KEGG   ORTHOLOGY: K13390
Entry
K13390                      KO                                     
Symbol
PSOMT1
Name
(R,S)-reticuline 7-O-methyltransferase [EC:2.1.1.291]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13390  PSOMT1; (R,S)-reticuline 7-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.291  (R,S)-reticuline 7-O-methyltransferase
     K13390  PSOMT1; (R,S)-reticuline 7-O-methyltransferase
Other DBs
RN: R08787 R08788
Genes
MING: 122067164 122088069
PSOM: 113338827
AG: AAQ01668(PSOMT1)
Reference
  Authors
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM
  Title
(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy.
  Journal
Plant J 36:808-19 (2003)
DOI:10.1046/j.1365-313X.2003.01928.x
  Sequence
LinkDB

KEGG   ENZYME: 2.1.1.291
Entry
EC 2.1.1.291                Enzyme                                 
Name
(R,S)-reticuline 7-O-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(R,S)-reticuline 7-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + (S)-reticuline = S-adenosyl-L-homocysteine + (S)-laudanine [RN:R10605];
(2) S-adenosyl-L-methionine + (R)-reticuline = S-adenosyl-L-homocysteine + (R)-laudanine [RN:R10606]
Reaction(KEGG)
R10605 R10606;
(other) R08787 R08788
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-reticuline [CPD:C02105];
(R)-reticuline [CPD:C05178]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
(S)-laudanine [CPD:C20712];
(R)-laudanine [CPD:C09555]
Comment
The enzyme from the plant Papaver somniferum (opium poppy) methylates (S)- and (R)-reticuline with equal efficiency and is involved in the biosynthesis of tetrahydrobenzylisoquinoline alkaloids.
History
EC 2.1.1.291 created 2013
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13390  (R,S)-reticuline 7-O-methyltransferase
Genes
MING122067164 122088069
PSOM113338827
Reference
1  [PMID:14675446]
  Authors
Ounaroon A, Decker G, Schmidt J, Lottspeich F, Kutchan TM
  Title
(R,S)-Reticuline 7-O-methyltransferase and (R,S)-norcoclaurine 6-O-methyltransferase of Papaver somniferum - cDNA cloning and characterization of methyl transfer enzymes of alkaloid biosynthesis in opium poppy.
  Journal
Plant J 36:808-19 (2003)
DOI:10.1046/j.1365-313X.2003.01928.x
  Sequence
Reference
2  [PMID:15353584]
  Authors
Weid M, Ziegler J, Kutchan TM
  Title
The roles of latex and the vascular bundle in morphine biosynthesis in the opium  poppy, Papaver somniferum.
  Journal
Proc Natl Acad Sci U S A 101:13957-62 (2004)
DOI:10.1073/pnas.0405704101
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.291
IUBMB Enzyme Nomenclature: 2.1.1.291
ExPASy - ENZYME nomenclature database: 2.1.1.291
BRENDA, the Enzyme Database: 2.1.1.291
LinkDB

KEGG   REACTION: R08787
Entry
R08787                      Reaction                               
Name
S-adenosyl-L-methionine:(S)-reticuline 7-O-methyltransferase
Definition
(S)-Reticuline + S-Adenosyl-L-methionine <=> Laudanine + S-Adenosyl-L-homocysteine
Equation
Reaction class
RC00003  C00019_C00021
RC00392  C02105_C17592
Enzyme
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K13390  (R,S)-reticuline 7-O-methyltransferase [EC:2.1.1.291]
Other DBs
RHEA: 10447
LinkDB

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