOS2)

PANU:

101019718

TGE:	112609895(NOS2)

MLEU:

105552048(NOS2)

RRO:	104669357(NOS2)

RBB:	108539959(NOS2)

TFN:	117067605(NOS2)

PTEH:

111520811(NOS2)

CANG:

105520008(NOS2)

CJC:	100403192(NOS2)

SBQ:	101041016(NOS2)

CIMI:

108296912(NOS2)

CSYR:

103274370(NOS2)

MMUR:

105857991(NOS2)

LCAT:

123620296(NOS2)

PCOQ:

105813504(NOS2)

OGA:	100958618(NOS2)

MMU:	18126(Nos2)

MCAL:

110304621(Nos2)

MPAH:

110331408(Nos2)

RNO:	24599(Nos2)

MCOC:

116076938(Nos2)

ANU:	117710677(Nos2)

MUN:	110550157(Nos2)

CGE:	100760062(Nos2)

MAUA:

101823656(Nos2)

PROB:

127218827(Nos2)

PLEU:

114691518(Nos2)

MORG:

121456433(Nos2)

MFOT:

126492340

AAMP:

119811441(Nos2)

NGI:	103724501(Nos2)

HGL:	101699617(Nos2)

CPOC:

100135576(Nos2)

CCAN:

109693015(Nos2)

DORD:

105985658(Nos2)

DSP:	122120264(Nos2)

PLOP:

125365394(Nos2)

NCAR:

124979775

OCU:

100008833

OPI:	101535394(NOS2)

TUP:	102471872(NOS2)

GVR:	103604568(NOS2)

CFA:	403822(NOS2)

CLUD:

112677685(NOS2)

VVP:	112933146(NOS2)

VLG:	121472657(NOS2)

NPO:	129515870(NOS2)

AML:	100470060(NOS2)

UMR:	103667420(NOS2)

UAH:	113269018(NOS2)

UAR:	123776978(NOS2)

ELK:

111151537

LLV:

125087863

MPUF:

101694448(NOS2)

MNP:	132003357(NOS2)

NVS:	122907665(NOS2)

ORO:	101380967(NOS2)

EJU:	114214012(NOS2)

ZCA:	113907948(NOS2)

MLX:	118025303(NOS2)

NSU:	110592813(NOS2)

FCA:	101087020(NOS2)

PYU:	121017178(NOS2)

PCOO:

112855216(NOS2)

PBG:	122485185(NOS2)

LRUF:

124513041

PTG:	102950049(NOS2)

PPAD:

109251875(NOS2)

PUC:

125927474

AJU:

106984382

HHV:	120246360(NOS2)

BTA:	282876(NOS2)

BOM:	102265893(NOS2)

BIU:	109574459(NOS2)

BBUB:

102401026(NOS2)

BBIS:

105003971(NOS2)

CHX:	100860742(NOS2)

OAS:	443078(NOS2)

BTAX:

128065005(NOS2)

ODA:	120866313(NOS2)

CCAD:

122448629(NOS2)

MBEZ:

129540556(NOS2)

SSC:	396859(NOS2)

CFR:	102518523(NOS2)

CBAI:

105071584(NOS2)

CDK:	105088198(NOS2)

VPC:	102534932(NOS2)

BACU:

103003780(NOS2)

LVE:	103074308(NOS2)

OOR:	101280638(NOS2)

DLE:

111185989

PCAD:

102990905(NOS2)

PSIU:

116745263(NOS2)

NASI:

112394495(NOS2)

ECB:	791246(NOS2)

EPZ:

103567002

EAI:	106844596(NOS2)

MYB:	102253125(NOS2)

MYD:	102768087(NOS2)

MMYO:

118672123(NOS2)

MLF:	102424107(NOS2)

MNA:	107533063(NOS2)

PKL:	118702516(NOS2)

EFUS:

103291698(NOS2)

HAI:	109385084(NOS2)

DRO:	112308600(NOS2)

SHON:

119003495(NOS2)

AJM:	119062015(NOS2)

PDIC:

114503016(NOS2)

PHAS:

123817124(NOS2)

MMF:	118634857(NOS2)

RFQ:	117012675(NOS2)

PALE:

102878456(NOS2)

PGIG:

120620943(NOS2)

PVP:	105291934(NOS2)

