KEGG   ORTHOLOGY: K13240
Entry
K13240                      KO                                     
Symbol
NOS1
Name
nitric-oxide synthase, brain [EC:1.14.13.39]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04020  Calcium signaling pathway
map04145  Phagosome
map04371  Apelin signaling pathway
map04713  Circadian entrainment
map04730  Long-term depression
map04926  Relaxin signaling pathway
map04970  Salivary secretion
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13240  NOS1; nitric-oxide synthase, brain
   00330 Arginine and proline metabolism
    K13240  NOS1; nitric-oxide synthase, brain
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
   04020 Calcium signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K13240  NOS1; nitric-oxide synthase, brain
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13240  NOS1; nitric-oxide synthase, brain
  09154 Digestive system
   04970 Salivary secretion
    K13240  NOS1; nitric-oxide synthase, brain
  09156 Nervous system
   04730 Long-term depression
    K13240  NOS1; nitric-oxide synthase, brain
  09159 Environmental adaptation
   04713 Circadian entrainment
    K13240  NOS1; nitric-oxide synthase, brain
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K13240  NOS1; nitric-oxide synthase, brain
   05014 Amyotrophic lateral sclerosis
    K13240  NOS1; nitric-oxide synthase, brain
   05022 Pathways of neurodegeneration - multiple diseases
    K13240  NOS1; nitric-oxide synthase, brain
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13240  NOS1; nitric-oxide synthase, brain
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
HSA: 4842(NOS1)
PTR: 467139(NOS1)
PPS: 100996089(NOS1)
GGO: 101147071(NOS1)
PON: 100433069(NOS1)
NLE: 100597250(NOS1)
MCC: 693781(NOS1)
MCF: 102123521(NOS1)
CATY: 105592744(NOS1)
PANU: 101025542(NOS1)
TGE: 112634545(NOS1)
RRO: 104675533(NOS1)
RBB: 108539288(NOS1)
TFN: 117089332(NOS1)
PTEH: 111537519(NOS1)
CJC: 100895717(NOS1)
SBQ: 101034544(NOS1)
CSYR: 103250172
MMUR: 105866961(NOS1)
OGA: 100946509(NOS1)
MMU: 18125(Nos1)
MCAL: 110294416(Nos1)
MPAH: 110312876(Nos1)
RNO: 24598(Nos1)
MCOC: 116068288(Nos1)
MUN: 110551884(Nos1)
CGE: 100758127(Nos1)
PLEU: 114699651(Nos1)
NGI: 103745523(Nos1)
HGL: 101711993(Nos1)
CPOC: 100729682(Nos1)
CCAN: 109686387(Nos1)
DORD: 105984213(Nos1)
DSP: 122099033(Nos1)
OCU: 100009243(NOS1)
OPI: 101522087(NOS1)
TUP: 102480558(NOS1)
CFA: 477498(NOS1)
VVP: 112932933(NOS1)
VLG: 121475796(NOS1)
AML: 100468087(NOS1)
UMR: 103661304(NOS1)
UAH: 113266817(NOS1)
UAR: 123778556(NOS1)
ELK: 111156411
LLV: 125082424
MPUF: 101692439(NOS1)
ORO: 101375441(NOS1)
EJU: 114219124(NOS1)
ZCA: 113913115(NOS1)
MLX: 118018518(NOS1)
FCA: 101100342(NOS1)
PYU: 121010269(NOS1)
PBG: 122470274(NOS1)
PTG: 102962715(NOS1)
PPAD: 109277571(NOS1)
AJU: 106971710(NOS1)
HHV: 120232363(NOS1)
BTA: 536132(NOS1)
BOM: 102280537(NOS1)
BIU: 109571319(NOS1)
BBUB: 102400136(NOS1)
CHX: 102185490(NOS1)
OAS: 443533(NOS1)
ODA: 120871573(NOS1)
CCAD: 122423224(NOS1)
SSC: 100520934(NOS1)
CFR: 102508946(NOS1)
CBAI: 105075702(NOS1)
CDK: 105104911(NOS1)
VPC: 102542069(NOS1)
BACU: 103008209(NOS1)
LVE: 103090138(NOS1)
OOR: 101273057(NOS1)
DLE: 111186931(NOS1)
PCAD: 102991967(NOS1)
PSIU: 116738822(NOS1)
ECB: 100051079(NOS1)
EPZ: 103547950(NOS1)
EAI: 106839766(NOS1)
MYB: 102260489(NOS1)
MYD: 102763635(NOS1)
MMYO: 118678505(NOS1)
MLF: 102433074(NOS1)
MNA: 107528483(NOS1)
PKL: 118725282(NOS1)
HAI: 109382238(NOS1)
DRO: 112310614(NOS1)
SHON: 118991149(NOS1)
AJM: 119057483(NOS1)
PDIC: 114509381(NOS1)
PHAS: 123820989(NOS1)
MMF: 118639832(NOS1)
RFQ: 117017522(NOS1)
PALE: 102884569(NOS1)
PGIG: 120606760(NOS1)
PVP: 105289401(NOS1)
RAY: 107513162(NOS1)
MJV: 108397443(NOS1)
TOD: 119244938(NOS1)
SARA: 101559239(NOS1)
LAV: 100673992(NOS1)
TMU: 101342004
DNM: 101411311(NOS1)
MDO: 100013712(NOS1)
GAS: 123256892(NOS1)
SHR: 100921140(NOS1)
PCW: 110222812(NOS1)
OAA: 100093259(NOS1)
GGA: 427721(NOS1)
PCOC: 116228339(NOS1)
MGP: 100538441(NOS1)
CJO: 107321466(NOS1)
NMEL: 110406170(NOS1)
APLA: 101798766(NOS1)
ACYG: 106045554(NOS1)
AFUL: 116496320(NOS1)
TGU: 100231414(NOS1) 116807264
LSR: 110474155(NOS1)
SCAN: 103818226(NOS1)
PMOA: 120510300(NOS1)
OTC: 121344475(NOS1)
PRUF: 121364923(NOS1)
GFR: 102042821(NOS1)
FAB: 101820761(NOS1)
PHI: 102106809(NOS1)
PMAJ: 107211573(NOS1)
CCAE: 111936662(NOS1)
CCW: 104695038(NOS1)
ETL: 114071586(NOS1)
