KEGG   ORTHOLOGY: K13302
Entry
K13302                      KO                                     
Symbol
SGK1
Name
serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]
Pathway
map04068  FoxO signaling pathway
map04148  Efferocytosis
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04960  Aldosterone-regulated sodium reabsorption
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
   04151 PI3K-Akt signaling pathway
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
   04150 mTOR signaling pathway
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K13302  SGK1; serum/glucocorticoid-regulated kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K13302  SGK1; serum/glucocorticoid-regulated kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  SGK family [OT]
   K13302  SGK1; serum/glucocorticoid-regulated kinase 1
Genes
HSA: 6446(SGK1)
PTR: 463011(SGK1)
PPS: 100984960(SGK1)
GGO: 101132422(SGK1)
PON: 129047236(SGK1)
PPYG: 129037979
NLE: 100586194(SGK1)
HMH: 116472584(SGK1)
SSYN: 129473745(SGK1)
MCC: 713082(SGK1)
MCF: 101866184(SGK1)
MTHB: 126952874
MNI: 105465645(SGK1)
CSAB: 103240340(SGK1)
CATY: 105600428
PANU: 101017114(SGK1)
TGE: 112623602(SGK1)
MLEU: 105547766(SGK1)
RRO: 104678238
RBB: 108531834(SGK1)
TFN: 117097504
PTEH: 111554889(SGK1)
CANG: 105526195(SGK1)
CJC: 100389266(SGK1)
SBQ: 101046433(SGK1)
CIMI: 108297394(SGK1)
ANAN: 105732368(SGK1)
CSYR: 103276717(SGK1)
MMUR: 105857243(SGK1)
LCAT: 123633293
PCOQ: 105827188(SGK1)
OGA: 100948095(SGK1)
MMU: 20393(Sgk1)
MCAL: 110302862(Sgk1)
MPAH: 110338537(Sgk1)
RNO: 29517(Sgk1)
MCOC: 116097831(Sgk1)
ANU: 117700994(Sgk1) 117701891 117717336
MUN: 110550419(Sgk1)
CGE: 100771433(Sgk1)
MAUA: 101829943(Sgk1)
PROB: 127215060(Sgk1)
MORG: 121449339
MFOT: 126511965
AAMP: 119821263(Sgk1)
NGI: 103724913(Sgk1) 103733926
HGL: 101708117(Sgk1)
CPOC: 100720058(Sgk1)
CCAN: 109697937(Sgk1)
DORD: 105993569(Sgk1)
DSP: 122107005(Sgk1) 122114215
PLOP: 125357304(Sgk1)
NCAR: 124988613
MMMA: 107155549(Sgk1)
OCU: 100008723(SGK1)
OPI: 101526325(SGK1)
TUP: 102499967(SGK1)
GVR: 103596668(SGK1)
CFA: 403647(SGK1)
CLUD: 112644153(SGK1)
VVP: 112919455(SGK1)
VLG: 121484830(SGK1)
NPO: 129509226(SGK1)
AML: 100468926(SGK1)
UMR: 103663385(SGK1)
UAH: 113259468
UAR: 123797568(SGK1)
ELK: 111147659
LLV: 125102732
MPUF: 101678505(SGK1)
MNP: 132018177(SGK1)
MLK: 131833777(SGK1)
NVS: 122906460(SGK1)
ORO: 101378055(SGK1)
EJU: 114206626 114225658
ZCA: 113924665 113927108(SGK1)
MLX: 118000805(SGK1)
NSU: 110583655(SGK1)
LWW: 102735522(SGK1)
FCA: 101098954(SGK1)
PYU: 121013433(SGK1)
PCOO: 112862092(SGK1)
PBG: 122490011(SGK1)
PVIV: 125166306(SGK1)
LRUF: 124528063
PTG: 102966723(SGK1)
PPAD: 109249901(SGK1)
PUC: 125937990
AJU: 106976864
HHV: 120238347(SGK1)
BTA: 515854(SGK1)
BOM: 102272039(SGK1)
BIU: 109563967
BBUB: 102405402(SGK1)
BBIS: 104991686(SGK1)
CHX: 102176607(SGK1)
OAS: 101107709(SGK1)
BTAX: 128053038(SGK1)
ODA: 120863053(SGK1)