RAY:	107497410(NOS2)

MJV:	108397044(NOS2)

TOD:	119231002(NOS2)

SARA:

101548820(NOS2)

LAV:	100676634(NOS2)

TMU:

101356579

ETF:	101657111(NOS2)

DNM:	101440596(NOS2)

MDO:	100024271(NOS2)

GAS:	123247380(NOS2)

SHR:	100927789(NOS2)

AFZ:

127558946

PCW:	110192171(NOS2)

OAA:	100075386(NOS2)

GGA:	395807(NOS2)

PCOC:

116227904(NOS2)

MGP:	692136(NOS2)

CJO:	107322733(NOS2)

TPAI:

128083623(NOS2)

LMUT:

125702893(NOS2)

NMEL:

110407551(NOS2)

APLA:

101804455(NOS2)

ACYG:

106043795(NOS2)

CATA:

118255021(NOS2)

AFUL:

116497109(NOS2)

TGU:	100230954(NOS2)

LSR:	110471958(NOS2)

SCAN:

103820198(NOS2)

PMOA:

120507736(NOS2)

OTC:	121347051(NOS2)

PRUF:

121361668(NOS2)

GFR:	102044468(NOS2)

FAB:	101817488(NOS2)

OMA:	130260939(NOS2)

PHI:	102108817(NOS2)

PMAJ:

107212812(NOS2)

CCAE:

111937881(NOS2)

CCW:	104690967(NOS2)

CBRC:

103613367(NOS2)

ETL:	114057504(NOS2)

ZAB:	102070665(NOS2)

ACHL:

103805056(NOS2)

SVG:	106856057(NOS2)

MMEA:

130581382(NOS2)

HRT:	120761199(NOS2)

FPG:	101921726(NOS2)

FCH:	102048023(NOS2)

CLV:	102086291(NOS2)

EGZ:	104121908(NOS2)

NNI:	104016248(NOS2)

PCRI:

104035562(NOS2)

PLET:

104627554(NOS2)

EHS:	104513636(NOS2)

PCAO:

104050690(NOS2)

ACUN:

113487234(NOS2)

TALA:

104367550(NOS2)

PADL:

103912519(NOS2)

AFOR:

103898064(NOS2)

ACHC:

115346926(NOS2)

HALD:

104317908(NOS2)

HLE:	104835702(NOS2)

AGEN:

126039417

GCL:

127024263

CCRI:

104166875(NOS2)

CSTI:

104553108(NOS2)

CMAC:

104482031(NOS2)

MUI:	104545313(NOS2)

BREG:

104632464(NOS2)

FGA:	104075862(NOS2)

GSTE:

104263062(NOS2)

LDI:	104345493(NOS2)

MNB:	103775445(NOS2)

OHA:	104328059(NOS2)

NNT:

104407941

SHAB:

115602033(NOS2)

DPUB:

104302645(NOS2)

PGUU:

104470022(NOS2)

ACAR:

104528156(NOS2)

CPEA:

104398937(NOS2)

AVIT:

104271221(NOS2)

CVF:	104283292(NOS2)

RTD:	128912569(NOS2)

CUCA:

104064984(NOS2)

TEO:	104375919(NOS2)

BRHI:

104500603(NOS2)

AAM:	106498669(NOS2)

AROW:

112968206(NOS2)

NPD:	112954567(NOS2)

TGT:	104580601(NOS2)

DNE:	112987008(NOS2)

SCAM:

104154153(NOS2)

ASN:	102375419(NOS2)

AMJ:	106737013(NOS2)

CPOO:

109317113(NOS2)

GGN:	109293229(NOS2)

PSS:	102446334(NOS2)

CMY:	102946684(NOS2)

CCAY:

125623905(NOS2)

DCC:	119844593(NOS2)

CPIC:

101941684(NOS2)

TST:	117867669(NOS2)

CABI:

116824205(NOS2)

MRV:	120387127(NOS2)

ACS:	100561200(nos2)

PVT:	110088446(NOS2)

SUND:

121917020

PBI:	103051066(NOS2)

PMUR:

107296204(NOS2)

CTIG:

120307132(NOS2)

TSR:	106555338(NOS2)

PGUT:

117667437(NOS2)

APRI:

131188759(NOS2)

PTEX:

113442549(NOS2)

NSS:	113422013(NOS2)

VKO:	123023387(NOS2)

PMUA:

114585803(NOS2)

PRAF:

128402843(NOS2)

ZVI:	118097243(NOS2)

HCG:	128336087 128336139 128336146

GJA:	107119447(NOS2)

STOW:

125425385

EMC:	129344471(NOS2)

XLA:	108708038(nos2.L) 108708888(nos2.S)

XTR:	100494698(nos2)

NPR:	108801680(NOS2)

RTEM:

120927627(NOS2)

BBUF:

120994733(NOS2)

BGAR:

122930441 122931705

MUO:	115482590(NOS2)

GSH:	117349261(NOS2)

DRE:	404036(nos2a) 563654(nos2b)

SRX:	107719931 107756441

SANH:

107660266 107666185 107683435(nos2)

SGH:	107553584 107588374 107592916(nos2)

CCAR:

109080897 109103595 109103596

CAUA:

113058570 113075348 113078755 113114808

CGIB:

127972108 128000231 128028555

PTET:

122346123(nos2a) 122358436(nos2b)

LROH:

127166110(nos2a) 127176742(nos2b)

OMC:	131520681(nos2b) 131540748(nos2a)

PPRM:

120461686(nos2a) 120473191(nos2b)

MAMB:

125249596(nos2b) 125267422(nos2a)

CIDE:

127494921 127512608

MASI:

127424490 127429764

TROS:

130565177(nos2b) 130570441(nos2a)

MANU:

129438178(nos2b) 129440617(nos2a)

IPU:	108277518 108278375(nos2b)

IFU:	128621605 128621616

PHYP:

113539231 113539397

SMEO:

124395037 124395094

TFD:	113645314 113645328

AMEX:

CMAO:

EEE:

CHAR:

SASA:

100136358(nos2)

STRU:

115206488(nos2)

OTW:	112266155 112267222

OMY:	100136036(nos2) 110507147

OGO:

124005468

ONE:	115115929 115141939

OKI:	109906100 109909545(nos2)

OKE:	118394545(nos2b) 118396987

SALP:

111949918 111960727(nos2)

SNH:	120018738 120028669

CCLU:

121568339(nos2b)

ELS:	105013989(nos2) 109615805

SFM:	108932266(nos2)

PKI:	111856407(nos2)

LOC:	102692649(nos2)

PSPA:

121308730(nos2b)

ARUT:

117429557 117430593

PSEX:

120531344(nos2b)

LCM:	102354990(NOS2)

CMK:	103183299(nos2b)

RTP:	109927199(nos2)

CPLA:

122563948

LERI:

129710541(nos2b)

BCOO:

DMK:

DPZ:

CSCU:

UDV:

SDM:

LPOL:

LAK:	106163703 106176019

HSY:

130628992

CFJ:	CFIO01_00348

RSX:	RhiXN_05970

» show all

Reference

PMID:7682706

Authors

Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR

Title

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

Journal

Proc Natl Acad Sci U S A 90:3491-5 (1993)
DOI:10.1073/pnas.90.8.3491

Sequence

[hsa:4843]

LinkDB

ORTHOLOGY: K13242

Entry

K13242                      KO

Symbol

NOS3

Name

nitric-oxide synthase, endothelial [EC:1.14.13.39]

Pathway

map00220

Arginine biosynthesis

map00330

Arginine and proline metabolism

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04066

HIF-1 signaling pathway

map04071

Sphingolipid signaling pathway

map04151

PI3K-Akt signaling pathway

map04370

VEGF signaling pathway

map04371

Apelin signaling pathway

map04611

Platelet activation

map04915

Estrogen signaling pathway

map04921

Oxytocin signaling pathway

map04926

Relaxin signaling pathway

map04931

Insulin resistance

map04933

AGE-RAGE signaling pathway in diabetic complications

map05415

Diabetic cardiomyopathy

map05417

Lipid and atherosclerosis

map05418

Fluid shear stress and atherosclerosis

Reaction

R00111

N-(omega)-hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00557

L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)