ZAB: 102072905(NOS1)
FPG: 101916747(NOS1)
FCH: 102047821(NOS1)
CLV: 102093432(NOS1)
EGZ: 104129871(NOS1)
NNI: 104010553(NOS1)
ACUN: 113486129(NOS1)
TALA: 104361402(NOS1)
PADL: 103913684(NOS1)
ACHC: 115346336(NOS1)
AAM: 106493898(NOS1)
AROW: 112976786(NOS1)
NPD: 112950374(NOS1)
DNE: 112994650(NOS1)
ASN: 102380334(NOS1)
AMJ: 102561243(NOS1)
CPOO: 109312966(NOS1)
GGN: 109290264(NOS1)
PSS: 102444149(NOS1)
CMY: 102941829(NOS1)
CPIC: 101937660(NOS1)
TST: 117888179(NOS1)
CABI: 116836436(NOS1)
MRV: 120386165(NOS1)
ACS: 100562233(nos1)
PVT: 110090104(NOS1)
SUND: 121916538(NOS1)
PBI: 103052972(NOS1)
PMUR: 107295430(NOS1)
PGUT: 117657845(NOS1)
VKO: 123032750(NOS1)
PMUA: 114587067(NOS1)
ZVI: 118075983(NOS1)
GJA: 107112296(NOS1)
XLA: 108707179(nos1.S) 373705(nos1.L)
XTR: 100497595(nos1)
NPR: 108785232(NOS1)
RTEM: 120932977(NOS1)
BBUF: 120991402(NOS1)
BGAR: 122935037(NOS1)
DRE: 60658(nos1)
SRX: 107726721 107755829(nos1)
SANH: 107668720 107704495(nos1)
SGH: 107599142(nos1) 107599638
IPU: 108255344(nos1)
PHYP: 113537215(nos1)
SMEO: 124380832(nos1)
AMEX: 103046065(nos1)
EEE: 113577767(nos1)
TRU: 101066909(nos1)
LCO: 104923687(nos1)
NCC: 104967506(nos1)
CGOB: 115014031(nos1)
ELY: 117252891(nos1)
PLEP: 121943974(nos1)
SLUC: 116054158(nos1)
ECRA: 117944931(nos1)
PFLV: 114555256(nos1)
GAT: 120830799(nos1)
PPUG: 119225179(nos1)
MSAM: 119892185(nos1)
CUD: 121510247(nos1)
MZE: 101485683(nos1)
ONL: 100534582(nos1)
OAU: 116325579(nos1)
OLA: 100049502(nos1)
OML: 112148312(nos1)
XMA: 102233853(nos1)
XCO: 114154866(nos1)
XHE: 116729879(nos1)
PRET: 103469871(nos1)
PFOR: 103134950(nos1)
PLAI: 106945253(nos1)
PMEI: 106919449(nos1)
GAF: 122827934(nos1)
CVG: 107087335(nos1)
CTUL: 119788886(nos1)
GMU: 124878013(nos1)
NFU: 107386248(nos1)
KMR: 108246938(nos1)
ALIM: 106519449(nos1)
NWH: 119413183(nos1)
AOCE: 111572539(nos1)
CSEM: 103396877 103397851(nos1)
POV: 109637139(nos1)
SSEN: 122769681(nos1)
HHIP: 117768184(nos1)
LCF: 108903114(nos1)
SDU: 111227324(nos1)
SLAL: 111663111(nos1)
XGL: 120805277(nos1)
HCQ: 109525272(nos1)
BPEC: 110155016(nos1)
MALB: 109959109(nos1)
SASA: 100136388(nos1) 106585241
OTW: 112248861(nos1) 112262564
OMY: 100136347(nos1) 110535113
OGO: 124034044(nos1) 124035286
ONE: 115111915(nos1)
SNH: 120043829(nos1) 120062808
ELS: 105031277(nos1)
SFM: 108927312(nos1)
PKI: 111851114 111852748(nos1)
AANG: 118206631(nos1)
LOC: 102699252(nos1)
LCM: 102348281(NOS1)
CMK: 103184386(nos1)
RTP: 109914181(nos1) 109922224
CIN: 100183039
DME: Dmel_CG6713(Nos)
DER: 6542987
DSE: 6612066
DSI: Dsimw501_GD22223(Dsim_GD22223)
DAN: 6496893
DSR: 110183462
DPE: 6596585
DMN: 108163699
DWI: 6641760
DGR: 6566802
DAZ: 108609612
DNV: 108658145
DHE: 111601524
DVI: 6629111
MDE: 101891936
SCAC: 106083069
LCQ: 111681704
ACOZ: 120957719
AARA: 120901512
AAG: 5572370
CPII: 120432426
CNS: 116341093
AME: 503861(NOS)
ACER: 107998213
ALAB: 122712365
BIM: 100749227
BBIF: 117209160
BVK: 117239566
BVAN: 117165749
BTER: 100650517
BPYO: 122566286
CCAL: 108625325
OBB: 114871710
MGEN: 117222304
NMEA: 116434882
CGIG: 122398338
SOC: 105200228
MPHA: 105829748
AEC: 105149468
ACEP: 105625167
PBAR: 105432905
VEM: 105557978
HST: 105183230
DQU: 106744004
CFO: 105250272
FEX: 115240251
LHU: 105675559
PGC: 109856190
OBO: 105286125
PCF: 106793080
PFUC: 122516940
VPS: 122628777
NVI: 100313941(Nos)
CSOL: 105360744
MDL: 103570884
CGLO: 123264608
FAS: 105263042
DAM: 107044602
AGIF: 122848352
CCIN: 107269169
TCA: 655549
DPA: 109546644
SOY: 115884119
CSET: 123313082
AGB: 108908391
LDC: 111501949
NVL: 108558954
APLN: 108740077
OTU: 111427474
BMOR: 100144542(NOS2) 692510(NOS1)
API: 100160390
DNX: 107172687
AGS: 114128082
RMD: 113551041
BTAB: 109031807
DCI: 103519178
CLEC: 106661589
HHAL: 106678228
NLU: 111044297
FOC: 113213110
ZNE: 110828058
CSEC: 111862897
FCD: 110850636
DMK: 116928975
PJA: 122253978
HAME: 121863979
PTRU: 123510911
HAZT: 108677990
DSV: 119446119
RSAN: 119390050
RMP: 119161273
TUT: 107370056
DPTE: 113792010
DFR: 124499006
PTEP: 107440636
SDM: 118197261
PCAN: 112563084
CRG: 105322950
MYI: 110460719
PMAX: 117333205
MMER: 123533726
LAK: 106169208
NVE: 5511062
EPA: 110253339
PDAM: 113685754
XEN: 124433818
HMG: 101240122
 » show all
Reference
PMID:7528745
  Authors
Hall AV, Antoniou H, Wang Y, Cheung AH, Arbus AM, Olson SL, Lu WC, Kau CL, Marsden PA
  Title
Structural organization of the human neuronal nitric oxide synthase gene (NOS1).