CCAD: 122434060(SGK1)
MBEZ: 129561018(SGK1)
SSC: 100625739(SGK1)
CFR: 102516719(SGK1)
CBAI: 105077247(SGK1)
CDK: 105096363(SGK1)
VPC: 102537028(SGK1) 107033172
BACU: 103016100(SGK1)
BMUS: 118889154 118905080(SGK1)
LVE: 103071928(SGK1)
OOR: 101281043(SGK1)
DLE: 111165956 111177220
PCAD: 102987463(SGK1) 112065033
PSIU: 116759483 116763384
NASI: 112398354 112409111
ECB: 100073151(SGK1)
EPZ: 103556350
EAI: 106837176(SGK1)
MYB: 102250674(SGK1)
MYD: 102766031(SGK1)
MMYO: 118660084(SGK1)
MLF: 102421134(SGK1)
MDT: 132236906
PKL: 118705938(SGK1)
EFUS: 103305472(SGK1)
MNA: 107530994(SGK1)
DRO: 112297072(SGK1)
SHON: 118986683
AJM: 119039939(SGK1)
PDIC: 114494180(SGK1)
PHAS: 123821687(SGK1)
MMF: 118621399(SGK1)
PPAM: 129067792(SGK1)
HAI: 109371924(SGK1)
RFQ: 117019130(SGK1)
PALE: 102891704
PGIG: 120615796
PVP: 105289483
RAY: 107516175(SGK1)
MJV: 108394031(SGK1)
TOD: 119252895(SGK1)
SARA: 101551219(SGK1)
SETR: 126029731(SGK1)
LAV: 100666881
TMU: 101349244
ETF: 101654490(SGK1)
DNM: 101434507
MDO: 100025435(SGK1)
GAS: 123247938(SGK1)
SHR: 100935143(SGK1)
AFZ: 127562233
PCW: 110208905(SGK1)
TVP: 118856493(SGK1)
OAA: 100073891(SGK1)
GGA: 395133(SGK1)
PCOC: 116240381(SGK1)
MGP: 100541500(SGK1)
CJO: 107311699(SGK1)
TPAI: 128080821(SGK1)
LMUT: 125689446(SGK1)
NMEL: 110390596
APLA: 101801765
ACYG: 106032508
CATA: 118243957(SGK1)
AFUL: 116487835(SGK1)
TGU: 100219883(SGK1)
LSR: 110476052(SGK1)
SCAN: 103820550(SGK1)
PMOA: 120501191
OTC: 121346155(SGK1)
PRUF: 121354838(SGK1)
GFR: 102037330(SGK1)
FAB: 101810101(SGK1)
OMA: 130250982(SGK1)
PHI: 102101880(SGK1)
PMAJ: 107202355
CCAE: 111927653(SGK1)
CCW: 104690470(SGK1)
CBRC: 103619327(SGK1)
ETL: 114065221(SGK1)
ZAB: 102075037(SGK1)
ZLE: 135445528(SGK1)
ACHL: 103808494(SGK1)
SVG: 106851917(SGK1)
MMEA: 130572604(SGK1)
HRT: 120749959(SGK1)
SATI: 136359105(SGK1)
FPG: 101924246(SGK1)
FCH: 102052186
CCRI: 104166189(SGK1)
NNT: 104406971(SGK1)
SHAB: 115609508
ACUN: 113478259(SGK1)
TALA: 104356280(SGK1)
ACHC: 115344814(SGK1)
HALD: 104316787(SGK1)
HLE: 104836223(SGK1)
AGEN: 126038455
GCL: 127013998
CSTI: 104550554(SGK1)
LDI: 104340935(SGK1)
MNB: 103772288(SGK1)
DPUB: 104306970(SGK1)
AVIT: 104270997(SGK1)
BRHI: 104500561(SGK1)
EGZ: 104131203(SGK1)
NNI: 104008826(SGK1)
PCRI: 104025225(SGK1)
PCAO: 104048992(SGK1)
PADL: 103912698(SGK1)
AFOR: 103900743(SGK1)
FGA: 104084047(SGK1)
GSTE: 104264026(SGK1)
CLV: 102094792(SGK1)
MUI: 104540732(SGK1)
PGUU: 104468219(SGK1)
PLET: 104621612(SGK1)
EHS: 104504021(SGK1)
CMAC: 104477406(SGK1)
CUCA: 104058233
TEO: 104374767(SGK1)
BREG: 104636346(SGK1)
OHA: 104327068(SGK1)
ACAR: 104529266
CPEA: 104390056(SGK1)
CVF: 104282104(SGK1)
RTD: 128906765(SGK1)
AAM: 106498005(SGK1)
AROW: 112970150(SGK1)
NPD: 112954908(SGK1)
TGT: 104571671(SGK1)
DNE: 112995692
SCAM: 104153137
ASN: 102371183(SGK1)
AMJ: 102576261(SGK1)
CPOO: 109312037(SGK1)
GGN: 109299744
PSS: 102450219(SGK1)
CMY: 102932644(SGK1)
CCAY: 125634151(SGK1)
DCC: 119854098(SGK1)
