Entry
Name
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase;
FldA;
cinnamoyl-CoA:phenyllactate CoA-transferase
Class
Transferases;
Transferring sulfur-containing groups;
CoA-transferases
BRITE hierarchy
Sysname
3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase
Reaction(IUBMB)
(1) (E)-cinnamoyl-CoA + (R)-(phenyl)lactate = (E)-cinnamate + (R)-(phenyl)lactoyl-CoA [RN:
R07796 ];
(2) (E)-4-coumaroyl-CoA + (R)-3-(4-hydroxyphenyl)lactate = 4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA [RN:
R12492 ];
(3) 3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = 3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA [RN:
R12493 ]
Reaction(KEGG)
Substrate
(E)-cinnamoyl-CoA [CPD:
C16256 ];
(R)-(phenyl)lactate;
(E)-4-coumaroyl-CoA [CPD:
C00223 ];
(R)-3-(4-hydroxyphenyl)lactate [CPD:
C03964 ];
3-(indol-3-yl)acryloyl-CoA [CPD:
C22207 ];
(R)-3-(indol-3-yl)lactate [CPD:
C22006 ]
Product
(E)-cinnamate [CPD:
C00423 ];
(R)-(phenyl)lactoyl-CoA;
4-coumarate [CPD:
C00811 ];
(R)-3-(4-hydroxyphenyl)lactoyl-CoA [CPD:
C22205 ];
3-(indol-3-yl)acrylate [CPD:
C21283 ];
(R)-3-(indol-3-yl)lactoyl-CoA [CPD:
C22206 ]
Comment
The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It forms a complex with EC
4.2.1.175 , (R)-3-(aryl)lactoyl-CoA dehydratase.
History
EC 2.8.3.17 created 2003, modified 2019
Pathway
ec00960 Tropane, piperidine and pyridine alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K13607 cinnamoyl-CoA:phenyllactate CoA-transferase
Genes
PIV : NCTC13079_00074(frc)
» show all
Taxonomy
Reference
Authors
Dickert S, Pierik AJ, Linder D, Buckel W
Title
The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes.
Journal
Sequence
Reference
Authors
Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL
Title
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.8.3.17
ExPASy - ENZYME nomenclature database: 2.8.3.17
LinkDB
All DBs