  Journal
J Biol Chem 269:33082-90 (1994)
  Sequence
[hsa:4842]
LinkDB

KEGG   ORTHOLOGY: K13241
Entry
K13241                      KO                                     
Symbol
NOS2
Name
nitric-oxide synthase, inducible [EC:1.14.13.39]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04020  Calcium signaling pathway
map04066  HIF-1 signaling pathway
map04146  Peroxisome
map04371  Apelin signaling pathway
map04926  Relaxin signaling pathway
map05010  Alzheimer disease
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05133  Pertussis
map05140  Leishmaniasis
map05142  Chagas disease
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05200  Pathways in cancer
map05222  Small cell lung cancer
Disease
H00017  Esophageal cancer
H00361  Malaria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13241  NOS2; nitric-oxide synthase, inducible
   00330 Arginine and proline metabolism
    K13241  NOS2; nitric-oxide synthase, inducible
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04066 HIF-1 signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
   04020 Calcium signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K13241  NOS2; nitric-oxide synthase, inducible
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K13241  NOS2; nitric-oxide synthase, inducible
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K13241  NOS2; nitric-oxide synthase, inducible
  09171 Infectious disease: bacterial
   05133 Pertussis
    K13241  NOS2; nitric-oxide synthase, inducible
   05152 Tuberculosis
    K13241  NOS2; nitric-oxide synthase, inducible
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05145 Toxoplasmosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05140 Leishmaniasis
    K13241  NOS2; nitric-oxide synthase, inducible
   05142 Chagas disease
    K13241  NOS2; nitric-oxide synthase, inducible
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K13241  NOS2; nitric-oxide synthase, inducible
   05014 Amyotrophic lateral sclerosis
    K13241  NOS2; nitric-oxide synthase, inducible
   05022 Pathways of neurodegeneration - multiple diseases
    K13241  NOS2; nitric-oxide synthase, inducible
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13241  NOS2; nitric-oxide synthase, inducible
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
HSA: 4843(NOS2)
PTR: 455026(NOS2)
PPS: 100976546(NOS2)
GGO: 101134923(NOS2)
PON: 100436584(NOS2)
NLE: 100589003(NOS2)
MCC: 114673005 706921(NOS2)
MCF: 102121432(NOS2)
CSAB: 103242598 103242600(NOS2)
CATY: 105591502(NOS2)
PANU: 101019718
TGE: 112609895(NOS2)
RRO: 104669357(NOS2)
RBB: 108539959(NOS2)
TFN: 117067605(NOS2)
PTEH: 111520811(NOS2)
CJC: 100403192(NOS2)
SBQ: 101041016(NOS2)
CSYR: 103274370(NOS2)
MMUR: 105857991(NOS2)
OGA: 100958618(NOS2)
MMU: 18126(Nos2)
MCAL: 110304621(Nos2)
MPAH: 110331408(Nos2)
RNO: 24599(Nos2)
MCOC: 116076938(Nos2)
MUN: 110550157(Nos2)
CGE: 100760062(Nos2)
PLEU: 114691518(Nos2)
NGI: 103724501(Nos2)
HGL: 101699617(Nos2)
CPOC: 100135576(Nos2)
CCAN: 109693015(Nos2)
DORD: 105985658(Nos2)
DSP: 122120264(Nos2)
OCU: 100008833(NOS2)
OPI: 101535394(NOS2)
TUP: 102471872(NOS2)
CFA: 403822(NOS2)
VVP: 112933146(NOS2)
VLG: 121472657(NOS2)
AML: 100470060(NOS2)
UMR: 103667420(NOS2)
UAH: 113269018(NOS2)
UAR: 123776978(NOS2)
ELK: 111151537
LLV: 125087863
MPUF: 101694448(NOS2)
ORO: 101380967(NOS2)
EJU: 114214012(NOS2)
ZCA: 113907948(NOS2)
MLX: 118025303(NOS2)
FCA: 101087020(NOS2)
PYU: 121017178(NOS2)
PBG: 122485185(NOS2)
PTG: 102950049(NOS2)
PPAD: 109251875(NOS2)
AJU: 106984382(NOS2)
HHV: 120246360(NOS2)
BTA: 282876(NOS2)
BOM: 102265893(NOS2)
BIU: 109574459(NOS2)
BBUB: 102401026(NOS2)
CHX: 100860742(NOS2)
OAS: 443078(NOS2)
ODA: 120866313(NOS2)
CCAD: 122448629(NOS2)
SSC: 396859(NOS2)
CFR: 102518523(NOS2)
CBAI: 105071584(NOS2)
CDK: 105088198(NOS2)
VPC: 102534932(NOS2)
BACU: 103003780(NOS2)
LVE: 103074308(NOS2)
OOR: 101280638(NOS2)
DLE: 111185989
PCAD: 102990905(NOS2)
PSIU: 116745263(NOS2)
ECB: 791246(NOS2)
EPZ: 103567002
EAI: 106844596(NOS2)
MYB: 102253125(NOS2)
MYD: 102768087(NOS2)
MMYO: 118672123(NOS2)
MLF: 102424107(NOS2)
MNA: 107533063(NOS2)
PKL: 118702516(NOS2)
HAI: 109385084(NOS2)
DRO: 112308600(NOS2)
SHON: 119003495(NOS2)
AJM: 119062015(NOS2)
PDIC: 114503016(NOS2)
PHAS: 123817124(NOS2)
MMF: 118634857(NOS2)
RFQ: 117012675(NOS2)
PALE: 102878456(NOS2)
PGIG: 120620943(NOS2)
PVP: 105291934(NOS2)
RAY: 107497410(NOS2)
MJV: 108397044(NOS2)
TOD: 119231002(NOS2)
SARA: 101548820(NOS2)
LAV: 100676634(NOS2)
TMU: 101356579
DNM: 101440596(NOS2)
MDO: 100024271(NOS2)
GAS: 123247380(NOS2)
SHR: 100927789(NOS2)
PCW: 110192171(NOS2)
OAA: 100075386(NOS2)
GGA: 395807(NOS2)
PCOC: 116227904(NOS2)
MGP: 692136(NOS2)
CJO: 107322733(NOS2)
NMEL: 110407551(NOS2)
APLA: 101804455(NOS2)
ACYG: 106043795(NOS2)
AFUL: 116497109(NOS2)
TGU: 100230954(NOS2)
LSR: 110471958(NOS2)
SCAN: 103820198(NOS2)
PMOA: 120507736(NOS2)
OTC: 121347051(NOS2)
PRUF: 121361668(NOS2)
GFR: 102044468(NOS2)
FAB: 101817488(NOS2)
PHI: 102108817(NOS2)
PMAJ: 107212812(NOS2)
CCAE: 111937881(NOS2)
CCW: 104690967(NOS2)
ETL: 114057504(NOS2)
ZAB: 102070665(NOS2)
FPG: 101921726(NOS2)
FCH: 102048023(NOS2)
CLV: 102086291(NOS2)
EGZ: 104121908(NOS2)
NNI: 104016248(NOS2)
ACUN: 113487234(NOS2)
TALA: 104367550(NOS2)
PADL: 103912519(NOS2)
ACHC: 115346926(NOS2)
AAM: 106498669(NOS2)
AROW: 112968206(NOS2)
NPD: 112954567(NOS2)
DNE: 112987008(NOS2)
ASN: 102375419(NOS2)
AMJ: 106737013(NOS2)
CPOO: 109317113(NOS2)
GGN: 109293229(NOS2)
PSS: 102446334(NOS2)
CMY: 102946684(NOS2)
CPIC: 101941684(NOS2)
TST: 117867669(NOS2)
CABI: 116824205(NOS2)
MRV: 120387127(NOS2)
ACS: 100561200(nos2)
PVT: 110088446(NOS2)
SUND: 121917020
PBI: 103051066(NOS2)
PMUR: 107296204(NOS2)
TSR: 106555338(NOS2)
PGUT: 117667437(NOS2)
VKO: 123023387(NOS2)
PMUA: 114585803(NOS2)
ZVI: 118097243(NOS2)
GJA: 107119447(NOS2)
XLA: 108708038(nos2.L) 108708888(nos2.S)
XTR: 100494698(nos2)
NPR: 108801680(NOS2)
RTEM: 120927627(NOS2)
BBUF: 120994733(NOS2)
DRE: 404036(nos2a) 563654(nos2b)
IPU: 108277518 108278375(nos2b)
EEE: 113591429
SASA: 100136358(nos2)
OMY: 100136036(nos2) 110507147
OGO: 124005468
SALP: 111949918 111960727(nos2)
ELS: 105013989(nos2) 109615805
SFM: 108932266(nos2)
PKI: 111856407(nos2)
LOC: 102692649(nos2)
PSPA: 121308730(nos2b)
LCM: 102354990(NOS2)
CMK: 103183299(nos2b)
RTP: 109927199(nos2)
DMK: 116926468
CSCU: 111619022
SDM: 118194050
 » show all
Reference
PMID:7682706
  Authors
Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR
  Title
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.
