KEGG   ORTHOLOGY: K13315
Entry
K13315                      KO                                     
Symbol
eryBII, tylCII, tylC1, calS12, atmS12
Name
NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase [EC:1.1.1.-]
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01250  Biosynthesis of nucleotide sugars
Module
M00798  dTDP-L-mycarose biosynthesis
M00799  dTDP-L-oleandrose biosynthesis
Reaction
R11051  dTDP-4-oxo-2,6-dideoxy-D-allose:NADP+ 3-oxidoreductase
R11474  dTDP-4-oxo-2-deoxy-beta-L-xylose:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K13315  eryBII, tylCII, tylC1, calS12, atmS12; NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase
Other DBs
COG: COG0656 COG0667
Genes
NTP: CRH09_07940
SALB: XNR_0575
SMA: SAVERM_952(aveBVIII)
SVL: Strvi_3808
SRC: M271_06425
SMAL: SMALA_6642 SMALA_7127
SSOI: I1A49_36985 I1A49_39415
SBH: SBI_00412
SALS: SLNWT_7314
SAMB: SAM23877_5605(srm32)
SNR: SNOUR_10085
STRD: NI25_08110
SAUO: BV401_39265
SVU: B1H20_22655
SPUN: BFF78_11185
SALJ: SMD11_1675
SGF: HEP81_07906
SLF: JEQ17_40475
SCAE: IHE65_08955
SANT: QR300_05445
SJN: RI060_04585
SFIY: F0344_35040
SCY: SCATT_p15380
KCH: O1G21_27240
HALT: IM660_06075
AER: AERYTH_15895
NDA: Ndas_4717
NFE: HUT17_04625
NAKE: KGD83_01570
SNAH: OUQ99_30580
AMAZ: LUW76_46725
NOA: BKM31_41575
SEN: SACE_0727(eryBII)
SSYI: EKG83_41970
ACTI: UA75_16850
ACTA: C1701_26010
CROS: N8J89_20435 N8J89_26390
SAQ: Sare_2035
MAU: Micau_0512
MIL: ML5_0703
MICB: MicB006_0526
MTUA: CSH63_22665
MICH: FJK98_02825
MTEM: GCE86_28170
MCAB: HXZ27_02715
MSAG: GCM10017556_30820
MCHL: PVK74_23645
MFEU: H1D33_09350
MPRN: Q3V37_18425
MHAW: RMN56_09020
MCAY: PVK37_08720
MICF: QQG74_14070
AFS: AFR_20845
PLK: CIK06_02735
PLAB: C6361_19570 C6361_20445
PLAT: C6W10_23315 C6W10_29175
PFLA: Pflav_075510
PSUU: Psuf_058590
ATL: Athai_65830
PRY: Prubr_20260
CATI: CS0771_17090
NHY: JQS43_06870 JQS43_23665
SNA: Snas_1656 Snas_3318
AEY: CDG81_13155
AG: AAD41821(tylCII) AAG13914(MegBIIb) AAG13922(MegBIIa) AAM70349(calS12) ABC02798(atmS12)
 » show all
Reference
PMID:10658660
  Authors
Bate N, Butler AR, Smith IP, Cundliffe E
  Title
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin.
  Journal
Microbiology 146 ( Pt 1):139-46 (2000)
DOI:10.1099/00221287-146-1-139
  Sequence
[ag:AAD41821]
Reference
PMID:15984840
  Authors
Takahashi H, Liu YN, Chen H, Liu HW
  Title
Biosynthesis of TDP-l-mycarose: the specificity of a single enzyme governs the outcome of the pathway.
  Journal
J Am Chem Soc 127:9340-1 (2005)
DOI:10.1021/ja051409x
LinkDB

KEGG   REACTION: R11051
Entry
R11051                      Reaction                               
Name
dTDP-4-oxo-2,6-dideoxy-D-allose:NADP+ 3-oxidoreductase
Definition
dTDP-3,4-dioxo-2,6-dideoxy-D-glucose + NADPH + H+ <=> dTDP-4-oxo-2,6-dideoxy-D-allose + NADP+
Equation
C06620 + C00005 + C00080 <=> C11928 + C00006
Reaction class
RC00001  C00005_C00006
RC00897  C06620_C11928
Enzyme
1.1.1.-
Pathway
rn00523  Polyketide sugar unit biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01250  Biosynthesis of nucleotide sugars
Module
M00798  dTDP-L-mycarose biosynthesis
M00799  dTDP-L-oleandrose biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R11051  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose + NADPH + H+ <=> dTDP-4-oxo-2,6-dideoxy-D-allose + NADP+
Orthology
K13315  NDP-hexose C3-ketoreductase / dTDP-4-oxo-2-deoxy-alpha-D-pentos-2-ene 2,3-reductase [EC:1.1.1.-]
LinkDB

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