R00558

L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

Disease

H01529

Avascular necrosis of femoral head

H01633

High blood pressure

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13242  NOS3; nitric-oxide synthase, endothelial
   00330 Arginine and proline metabolism
    K13242  NOS3; nitric-oxide synthase, endothelial
09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04371 Apelin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04066 HIF-1 signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04020 Calcium signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04071 Sphingolipid signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04022 cGMP-PKG signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04151 PI3K-Akt signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K13242  NOS3; nitric-oxide synthase, endothelial
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04921 Oxytocin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04926 Relaxin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
   05418 Fluid shear stress and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
   05415 Diabetic cardiomyopathy
    K13242  NOS3; nitric-oxide synthase, endothelial
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K13242  NOS3; nitric-oxide synthase, endothelial
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13242  NOS3; nitric-oxide synthase, endothelial
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13242  NOS3; nitric-oxide synthase, endothelial

Other DBs

GO:

0004517

Genes

HSA:	4846(NOS3)

PTR:	463893(NOS3)

PPS:	100974638(NOS3)

GGO:	101128007(NOS3)

PON:	100447953(NOS3)

NLE:	100592456(NOS3)

HMH:	116814534(NOS3)

MCC:	714231(NOS3)

MCF:	102143504(NOS3)

MTHB:

126951570

MNI:	105474900(NOS3)

CSAB:

103227233(NOS3)

CATY:

105584734(NOS3)

PANU:

101024888(NOS3)

TGE:	112620359(NOS3)

MLEU:

105542707(NOS3)

RRO:	104675393(NOS3)

RBB:	108532525(NOS3)

TFN:	117072600(NOS3)

PTEH:

111551457(NOS3)

CANG:

105511327(NOS3)

CJC:	100405019(NOS3)

SBQ:	101034220(NOS3)

CIMI:

108297770(NOS3)

CSYR:

103275280(NOS3)

MMUR:

105883168(NOS3)

LCAT:

123647518(NOS3)

PCOQ:

105824632(NOS3)

OGA:	100956703(NOS3)

MMU:	18127(Nos3)

MCAL:

110293897(Nos3)

MPAH:

110315110(Nos3)

RNO:	24600(Nos3)

MCOC:

116097543(Nos3)

ANU:	117720753(Nos3)

MUN:	110562552(Nos3)

CGE:	100769961(Nos3)

MAUA:

101838293(Nos3)

PROB:

127235683(Nos3)

PLEU:

114700088(Nos3)

MORG:

121439958(Nos3)

MFOT:

126489431

AAMP:

119807052(Nos3)

NGI:	103745303(Nos3)

HGL:	101711110(Nos3)

CPOC:

100135577(Nos3)

CCAN:

109694442(Nos3)

DORD:

105993873(Nos3)

DSP:	122105913(Nos3)

PLOP:

125347314(Nos3)

NCAR:

124990691

OCU:	100009498(NOS3) 127493711

OPI:	101520691(NOS3)

TUP:	102495986(NOS3)

GVR:	103585106(NOS3)

CFA:	403784(NOS3)

CLUD:

112663787(NOS3)

VVP:	112916218(NOS3)

VLG:	121489275(NOS3)

NPO:	129515953(NOS3)

AML:	100483990(NOS3)

UMR:	103660958(NOS3)

UAH:	113241474(NOS3)

UAR:	123788781(NOS3)

ELK:

111154402

LLV:

125081326

MPUF:

101673532(NOS3)

MNP:	132015570(NOS3)

NVS:	122905198(NOS3)

ORO:	101382350(NOS3)

EJU:	114198019(NOS3)

ZCA:	113911718(NOS3)

MLX:	118026800(NOS3)

NSU:	110582947(NOS3)

LWW:	102740880 102741156

FCA:	101096463(NOS3)

PYU:	121022952(NOS3)

PCOO:

112866504(NOS3)

PBG:	122488527(NOS3)

LRUF:

124524465

PTG:	102967516(NOS3)

PPAD:

109252365(NOS3)

PUC:

125930302

AJU:

106969560

HHV:	120230927(NOS3)

BTA:	287024(NOS3)

BOM:	102267556(NOS3)

BIU:	109557793(NOS3)

BBUB:

102408451(NOS3)

BBIS:

105001191(NOS3)

CHX:	102185338(NOS3)

OAS:	443077(NOS3)

BTAX:

128046225(NOS3)

ODA:	120877875(NOS3)

MBEZ:

129552779(NOS3)

SSC:	397557(NOS3)

CFR:	102524296(NOS3)

CBAI:

105067010(NOS3)

CDK:	105105831(NOS3)

VPC:	102536194(NOS3)

BACU:

103017861(NOS3)

LVE:	103087259(NOS3)

OOR:	101280520(NOS3)

DLE:	111176849(NOS3)

PCAD:

102985806(NOS3)

PSIU:

116759107(NOS3)

NASI:

112405905(NOS3)

ECB:	100063339(NOS3)

EPZ:	103540937(NOS3)

EAI:	106823361(NOS3)

MYB:	102256555(NOS3)

MYD:	102764374(NOS3)

MMYO:

118679429(NOS3)

MLF:	102436714(NOS3)

MNA:	107524933(NOS3)

PKL:	118704763(NOS3)

EFUS:

103301781(NOS3)

HAI:	109389680(NOS3)

DRO:	112308288(NOS3)

SHON:

118975507(NOS3)

AJM:	119039263(NOS3)

PDIC:

114508069(NOS3)

PHAS:

123817951(NOS3)

MMF:	118620067(NOS3)

RFQ:	117018217(NOS3)

PALE:

102879945(NOS3)

PGIG:

120601518(NOS3)

PVP:	105303769(NOS3)

RAY:	107520319(NOS3)

MJV:	108391841(NOS3)

TOD:	119251590(NOS3)

SARA:

101547011(NOS3)

LAV:	100668912(NOS3)

TMU:

101356953

ETF:	101644765(NOS3)

DNM:	101433723(NOS3)

MDO:	100018035(NOS3)

GAS:	123250621(NOS3)

SHR:	100913437(NOS3)

AFZ:

127564122

PCW:	110201937(NOS3)

OAA:	100091599(NOS3)

GGA:

107057170

PCOC:

116242834(NOS3)

MGP:

100545552

CJO:	107308662(NOS3)

TPAI:

128085808(NOS3)

LMUT:

125696090(NOS3)

CATA:

118251735(NOS3)

AFUL:

116486135(NOS3)

TGU:	115493592(NOS3)

LSR:	110475121(NOS3)

PMOA:

120510540(NOS3)

OTC:	121334878(NOS3)

PRUF:

121356981(NOS3)

OMA:	130249115(NOS3)

PHI:	102112141(NOS3)

ETL:	114068013(NOS3)

SVG:	106861781(NOS3)

MMEA:

130574590(NOS3)

FPG:	101918492(NOS3)

FCH:	102057360(NOS3)

HLE:	104829386(NOS3)

AGEN:

126037657

SHAB:

115610765(NOS3)

DPUB:

104298517(NOS3)

AROW:

112963744(NOS3)

NPD:

112958193

DNE:

112978916

ASN:	102381196(NOS3)

AMJ:	102575253(NOS3)

CMY:	102942806(NOS3)

CCAY:

125632956(NOS3)

DCC:	119851036(NOS3)

CPIC:

101952927(NOS3)

TST:	117871954(NOS3)

CABI:

116834210

MRV:	120397587(NOS3)

ACS:	100557597(nos3)

PVT:	110082598(NOS3)

SUND:

121934954(NOS3)

PBI:

103065136

CTIG:

120320267(NOS3)

TSR:	106544793(NOS3)

PGUT:

117669221(NOS3)

APRI:

131196506(NOS3)

VKO:	123019550(NOS3)

PMUA:

114607850(NOS3)

PRAF:

128423990(NOS3)

ZVI:	118092264(NOS3)

HCG:	128329346(NOS3)

GJA:	107118610(NOS3)

STOW:

125441159(NOS3)

EMC:	129337473(NOS3)

XLA:	108704634(nos3.L)

XTR:	100486016(nos3)

NPR:

108803428

RTEM:

120941752(NOS3)

BBUF:

121000747(NOS3)

BGAR:

122938595 122938785

MUO:	115465186(NOS3)

GSH:	117354473(NOS3)

LOC:

PSPA:

ARUT:

PSEX:

LERI:

OTA:	OT_ostta17g00030

» show all

Reference

PMID:1378832

Authors

Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD

Title

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

Journal

J Biol Chem 267:14519-22 (1992)

Sequence

[hsa:4846]

LinkDB

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