  Journal
Proc Natl Acad Sci U S A 90:3491-5 (1993)
DOI:10.1073/pnas.90.8.3491
  Sequence
[hsa:4843]
LinkDB

KEGG   ORTHOLOGY: K13242
Entry
K13242                      KO                                     
Symbol
NOS3
Name
nitric-oxide synthase, endothelial [EC:1.14.13.39]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04066  HIF-1 signaling pathway
map04071  Sphingolipid signaling pathway
map04151  PI3K-Akt signaling pathway
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04611  Platelet activation
map04915  Estrogen signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04931  Insulin resistance
map04933  AGE-RAGE signaling pathway in diabetic complications
map05415  Diabetic cardiomyopathy
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H01529  Avascular necrosis of femoral head
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13242  NOS3; nitric-oxide synthase, endothelial
   00330 Arginine and proline metabolism
    K13242  NOS3; nitric-oxide synthase, endothelial
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04371 Apelin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04066 HIF-1 signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04020 Calcium signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04071 Sphingolipid signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04022 cGMP-PKG signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04151 PI3K-Akt signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K13242  NOS3; nitric-oxide synthase, endothelial
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04921 Oxytocin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04926 Relaxin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
   05418 Fluid shear stress and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
   05415 Diabetic cardiomyopathy
    K13242  NOS3; nitric-oxide synthase, endothelial
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K13242  NOS3; nitric-oxide synthase, endothelial
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13242  NOS3; nitric-oxide synthase, endothelial
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13242  NOS3; nitric-oxide synthase, endothelial
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
HSA: 4846(NOS3)
PTR: 463893(NOS3)
PPS: 100974638(NOS3)
GGO: 101128007(NOS3)
PON: 100447953(NOS3)
NLE: 100592456(NOS3)
MCC: 714231(NOS3)
MCF: 102143504(NOS3)
CSAB: 103227233(NOS3)
CATY: 105584734(NOS3)
PANU: 101024888(NOS3)
TGE: 112620359(NOS3)
RRO: 104675393(NOS3)
RBB: 108532525(NOS3)
TFN: 117072600(NOS3)
PTEH: 111551457(NOS3)
CJC: 100405019(NOS3)
SBQ: 101034220(NOS3)
CSYR: 103275280(NOS3)
MMUR: 105883168(NOS3)
OGA: 100956703(NOS3)
MMU: 18127(Nos3)
MCAL: 110293897(Nos3)
MPAH: 110315110(Nos3)
RNO: 24600(Nos3)
MCOC: 116097543(Nos3)
MUN: 110562552(Nos3)
CGE: 100769961(Nos3)
PLEU: 114700088(Nos3)
NGI: 103745303(Nos3)
HGL: 101711110(Nos3)
CPOC: 100135577(Nos3)
CCAN: 109694442(Nos3)
DORD: 105993873(Nos3)
DSP: 122105913(Nos3)
OCU: 100009498(NOS3)
OPI: 101520691(NOS3)
TUP: 102495986(NOS3)
CFA: 403784(NOS3)
VVP: 112916218(NOS3)
VLG: 121489275(NOS3)
AML: 100483990(NOS3)
UMR: 103660958(NOS3)
UAH: 113241474(NOS3)
UAR: 123788781(NOS3)
ELK: 111154402
LLV: 125081326
MPUF: 101673532(NOS3)
ORO: 101382350(NOS3)
EJU: 114198019(NOS3)
ZCA: 113911718(NOS3)
MLX: 118026800(NOS3)
FCA: 101096463(NOS3)
PYU: 121022952(NOS3)
PBG: 122488527(NOS3)
PTG: 102967516(NOS3)
PPAD: 109252365(NOS3)
AJU: 106969560(NOS3)
HHV: 120230927(NOS3)
BTA: 287024(NOS3)
BOM: 102267556(NOS3)
BIU: 109557793(NOS3)
BBUB: 102408451(NOS3)
CHX: 102185338(NOS3)
OAS: 443077(NOS3)
ODA: 120877875(NOS3)
SSC: 397557(NOS3)
CFR: 102524296(NOS3)
CBAI: 105067010(NOS3)
CDK: 105105831(NOS3)
VPC: 102536194(NOS3)
BACU: 103017861(NOS3)
LVE: 103087259(NOS3)
OOR: 101280520(NOS3)
DLE: 111176849(NOS3)
PCAD: 102985806(NOS3)
PSIU: 116759107(NOS3)
ECB: 100063339(NOS3)
EPZ: 103540937(NOS3)
EAI: 106823361(NOS3)
MYB: 102256555(NOS3)
MYD: 102764374(NOS3)
MMYO: 118679429(NOS3)
MLF: 102436714(NOS3)
MNA: 107524933(NOS3)
PKL: 118704763(NOS3)
HAI: 109389680(NOS3)
DRO: 112308288(NOS3)
SHON: 118975507(NOS3)
AJM: 119039263(NOS3)
PDIC: 114508069(NOS3)
PHAS: 123817951(NOS3)
MMF: 118620067(NOS3)
RFQ: 117018217(NOS3)
PALE: 102879945(NOS3)
PGIG: 120601518(NOS3)
PVP: 105303769(NOS3)
RAY: 107520319(NOS3)
MJV: 108391841(NOS3)
TOD: 119251590(NOS3)
SARA: 101547011(NOS3)
LAV: 100668912(NOS3)
TMU: 101356953
DNM: 101433723(NOS3)
MDO: 100018035(NOS3)
GAS: 123250621(NOS3)
SHR: 100913437(NOS3)
PCW: 110201937(NOS3)
OAA: 100091599(NOS3)
GGA: 107057170
PCOC: 116242834(NOS3)
MGP: 100545552
CJO: 107308662(NOS3)
AFUL: 116486135(NOS3)
TGU: 115493592(NOS3)
LSR: 110475121(NOS3)
PMOA: 120510540(NOS3)
OTC: 121334878(NOS3)
PRUF: 121356981(NOS3)
PHI: 102112141(NOS3)
ETL: 114068013(NOS3)
FPG: 101918492(NOS3)
FCH: 102057360(NOS3)
AROW: 112963744(NOS3)
NPD: 112958193
DNE: 112978916
ASN: 102381196(NOS3)
AMJ: 102575253(NOS3)
CMY: 102942806(NOS3)
CPIC: 101952927(NOS3)
TST: 117871954(NOS3)
CABI: 116834210
MRV: 120397587(NOS3)
ACS: 100557597(nos3)
PVT: 110082598(NOS3)
SUND: 121934954(NOS3)
PBI: 103065136
TSR: 106544793(NOS3)
PGUT: 117669221(NOS3)
VKO: 123019550(NOS3)
PMUA: 114607850(NOS3)
ZVI: 118092264(NOS3)
GJA: 107118610(NOS3)
XLA: 108704634(nos3.L)
XTR: 100486016(nos3)
NPR: 108803428
RTEM: 120941752(NOS3)
BBUF: 121000747(NOS3)
LOC: 102697373
ARUT: 117400058
 » show all
Reference
PMID:1378832
  Authors
Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD
  Title
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.
