KEGG   ORTHOLOGY: K13396
Entry
K13396                      KO                                     
Symbol
E2.1.1.122
Name
(S)-tetrahydroprotoberberine N-methyltransferase [EC:2.1.1.122]
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00945  Sanguinarine biosynthesis, (S)-reticuline => sanguinarine
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K13396  E2.1.1.122; (S)-tetrahydroprotoberberine N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.122  (S)-tetrahydroprotoberberine N-methyltransferase
     K13396  E2.1.1.122; (S)-tetrahydroprotoberberine N-methyltransferase
Other DBs
RN: R04691 R08789
GO: 0030782
Genes
PSOM: 113295244 113317972 113320885 113323066
AG: AAY79177
Reference
  Authors
Liscombe DK, Facchini PJ
  Title
Molecular cloning and characterization of tetrahydroprotoberberine cis-N-methyltransferase, an enzyme involved in alkaloid biosynthesis in opium poppy.
  Journal
J Biol Chem 282:14741-51 (2007)
DOI:10.1074/jbc.M611908200
  Sequence
LinkDB

KEGG   ENZYME: 2.1.1.122
Entry
EC 2.1.1.122                Enzyme                                 
Name
(S)-tetrahydroprotoberberine N-methyltransferase;
tetrahydroprotoberberine cis-N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [RN:R04716]
Reaction(KEGG)
R04716;
(other) R04691 R08789
Substrate
S-adenosyl-L-methionine [CPD:C00019];
(S)-7,8,13,14-tetrahydroprotoberberine [CPD:C05204]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine [CPD:C05318]
Comment
Involved in the biosynthesis of isoquinoline alkaloids in plants.
History
EC 2.1.1.122 created 1999
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K13396  (S)-tetrahydroprotoberberine N-methyltransferase
Genes
PSOM113295244 113317972 113320885 113323066
Reference
1
  Authors
Rueffer, M., Zumstein, G., Zenk, M.H.
  Title
Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis.
  Journal
Phytochemistry 29:3727-3733 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.122
IUBMB Enzyme Nomenclature: 2.1.1.122
ExPASy - ENZYME nomenclature database: 2.1.1.122
BRENDA, the Enzyme Database: 2.1.1.122
CAS: 106878-42-6
LinkDB

KEGG   REACTION: R08789
Entry
R08789                      Reaction                               
Name
S-adenosyl-L-methionine:(S)-canadine N-methyltransferase
Definition
S-Adenosyl-L-methionine + (S)-Canadine <=> S-Adenosyl-L-homocysteine + (S)-N-Methylcanadine
Equation
Reaction class
RC00003  C00019_C00021
RC01197  C02915_C03329
Enzyme
Pathway
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00946  Noscapine biosynthesis, (S)-reticuline => noscapine
Orthology
K13396  (S)-tetrahydroprotoberberine N-methyltransferase [EC:2.1.1.122]
LinkDB

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