CPIC: 101936659(SGK1)
TST: 117874915
CABI: 116827542
MRV: 120400868(SGK1)
ACS: 100565714(sgk1)
ASAO: 132760985(SGK1)
PVT: 110071906(SGK1)
SUND: 121928903
PBI: 103054879
PMUR: 107289907(SGK1)
CTIG: 120299136(SGK1)
TSR: 106555854(SGK1)
PGUT: 117666282(SGK1)
APRI: 131192381
PTEX: 113439608(SGK1)
NSS: 113411194(SGK1)
VKO: 123020394
PMUA: 114594162(SGK1)
PRAF: 128410554(SGK1)
ZVI: 118082082(SGK1)
HCG: 128341611(SGK1)
GJA: 107111430(SGK1)
STOW: 125429283(SGK1)
EMC: 129325950(SGK1)
XLA: 399130(sgk1.L) 444618(sgk1.S)
XTR: 594981(sgk1)
NPR: 108794122
RTEM: 120937337(SGK1)
BBUF: 120998512(SGK1)
BGAR: 122934078(SGK1)
MUO: 115466887(SGK1)
GSH: 117357381(SGK1)
DRE: 324140(sgk1) 559050(sgk2b) 768159(si:ch211-195b13.1)
SRX: 107706345 107723736 107731568 107738591 107756394
SANH: 107671861 107672866 107687822 107701736 107702504
SGH: 107549055 107571333 107578381 107578731 107595908
CCAR: 109055590 109064023 109090243 109105363
CAUA: 113041413 113059621 113065600 113076495 113090778 113116653 113119230
CGIB: 127935928 127944578 127974735 127978839(si:ch211-195b13.1) 128011843 128030649
PTET: 122324014(si:ch211-195b13.1) 122328668(sgk1) 122359845(sgk2b)
LROH: 127154517(sgk1) 127178243(sgk2b) 127181632(si:ch211-195b13.1)
OMC: 131521596(sgk2b) 131526179(si:ch211-195b13.1) 131532422(sgk1)
PPRM: 120463096(sgk1) 120484280(sgk2b) 120485289(si:ch211-195b13.1)
RKG: 130075303(sgk1) 130087966(si:ch211-195b13.1) 130101924(sgk2b)
MAMB: 125243134(sgk2b) 125259684(sgk1) 125274706(si:ch211-195b13.1)
CIDE: 127497706 127501252(si:ch211-195b13.1) 127504569
CERY: 137008865(sgk1) 137027186(sgk2b) 137037103(si:ch211-195b13.1)
MASI: 127418670 127420563 127421493 127425664 127452876 127453719
TROS: 130557985(sgk2b) 130567197(si:ch211-195b13.1) 130572051(sgk1)
TDW: 130409041(sgk1) 130432895(sgk2b)
MANU: 129430559(sgk1) 129448054(sgk2b) 129455529(si:ch211-195b13.1)
IPU: 108256136(sgk2b) 108273319(si:ch211-195b13.1) 108276211
IFU: 128599976(sgk2b) 128615815(si:ch211-195b13.1) 128619921(sgk1)
PHYP: 113532886 113543898 113545593(sgk1)
SMEO: 124375412(sgk2b) 124382165(si:ch211-195b13.1) 124398971(sgk1)
TFD: 113658296(sgk2b) 113658895(sgk1) 113662830(si:ch211-195b13.1)
TVC: 132840517(sgk2b) 132842683(si:ch211-195b13.1) 132861963(sgk1)
TRN: 134300818(sgk2b) 134328478(si:ch211-195b13.1) 134333530(sgk1)
AMEX: 103022302(sgk2b) 103029224(sgk1) 103036792(si:ch211-195b13.1)
CMAO: 118798768(sgk2b) 118805276(si:ch211-195b13.1) 118822004
EEE: 113571961 113582925 113591530(sgk1)
CHAR: 105892152(si:ch211-195b13.1) 105894676(sgk1) 105897889(sgk2b)
TRU: 101068373 101075473(sgk1) 101079677
TFS: 130515909(sgk1) 130518827(si:ch211-195b13.1) 130533200(sgk2b)
TNG: GSTEN00030273G001 GSTEN00034014G001
LCO: 104923042 104925665(sgk1) 104937362
NCC: 104955017 104965738(sgk1)
TBEN: 117478021(si:ch211-195b13.1) 117480276(sgk2b) 117492628(sgk1)
CGOB: 115003513(sgk1) 115015956 115021740
PGEO: 117439763(sgk1) 117454924(si:ch211-195b13.1)