  Journal
J Biol Chem 267:14519-22 (1992)
  Sequence
[hsa:4846]
LinkDB

KEGG   ORTHOLOGY: K13427
Entry
K13427                      KO                                     
Symbol
NOA1
Name
nitric-oxide synthase, plant [EC:1.14.13.39]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04626  Plant-pathogen interaction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13427  NOA1; nitric-oxide synthase, plant
   00330 Arginine and proline metabolism
    K13427  NOA1; nitric-oxide synthase, plant
 09150 Organismal Systems
  09159 Environmental adaptation
   04626 Plant-pathogen interaction
    K13427  NOA1; nitric-oxide synthase, plant
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03009 Ribosome biogenesis
    K13427  NOA1; nitric-oxide synthase, plant
   03029 Mitochondrial biogenesis
    K13427  NOA1; nitric-oxide synthase, plant
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13427  NOA1; nitric-oxide synthase, plant
Ribosome biogenesis [BR:ko03009]
 Eukaryotic type
  Other ribosome biogenesis factors
   K13427  NOA1; nitric-oxide synthase, plant
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    K13427  NOA1; nitric-oxide synthase, plant
Other DBs
RN: R00111 R00557 R00558
GO: 0004517
Genes
ATH: AT3G47450(NOA1)
ALY: 9311909
CRB: 17885274
CSAT: 104711205 104780543 104790952
EUS: EUTSA_v10010252mg
BRP: 103873244
BNA: 106435290 106451204
BOE: 106336370
RSZ: 108805938
THJ: 104819450
CPAP: 110823388
CIT: 102609531
PVY: 116126567
MINC: 123224715
TCC: 18605348
GRA: 105764892
GAB: 108476635
DZI: 111291243
EGR: 104449744
VRA: 106779222
VAR: 108338876
VUN: 114168311
CCAJ: 109799300
APRC: 113864763
CAM: 101502582
LJA: Lj3g3v3640230.1(Lj3g3v3640230.1) Lj3g3v3640230.2(Lj3g3v3640230.2)
ADU: 107477402
AIP: 107629644
LANG: 109346733
RCN: 112194641
PPER: 18787454
PMUM: 103333445
PAVI: 110764709
PDUL: 117617733
MDM: 103439617
MNT: 21390065
CSV: 101215455
CMO: 103504692
BHJ: 120068223
MCHA: 111026165
CMAX: 111468852
CMOS: 111435614
CPEP: 111808842
RCU: 8289609
JCU: 105648618
MESC: 110609785
POP: 18094012
PEU: 105121408
PALZ: 118036030
JRE: 109021608
QLO: 115959749
TWL: 119984064
VVI: 100265605
VRI: 117908764
SLY: 778272
SPEN: 107014849
SOT: 102577659
CANN: 107863453
NTA: 107785662 107819728(NOS1)
NSY: 104222140
NTO: 104094540
NAU: 109209591
INI: 109151404
ITR: 116020980
SIND: 105160612
OEU: 111390921
EGT: 105971858
HAN: 110915439
ECAD: 122587094
LSV: 111901618
CCAV: 112521376
DCR: 108219256
CSIN: 114302122
BVG: 104906620
SOE: 110782360
NNU: 104602366
MING: 122064357
TSS: 122664231
NCOL: 116253542
OSA: 4328006
DOSA: Os02t0104700-01(Os02g0104700)
OBR: 102721991
BDI: 100824396
ATS: 109734442
SBI: 8066480
ZMA: 100381773
SITA: 101766392
SVS: 117849152
PHAI: 112884304
PDA: 103710739
EGU: 105059520
MUS: 103973495
DCT: 110108324
PEQ: 110019759
AOF: 109822646
ATR: 18428833
PPP: 112284854
APRO: F751_5878
TAN: TA14095
 » show all
Reference
  Authors
Li JH, Liu YQ, Lu P, Lin HF, Bai Y, Wang XC, Chen YL
  Title
A signaling pathway linking nitric oxide production to heterotrimeric G protein and hydrogen peroxide regulates extracellular calmodulin induction of stomatal closure in Arabidopsis.
  Journal
Plant Physiol 150:114-24 (2009)
DOI:10.1104/pp.109.137067
LinkDB

KEGG   ENZYME: 1.14.13.39
Entry
EC 1.14.13.39               Enzyme                                 
Name
nitric-oxide synthase (NADPH);
NOS (gene name);
nitric oxide synthetase (ambiguous);
endothelium-derived relaxation factor-forming enzyme;
endothelium-derived relaxing factor synthase;
NO synthase (ambiguous);
NADPH-diaphorase (ambiguous)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Reaction(IUBMB)
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O (overall reaction) [RN:R00557];
(1a) 2 L-arginine + 2 NADPH + 2 H+ + 2 O2 = 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O  [RN:R00558];
(1b) 2 Nomega-hydroxy-L-arginine + NADPH + H+ + 2 O2 = 2 L-citrulline + 2 nitric oxide + NADP+ + 2 H2O [RN:R00111]
Reaction(KEGG)
Substrate
L-arginine [CPD:C00062];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007];
Nomega-hydroxy-L-arginine
Product
L-citrulline [CPD:C00327];
nitric oxide [CPD:C00533];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
Nomega-hydroxy-L-arginine
Comment
The enzyme consists of linked oxygenase and reductase domains. The eukaryotic enzyme binds FAD, FMN, heme (iron protoporphyrin IX) and tetrahydrobiopterin, and its two domains are linked via a regulatory calmodulin-binding domain. Upon calcium-induced calmodulin binding, the reductase and oxygenase domains form a complex, allowing electrons to flow from NADPH via FAD and FMN to the active center. The reductase domain of the enzyme from the bacterium Sorangium cellulosum utilizes a [2Fe-2S] cluster to transfer the electrons from NADPH to the active center. cf. EC 1.14.14.47, nitric-oxide synthase (flavodoxin).
History
EC 1.14.13.39 created 1992, modified 2012, modified 2017
Pathway
ec00220  Arginine biosynthesis
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13240  nitric-oxide synthase, brain
K13241  nitric-oxide synthase, inducible
K13242  nitric-oxide synthase, endothelial
K13427  nitric-oxide synthase, plant
Genes
HSA4842(NOS1) 4843(NOS2) 4846(NOS3)
PTR455026(NOS2) 463893(NOS3) 467139(NOS1)
PPS100974638(NOS3) 100976546(NOS2) 100996089(NOS1)
GGO101128007(NOS3) 101134923(NOS2) 101147071(NOS1)
PON100433069(NOS1) 100436584(NOS2) 100447953(NOS3)
NLE100589003(NOS2) 100592456(NOS3) 100597250(NOS1)
MCC114673005 693781(NOS1) 706921(NOS2) 714231(NOS3)
MCF102121432(NOS2) 102123521(NOS1) 102143504(NOS3)
CSAB103227233(NOS3) 103242598 103242600(NOS2)
CATY105584734(NOS3) 105591502(NOS2) 105592744(NOS1)
PANU101019718 101024888(NOS3) 101025542(NOS1)
