KEGG ORTHOLOGY: K13394

ORTHOLOGY: K13394

Entry

K13394                      KO

Symbol

COR1

Name

codeinone reductase [EC:1.1.1.247]

Pathway

map00950

Isoquinoline alkaloid biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00944

Morphine biosynthesis, (S)-reticuline => morphine

Reaction

R03592

morphine:NAD(P)+ 6-oxidoreductase

R05124

codeine:NADP+ oxidoreductase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13394  COR1; codeinone reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.247  codeinone reductase (NADPH)
     K13394  COR1; codeinone reductase

Other DBs

GO:

0047036

Genes

MING:

122080318

PSOM:

113293958 113294469 113328200 113328201

AG:	AAF13736(COR1)

Reference

PMID:10417697

Authors

Unterlinner B, Lenz R, Kutchan TM

Title

Molecular cloning and functional expression of codeinone reductase: the penultimate enzyme in morphine biosynthesis in the opium poppy Papaver somniferum.

Journal

Plant J 18:465-75 (1999)
DOI:10.1046/j.1365-313X.1999.00470.x

Sequence

[ag:AAF13736]

LinkDB

ENZYME: 1.1.1.247

Entry

EC 1.1.1.247                Enzyme

Name

codeinone reductase (NADPH)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

codeine:NADP+ oxidoreductase

Reaction(IUBMB)

codeine + NADP+ = codeinone + NADPH + H+ [RN:R05124]

Reaction(KEGG)

R05124;
(other) R03592

Substrate

codeine [CPD:C06174];
NADP+ [CPD:C00006]

Product

codeinone [CPD:C06171];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Catalyses the reversible reduction of codeinone to codeine, which is a direct precursor of morphine in the opium poppy plant, Papaver somniferum.

History

EC 1.1.1.247 created 1999, modified 2001

Pathway

ec00950

Isoquinoline alkaloid biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K13394

codeinone reductase

Genes

MING:

122080318

PSOM:

113293958 113294469 113328200 113328201

Reference

Authors

Lenz R, Zenk MH.

Title

Stereoselective reduction of codeinone, the penultimate step during morphine biosynthesis in Papaver somniferum.

Journal

Tetrahedron Lett 36:2449-2452 (1995)

Reference

2 [PMID:7588736]

Authors

Lenz R, Zenk MH.

Title

Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants.

Journal

Eur J Biochem 233:132-9 (1995)
DOI:10.1111/j.1432-1033.1995.132_1.x

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.247

IUBMB Enzyme Nomenclature:

1.1.1.247

ExPASy - ENZYME nomenclature database:

1.1.1.247

BRENDA, the Enzyme Database:

1.1.1.247

CAS:	153302-41-1

LinkDB

REACTION: R03592

Entry

R03592                      Reaction

Name

morphine:NAD(P)+ 6-oxidoreductase

Definition

Morphine + NADP+ <=> Morphinone + NADPH + H+

Equation

C01516 + C00006 <=> C01735 + C00005 + C00080

Comment

NAD+ (see R03591)

Reaction class

RC00001

C00005_C00006

RC00206

C01516_C01735

Enzyme

1.1.1.218 1.1.1.247

Pathway

rn00950

Isoquinoline alkaloid biosynthesis

rn01100

Metabolic pathways

rn01110

Biosynthesis of secondary metabolites

Module

M00944

Morphine biosynthesis, (S)-reticuline => morphine

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.218
     R03592  Morphine + NADP+ <=> Morphinone + NADPH + H+
    1.1.1.247
     R03592  Morphine + NADP+ <=> Morphinone + NADPH + H+

Orthology

K03378

morphine 6-dehydrogenase [EC:1.1.1.218]

K13394

codeinone reductase [EC:1.1.1.247]

Other DBs

RHEA:

14324

LinkDB

DBGET integrated database retrieval system