GACU: 117553922(sgk2b) 117558085(sgk1) 117559327(si:ch211-195b13.1)
EMAC: 134861693(sgk2b) 134874813(si:ch211-195b13.1) 134876705(sgk1)
ELY: 117263820(si:ch211-195b13.1) 117266180(sgk2b) 117270714(sgk1)
EFO: 125892643(sgk2b) 125896538(sgk1) 125904954(si:ch211-195b13.1)
PLEP: 121945541(sgk2b) 121955154(sgk1) 121957512(si:ch211-195b13.1)
SLUC: 116047187(si:ch211-195b13.1) 116049499(sgk2b) 116066033(sgk1)
ECRA: 117945866(sgk2b) 117956883(si:ch211-195b13.1) 117961438(sgk1)
ESP: 116674520 116702173 116706054(sgk1)
PFLV: 114556999 114567573 114573330(sgk1)
GAT: 120807809(sgk1) 120826054(si:ch211-195b13.1)
PPUG: 119195264(sgk1) 119219595(si:ch211-195b13.1)
AFB: 129097060(si:ch211-195b13.1) 129106837(sgk1) 129109325(sgk2b)
CLUM: 117727084(sgk1) 117738922(si:ch211-195b13.1)
PSWI: 130196062(si:ch211-195b13.1) 130202686(sgk1)
MSAM: 119897652(sgk2b) 119908795(sgk1) 119909745(si:ch211-195b13.1)
SCHU: 122863241(sgk1) 122865010(si:ch211-195b13.1) 122881638(sgk2b)
CUD: 121514278(sgk2b) 121521495 121524097(si:ch211-195b13.1)
ALAT: 119005662(sgk2b) 119012632(sgk1) 119016743(si:ch211-195b13.1)
MZE: 101469250 101475491 101484635(sgk1)
ONL: 100690652 100696638 100698826(sgk1)
OAU: 116309560(sgk1) 116331376(sgk2b) 116333540(si:ch211-195b13.1)
OLA: 101162537 101169880 101173276(sgk1)
OML: 112143993(sgk2b) 112157984(sgk1) 112161612(si:ch211-195b13.1)
CSAI: 133418631(sgk1) 133441004(sgk2b) 133460757 133461363
XMA: 102224351 102230112(sgk1) 102236366
XCO: 114141844 114156054 114158439(sgk1)
XHE: 116716928 116731773 116733841(sgk1)
PRET: 103457665(sgk1) 103473069 103478672
PFOR: 103138668(sgk1) 103140851 103154962
PLAI: 106935479 106945799(sgk1) 106963873
PMEI: 106911072 106926752(sgk1) 106929190
GAF: 122825024(sgk1) 122830830(sgk2b) 122843312(si:ch211-195b13.1)
PPRL: 129351156(sgk1) 129371270(sgk2b) 129375732(si:ch211-195b13.1)
CVG: 107081636 107097378(sgk1) 107102671
CTUL: 119787276(sgk2b) 119788364(sgk1) 119792609(si:ch211-195b13.1)
GMU: 124865951(sgk2b) 124879880(si:ch211-195b13.1) 124882051(sgk1)
NFU: 107372622 107377484(sgk1) 107379638
KMR: 108241115(sgk2b) 108242480(sgk1) 108251730(si:ch211-195b13.1)
ALIM: 106522582 106524886(sgk1) 106529406
NWH: 119410064(sgk2b) 119418529(sgk1) 119425651(si:ch211-195b13.1)
AOCE: 111562467(sgk1) 111562595 111563485
MCEP: 124998970(sgk1) 125016755(sgk2b) 125019992
CSEM: 103388196 103393944 103398704(sgk1)
POV: 109632568(sgk1) 109633033 109642399
SSEN: 122775081(sgk2b) 122784132(sgk1) 122786220(si:ch211-195b13.1)
HHIP: 117757978(sgk1) 117770584(si:ch211-195b13.1) 117776559(sgk2b)
HSP: 118099595(sgk1) 118113768(sgk2b) 118125086(si:ch211-195b13.1)
PPLT: 128449614(sgk2b) 128459925 128461746(si:ch211-195b13.1)
SMAU: 118290214(sgk1) 118292146(si:ch211-195b13.1) 118311122(sgk2b)
LCF: 108889640 108896848 108899469(si:ch211-195b13.1)
SDU: 111230498 111235898(sgk1) 111237181
SLAL: 111650865 111651204(sgk1) 111655039