TGE112609895(NOS2) 112620359(NOS3) 112634545(NOS1)
RRO104669357(NOS2) 104675393(NOS3) 104675533(NOS1)
RBB108532525(NOS3) 108539288(NOS1) 108539959(NOS2)
TFN117067605(NOS2) 117072600(NOS3) 117089332(NOS1)
PTEH111520811(NOS2) 111537519(NOS1) 111551457(NOS3)
CJC100403192(NOS2) 100405019(NOS3) 100895717(NOS1)
SBQ101034220(NOS3) 101034544(NOS1) 101041016(NOS2)
CSYR103250172 103274370(NOS2) 103275280(NOS3)
MMUR105857991(NOS2) 105866961(NOS1) 105883168(NOS3)
OGA100946509(NOS1) 100956703(NOS3) 100958618(NOS2)
MMU18125(Nos1) 18126(Nos2) 18127(Nos3)
MCAL110293897(Nos3) 110294416(Nos1) 110304621(Nos2)
MPAH110312876(Nos1) 110315110(Nos3) 110331408(Nos2)
RNO24598(Nos1) 24599(Nos2) 24600(Nos3)
MCOC116068288(Nos1) 116076938(Nos2) 116097543(Nos3)
MUN110550157(Nos2) 110551884(Nos1) 110562552(Nos3)
CGE100758127(Nos1) 100760062(Nos2) 100769961(Nos3)
PLEU114691518(Nos2) 114699651(Nos1) 114700088(Nos3)
NGI103724501(Nos2) 103745303(Nos3) 103745523(Nos1)
HGL101699617(Nos2) 101711110(Nos3) 101711993(Nos1)
CPOC100135576(Nos2) 100135577(Nos3) 100729682(Nos1)
CCAN109686387(Nos1) 109693015(Nos2) 109694442(Nos3)
DORD105984213(Nos1) 105985658(Nos2) 105993873(Nos3)
DSP122099033(Nos1) 122105913(Nos3) 122120264(Nos2)
OCU100008833(NOS2) 100009243(NOS1) 100009498(NOS3)
OPI101520691(NOS3) 101522087(NOS1) 101535394(NOS2)
TUP102471872(NOS2) 102480558(NOS1) 102495986(NOS3)
CFA403784(NOS3) 403822(NOS2) 477498(NOS1)
VVP112916218(NOS3) 112932933(NOS1) 112933146(NOS2)
VLG121472657(NOS2) 121475796(NOS1) 121489275(NOS3)
AML100468087(NOS1) 100470060(NOS2) 100483990(NOS3)
UMR103660958(NOS3) 103661304(NOS1) 103667420(NOS2)
UAH113241474(NOS3) 113266817(NOS1) 113269018(NOS2)
UAR123776978(NOS2) 123778556(NOS1) 123788781(NOS3)
ELK111151537 111154402 111156411
LLV125081326 125082424 125087863
MPUF101673532(NOS3) 101692439(NOS1) 101694448(NOS2)
ORO101375441(NOS1) 101380967(NOS2) 101382350(NOS3)
EJU114198019(NOS3) 114214012(NOS2) 114219124(NOS1)
ZCA113907948(NOS2) 113911718(NOS3) 113913115(NOS1)
MLX118018518(NOS1) 118025303(NOS2) 118026800(NOS3)
FCA101087020(NOS2) 101096463(NOS3) 101100342(NOS1)
PYU121010269(NOS1) 121017178(NOS2) 121022952(NOS3)
PBG122470274(NOS1) 122485185(NOS2) 122488527(NOS3)
PTG102950049(NOS2) 102962715(NOS1) 102967516(NOS3)
PPAD109251875(NOS2) 109252365(NOS3) 109277571(NOS1)
AJU106969560(NOS3) 106971710(NOS1) 106984382(NOS2)
HHV120230927(NOS3) 120232363(NOS1) 120246360(NOS2)
BTA282876(NOS2) 287024(NOS3) 536132(NOS1)
BOM102265893(NOS2) 102267556(NOS3) 102280537(NOS1)
BIU109557793(NOS3) 109571319(NOS1) 109574459(NOS2)
BBUB102400136(NOS1) 102401026(NOS2) 102408451(NOS3)
CHX100860742(NOS2) 102185338(NOS3) 102185490(NOS1)
OAS443077(NOS3) 443078(NOS2) 443533(NOS1)
ODA120866313(NOS2) 120871573(NOS1) 120877875(NOS3)
CCAD122423224(NOS1) 122448629(NOS2)
SSC100520934(NOS1) 396859(NOS2) 397557(NOS3)
CFR102508946(NOS1) 102518523(NOS2) 102524296(NOS3)
CBAI105067010(NOS3) 105071584(NOS2) 105075702(NOS1)
CDK105088198(NOS2) 105104911(NOS1) 105105831(NOS3)
VPC102534932(NOS2) 102536194(NOS3) 102542069(NOS1)
BACU103003780(NOS2) 103008209(NOS1) 103017861(NOS3)
LVE103074308(NOS2) 103087259(NOS3) 103090138(NOS1)
OOR101273057(NOS1) 101280520(NOS3) 101280638(NOS2)
DLE111176849(NOS3) 111185989 111186931(NOS1)
PCAD102985806(NOS3) 102990905(NOS2) 102991967(NOS1)
PSIU116738822(NOS1) 116745263(NOS2) 116759107(NOS3)
ECB100051079(NOS1) 100063339(NOS3) 791246(NOS2)
EPZ103540937(NOS3) 103547950(NOS1) 103567002
EAI106823361(NOS3) 106839766(NOS1) 106844596(NOS2)
MYB102253125(NOS2) 102256555(NOS3) 102260489(NOS1)
MYD102763635(NOS1) 102764374(NOS3) 102768087(NOS2)
MMYO118672123(NOS2) 118678505(NOS1) 118679429(NOS3)
MLF102424107(NOS2) 102433074(NOS1) 102436714(NOS3)
MNA107524933(NOS3) 107528483(NOS1) 107533063(NOS2)
PKL118702516(NOS2) 118704763(NOS3) 118725282(NOS1)
HAI109382238(NOS1) 109385084(NOS2) 109389680(NOS3)
DRO112308288(NOS3) 112308600(NOS2) 112310614(NOS1)
SHON118975507(NOS3) 118991149(NOS1) 119003495(NOS2)
AJM119039263(NOS3) 119057483(NOS1) 119062015(NOS2)
PDIC114503016(NOS2) 114508069(NOS3) 114509381(NOS1)
PHAS123817124(NOS2) 123817951(NOS3) 123820989(NOS1)
MMF118620067(NOS3) 118634857(NOS2) 118639832(NOS1)
RFQ117012675(NOS2) 117017522(NOS1) 117018217(NOS3)
PALE102878456(NOS2) 102879945(NOS3) 102884569(NOS1)
PGIG120601518(NOS3) 120606760(NOS1) 120620943(NOS2)
PVP105289401(NOS1) 105291934(NOS2) 105303769(NOS3)
RAY107497410(NOS2) 107513162(NOS1) 107520319(NOS3)
MJV108391841(NOS3) 108397044(NOS2) 108397443(NOS1)
TOD119231002(NOS2) 119244938(NOS1) 119251590(NOS3)
SARA101547011(NOS3) 101548820(NOS2) 101559239(NOS1)
LAV100668912(NOS3) 100673992(NOS1) 100676634(NOS2)
TMU101342004 101356579 101356953
DNM101411311(NOS1) 101433723(NOS3) 101440596(NOS2)
MDO100013712(NOS1) 100018035(NOS3) 100024271(NOS2)
GAS123247380(NOS2) 123250621(NOS3) 123256892(NOS1)
SHR100913437(NOS3) 100921140(NOS1) 100927789(NOS2)
PCW110192171(NOS2) 110201937(NOS3) 110222812(NOS1)
OAA100075386(NOS2) 100091599(NOS3) 100093259(NOS1)
GGA107057170 395807(NOS2) 427721(NOS1)
PCOC116227904(NOS2) 116228339(NOS1) 116242834(NOS3)
MGP100538441(NOS1) 100545552 692136(NOS2)
CJO107308662(NOS3) 107321466(NOS1) 107322733(NOS2)
NMEL110406170(NOS1) 110407551(NOS2)
APLA101798766(NOS1) 101804455(NOS2)
ACYG106043795(NOS2) 106045554(NOS1)
AFUL116486135(NOS3) 116496320(NOS1) 116497109(NOS2)
TGU100230954(NOS2) 100231414(NOS1) 115493592(NOS3) 116807264
LSR110471958(NOS2) 110474155(NOS1) 110475121(NOS3)
SCAN103818226(NOS1) 103820198(NOS2)
PMOA120507736(NOS2) 120510300(NOS1) 120510540(NOS3)
OTC121334878(NOS3) 121344475(NOS1) 121347051(NOS2)
PRUF121356981(NOS3) 121361668(NOS2) 121364923(NOS1)
GFR102042821(NOS1) 102044468(NOS2)
FAB101817488(NOS2) 101820761(NOS1)
PHI102106809(NOS1) 102108817(NOS2) 102112141(NOS3)
PMAJ107211573(NOS1) 107212812(NOS2)
CCAE111936662(NOS1) 111937881(NOS2)
CCW104690967(NOS2) 104695038(NOS1)
ETL114057504(NOS2) 114068013(NOS3) 114071586(NOS1)
ZAB102070665(NOS2) 102072905(NOS1)
FPG101916747(NOS1) 101918492(NOS3) 101921726(NOS2)
FCH102047821(NOS1) 102048023(NOS2) 102057360(NOS3)
CLV102086291(NOS2) 102093432(NOS1)
EGZ104121908(NOS2) 104129871(NOS1)
NNI104010553(NOS1) 104016248(NOS2)
ACUN113486129(NOS1) 113487234(NOS2)
TALA104361402(NOS1) 104367550(NOS2)
PADL103912519(NOS2) 103913684(NOS1)
ACHC115346336(NOS1) 115346926(NOS2)
AAM106493898(NOS1) 106498669(NOS2)
AROW112963744(NOS3) 112968206(NOS2) 112976786(NOS1)
NPD112950374(NOS1) 112954567(NOS2) 112958193
DNE112978916 112987008(NOS2) 112994650(NOS1)
ASN102375419(NOS2) 102380334(NOS1) 102381196(NOS3)
AMJ102561243(NOS1) 102575253(NOS3) 106737013(NOS2)
CPOO109312966(NOS1) 109317113(NOS2)
GGN109290264(NOS1) 109293229(NOS2)
PSS102444149(NOS1) 102446334(NOS2)
CMY102941829(NOS1) 102942806(NOS3) 102946684(NOS2)
CPIC101937660(NOS1) 101941684(NOS2) 101952927(NOS3)
TST117867669(NOS2) 117871954(NOS3) 117888179(NOS1)
CABI116824205(NOS2) 116834210 116836436(NOS1)
MRV120386165(NOS1) 120387127(NOS2) 120397587(NOS3)
ACS100557597(nos3) 100561200(nos2) 100562233(nos1)
PVT110082598(NOS3) 110088446(NOS2) 110090104(NOS1)
SUND121916538(NOS1) 121917020 121934954(NOS3)
PBI103051066(NOS2) 103052972(NOS1) 103065136
PMUR107295430(NOS1) 107296204(NOS2)
TSR106544793(NOS3) 106555338(NOS2)
PGUT117657845(NOS1) 117667437(NOS2) 117669221(NOS3)
VKO123019550(NOS3) 123023387(NOS2) 123032750(NOS1)
PMUA114585803(NOS2) 114587067(NOS1) 114607850(NOS3)
ZVI118075983(NOS1) 118092264(NOS3) 118097243(NOS2)
GJA107112296(NOS1) 107118610(NOS3) 107119447(NOS2)
XLA108704634(nos3.L) 108707179(nos1.S) 108708038(nos2.L) 108708888(nos2.S) 373705(nos1.L)
XTR100486016(nos3) 100494698(nos2) 100497595(nos1)
NPR108785232(NOS1) 108801680(NOS2) 108803428
RTEM120927627(NOS2) 120932977(NOS1) 120941752(NOS3)
BBUF120991402(NOS1) 120994733(NOS2) 121000747(NOS3)
BGAR122930441 122931705 122935037(NOS1) 122938595 122938785
DRE404036(nos2a) 563654(nos2b) 60658(nos1)
SRX107719931 107726721 107755829(nos1) 107756441
SANH107660266 107666185 107668720 107683435(nos2) 107704495(nos1)
SGH107553584 107588374 107592916(nos2) 107599142(nos1) 107599638
CCAR109079125 109079156 109080897 109103595 109103596
CAUA113058570 113068104 113072250 113075348 113078755 113114808
IPU108255344(nos1) 108277518 108278375(nos2b)
PHYP113537215(nos1) 113539231 113539397
SMEO124380832(nos1) 124395037 124395094
AMEX103026958 103031688 103046065(nos1)
EEE113577767(nos1) 113591429
TRU101066909(nos1)
TNGGSTEN00029052G001
LCO104923687(nos1)
NCC104967506(nos1)
CGOB115014031(nos1)
ELY117252891(nos1)
PLEP121943974(nos1)
SLUC116054158(nos1)
ECRA117944931(nos1)
PFLV114555256(nos1)
GAT120830799(nos1)
PPUG119225179(nos1)
MSAM119892185(nos1)
CUD121510247(nos1)
MZE101485683(nos1)
ONL100534582(nos1)
OAU116325579(nos1)
OLA100049502(nos1)
OML112148312(nos1)
XMA102233853(nos1)
XCO114154866(nos1)
XHE116729879(nos1)
PRET103469871(nos1)
PFOR103134950(nos1)
PLAI106945253(nos1)
PMEI106919449(nos1)
GAF122827934(nos1)
CVG107087335(nos1)
CTUL119788886(nos1)
GMU124878013(nos1)
NFU107386248(nos1)
KMR108246938(nos1)
ALIM106519449(nos1)
NWH119413183(nos1)
AOCE111572539(nos1)
CSEM103396877 103397851(nos1)
POV109637139(nos1)
SSEN122769681(nos1)
HHIP117768184(nos1)
LCF108903114(nos1)
SDU111227324(nos1)
SLAL111663111(nos1)
XGL120805277(nos1)
HCQ109525272(nos1)
BPEC110155016(nos1)
MALB109959109(nos1)
SASA100136358(nos2) 100136388(nos1) 106585241
OTW112248861(nos1) 112262564 112266155 112267222
OMY100136036(nos2) 100136347(nos1) 110507147 110535113
OGO124005468 124034044(nos1) 124035286
ONE115111915(nos1) 115115929 115141939
SALP111949918 111958203 111960727(nos2) 111974596
SNH120018738 120028669 120043829(nos1) 120062808
ELS105013989(nos2) 105031277(nos1) 109615805
SFM108927312(nos1) 108932266(nos2)
PKI111851114 111852748(nos1) 111856407(nos2)
AANG118206631(nos1)
LOC102692649(nos2) 102697373 102699252(nos1)
PSPA121296840 121299518 121308730(nos2b) 121312985 121314660
ARUT117394670 117394704 117400058 117426910 117428352 117429557 117430593
LCM102348281(NOS1) 102354990(NOS2)
CMK103183299(nos2b) 103184386(nos1)
RTP109914181(nos1) 109922224 109927199(nos2)
BFO118404760 118413899 118426508
BBEL109469130 109475091 109479447
CIN100183039
SCLV120325991 120326000
SPU100888109 587111
APLC110976884 110976936
DMEDmel_CG6713(Nos)
DER6542987
DSE6612066
DSIDsimw501_GD22223(Dsim_GD22223)
DYADyak_GE13295
DAN6496893
DSR110183462
DPODpse_GA19805
DPE6596585
DMN108163699
DWI6641760
DGR6566802
DMODmoj_GI17812
DAZ108609612
DNV108658145
DHE111601524
DVI6629111
CCAT101456696 101457075
BOD106620796 106621192
MDE101891936
SCAC106083069
LCQ111681704
AGAAgaP_AGAP008255 AgaP_AGAP008257
ACOZ120957719
AARA120901512
AAG5572370
AALB109402508 109416795
CQUCpipJ_CPIJ000366 CpipJ_CPIJ019871
CPII120432426
CNS116341093
AME503861(NOS)
ACER107998213
ALAB122712365
BIM100749227
BBIF117209160
BVK117239566
BVAN117165749
BTER100650517
BPYO122566286
CCAL108625325
OBB114871710
MGEN117222304
NMEA116434882
CGIG122398338
SOC105200228
MPHA105829748
AEC105149468
ACEP105625167
PBAR105432905
VEM105557978
HST105183230
DQU106744004
CFO105250272
FEX115240251
LHU105675559
PGC109856190
OBO105286125
PCF106793080
PFUC122516940
VPS122628777
NVI100313941(Nos)
CSOL105360744
MDL103570884
CGLO123264608
FAS105263042
DAM107044602
AGIF122848352
CCIN107269169
TCA655549
DPA109546644
SOY115884119
ATD109603629 109606901
CSET123313082
AGB108908391
LDC111501949
NVL108558954
APLN108740077
PPYR116177033 116177043
OTU111427474
BMOR100144542(NOS2) 692510(NOS1)
BMAN114243188 114243206
MSEX115445277 115445279