XGL: 120784699(sgk2b) 120786385(si:ch211-195b13.1) 120789094(sgk1)
HCQ: 109513527 109529014 109531787(sgk1)
SSCV: 125975406 125987351(si:ch211-195b13.1) 125990418
SBIA: 133490834(si:ch211-195b13.1) 133496596 133501198(sgk2b)
PEE: 133395970(si:ch211-195b13.1) 133416757(sgk1)
PTAO: 133468689(sgk1) 133470766(si:ch211-195b13.1)
BPEC: 110153756(sgk1) 110162628 110171528
MALB: 109956374(sgk1) 109958789 109964129
BSPL: 114842425(sgk2b) 114849464(sgk1) 114865228(si:ch211-195b13.1)
SJO: 128365918(sgk2b) 128373764(si:ch211-195b13.1) 128376717(sgk1)
SASA: 106570356(SGK1) 106589037 106591125(SGK1) 106592818 106593510 106593595 106594083
STRU: 115174101 115175621 115187313
OTW: 112229574 112237373(sgk1) 112264320 121846459
OMY: 110488097 110496705 110522663(sgk1) 110529254
OGO: 123990459 123995746(sgk1) 124012717 124028732 124043318(si:ch211-195b13.1)
ONE: 115115172 115131388
OKI: 109903454 109907143 116356201(sgk1)
OKE: 118371394 118373881 118382187 118397995 127931536(sgk1)
SALP: 111955269 111955417
SNH: 120022563 120027205 120030978 120048857
CCLU: 121542333 121542422 121548479 121555444 121571875 121586798
ELS: 105012349 105018004(sgk1) 105018926
SFM: 108921050(sgk1) 108931874 108937441
PKI: 111839665 111841179(sgk1) 111844555
AANG: 118219923(sgk2b) 118229771(sgk1) 118234227(si:ch211-195b13.1)
LOC: 102691934 102695315(sgk1)
PSPA: 121308260(si:ch211-195b13.1) 121315862 121316985
ARUT: 117403374 117411073 117412906 117413751
PSEX: 120517426(si:ch211-195b13.1) 120525443(sgk1)
LCM: 102356269 102364173
CMK: 103179483(si:ch211-195b13.1) 103185144(s-sgk1)
RTP: 109926745 109934538(sgk1)
CPLA: 122547699(sgk1) 122563524(si:ch211-195b13.1)
HOC: 132829853(si:ch211-195b13.1) 132832089(sgk1)
LERI: 129697428(sgk1) 129709895(si:ch211-195b13.1)
PMRN: 116945231 116951040
LRJ: 133347440 133353336
BROR: 134539714
PVM: 113825060
PJA: 122242488
PCHN: 125029038
PMOO: 119574398
HAME: 121878376
PCLA: 123760293
CQD: 128686473
PTRU: 123516862
ESN: 127001271
MNZ: 135212592
HAZT: 108674106
PPOI: 119111029
TUT: 107366196
CVS: 136971791
CEL: CELE_W10G6.2(sgk-1)
CBR: CBG_16386(Cbr-sgk-1)
CRQ: GCK72_023166
NAI: NECAME_00087 NECAME_00088
ADF: 107329566
PSTR: Pst134EA_011875
MLR: MELLADRAFT_90441
RIE: OCT59_015370
TET: TTHERM_001504069 TTHERM_01388160
PTM: GSPATT00001504001 GSPATT00002191001 GSPATT00003883001 GSPATT00015946001
SPAR: SPRG_09607
TVA: TVAG_2v0770340 TVAG_2v1049140
 » show all
Reference
PMID:12649599
  Authors
Verrey F, Loffing J, Zecevic M, Heitzmann D, Staub O
  Title
SGK1: aldosterone-induced relay of Na+ transport regulation in distal kidney nephron cells.
  Journal
Cell Physiol Biochem 13:21-8 (2003)
DOI:10.1159/000070246
Reference
PMID:9114008
  Authors
Waldegger S, Barth P, Raber G, Lang F
  Title
Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.
  Journal
Proc Natl Acad Sci U S A 94:4440-5 (1997)
DOI:10.1073/pnas.94.9.4440
  Sequence
[hsa:6446]
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