DPLKGM_202094
BANY112048436 112048444
PMAC106718432 106718546
PPOT106104091 106105182
PXU106128430 106128432
PRAP110995634 110995640
ZCE119834982 119834983
HAW110378704 110378714
TNL113504450 113504511 113504548
OFU114365595 114365602
PXY105388815 105388816
API100160390
DNX107172687
AGS114128082
RMD113551041
BTAB109031807
DCI103519178
CLEC106661589
HHAL106678228
NLU111044297
PHUPhum_PHUM176630
FOC113213110
ZNE110828058
CSEC111862897
FCD110850636
DPXDAPPUDRAFT_314346 DAPPUDRAFT_49977
DMK116926468 116928975
PVM113823177 113828626
PJA122253978
HAME121863979
PCLA123754516 123754968 123755062 123759937
PTRU123510911
HAZT108677990
ISCIscW_ISCW018074
DSV119446119
RSAN119390050
RMP119161273
TUT107370056
DPTE113792010
DFR124499006
CSCU111619022 111620432 111620451
PTEP107440636
SDM118194050 118197261
LGILOTGIDRAFT_197993
PCAN112563084
GAE121368198 121368682 121390711 121391199
HRF124112147 124116041 124116043 124150822
HRJ124254027 124254028 124275692 124278491
CRG105322950
MYI110460719
PMAX117333205
MMER123533726
LAK106163703 106169208 106176019
NVE5511062
EPA110253339
ATEN116290507 116290867
ADF107337967 107341488 107355966
AMIL114957458 114967140
PDAM113685754
SPIS111339078 111345090
DGT114523867 114524113
XEN124433818
HMG101240122
TADTRIADDRAFT_18893 TRIADDRAFT_19964 TRIADDRAFT_31504
ATHAT3G47450(NOA1)
ALY9311909
CRB17885274
CSAT104711205 104780543 104790952
EUSEUTSA_v10010252mg
BRP103873244
BNA106435290 106451204
BOE106336370
RSZ108805938
THJ104819450
CPAP110823388
CIT102609531
CICCICLE_v10004670mg
PVY116126567
MINC123224715
TCC18605348
GRA105764892
GHI107933448 107955121
GAB108476635
DZI111291243
EGR104449744
GMX100781340 100798614
GSJ114378370 114425871
PVUPHAVU_011G015300g
VRA106779222
VAR108338876
VUN114168311
CCAJ109799300
APRC113864763
MTRMTR_2g060420
CAM101502582
LJALj3g3v3640230.1(Lj3g3v3640230.1) Lj3g3v3640230.2(Lj3g3v3640230.2)
ADU107477402
AIP107629644
AHF112737290 112789366
LANG109346733
FVE101301911 101307253
RCN112194641
PPER18787454
PMUM103333445
PAVI110764709
PDUL117617733
MDM103439617
PXB103959816 103961947
ZJU107408397 107414210
MNT21390065
CSV101215455
CMO103504692
BHJ120068223
MCHA111026165
CMAX111468852
CMOS111435614
CPEP111808842
RCU8289609
JCU105648618
HBR110662682 110663877
MESC110609785
POP18094012
PEU105121408
PALZ118036030
JRE109021608
QSU111998951 112029395 112040032
QLO115959749
TWL119984064
VVI100265605
VRI117908764
SLY778272
SPEN107014849
SOT102577659
CANN107863453
NTA107785662 107819728(NOS1)
NSY104222140
NTO104094540
NAU109209591
INI109151404
ITR116020980
SIND105160612
OEU111390921
EGT105971858
SSPL121755293 121756935
HAN110915439
ECAD122587094
LSV111901618
CCAV112521376
DCR108219256
CSIN114302122
BVG104906620
SOE110782360
CQI110689346 110717554
NNU104602366
MING122064357
TSS122664231
PSOM113297229 113302433
NCOL116253542
OSA4328006
DOSAOs02t0104700-01(Os02g0104700)
OBR102721991
BDI100824396
ATS109734442
TDC119319238 119323707
TAES123131611 123135406 123142968
SBI8066480
ZMA100381773
SITA101766392
SVS117849152
PVIR120654364 120661573
PHAI112884304
PDA103710739
EGU105059520
MUS103973495
DCT110108324
PEQ110019759
AOF109822646
ATR18428833
SMOSELMODRAFT_164227 SELMODRAFT_87746
PPP112284854
VCNVOLCADRAFT_120437
MNGMNEG_12684
CSLCOCSUDRAFT_26953
CVRCHLNCDRAFT_141029
APROF751_5878
OTAOT_ostta04g02630 OT_ostta17g00030
BPGBathy06g04850
MISMICPUN_58144
CFJCFIO01_00348
NPAUCRNP2_4118
TANTA14095
 » show all
Reference
1  [PMID:1689048]
  Authors
Bredt DS, Snyder SH.
  Title
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
  Journal
Proc Natl Acad Sci U S A 87:682-5 (1990)
DOI:10.1073/pnas.87.2.682
Reference
2  [PMID:1706713]
  Authors
Stuehr DJ, Kwon NS, Nathan CF, Griffith OW, Feldman PL, Wiseman J
  Title
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
  Journal
J Biol Chem 266:6259-63 (1991)
Reference
3  [PMID:11279231]
  Authors
Stuehr D, Pou S, Rosen GM
  Title
Oxygen reduction by nitric-oxide synthases.
  Journal
J Biol Chem 276:14533-6 (2001)
DOI:10.1074/jbc.R100011200
Reference
4  [PMID:19805284]
  Authors
Agapie T, Suseno S, Woodward JJ, Stoll S, Britt RD, Marletta MA
  Title
NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum.
  Journal
Proc Natl Acad Sci U S A 106:16221-6 (2009)
DOI:10.1073/pnas.0908443106
Reference
5  [PMID:21119059]
  Authors
Foresi N, Correa-Aragunde N, Parisi G, Calo G, Salerno G, Lamattina L
  Title
Characterization of a nitric oxide synthase from the plant kingdom: NO generation from the green alga Ostreococcus tauri is light irradiance and growth phase dependent.
  Journal
Plant Cell 22:3816-30 (2010)
DOI:10.1105/tpc.109.073510
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.39
IUBMB Enzyme Nomenclature: 1.14.13.39
ExPASy - ENZYME nomenclature database: 1.14.13.39
BRENDA, the Enzyme Database: 1.14.13.39
CAS: 125978-95-2
LinkDB

KEGG   REACTION: R00557
Entry
R00557                      Reaction                               
Name
L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
Definition
2 L-Arginine + 4 Oxygen + 3 NADPH + 3 H+ <=> 2 Nitric oxide + 2 L-Citrulline + 3 NADP+ + 4 H2O
Equation
2 C00062 + 4 C00007 + 3 C00005 + 3 C00080 <=> 2 C00533 + 2 C00327 + 3 C00006 + 4 C00001
Comment
multi-step reaction (see R00558+R00111)
NADH (see R10106)
Reaction class
RC00001  C00005_C00006
RC00177  C00062_C00327
Enzyme
Pathway
rn00220  Arginine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K13240  nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  nitric-oxide synthase, inducible [EC:1.14.13.39]
K13242  nitric-oxide synthase, endothelial [EC:1.14.13.39]
K13427  nitric-oxide synthase, plant [EC:1.14.13.39]
Other DBs
RHEA: 19900
LinkDB

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